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炎症性破骨細胞の同定とその特異的プロテアーゼに着目した骨破壊防御法の開発

Research Project

Project/Area Number 19659099
Research Category

Grant-in-Aid for Challenging Exploratory Research

Allocation TypeSingle-year Grants
Research Field Experimental pathology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

高柳 広 (2008-2009)  Tokyo Medical and Dental University, 医歯学総合研究科, 教授 (20334229)

朝霧 成挙 (2007)  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, COE拠点形成特任講師 (20372435)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥3,200,000 (Direct Cost: ¥3,200,000)
Fiscal Year 2009: ¥900,000 (Direct Cost: ¥900,000)
Fiscal Year 2008: ¥1,400,000 (Direct Cost: ¥1,400,000)
Fiscal Year 2007: ¥900,000 (Direct Cost: ¥900,000)
Keywords自己免疫 / 関節リウマチ / カテプシン / Toll-like receptor(TLR) / プロテアーゼ / 樹状細胞 / Th17細胞 / IκBζ / 自然免疫 / Toll-like receptor (TLR) / サイトカイン
Research Abstract

1.LPS刺激により炎症性破骨細胞(iOC)においてIκBζの発現誘導が認められたため、レトロウイルスベクターを用いたRNAi法や過剰発現系を用いて、破骨細胞におけるIκBζの機能解析を行った。2.炎症性骨破壊ではTh17細胞が破骨細胞誘導性T細胞として機能する。そこでTh17細胞におけるIκBζの役割についても検討したところ、Th17細胞分化に伴いIκBζの発現が誘導されることを見出した。IκBζ欠損マウス由来のT細胞では、Th17細胞分化に障害が認められ、今後IκBζを標的としたTh17細胞制御が炎症性骨破壊治療に有効であることを明らかにし、これを報告した(11.研究発表の岡本一男らによる研究成果)。3.樹状細胞でのTLR9シグナルに対するカテプシンK阻害剤の作用機序について検討した。TLR9下流のERK、NF-κB、IRFの活性化は全てカテプシンK阻害剤によって抑えられた。一方、二重標識したTLR9を用いた蛍光共鳴エネルギー転移解析から、CpG刺激によるTLR9の立体構造変化はカテプシンK阻害剤による影響を受けないことが分かり、カテプシンK阻害剤はTLR9下流直下の活性化機序に作用することが示された。4.カテプシンK阻害剤と異なり、アポトーシスを引き起こす効果を持つビスフォスフォネート製剤はiOCに対して抑制効果が低い。iOCを用いた遺伝子発現プロファイルから、抗アポトーシス分子・Bcl-2の高発現がiOCのアポトーシス抵抗性獲得の原因であることが示唆された。このようなiOCの特性を考慮に入れた治療法が炎症性骨破壊治療に必要であることを明らかにした。

Report

(3 results)
  • 2009 Annual Research Report
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (124 results)

All 2010 2009 2008 2007 Other

All Journal Article (44 results) (of which Peer Reviewed: 15 results) Presentation (73 results) Book (2 results) Remarks (3 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Roles of IL-6 and PTHrP in osteoclast formation associated with oral cancers : The significance of IL-6 synthesized by stromal cells in response to cancer cells.2010

    • Author(s)
      栢森高
    • Journal Title

      American Journal of Pathology 176

      Pages: 968-80

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The unexpected link between osteoclasts and the immune system2010

    • Author(s)
      高柳広
    • Journal Title

      Advances in Experimental Medicine and Biology(Review) 658

      Pages: 61-68

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Blimp1-mediated repression of negative regulators is required for osteoclast differentiation.2010

    • Author(s)
      西川恵三
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America 16

      Pages: 3117-3122

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ly49Q, an ITIM-bearing NK receptor, positively regulates osteoclast differentiation2010

    • Author(s)
      林幹人
    • Journal Title

      Biochemical and Biophysical Research Communications 393

      Pages: 432-438

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IκBζ regulates T_H17 development by cooperating with ROR nuclear receptors2010

    • Author(s)
      岡本一男
    • Journal Title

      Nature 464

      Pages: 1381-1385

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteoclasts and the immune systems2009

