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がん病変組織を画像化して早期発見を普遍化する新規な高性能MRI造影剤の研究開発

Research Project

Project/Area Number 19650112
Research Category

Grant-in-Aid for Exploratory Research

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionShizuoka University

Principal Investigator

山下 光司  静岡大学, 創造科学技術院大学院, 教授 (60110748)

Co-Investigator(Kenkyū-buntansha) 阪原 晴海  浜松医科大学, 医学部, 教授 (10187031)
藤江 三千男  浜松医科大学, 医学部, 技術専門職員 (90397373)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,100,000 (Direct Cost: ¥3,100,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
KeywordsMRI / 血管・がん造影 / 作用機序 / 構造-活性相関 / 物理的性質 / 生体内分子認識 / 緩和率 / 基礎研究
Research Abstract

当該研究の「研究の目的」及び「研究実施計画書」に沿って行った平成19~20年度の研究実績の概要を以下に記す。
糖を外殻に配置した糖デンドリマー型配位子とそのGd錯体の調製方法として次の5つのカテゴリーを組み合わせて、9パターン数十種類の新規なMRI造影剤を調製した。
カテゴリー:(a)鎖式/環式、(b)対称型/非対称型、(c)糖誘導体/非糖誘導体、(d)加水分解経路/非加水分解経路、(e)主鎖置換基/末端置換基
9パターン:(1-1)鎖式/対称/糖/非加水分解/末端、(1-2)鎖式/対称/非糖/非加水分解/末端、(1-3)鎖式/非対称/糖/非加水分解/末端、(1-4)鎖式/非対称/非糖/非加水分解/末端、(2)鎖式/対称/糖/加水分解/末端、(3)環式、(4)その他(主鎖置換、複合機能化、等)
In vitro評価:パターン(2)において縦緩和率(r1)30[s^<-1>・mM^<-1>]、パターン(1-3)においてr1=24[s^<-1>・mM^<-1>]を得た(目標値r1≒35[s^<-1>・mM^<-1>]の達成率70~85%)。また、パターン(1-2)において糖以外の基によるr1増強効果(例えば、フェニル基ではr1=11[s^<-1>・mM^<-1>])を確認した。
In vivo評価:従来品Gd-DTPAと比較して顕著な優位性は次の点であった。(1)血管造影について:パターン(2)では24時間、パターン(1-1)では2時間の十分な造影効果が見られた。(2)がん造影について:パターン(2)では極めて鮮明ながんの造影(濃度1/2)ができた。また、パターン(1-3)では初期がん(1.2mm程度のがん)造影(濃度1/8)に成功した(達成率80%)。
血管貯留性・生体内分子認識:パターン(2)ではin vivo評価により強い生体内分子認識を確認した。パターン(1-1)ではin vitro評価(二次元電気泳動、放射性^<153>Gd錯体)により弱いアルブミン認識を示した。分子設計ソフトもアルブミン-造影剤相互作用を支持した。
安全性試験:3種類のGd錯体に対して毒性の問題はなかった。
当該の基礎研究の達成度は80%程度であった。パターン(1)に対しては糖及びその他の機能性残基との複合化、パターン(2)に対しては造影剤の再現性、等の今後の課題が明らかになった。

Report

(2 results)
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (74 results)

All 2011 2010 2009 2008 2007 Other

All Journal Article (10 results) (of which Peer Reviewed: 10 results) Presentation (52 results) Book (4 results) Remarks (2 results) Patent(Industrial Property Rights) (6 results) (of which Overseas: 1 results)

  • [Journal Article] Development and pharmacologic characterization of deoxybromophospha sugar derivatives with antileukemic activity2009

    • Author(s)
      Satoki Nakamura, Mitsuji Yamashita, Daisuke Yokota, Isao Hirano, Takashi Ono, Michi Fujie, Kiyoshi Shibata, Taishi Niimi, Takuya Suyama, Kasthuraiah Maddali, Akikazu Asai, Junko Yamashita, Yukiko Iguchi, Kazunori Ohnishi
    • Journal Title

