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水素ガス吸引による虚血再潅流障害の軽減

Research Project

Project/Area Number 19659331
Research Category

Grant-in-Aid for Exploratory Research

Allocation TypeSingle-year Grants
Research Field General surgery
Research InstitutionNippon Medical School

Principal Investigator

太田 成男  Nippon Medical School, 大学院・医学研究科, 教授 (00125832)

Co-Investigator(Kenkyū-buntansha) 大澤 郁朗  日本医科大学, 老人病研究所, 講師 (30343586)
Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,300,000 (Direct Cost: ¥3,300,000)
Fiscal Year 2008: ¥1,300,000 (Direct Cost: ¥1,300,000)
Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywords水素ガス / 活性酸素 / 酸化ストレス / ミトコンドリア / 虚血再灌流
Research Abstract

組織が虚血再灌流(I/R)に曝露されると、再灌流の早期段階でROSが大規模に生成され、肝、脳、心臓および腎など様々な臓器の組織に深刻な障害を引き起こす。これまで酸化ストレスによる1/R傷害は基礎研究および臨床研究の重要な焦点とされてきた。
I/R誘発性臓器障害の考えられる基礎的な機序は、多くの因子が関与し、相互依存的であり、低酸素症、炎症反応およびフリーラジカル障害に関与している。I/R傷害の病因は未だ解明されていないが、酸素フリーラジカルが重要な役割を担っていることは明らかである。それゆえI/R傷害への臨床的対応としては、フリーラジカル・スカベンジャーが実用的であると考えられている。実際に、これまでにもnicaraven, MCL-186,MESNA,およびαトコフェロールとGdCl_3などの多くの薬剤が、I/R傷害を予防するためのスカベンジャーとして試みられてきた。
私たちは、2007年に水素分子がラットの中脳動脈閉塞モデルを用いた研究で、水素分子が治療的抗酸化活性を呈することを報告した。また、昨年は、肝臓の虚血再灌流障害が、水素ガス吸引によって軽減されること、ヘリウムでは効果がなかったことを示した。虚血再灌流障害で、最も患者が多く、適用可能性が高いのは心筋梗塞であると予測されるので、心筋の虚血再灌流障害に対する水素ガスの吸引効果をラットモデルを用いて調べた。
結果は、水素ガスを吸引させると虚血状態でも心臓内に水素が浸透しることが確認できた。また、心筋梗塞モデルラットで水素ガスを吸引させることで、梗塞層が小さくなり、心機能の低下も抑制された。分離した心臓を用いても虚血再灌流障害を水素は抑制することが明らかとなった。

Report

(2 results)
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (24 results)

All 2009 2008 2007 Other

All Journal Article (13 results) (of which Peer Reviewed: 13 results) Presentation (8 results) Book (1 results) Remarks (2 results)

  • [Journal Article] Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease.2009

    • Author(s)
      Fu Y, et al.
    • Journal Title

      Neurosci. Letters (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug cisplatin without compromising anti-tumor activity in mice.2009

    • Author(s)
      Nakashima-Kamimura N, et al.
    • Journal Title

      Cancer Chemother Phrmacol. (in press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Consumption of molecular hydrogen prevents the stress-induced impairments in hippocampus-dependent learning tasks during chronic physical restraint in mice.2009

    • Author(s)
      Nagata K, et al.
    • Journal Title

      Neuropsychopharmacology 34

      Pages: 501-508

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Consumption of hydrogen water prevents atherosclerosis in apolipoprotein E knockout mice.2008

    • Author(s)
      Ohsawa I, et al.
    • Journal Title

      Biochem. Biophys. Res. Commun. 377

      Pages: 1195-1198

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogen therapy reduces apoptosis in neonatal hypoxia-ischemia ratmodel.2008

    • Author(s)
      Cai J, et al.
    • Journal Title

      Neurosci Lett. 441

      Pages: 167-172

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhalation of hydrogen gas reduces infarct size in the rat model of myocardial ischemia-reperfusion injury.2008

    • Author(s)
      Hayashida K., et al.
    • Journal Title

      Biochem Biophys Res Commun. 373

      Pages: 30-35

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoprotective role of mitochondrial amyloid beta peptide-binding alcohol dehydrogenase against a cytotoxic aldehyde.2008

    • Author(s)
      Murakami Y, Ohsawa I, Kasahara T., Ohta S
    • Journal Title

      Neurobiol Aging 83(In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals.2007

    • Author(s)
      Ohsawa, I., Ishikawa, M., Takahashi, K., Watanabe, M., Nishimaki, K., Yamagata, K., Katsura, K. -L, Katayama, Y., Asoh, S. Ohta, S.
    • Journal Title