    • Author(s)
      中島友紀
    • Journal Title

      Journal of Bone and Mineral Metabolism(Review) 27

      Pages: 519-529

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Osteoimmunology : crosstalk between the immune and bone systems2009

    • Author(s)
      中島友紀
    • Journal Title

      Journal of Clinical Immunology(Review) 29

      Pages: 555-567

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Rheumatoid arthritis associated with osteopetrosis2009

    • Author(s)
      門野夕峰
    • Journal Title

      Modern Rheumatology 19

      Pages: 687-90

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NFATc1 Mediates Toll-Like Receptor-Independent Innate Immune Responses during Trypanosoma cruzi Indection2009

    • Author(s)
      香山尚子
    • Journal Title

      PLoS Pathogens 5

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mysteries in Ca^<2+> Signaling During Osteoclast Differentiation2009

    • Author(s)
      古賀貴子
    • Journal Title

      IBMS BoneKEy

      Pages: 301-306

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Interferon Regulatory Factor-8 Regulates Bone Metabolism by Suppressing Osteoclastogenesis.2009

    • Author(s)
      Baohong Zhao
    • Journal Title

      Nature Medicine 15

      Pages: 1066-1071

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ca^<2+>-NFATc1 signaling is an essential axis of osteoclast differentiation2009

    • Author(s)
      古賀貴子
    • Journal Title

      Immunological Reviews(Review) 231

      Pages: 241-256

    • Related Report
      2009 Annual Research Report
  • [Journal Article] The interactions and shared mechanisms of T cells and osteoclasts2009

    • Author(s)
      Hans-Juergen Gober
    • Journal Title

      Inflammation and Regeneration(Review) 29

      Pages: 239-248

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Osteoimmunology and the effects of the immune system on bone2009

    • Author(s)
      高柳広
    • Journal Title

      Nature Reviews Rheumatology(Review) 5

      Pages: 667-76

    • Related Report
      2009 Annual Research Report
  • [Journal Article] A unique domain in RANK is required for Gab2 and PLCgamma2 bindiine to establish osteoclastogenic signals2009

    • Author(s)
      田口祐
    • Journal Title

      Genes to Cells 14

      Pages: 1331-1345

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 破骨細胞分化を司る免疫制御分子ネットワーク2009

    • Author(s)
      篠原正浩
    • Journal Title

      実験医学 27

      Pages: 852-859

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 概論 骨と免疫の不可分な関係に立脚した新たな生体理解2009

    • Author(s)
      高柳広
    • Journal Title

      実験医学 27

      Pages: 846-851

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 骨免疫学のアップデート-臨床への展開-2009

    • Author(s)
      高柳広
    • Journal Title

      日本臨床 67

      Pages: 1031-1037

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 破骨細胞分化決定の分子メカニズムと骨免疫学2009

    • Author(s)
      高柳広
    • Journal Title

      臨床血液 50

      Pages: 447-452

    • NAID

      10024960212

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 骨破壊制御の新たなアプローチ2009

    • Author(s)
      中島友紀
    • Journal Title

      医薬ジャーナル社 45

      Pages: 87-92

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 自己免疫性関節炎とカテプシンKの関連を探る2009

    • Author(s)
      岡本一男
    • Journal Title

      分子リウマチ治療 2

      Pages: 13-18

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Overview-Osteoimmunology-2009

    • Author(s)
      高柳広
    • Journal Title

      THE BONE 23

      Pages: 25-29

    • Related Report
      2009 Annual Research Report
  • [Journal Article] 特集 骨・軟骨疾患の分子医学(3)Osteoimmunologyの現状と展望2009

    • Author(s)
      高柳広
    • Journal Title

      Bio Clinica 25

      Pages: 25-31

    • Related Report
      2009 Annual Research Report
  • [Journal Article] Inhibitorjr immuno globulin-like receptors LILRB and PIR-B negativelv regulate osteoclast development.2008

    • Author(s)
      Mori, Y., et al.
    • Journal Title

      J Immunol 181

      Pages: 4742-4751

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The tumor necrosis factor family receptors RANK and CD40 cooperatively establish the thymic medullary microenvironment and self-tolerance.2008