      Investigational New Drugs

      Volume: (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A new approach toward light-harvesting reverse micelles from donor-acceptor miscible blends2009

    • Author(s)
      Takahashi, Masaki; Nishizawa, Natsuko; Ohno, Shuhei; Kakita, Masahiro; Fujita, Norifumi; Yamashita, Mitsuji; Sengoksuya; Yoda, Hidemi
    • Journal Title

      Tetrahedron

      Volume: 65(13) Pages: 2669-2677

    • NAID

      120001820436

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of light-harvesting reverse micelles in nanoscopic dimensions2009

    • Author(s)
      Takahashi, Masaki; Ichihashi, Yasunori; Nishizawa, Natsuko; Ohno, Shuhei; Fujit, Norifumi; Yamashita, Mitsuji; Sengoku, Tetsuya; Yoda, Hidemi
    • Journal Title

      J.Photochem.Photobiology, A : Chemistry

      Volume: 203(1) Pages: 56-63

    • NAID

      120001820435

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preparation and characterization of phospholanes and phospha sugars as novel anti-cancer agents2008

    • Author(s)
      Satoru Ito, Mitsuji Yamashita, Taishi Niimi, Michio Fujie, Valluru Krishna Reddy, Hirono Totsuka, Buchammagari Haritha, Maddali Kasthuraiah, Satoki Nakamura, Kazuhide Asai, Takuya Suyama, Junko Yamashita, Yukiko Iguchi, Gang Yu, Tatsuo Oshikawa
    • Journal Title

      Heterocyclic Communications

      Volume: (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A novel phospha sugar analogue : synthesis and evaluation of 2,3-dibromo-3-methyl-1-phenylphospholane 1-oxide having potential anti-prolifer ative effects for human tumors2008

    • Author(s)
      Michio Fujie, Satoki Nakamura, Hidekazu Asai, Junko Yamashita, Keita Kiyofuji, Mitsuji Yamashita
    • Journal Title

      J.Environ.Biology

      Volume: (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of low-temperature surface-wave plasma treatment with various gases on surface modification of chitosan2008

    • Author(s)
      Ogino, Akihisa; Krai, Martin; Yamashita, Mitsuji; Nagatsu, Masaaki
    • Journal Title

      Applied Surface Science

      Volume: 255(5,Pt.1) Pages: 2347-2352

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low-Temperature Nitrogen Introduction onto Polyurethance Surface Using Surface-Wave Excited N_2/H_2 Plasma2007

    • Author(s)
      M.Kral, A.Ogino, K.Narushima, N.Inagaki, M.Yamashita, M.Nagatsu
    • Journal Title

      Japanese Journal of Applied Physics 46(11)

      Pages: 7470-7474

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Studies on preparation and characterization of novel MRI contrast agents for targeting organs and blood vessels2007

    • Author(s)
      Yu Gang, M.Yamashita, K.Aoshima, M.Kobayashi, T.Kato, N.Kamikage, M.Takahashi, H.Takayanagi, T.Oshikawa, Laurent S., Burtea C., Vander Elst L., Muller R.N., Y.Takehara, H.Sakahara
    • Journal Title

      Heterocyclic Communications 13(2-3)

      Pages: 101-108

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A glycosylated complex of gadolinium,a new potential contrast agent for magnetic resonance angiography2007

    • Author(s)
      Yu Gang, M.Yamashita, K.Aoshima, M.Takahashi, T.Oshikawa, H.Takayanagi, Laurent S., Burtea C., Vander Elst L., Muller R.N.
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters 17(8)

      Pages: 2246-2249

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 1,3,8,10-Tetrahydro-2,9-diazadibenzo[cd,lm]perylenes: synthesis of reduced perylene bisimide analogues2007

    • Author(s)
      M.Takahashi, Y.Suzuki, Y.Ichihashi, M.Yamashita, H.Kawai
    • Journal Title

