Role of T cells in the onset of postherpetic neuralgia.

Research Project

Project/Area Number	19603013
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Pain science
Research Institution	International University of Health and Welfare
Principal Investigator	TAKEDA Masako International University of Health and Welfare, 大学病院, 講師 (50433628)
Co-Investigator(Kenkyū-buntansha)	高崎一朗富山大学, 生命科学先端研究センター, 助教 (00397176)
Co-Investigator(Renkei-kenkyūsha)	TAKASAKI Ichiro (00397176)
Project Period (FY)	2007 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000) Fiscal Year 2009: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000) Fiscal Year 2007: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords	帯状疱疹後神経痛 / HLA遺伝子 / 帯状疱疹痛モデルマウス / T細胞 / 帯状庖疹後神経痛 / MHC遺伝子 / 帯状疱疹後痛モデルマウス / CD4陽性T細胞欠損マウス
Research Abstract	Dorsal Root Ganglion (DRG) in the postherpetic neuralgia model mouse have shown the possibility that CD4 positive T cells are involved in the onset of postherpetic neuralgia. If CD4 positive T cells are involved in the onset of postherpetic neuralgia, CD4 knockout mouse will not develop to postherpetic neuralgia from herpes zoster. But in this study, there were no significant differences between control mouse and CD4 knockout mouse as to the onset of postherpetic neuralgia. Therefore it is suggested that MHC genes (H-2^b) itself are directly involved in the onset of postherpetic neuralgia.