Development of Novel Photosensitizers having Biofunctional Moieties for QOL-oriented Photodynamic Therapy
Project/Area Number |
19614009
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
光生命科学
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Research Institution | Nara Women's University |
Principal Investigator |
OBATA Makoto Nara Women's University, 大学院・人間文化研究科, 助教 (70343267)
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Co-Investigator(Kenkyū-buntansha) |
YANO Shigenobu 京都大学, 産学官連携センター, 寄付研究部門教員 (60011186)
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Project Period (FY) |
2007 – 2008
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Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2008: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2007: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 光生命科学 / 光医療 / 光線力学療法 / 光増感剤 / ペプチド / 活性酸素 / 1,3-双極子付加環化反応 / 一重項酸素 |
Research Abstract |
メソ位にペンタフルオロフェニル基を有するポルフィリン(フッ素ポルフィリン)の高い反応性を利用して生理活性分子を連結した光線力学療法用PDT光増感剤の開発を行った。特にチオレートアニオンによる求核置換反応およびアゾメチンイリドによる1, 3-双極子付加反応を利用して生理活性分子を連結可能な光増感剤の合成法を検討した。また1, 3-双極子付加反応により構造明確なフッ素クロリン金属錯体を合成し、細胞内環境における重原子効果の観測に初めて成功した。
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Report
(3 results)
Research Products
(24 results)
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[Journal Article] In Vitro Heavy-Atom Effect of Palladium(II)and Platinum(II)Complexes of Pyrrolidine-Fused Chlorin in Photodynamic Therapy,2009
Author(s)
Makoto, Obata, Shiho, Hirohara, Rika, Tanaka, Isamu, Kinoshita, Kei, Ohkubo, Shunichi, Fukuzumi, Masao, Tanihara, Shigenobu, Yano
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Journal Title
Related Report
Peer Reviewed
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[Journal Article] Synthesis and Photocytotoxicity of S-Glucosylated 5,10,15,20-Tetrakis(tetrafluorophenyl)porphyrin Metal Complexes as Efficient 1O2-Generating Glycoconjugates2009
Author(s)
Shiho, Hirohara, Makoto, Obata, Hiroki, Alitomo, Kohei, Sharyo, Tsuyoshi, Ando, Shigenobu, Yano, Masao, Tanihara
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Journal Title
Bioconjugate Chem. (in press)
Related Report
Peer Reviewed
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[Journal Article] Structure-Photodynamic Effect Relationships of 24 Glycoconjugated Photosensitizers in HeLa Cells2008
Author(s)
Shiho, Hirohara, Makoto, Obata, Hiroki, Alitomo, Kohei, Sharyo, Shin-ichi, Ogata, Chikara, Ohtsuki, Shigenobu, Yano, Tsuyoshi, Ando, Masao, Tanihara
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Journal Title
Biol. Pharm. Bull. 31
Pages: 2265-2272
NAID
Related Report
Peer Reviewed
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[Journal Article] Sugar-dependent photodynamic effect of glycoconjugated porphyrins : A study on photocytotoxicity, photophysical properties and binding behavior to bovine serum albumin(BSA)2007
Author(s)
Makoto, Obata, Shiho, Hirohara, Kohei, Sharyo, Hiroki, Alitomo, Kazumi, Kajiwara, Shin-ichi, Ogata, Masao, Tanihara, Chikara, Ohtsuki, Shigenobu, Yano
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Journal Title
Biochim. Biophys. Acta 1770
Pages: 1204-1211
Related Report
Peer Reviewed
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[Journal Article] Synthesis and Photophysical Properties of Rhodamine B Dye-bearing Poly(isobutyl methacrylate-co-2,2,2-trifluoroethyl methacrylate) as a Temperature-Sensing Polymer Film"2007
Author(s)
Makoto, Obata, Mako, Morita, Kayoko, Nakase, Kazunori, Mitsuo, Keisuke, Asai, Shiho, Hirohara, Shigenobu, Yano
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Journal Title
J. Polym. Sci. A Chem 45
Pages: 2876-2885
Related Report
Peer Reviewed
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[Journal Article] Optical oxygen-sensing properties of porphyrin derivatives anchored on ordered porous aluminium oxide plates2007
Author(s)
Naoko, Araki, Yutaka, Amao, Takuzo, Funabiki, Masanobu, Kamitakahara, Chikara, Ohtsuki, Kazunori, Mitsuo, Keisuke, Asai, Makoto, Obata, Shigenobu, Yano
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Journal Title
Photochem. Photobiol. Sci. 6
Pages: 794-803
Related Report
Peer Reviewed
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[Presentation] Synthesis of Glycoconjugated Fluorochlorin Derivatives and Their Application for Photodynamic Therapy (PDT)2007
Author(s)
Shiho, Sakuma, Makoto, Obata, Yuji, Mikata, Takuzo, Funabiki, Shigenobu, Yano
Organizer
14th International SPACC-CSJ Synposium
Place of Presentation
National Taiwan University (Taipei, Taiwan)
Year and Date
2007-12-20
Related Report
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[Presentation] Novel Approach for the Synthesis of Fluorochlorin Derivatives by Radical Addition and Their Application for Photodynamic Therapy (PDT)2007
Author(s)
Eiko, Otake, Makoto, Obata, Yuji, Mikata, Takuzo, Funabiki, Shigenobu, Yano
Organizer
14th International SPACC-CSJ Synposium
Place of Presentation
National Taiwan University(Taipei, Taiwan)
Year and Date
2007-12-20
Related Report
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[Presentation] Synthesis, Characterization and In Vitro Photocytotoxicity of Novel Fluorinated Metallochlorins for Photodynamic Therapy Photosensitizers2007
Author(s)
Makoto, Obata, Shiho, Hirohara, Masao, Tanihara, Rika, Tanaka, Isamu, Kinoshita, Kei, Ohkubo, Shunichi, Fukuzumi, Shigenobu, Yano
Organizer
14th International SPACC-CSJ Synposium
Place of Presentation
National Taiwan University (Taipei, Taiwan)
Year and Date
2007-12-20
Related Report
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[Presentation] Synthesis of Polymers having Photosensitizing Moieties for Pressure/Temperature-Sensitive Paint and Photodynamic Therapy2007
Author(s)
Makoto, Obata, Kazunori, Mitsuo, Hiroki, Nagai, Keisuke, Asai, Kazue, Wakashi, Shiho, Hirohara, Masao, Tanihara, Atsushi, Narumi, Toyoji, Kakuchi, Shigenobu, Yano
Organizer
International Symposium on Advanced Macromolecules and Nano-materials with Precisely Designed Architectures
Place of Presentation
Hokkaido University
Year and Date
2007-10-04
Related Report
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