      Science Direct 48

      Pages: 357-359

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 新規リン糖誘導体の合成およびがんに対する生理活性評価2011

    • Author(s)
      浅井一秀、山下光司、新美大志、藤江三千男、陶山拓也、井口由紀子、山下純子、中村悟己
    • Organizer
      第38回複素環化学討論会
    • Place of Presentation
      福山
    • Year and Date
      2011-11-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 糖デンドリマー型MRI造影剤の開発研究2011

    • Author(s)
      山下光司、青木峻、尾崎伸久、杉山雅紀、BITRAGUANTA, Siva Kumaru、ARIGALA, Uma Ravi Sankar、山下純子、藤江三千男、竹原康雄、於剛、阪原晴海
    • Organizer
      日本化学会第89春季年会
    • Place of Presentation
      千葉
    • Year and Date
      2011-03-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] リン糖抗がん剤の開発研究2011

    • Author(s)
      山下純子、山下光司、浅井一秀、山田学、藤江三千男、中村悟己
    • Organizer
      日本化学会第89春季年会
    • Place of Presentation
      千葉
    • Year and Date
      2011-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 含ハロゲン新規リン糖誘導体の合成及び評価2011

    • Author(s)
      蔵下誉、山下光司、新美大志、藤江三千男、山下純子、陶山拓也、浅井一秀、井口由紀子、森雅人、中村悟己
    • Organizer
      日本化学会第89春季年会
    • Place of Presentation
      千葉
    • Year and Date
      2011-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] Studies on Novel MRI Contrast Agents Having a Nano-sized Sugar-ball-dendrimer Flame Work for Imaging Specific Organs, Blood Vessels, and Tumors2011

    • Author(s)
      Siva Kumar Bitragunta, Uma Ravi Sankar Arigala, Takashi Aoki, Masaki Sugiyama, Keisuke Ogawa, Nobuhisa Ozaki, Michio Fujie, Kengo Aoshima, Junko Yamashita, Mitsuji Yamashita, Yasuo Takehara, Harumi Sakahara
    • Organizer
      2^<nd> Nano-Bio Symposium 2009
    • Place of Presentation
      静岡
    • Year and Date
      2011-03-06
    • Related Report
      2008 Annual Research Report
  • [Presentation] がんを安全・高感度で鮮明に画像化できるナノサイズシュガーボールデンドリマー型新規MRI造影剤の開発研究2011

    • Author(s)
      山下光司
    • Organizer
      厚生労働科学研究費研究医療機器開発推進研究ナノメディシン研究成果報告会
    • Place of Presentation
      東京
    • Year and Date
      2011-02-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] がんを安全・高感度で鮮明に画像化できるナノサイズシュガーボールデンドリマー型新規MRI造影剤の開発研究2010

    • Author(s)
      山下光司
    • Organizer
      内閣府:ナノバイオテクノロジー連携群成果報告会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] がん撲滅を目指した医用材料の開発-糖デンドリマー型MRI造影剤及びリン糖抗がん剤の開発研究2010

    • Author(s)
      山下光司
    • Organizer
      日本薬学会東海支部特別講演会
    • Place of Presentation
      静岡
    • Year and Date
      2010-12-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] がんの早期発見・早期治療を目指す医用材料-ブロモ基を環構造に有する含リン複素環化合物あるいはリン糖誘導体の合成と生理活性の評価2010

    • Author(s)
      山下光司、山下純子、藤江三千男、陶山卓也、新美大志、清藤圭太、山田学、中村悟己、竹原康雄、阪原晴海
    • Organizer
      第35回有機典型元素化学討論会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規リン糖誘導体の合成およびがんに対する生理活性評価2010

    • Author(s)
      浅井一秀、山下光司、藤江三千男、中村悟己、陶山拓也、井口由紀子、山下純子
    • Organizer
      第35回有機典型元素化学討論会
    • Place of Presentation
      東京
    • Year and Date
      2010-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] ブロモ基を有する含リン複素環化合物あるいはリン糖誘導体の合成と生理活性2010