    • Author(s)
      Akiyama, T., et al.
    • Journal Title

      Immunity 29

      Pages: 438-450

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The cytokine RANKL produced by positively selected thymocytes fosters medullary thymic epithelial cells that express autoimmune regulator.2008

    • Author(s)
      Hikosaka. Y., et al.
    • Journal Title

      Immunity 29

      Pages: 438-450

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tyrosine kinases Btk and Tec regulate osteoclast differentiationby linking RANK and ITAM signals.2008

    • Author(s)
      Shinohara, M., et al.
    • Journal Title

      Cell 132

      Pages: 794-806

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cathepsin K-dependent toll-like receptor 9 signaling revealed in experimental arthritis.2008

    • Author(s)
      Asagiri, M., et al.
    • Journal Title

      Science 319

      Pages: 624-627

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The dynamic interplay between osteoclasts and the immune system.2008

    • Author(s)
      Nakashima, T., et al.
    • Journal Title

      Arch Biochem Biophys (Highlight Issue : Bone Remodeling) 473

      Pages: 166-171

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自己免疫疾患にかかわるcathepsin Kの新たな役割2008

    • Author(s)
      岡本一男, 他
    • Journal Title

      実験医学 26

      Pages: 182-187

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 破骨細胞分化制御と骨免疫学2008

    • Author(s)
      高柳広
    • Journal Title

      最新医学 63

      Pages: 2176-2181

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 自己免疫性炎症におけるカテプシンKとToll-like receptor9の役割2008

    • Author(s)
      國上敏浩, 他
    • Journal Title

      内分泌・糖尿病科 27

      Pages: 264-269

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 骨免疫学研究の歴史とup to date2008

    • Author(s)
      古賀貴子, 他
    • Journal Title

      リウマチ科 40

      Pages: 105-111

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 破骨細胞分化シグナルと骨免疫学(第18回婦人科骨粗程症研究会、特別講演I)2008

    • Author(s)
      高柳広
    • Journal Title

      Osteoporosis Japan 16

      Pages: 446-455

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 炎症性骨破壊におけるThl7細胞の役割-Th17細胞による破骨細胞制御のメカニズム2008

    • Author(s)
      岡本一男, 他
    • Journal Title

      医学のあゆみ 226

      Pages: 291-294

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 関節破壊のメカニズム2008

    • Author(s)
      高柳広
    • Journal Title

      整形外科 59

      Pages: 850-854

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 骨免疫学の最先端2008

    • Author(s)
      中島友紀, 他
    • Journal Title

      Mebio 25

      Pages: 24-35

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 免疫と骨 : 骨免疫学Osteoimmunologyの幕開け2008

    • Author(s)
      林幹人, 他
    • Journal Title

      臨床検査 52

      Pages: 556-560

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 骨免疫学2008

    • Author(s)
      高柳広
    • Journal Title

      The BONE 22

      Pages: 57-61

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 破骨細胞形成のメカニズムー新たな骨破壊疾患治療法の可能性2008

    • Author(s)
      篠原正浩, 他
    • Journal Title

      DENTAL DIAMOND 33

      Pages: 68-71

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Osteoimmunologyと破骨細胞2008

    • Author(s)
      高柳広
    • Journal Title

      医学部のあゆみ 別冊 骨粗鬆症-臨床と研究の最新動向

      Pages: 37-45

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 関節リウマチ骨破壊のメカニズムと骨免疫学(第8回日本リウマチ財団中国・四国リウマチ外科セミナー記録集)2008

    • Author(s)
      高柳広
    • Journal Title

      Pharia Medica 26

      Pages: 27-31

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Cathepsin K-Dependent Toll-like Receptor 9 Signaling Revealed in Experimental Arthritis2008

    • Author(s)
      Asagiri, M., Hirai, T., Kunigami, T., Kamano, S., Gober, HJ., Okamoto, K., Nishikawa, K., Latz, E., Golenbock, DT., Aoki, K., Ohya, K., Imai, Y., Morishita, Y., Miyazono, K., Kato, S., Saftig, P., Takayanagi, H.
    • Journal Title