      Nat. Med. 13

      Pages: 688-694

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhalation of hydrogen gas suppresses hepatic injury caused by ischemia/reperfusion through reducing oxidative stress.2007

    • Author(s)
      Fukuda, KI., Asoh, S., Ishikawa, M., Yamamoto, Y., Ohta, S
    • Journal Title

      Biochem. Biophys. Res. Commun. 361

      Pages: 670-674

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transduction of anti-cell death protein FNK protects isolated rat hearts from myocardial infarction induced by ischemia/reperfusion.2007

    • Author(s)
      Arakawa, M., Yasutake, M., Asoh, S., Miyamoto, M., Takano, T., Ohta, S.
    • Journal Title

      Life Sci. 80

      Pages: 2076-2084

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Protein Derived From the Fusion of TAT Peptide and FNK, aBcl-X_L Derivative, prevents Cochlear Hair Cell Death From Aminoglycoside Ototoxicity In Vivo2007

    • Author(s)
      Kashio, A., Sakamoto, T., Suzukawa, K., Asoh, S., Ohta, S., Yamasoba, T.
    • Journal Title

      J Neurosci Res. 85

      Pages: 1403-1412

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevention of Chemotherapy-Induced Alopecia by anti-death FNK protein.2007

    • Author(s)
      Nakashima-Kamimura, N. Nishimaki, K., Mori, T., Asoh, S., Ohta S.
    • Journal Title

      Life Sci. 82

      Pages: 218-225

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anti-apoptotic PTD-FNK protein suppresses lipopolysaccharide-induced acute lung injury in rats Experimental and Molecular Pathology2007

    • Author(s)
      Chen H, Zhang L, Jin Z, Jin E, Fujiwara M, Ghazizadeh M, Asoh S, Ohta S, Kawanami O
    • Journal Title

      Exp. Mol. Pathol 83

      Pages: 377-384

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 水素水の基礎と臨床応用の可能性.2009

    • Author(s)
      太田成男
    • Organizer
      日本抗加齢学会
    • Place of Presentation
      東京
    • Year and Date
      2009-01-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] Hydrogen acts as a therapeutic and preventive antioxidant.2008

    • Author(s)
      Ohta, S.
    • Organizer
      The_seventh European Meeting on Mitochondrial Pathology
    • Place of Presentation
      Stockholm Sweden
    • Related Report
      2008 Annual Research Report
  • [Presentation] 水素の抗酸化治療への適応と将来展望・・水素ガスおよび水素水の広がる期待2007

    • Author(s)
      太田 成男
    • Organizer
      日本機能水学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-11-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] The role of mitochondrial amyloid beta peptide-binding alcohol dehydrogenease(ABAD)in detoxification of toxic aldehydes in Alzheimer's disease2007

    • Author(s)
      Ohsawa Ikuroh
    • Organizer
      8th Asia/Oceana regional congress of gerontology and geriatrics
    • Place of Presentation
      Beijing, China
    • Year and Date
      2007-11-20
    • Related Report
      2007 Annual Research Report
  • [Presentation] 抗酸化療法:水素は細胞障害性酸化ラジカルを選択的に還元することで治療に有効な抗酸化剤として作用する。2007

    • Author(s)
      太田 成男
    • Organizer
      世界アンチエイジング日本会議
    • Place of Presentation
      東京
    • Year and Date
      2007-06-16
    • Related Report
      2007 Annual Research Report
  • [Presentation] An Efficient Antioxidant by Molecular Hydrogen as a Novel Concept.2007

    • Author(s)
      Shigeo Ohta
    • Organizer
      15th Annual world congress on anti-aging medicine & regenerative biomedical technogies
    • Place of Presentation
      USA Las Vegas
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新しい抗酸化治療法:細胞傷害性酸素ラジカルの水素による選択的還元。2007

    • Author(s)
      大澤 郁朗
    • Organizer
      第30回日本分子生物学会第80回日本生化学会合同大会
    • Place of Presentation
      横浜
    • Related Report
      2007 Annual Research Report
  • [Presentation] Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals in the nervous system2007

    • Author(s)
      Ohsawa Ikuroh
    • Organizer
      IPA 2007 Osaka Siler Congress
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report
  • [Book] ミトコンドリアのちから2007

    • Author(s)
      瀬名秀明・太田成男
    • Total Pages
      423
    • Publisher
      新潮社
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.ig.nms.ac.jp/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.nms.ac.jp/ig/biocell/

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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