    • Author(s)
      山下光司、藤江三千男、浅井一秀、新美大志、マッダリ カスツライアー、陶山拓也、山下純子、井口由紀子、中村悟己
    • Organizer
      第38回複素環化学討論会
    • Place of Presentation
      福山
    • Year and Date
      2010-11-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] 湿潤時潤滑性医用高分子の開発と評価-PVPのPURカテーテルへの固定化-2010

    • Author(s)
      大嶽祐八・山下光司・高橋健・福元美奈子・都筑有香
    • Organizer
      日本バイオマテリアル学会シンポジウム2008
    • Place of Presentation
      東京
    • Year and Date
      2010-11-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 血管内貯留性MRI造影剤の調製と血管及び肝細胞がん等の描出2010

    • Author(s)
      山下光司、竹原康雄
    • Organizer
      メディカルィノベーションフォーラム2008
    • Place of Presentation
      浜松
    • Year and Date
      2010-11-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新規リン糖誘導体の合成およびがんに対する生理活性評価2010

    • Author(s)
      浅井一秀、山下光司、藤江三千男、陶山拓也、井口由紀子、山下純子、中村悟己
    • Organizer
      中部科学関係学協会支部連合秋季大会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-11-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] がんの早期発見・早期治療の為の医用材料開発研究2010

    • Author(s)
      山下光司、青木峻、尾崎伸久・杉山雅紀、山下純子、藤江三千男、竹原康雄、阪原晴海
    • Organizer
      中部科学関係学協会支部連合秋季大会
    • Place of Presentation
      名古屋
    • Year and Date
      2010-11-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] がんの撲滅を目指す医用材料2010

    • Author(s)
      山下光司
    • Organizer
      東海コンファレンス2008in静岡
    • Place of Presentation
      浜松
    • Year and Date
      2010-10-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新しいMR用blood poo1造影剤による肝細胞癌の信号増強効果に関する実験的研究2010

    • Author(s)
      竹原康雄、青木峻、山下光司、藤江三千男、村松克晃、阪原晴海、定藤規弘、竹田浩康
    • Organizer
      第36回日本磁気共鳴医学会大会
    • Place of Presentation
      旭川
    • Year and Date
      2010-09-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] 癌(がん)の早期発見・早期治療のための医用材料のイノベーション2010

    • Author(s)
      山下光司、於剛、BITRAGUNTASIVA KUMAR、UMA RAVI SHANKAR、阪原晴海、間賀田泰寛、竹原康雄、中村悟己、藤江三千男
    • Organizer
      イノベーションジャパン2008
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report
  • [Presentation] がん撲滅を目指した医療材料の開発-がんの早期発見・早期治療のための医療材料のイノベーション2010

    • Author(s)
      山下光司、阪原晴海、竹原康雄、中村悟己、藤江三千男
    • Organizer
      テクノフェスタin浜松
    • Place of Presentation
      浜松
    • Related Report
      2008 Annual Research Report
  • [Presentation] SYNTHESIS AND EVALUATION OF CHEMICALLY-MODIFIED NOVEL MRICONTRAST AGENTS WITH SUGARS2008

    • Author(s)
      Takashi Aoki, Mitsuji Yamashita, Keisuke Ogawa, Nobuhisa Ozaki, Michio Fujie, Masaki Sugiyama, Kengo Aoshima, Sayaka Mizuno, Nao Kamikage, Junko Yamashita, Gang Yu, Vallum Krishna Reddy, Tatsuo Oshikawa, Yasuo Takehara, Harumi Sakahara, Sofie Laurent, Carmen Burtea, L.Vander Elst, Robert N.Muller
    • Organizer
      11^<th> Bratislava Symposium on Sacharides (11BSS)
    • Place of Presentation
      Smolenice Castle, Slovakia
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] SYNTHESIS AND ANTI CANCER BIOACTIVITY EVALUATION OF SOME NOVEL PHOSHA SUGAR DERIVATIVES2008