      Science 319

      Pages: 624-627

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NFAT機能の骨免疫学的考察2007

    • Author(s)
      朝霧成挙, 高柳広
    • Journal Title

      骨・関節・靱帯 20

      Pages: 781-788

    • Related Report
      2007 Annual Research Report
  • [Presentation] Mechanism of osteoclast differentiation2010

    • Author(s)
      高柳広
    • Organizer
      14th International Congress of Endocrinology ICE2010JES-Sponsored Symposia、第83回日本内分泌学会学術総会
    • Place of Presentation
      京都
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] Osteoimmunology2010

    • Author(s)
      高柳広
    • Organizer
      第30回東北免疫研究会 特別講演
    • Place of Presentation
      宮城
    • Year and Date
      2010-03-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨免疫学とオステオネットワーク2010

    • Author(s)
      高柳広
    • Organizer
      第9回日本再生医療学会総会 ランチョンセミナー
    • Place of Presentation
      広島
    • Year and Date
      2010-03-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 作用機序「カテプシンKとTLR9シグナル活性化」2010

    • Author(s)
      高柳広
    • Organizer
      NC-2300基礎研究会
    • Place of Presentation
      東京
    • Year and Date
      2010-03-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] Different Ca^<2+> sensitivity of the development of T-lineage cells.2010

    • Author(s)
      Oh-hora, M., 高柳広, Rao, A.
    • Organizer
      Keystone Symposia(poster)
    • Place of Presentation
      Colorado U.S.A.
    • Year and Date
      2010-02-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨代謝と免疫学の接点2010

    • Author(s)
      高柳広
    • Organizer
      第52回分子生命科学セミナー
    • Place of Presentation
      佐賀
    • Year and Date
      2010-02-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] 破骨細胞分化における正と負のシグナルのバランス維持機構2010

    • Author(s)
      高柳広
    • Organizer
      松本歯科大学 大学院セミナー
    • Place of Presentation
      長野
    • Year and Date
      2010-02-12
    • Related Report
      2009 Annual Research Report
  • [Presentation] リウマチにおける新たなサイトカインについて2009

    • Author(s)
      高柳広
    • Organizer
      第32回日本分子生物学会 リウマチサイトカイン研究会
    • Place of Presentation
      横浜
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] Bone destruction in arthritis and osteoimmunology2009

    • Author(s)
      高柳広
    • Organizer
      Rheumatology Association, R.O.C.(Taiwan)
    • Place of Presentation
      Yilan, Taiwan
    • Year and Date
      2009-12-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Osteoimmunologyの最先端2009

    • Author(s)
      高柳広
    • Organizer
      第37回日本臨床免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2009-11-14
    • Related Report
      2009 Annual Research Report
  • [Presentation] RANK Ligand and Osteoimmunology2009

    • Author(s)
      高柳広
    • Organizer
      第26回内藤コンファレンス
    • Place of Presentation
      淡路
    • Year and Date
      2009-11-07
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identification of novel genes regulated by NFATc1 in osteoclastogenesis2009

    • Author(s)
      中島友紀、林幹人、高柳広
    • Organizer
      第26回内藤コンファレンス(ポスター)
    • Place of Presentation
      淡路
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Molecular Mechanisms of Monocyte Lineage Commitment and Function2009

    • Author(s)
      高柳広
    • Organizer
      ACR/ARHP Scientific Meeting
    • Place of Presentation
      Philadelphia, U.S.A.
    • Year and Date
      2009-10-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 関節リウマチにおける骨破壊とRANKL2009

    • Author(s)
      高柳広
    • Organizer
      第34回東京都リウマチ膠原病懇話会
    • Place of Presentation
      東京
    • Year and Date
      2009-10-03
    • Related Report
      2009 Annual Research Report
  • [Presentation] Beckman Research Institute of the City of Hope, Division of Hematopietic Stem Cell and Leukemia Research2009

    • Author(s)
      高柳広
    • Organizer
      Osteoimmunology-interaction between bone and the immune system
    • Place of Presentation
      Los Angeles, U.S.A.
    • Year and Date
      2009-09-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] Fcγ Receptors Control Bone Homeostasis by Regulating Costimulation Signals in Osteoclast Lineage Cells2009