    • Author(s)
      Kazuhide Asai, Mitsuji Yamashita, Satoru Ito, Michio Fujie, Satoki Nakamura, Takuya Suyama, Yukiko Iguchi, Junko Yamashita
    • Organizer
      11^<th> Bratislava Symposium on Sacharides (11BSS)
    • Place of Presentation
      Smolenice Castle, Slovakia
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Research on Cancer Finding and Chemotherapy at the Early Stage---Syntheses and Evaluations of Novel Sugar-Ball-Dendrimer MRI Contrast Agents and Phospha Sugars by Sugar Modification2008

    • Author(s)
      Mitsuji Yamashita, Takashi Aoki, Satoru Ito, Keisuke Ogawa, Nobuhisa Ozaki, Michio Fujie, Gang Yu, Kengo Aoshima, Masaki Sugiyama, Nao Kamikage, Junko Yamashita, Yasuo Takehara, Harumi Sakahara, Hisao Takayanagi, Tatsuo Oshikawa, Sofie Laurent, Carmen Burtea, L.Vander Elst, Robert N.Muller
    • Organizer
      11^<th> Bratislava Symposium on Sacharides (11BSS)
    • Place of Presentation
      Smolenice Castle, Slovakia
    • Year and Date
      2008-09-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Research on Novel Materials for Cancer Finding and Chemotherapy at the Early Stage---Novel MRI Contrast Agents with Sugar Ball Dendrimer Structures and Novel Ant-tumor Agents with Phospha Sugar or Phosphorus Heterocyclic Structures and Their Evaluation2008

    • Author(s)
      Mitsuji Yamashita, Michio Fujie, Kazuhide Asai, Takuya Suyama, Junko Yamashita, Satoru Ito, Valluru Krishna Reddy, Hirono Totsuka, Junko Yamashita, Keisuke Ogawa, Nobuhisa Ozaki, Satoki Nakamura, Takashi Aoki, Nobuhisa Ozaki, Gang Yu, Kengo Aoshima, Masatsugu Kobayashi, Tatsunori Kato, Nao Kamikage, Yasuo Takehara, Harumi Sakahara, Hisao Takayanagi, Tatsuo Oshikawa, Sofie Laurent, Carmen Burtea, L.Vander Elst, Robert N.Muller
    • Organizer
      Inter-Academia 2008
    • Place of Presentation
      Pecs, Hungary
    • Year and Date
      2008-09-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Preparation and Evaluation of Biocompatible Medical Materials Lubricative Medical Materials Modified by PVP (Poly-VinylPrrolidone)2008

    • Author(s)
      Yuya Otake, Mitsuji Yamashita, Takeshi Takahashi, Satoru Ito, Keita Kiyofuji, Hidetomo Mikami, Tomokazu Ogawa, Minako Fukumoto
    • Organizer
      Inter-Academia 2008
    • Place of Presentation
      Pecs, Hungary
    • Year and Date
      2008-09-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] Preparation and Evaluation of Super-hydrophilic Medical Coating Materials Bearing Phosphate Groups2008

    • Author(s)
      Honami Kashihira, Mitsuji Yamashita, Yugo Kosaka, Masataka Inuzuka, Hiroshi Nakagomi, Soichiro Abe
    • Organizer
      Inter-Academia 2008
    • Place of Presentation
      Pecs, Hungary
    • Year and Date
      2008-09-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Studies on Novel MRI Contrast Agents Having a Sugar-Ball-Dendrimer Flame Work for R & D of Imaging Specific Organs, Blood Vessels, and Tumors2008

    • Author(s)
      Mitsuji Yamashita, Takashi Aoki, Keisuke Ogawa, Nobuhisa Ozaki, Michio Fujie, Krishna Reddy Valluru, Gang Yu, Kengo Aoshima, Masatsugu Kobayashi, Tatsunori Kato, Nao Kamikage, Junko Yamashita, Yasuo Takehara, Harumi Sakahara, Hisao Takayanagi, Tatsuo Oshikawa, Sofie Laurent, Carmen Burtea, L.Vander Elst, Robert N.Muller
    • Organizer
      24^<th> International Carbohydrate Symposium (ICS) (ICS2008)
    • Place of Presentation
      Oslo, Norway
    • Year and Date
      2008-07-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Medical Materials for Ultra Earlier Finding and Curing Cancers ; Syntheses and Evaluation of Anhydro- and Deoxybromo-phospha Sugars or Epoxy- and Bromo-Phospholanes for Leukemia Cells2008

    • Author(s)
      Junko Yamashita, Mitsuji YamashitaMichio Fujie, Taishi Niimi, Kazuhide Asai, Takuya Suyama, Hirono Totsuka, Valluru Krihna Reddy, Satoru Ito, Satoki Nakamura
    • Organizer
      24^<th> International Carbohydrate Symposium (ICS) (ICS2008)
    • Place of Presentation
      Oslo, Norway
    • Year and Date
      2008-07-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] Construction of DDS of Gd-DTPA Complex with Sugar Ball Dendrimer for Drawing Blood Vessels and Tumors by MRI2008

    • Author(s)
      Mitsuji Yamashita, Takashi Aoki, Keisuke Ogawa, Nobuyuki Ozaki, Michio Fujie, Junko Yamashita, Kengo Aoshima, Nao Kamikage, Gang Yu, Tatsuo Oshikawa, Yasuo Takehara, Harumi Sakahara, Sophie Laurent, Carmen Burtea, L.Vander Elst, Robert N.Muller
    • Organizer
      International Conference on Organo Metalic Chemistry (ICOMC) 2008
    • Place of Presentation
      Rennes, France
    • Year and Date
      2008-07-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] RESEARCH ON CANCER FINDING AND CHEMOTHERAPY AT THE EARLY STAGE---EPOXIDATION AND BROMINATION OF 2-PHOSPHOLENES FOR PREPARATION OF PHOSPHA SUGARS AND THEIR BIOLOGICAL ACTIVITY2008

    • Author(s)
      Mitsuji Yamashita, Michio Fujie, Taishi Niimi, Takuya Suyama, Kazuhide Asai, Satoru Ito, Valluru Krishna Reddy, Hirono Totsuka, Junko Yamashita, Keisuke Ogawa, Nobuhisa Ozaki, Satoki Nakamura
    • Organizer
      XV International Conference on Chemistry of Phosphorus Compounds (ICCPC-XV)
    • Place of Presentation
      Saint-Petersburg, Russia
    • Year and Date
      2008-05-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 組織認識部位として糖鎖を導入した新規MRI造影剤の合成と評価2008

    • Author(s)
      尾崎 伸久
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      立教大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新規なリン糖あるいはボスホラン類の置換フェニル誘導体の合成およびそれらの生理活性に関する研究2008

    • Author(s)
      浅井 一秀
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      立教大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] 湿潤時潤滑性医用高分子材料の開発2008

    • Author(s)
      大嶽 祐八
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      立教大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] リン酸基を導入した超親水性医用コート材料の作製と評価2008

    • Author(s)
      樫平 帆波
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      立教大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] 糖によりGd-DTPAを化学修飾した新規MRI造影剤の合成と評価2008

    • Author(s)
      杉山 雅紀
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      立教大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] がんを早期発見・早期治療するMRI造影剤およびC-P結合を持っリン糖・複素環化合物の開発とin vitroおよびin vivo評価2007

    • Author(s)
      浅井 一秀
    • Organizer
      第1回リン化合物討論会(第28回C-P化合物研究会)
    • Place of Presentation
      京大会館
    • Year and Date
      2007-12-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] Highly stereoselective and stereospecific epoxidation of 2-phospholenes and N-glycosides of phospha sugars and their bioassays2007