    • Author(s)
      Hans-Jurgen Gober、古賀貴子、高柳広
    • Organizer
      第27回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 破骨細胞と骨免疫学2009

    • Author(s)
      高柳広
    • Organizer
      第27回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] New immune regulator of bone2009

    • Author(s)
      高柳広
    • Organizer
      The Bone & Teeth Gordon Research Conference
    • Place of Presentation
      Maine, U.S.A.
    • Year and Date
      2009-07-15
    • Related Report
      2009 Annual Research Report
  • [Presentation] Anti-Osteoclast Therapy for Bone Destruction in Inflammation2009

    • Author(s)
      高柳広
    • Organizer
      The 9^<th> World Congress on Inflammation
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-07-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] TNF-α and Bone Destruction in Arthritis-from the Viewpoint of Basic Research-2009

    • Author(s)
      高柳広
    • Organizer
      The 9^<th> World Congress on Inflammation
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-07-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Immune Regulation of Osteoclastogenesis2009

    • Author(s)
      高柳広
    • Organizer
      The 3^<rd> Global COE International Symposium, Tokyo Medical and Dental University
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-06-10
    • Related Report
      2009 Annual Research Report
  • [Presentation] 関節リウマチの骨破壊とIL-62009

    • Author(s)
      高柳広
    • Organizer
      第82回日本整形外科学会学術集会
    • Place of Presentation
      福岡
    • Year and Date
      2009-05-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] RANKL Signaling and Osteoimmunology2009

    • Author(s)
      高柳広
    • Organizer
      The 66^<th> KSBMB Annual Meeting, World Trade Center
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2009-05-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] New Immune Connections During Osteoclatogenesis2009

    • Author(s)
      高柳広
    • Organizer
      The 3^<rd> New York Skeletal Biology and Medicine Conference, Mount Sinai School of Medicine
    • Place of Presentation
      New York, U.S.A.
    • Year and Date
      2009-04-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] 関節リウマチ骨破壊への新たなアプローチ2009

    • Author(s)
      高柳広
    • Organizer
      第53回日本リウマチ学会総会・学術集会、第18回国際リウマチシンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2009-04-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 関節リウマチ骨破壊と骨免疫学2009

    • Author(s)
      高柳広
    • Organizer
      第37回九州リウマチ学会イブニングセミナー
    • Place of Presentation
      長崎
    • Year and Date
      2009-03-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] 関節リウマチ骨破壊と骨免疫学2009

    • Author(s)
      高柳広
    • Organizer
      兵庫県リウマチ医の会
    • Place of Presentation
      兵庫
    • Year and Date
      2009-03-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Osteoimmunology-Interact ions and shared mechanisms between theimmune system and bone.2009

    • Author(s)
      Takayanagi, H.
    • Organizer
      The Annual Symposium of IFReC (Immunology Frontier Research Center), Osaka University
    • Place of Presentation
      Osaka
    • Year and Date
      2009-02-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 炎症性骨破壊と骨免疫学2009

    • Author(s)
      高柳広
    • Organizer
      第32回皮膚脈管膠原病研究会
    • Place of Presentation
      京都
    • Year and Date
      2009-01-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 関節リウマチの骨破壊と骨免疫学2009

    • Author(s)
      高柳広
    • Organizer
      山口県整形外科医会
    • Place of Presentation
      山口
    • Year and Date
      2009-01-17
    • Related Report
      2008 Annual Research Report
  • [Presentation] 運動器疾患の分子ネットワークの解明と治療応用2009

    • Author(s)
      高柳広
    • Organizer
      ゲノムネットワークプロジェクト公開シンポジウム「ゲノムネットワークが拓く新しい医学・生物学」
    • Place of Presentation
      東京
    • Year and Date
      2009-01-16
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨免疫学研究の現状・課題・展望2009

    • Author(s)
      高柳広
    • Organizer
      第29回コスモ・バイオ バイオプロダクトセミナー
    • Place of Presentation
      東京、大阪
    • Related Report
      2009 Annual Research Report
  • [Presentation] 加齢に伴い発現変動する転写因子Mafの細胞分化に及ぼす影響2008

    • Author(s)
      西川恵三, 他
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Tecファミy ーチロシンキナーゼによる破骨細胞分化制御2008

    • Author(s)
      古賀貴子, 他
    • Organizer
      第31回日本分子生物学会年会・第81回日本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] ERK2と相互作用するタンパク質の探索2008

    • Author(s)
      春宮覚, 他
    • Organizer
      第31回日本分子生物学会年会・第81回目本生化学会大会合同大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-12-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecular lechanisi in osteoclastogenesis2008

    • Author(s)
      Takayanagi, H.
    • Organizer
      JSPS Core-to-Core Program International Workshop on Advanced Bone and Joint Science (ABJS)
    • Place of Presentation
      Tokyo
    • Year and Date
      2008-12-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] 関節リウマチ骨破壊と骨免疫学2008

    • Author(s)
      高柳広
    • Organizer
      病態代謝血管医学セミナー
    • Place of Presentation
      熊本
    • Year and Date
      2008-11-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Bone and Immune System2008

    • Author(s)
      Takayanagi, H.
    • Organizer
      Annual Meeting of Korean Endocrine Society
    • Place of Presentation
      Jeju, Korea
    • Year and Date
      2008-11-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] 『骨免疫学の最前線」破骨細胞の新たな制御メカニズム2008

    • Author(s)
      高柳広
    • Organizer
      第26回目本骨代謝学会学術集会ランチョンセミナー
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] RANKLと骨免疫学2008

    • Author(s)
      高柳広
    • Organizer
      第26回目本骨代謝学会学術集会イブニングセミナー
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] 加齢に伴う骨量減少の原因となる転写メカニズムの探索2008

    • Author(s)
      西川恵三, 他
    • Organizer
      第26回目本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] Thl7 Cytokines and their Effects2008

    • Author(s)
      Takayanagi, H.
    • Organizer
      2008 ACR Basic Research conference
    • Place of Presentation
      San Francisco
    • Year and Date
      2008-10-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] カテプシンKはT01l-like receptor 9シグナルを介して自己免疫性炎症を制御する2008

    • Author(s)
      國上敏浩, 他
    • Organizer
      第36回日本臨床免疫学会総会
    • Place of Presentation
      東京
    • Year and Date
      2008-10-18
    • Related Report
      2008 Annual Research Report
  • [Presentation] Molecular determinant in osteoclast differentiation2008

    • Author(s)
      高柳広
    • Organizer
      第70回日本血液学会総会
    • Place of Presentation
      京都
    • Year and Date
      2008-10-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 炎症性骨破壊と骨免疫学2008

    • Author(s)
      高柳広
    • Organizer
      第3回大阪皮膚アンチエイジング研究会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] The crucial role of RANKL in bone loss and canser metastasis.2008

    • Author(s)
      Nakashima T., et al.
    • Organizer
      The 13th Asia Pacific League of Associations for Rheumatology Congress
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Tec kinases form an osteoclastogenic signaling complex with SLPadaptor proteins2008

    • Author(s)
      Koga T., et al.
    • Organizer
      The 13th Asia Pacific League of Associations for Rheumatology Congress
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Therapeutic potential of Tec kinase inhibi tors on bone destruction2008

    • Author(s)
      Arai K., et al.
    • Organizer
      The 13th Asia Pacific League of Associations for Rheumatology Congress
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Tyrosine kinases Btk and Tec are essential for osteoclastdifferentiation2008

    • Author(s)
      Shinohara M., et al.
    • Organizer
      The 13th Asia Pacific League of Associations for Rheumatology Congress
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] A Novel Role of Cathepsin K In Autoimmunity : Regulation ofToll-Like Receptor 9 signal ing in Dendri tic Cells2008

    • Author(s)
      Okamoto M., et al.
    • Organizer
      The 13th Asia Pacific League of Associations for Rheumatology Congress
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] NFATcl-dependent program of osteoclast differentiation andfunction.2008