    • Author(s)
      M.Yamashita
    • Organizer
      17th International Conference on Phosphorus Chemistry
    • Place of Presentation
      Xiamen,China
    • Related Report
      2007 Annual Research Report
  • [Presentation] Preparation of 2,3-bromides and 2,3-epoxides of phospholanes as analogues of phospha sugars and their important biological activities2007

    • Author(s)
      M.Yamashita
    • Organizer
      21st International Congress for Heterocyclic Chemistry
    • Place of Presentation
      Sydney,Australia
    • Related Report
      2007 Annual Research Report
  • [Presentation] Highly stereoselective and stereosoecific epoxidation of 2-phospholenes to prepare bioactive phospha sugars and their N-Glycosides2007

    • Author(s)
      M.Yamashita
    • Organizer
      14th European Carbohydrate Symposium
    • Place of Presentation
      Luebeck,Germany
    • Related Report
      2007 Annual Research Report
  • [Presentation] Studies on novel contrast agents for specific organs,blood vessels,andtumors2007

    • Author(s)
      K.Ogawa
    • Organizer
      4th European Carbohydrate Symposium
    • Place of Presentation
      Luebeck,Germany
    • Related Report
      2007 Annual Research Report
  • [Presentation] Preparation and Characterization of Phospholenes and Phospha Sugarsas Novel Anti-cancer Agents2007

    • Author(s)
      M.Yamashita
    • Organizer
      5th Inter-academia 2007
    • Place of Presentation
      Hamamatsu,Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] Biocompatible medical materials: Preparation of lubricative medical materials modified by PVP (Poly-Vinyl Pyrolidone)2007

    • Author(s)
      Y.Otake
    • Organizer
      5th Inter-academia 2007
    • Place of Presentation
      Hamamatsu,Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] Synthesis and evaluation of novel Gd-DTPA-Sugar compounds as MRIcontrast agents2007

    • Author(s)
      N.Ozaki
    • Organizer
      5th Inter-academia 2007
    • Place of Presentation
      Hamamatsu,Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] Preparation and evaluation of super-hydrophilic coating materials bearing phosphate groups22007

    • Author(s)
      H.Kashihira
    • Organizer
      5th Inter-academia 2007
    • Place of Presentation
      Hamamatsu,Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] Research on Novel Sugar Dendrtic MRI Contrast Agents for Cancer and Phospha Sugar Anti-cancer Material2007

    • Author(s)
      M.Yamashita, J.Yamashita
    • Organizer
      4th Tumor Progression & Therapeutic Resistance Conference
    • Place of Presentation
      Philadelphia,PA.U.S.A.
    • Related Report
      2007 Annual Research Report
  • [Presentation] エポキシあるいはプロモ基を有する含リン複素環化合物あるいはリン糖誘導体の合成と生理活性2007

    • Author(s)
      山下 光司
    • Organizer
      第37回複素環化学討論会
    • Place of Presentation
      長野市若里市民文化ホール
    • Related Report
      2007 Annual Research Report
  • [Presentation] プロモ基を有する含リン複素環化合物あるいはリン糖誘導体の化学合成と生理活性評価2007

    • Author(s)
      陶山 拓也
    • Organizer
      第37回複素環化学討論会
    • Place of Presentation
      長野市若里市民文化ホール
    • Related Report
      2007 Annual Research Report
  • [Presentation] リン糖誘導体におけるリン上フェニル基の置換反応およびそれらの誘導体の生理活性に関する研究2007

    • Author(s)
      浅井 一秀
    • Organizer
      第37回複素環化学討論会
    • Place of Presentation
      長野市若里市民文化ホール
    • Related Report
      2007 Annual Research Report
  • [Presentation] Gd-DTPAを糖で化学修飾した新規MRI造影剤の合成及び評価2007

    • Author(s)
      青木 峻
    • Organizer
      第38回中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      三重大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新規リン糖誘導体の合成と生理活性の研究2007

    • Author(s)
      陶山 拓也
    • Organizer
      第38回中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      三重大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] 医療材料へのガラス基板に対する表面改質2007