    • Author(s)
      Hayashi M., et al.
    • Organizer
      The 13th Asia Pacific League of Associations for Rheumatology Congress
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of combined use of anti-rheumatic drugs on osteoclastdifferentiation.2008

    • Author(s)
      Suematsu A., et al.
    • Organizer
      The 13th Asia Pacific League of Associations for Rheumatology Congress
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-24
    • Related Report
      2008 Annual Research Report
  • [Presentation] Osteoclasts in Arthritis and Osteoimmunology2008

    • Author(s)
      Takayanagi, H.
    • Organizer
      The 13^<th> Asia Pacific League ofAssociations for Rheumatology Congress
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] Use of mouse genetics in bone biology and osteoimmunology.2008

    • Author(s)
      Takayanagi, H.
    • Organizer
      EMBO Practice Course on "Anatomy and Embryology of the Mouse"
    • Place of Presentation
      Zagreb, Croatia
    • Year and Date
      2008-09-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 新たな破骨細胞制御メカニズム2008

    • Author(s)
      高柳広
    • Organizer
      第28回骨形態計測学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] 関節リウマチ骨破壊と骨免疫学2008

    • Author(s)
      高柳広
    • Organizer
      東京骨関節フォーラム
    • Place of Presentation
      東京
    • Year and Date
      2008-07-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 免疫不全と骨代謝-Tecファミリーチロシンキナーゼによる破骨細胞分化制御-2008

    • Author(s)
      篠原正浩, 他
    • Organizer
      第2 9回日本炎症・再生医学会
    • Place of Presentation
      東京
    • Year and Date
      2008-07-10
    • Related Report
      2008 Annual Research Report
  • [Presentation] 関節リウマチ骨破壊と骨免疫2008

    • Author(s)
      高柳広
    • Organizer
      免疫シンフォニー
    • Place of Presentation
      大阪
    • Year and Date
      2008-06-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 関節リウマチ骨破壊と骨免疫学2008

    • Author(s)
      高柳広
    • Organizer
      城北関節炎・ RA ・ OA ・ AS談話会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] The role of Tec family kinases in osteoclast different iation2008

    • Author(s)
      Shinohara M., Gt al.
    • Organizer
      2nd International Conference on Osteoimmunology : Interactions of the Immune and Skeletal Systems
    • Place of Presentation
      Rhodos, Greece
    • Year and Date
      2008-06-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cathepsin K regulated TH17 cell polarization through toll-likereceptor 9 signal ing in dendritic cells2008

    • Author(s)
      Gober H. J., et al.
    • Organizer
      2nd International Conference on Osteoimmunology : Interactions of the Immune and Skeletal Systems
    • Place of Presentation
      Rhodos, Greece
    • Year and Date
      2008-06-13
    • Related Report
      2008 Annual Research Report
  • [Presentation] Unexpected link between osteoclast and the immune system2008

    • Author(s)
      Takayanagi, H.
    • Organizer
      2nd International Conference on Osteoimmunology : Inter act ions of the Immune and Skeletal Systems
    • Place of Presentation
      Rhodos, Greece
    • Year and Date
      2008-06-11
    • Related Report
      2008 Annual Research Report
  • [Presentation]2008

    • Author(s)
      高柳広
    • Organizer
      第86回膠原病研究会
    • Place of Presentation
      新潟
    • Year and Date
      2008-06-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] 関節リウマチ骨破壊と骨免疫学2008

    • Author(s)
      高柳広
    • Organizer
      埼玉医大整形同門会
    • Place of Presentation
      東京
    • Year and Date
      2008-05-31
    • Related Report
      2008 Annual Research Report
  • [Presentation] 関節リウマチの骨破壊と骨免疫学2008

    • Author(s)
      高柳広
    • Organizer
      第81回日本整形外科学会教育研修講演
    • Place of Presentation
      札幌
    • Year and Date
      2008-05-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] Tecファミリーキナーゼによる破骨細胞分化制御機構(The role of Tec family kinases in osteoclast differentiation)2008

    • Author(s)
      篠原正浩, 他
    • Organizer
      第52回日本リウマチ学会総会・学術集会ワークショップ32「骨代謝と骨粗鬆症」
    • Place of Presentation
      札幌
    • Year and Date
      2008-04-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] 破骨細胞の新たな制御メカニズム2008

    • Author(s)
      高柳広
    • Organizer
      第52回目本リウマチ学会総会・学術集会シンポジウム「関節リウマチ病態解明のトピックス」
    • Place of Presentation
      札幌
    • Year and Date
      2008-04-23
    • Related Report
      2008 Annual Research Report
  • [Presentation] カテプシンKはToll様受容体9シグナルを介して自己免疫性炎症疾患の重症度を決定する2008

    • Author(s)
      朝霧成挙, 他
    • Organizer
      第52回目本リウマチ学会総会・学術集会ワークショップ9「関節リウマチの病因・病態1」
    • Place of Presentation
      札幌
    • Year and Date
      2008-04-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] サイトカインと骨破壊2008

    • Author(s)
      高柳広
    • Organizer
      第52回日本リウマチ学会総会・学術集会イブニングセミナー
    • Place of Presentation
      札幌
    • Year and Date
      2008-04-22
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨溶解酵素カテプシンKはTLR9信号を制御して 自己免疫性炎症疾患の重症度を決定する2008

    • Author(s)
      朝霧成挙
    • Organizer
      第2回 Bone Research Seminar
    • Place of Presentation
      丸ビル(東京)
    • Year and Date
      2008-02-29
    • Related Report
      2007 Annual Research Report
  • [Presentation] Osteoclast-Independent Function of Cathepsin K : Regulation ofToll-like Receptor 9 Signaling in Autoimmunity.2008

    • Author(s)
      Okamoto, K., et al.
    • Organizer
      The 30th Annual Meeting of the AmericanSociety for Bone and Mineral Research.
    • Place of Presentation
      Montreal. Canada
    • Related Report
      2008 Annual Research Report
  • [Presentation] Tec Rinases, Therapeutic Targets for Bone Destructive Diseases.2008

    • Author(s)
      Shinohara M., et al.
    • Organizer
      The 30th Annual Meeting of the AmericanSociety for Bone and Mineral Research.
    • Place of Presentation
      Montreal, Canada
    • Related Report
      2008 Annual Research Report
  • [Presentation] Targeting Cathepsin K in autoimmune arthritis reveals its function in dendritic cells2007

    • Author(s)
      ASAGIRI Masataka, HIRAI Toshitake, KUNIGAMI Toshihiro, KAMANO Shunya, GOBER Hans-Juergen, OKAMOTO Kazuo, NISHIKAWA Keizo, MORISHITA Yasuyuki, TAKAYANAGI Hiroshi
    • Organizer
      第36回日本免疫学会総会・学術集会
    • Place of Presentation
      品川プリンスホテル(東京)
    • Year and Date
      2007-11-22
    • Related Report
      2007 Annual Research Report
  • [Book] 9 : Cytokine and Growth Factor Regulation of Osteoclastogenesis2009

    • Author(s)
      高柳広
    • Total Pages
      13
    • Publisher
      Cold Spring Harbor Laboratory Press The Skeletal System
    • Related Report
      2009 Annual Research Report
  • [Book] 炎症・再生医学事典 5.骨・関節-b.破骨細胞2009

    • Author(s)
      高柳広
    • Total Pages
      4
    • Publisher
      朝倉書店
    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://osteoimmunology.com/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://osteoimmunology.com/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://osteoimmunology.com/

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] カテプシン阻害剤を有効成分として含有するToll様受容体のシグナル伝達の調整剤2008

    • Inventor(s)
      高柳広、朝霧成挙、平井利武、
    • Industrial Property Rights Holder
      国立大学法人東京医科歯科大学、日本ケミファ株式会社
    • Filing Date
      2008-10-24
    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] カテプシン阻害剤を有効成分として含有するTo11様受容体のシグナル伝達の調整剤2007

    • Inventor(s)
      高柳広, 朝霧成挙, 平井利武
    • Industrial Property Rights Holder
      国立大学法人 東京医科歯科大学, 日本ケミフア株式会
    • Filing Date
      2007
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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