    • Author(s)
      中込 裕
    • Organizer
      第38回中部化学関係学協会支部連合秋季大会
    • Place of Presentation
      三重大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] がんの早期発見・早期治療を目指す医療材料-エポキシあるいはプロモ基を有する含リン複素環化合物あるいはリン糖誘導体の合成と生理活性2007

    • Author(s)
      山下 光司
    • Organizer
      第34回有機典型元素化学討論会
    • Place of Presentation
      大阪大学
    • Related Report
      2007 Annual Research Report
  • [Presentation] Gd-DTPAを糖で化学修飾した新規MRI造影剤の合成及び評価2007

    • Author(s)
      青木 峻
    • Organizer
      日本化学会第88春季年会
    • Place of Presentation
      立教大学
    • Related Report
      2007 Annual Research Report
  • [Book] Topics in Heterocyclic Chemistry-Bioactive Heterocycles II "Preparation, Structure, and Biological Properties of Phosphorus Heterocycles with a C-P Ring System2008

    • Author(s)
      Mitsuji Yamashita
    • Publisher
      Springer
    • Related Report
      2008 Annual Research Report
  • [Book] "Preparation, Structure, and Biological Property of Phosphorus Heterocycles with a C-P ring System", in Top Heterocyclic Chemistry Series Vol.82007

    • Author(s)
      M.Yamashita
    • Publisher
      Springer
    • Related Report
      2007 Annual Research Report
  • [Book] "Product class 2:0, P-and S, P-acetals", Science of Synthesis, Houben-Weyl2007

    • Author(s)
      M.Yamashita
    • Publisher
      Georg Thieme Verlag
    • Related Report
      2007 Annual Research Report
  • [Book] "Product class 7:N, P-and P, P-acetals", Science of Synthesis, Houben-Weyl2007

    • Author(s)
      M.Yamashita
    • Publisher
      Georg Thieme Verlag
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.jpc.shizuoka.ac.jp/~tcmyama/index.html

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.ipc.shizuoka.ac.jp/~tcmyama/index.html

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 親水性多孔質粒状基材およびその製造方法、該親水性多孔質粒状基材を有する親水性コート剤2008

    • Inventor(s)
      山下光司、樫平帆波
    • Industrial Property Rights Holder
      静岡TLO
    • Industrial Property Number
      2008-235423
    • Filing Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] ガドリニウム化合物及びMRI用造影剤2008

    • Inventor(s)
      三浦 紀生 山下 光司 尾崎 信久 阪原 晴海 竹原 康雄 藤江 三千男
    • Industrial Property Rights Holder
      コニカミノルタ静岡大学浜松医大
    • Industrial Property Number
      2008-038115
    • Filing Date
      2008-02-20
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] ガドリニウム錯体の製造方法2008

    • Inventor(s)
      三浦 紀生 山下 光司 小川 圭介 阪原 晴海 竹原 康雄 藤江 三千男
    • Industrial Property Rights Holder
      コニカミノルタ静岡大学浜松医大
    • Industrial Property Number
      2008-038116
    • Filing Date
      2008-02-20
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 医療用具の製造方法2008

    • Inventor(s)
      山下 光司 大嶽 祐八 高橋 健
    • Industrial Property Rights Holder
      静岡大学クリニカルセプライ
    • Industrial Property Number
      2008-060265
    • Filing Date
      2008-03-10
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] 含リン化合物及び抗腫瘍剤2007

    • Inventor(s)
      山下 光司 藤江 三千男 中村 悟己
    • Industrial Property Rights Holder
      静岡大学 藤江 三千男 中村 悟己
    • Industrial Property Number
      2007-035083
    • Filing Date
      2007-04-09
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] ガドリニウム化合物及びMRI用造影剤2007

    • Inventor(s)
      三浦 紀生 山下 光司
    • Industrial Property Rights Holder
      コニカミノルタ静岡大学
    • Filing Date
      2007-09-20
    • Related Report
      2007 Annual Research Report
    • Overseas

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Published: 2007-04-01   Modified: 2016-04-21  

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