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Development of a Hemolysis Simulator based on the Deformation Analysis of individual Red Blood Cells

Research Project

Project/Area Number 19680024
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Biomedical engineering/Biological material science
Research InstitutionOsaka University

Principal Investigator

NAKAMURA Masanori  Osaka University, 臨床医工学融合研究教育センター, 特任准教授(常勤) (20448046)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥25,610,000 (Direct Cost: ¥19,700,000、Indirect Cost: ¥5,910,000)
Fiscal Year 2009: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2008: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2007: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Keywords赤血球 / 溶血 / 計算力学 / 数値流体力学 / メゾスコピック解析
Research Abstract

Studies have been conducted for the aim of developing a hemolysis simulator based on the deformation analysis of a single red blood cell (RBC). The dynamic motion of an RBC in a flow field is calculated based on the minimum energy principle. The results for simple steady and unsteady shear flows well agreed with experimental results, corroborating the proposed RBC model. We then simulated RBC in bifurcated flows where a RBC was experimentally observed to lyse upon impingement against the apex of bifurcation. A careful investigation of the RBC deformation revealed buckling of the membrane upon collision against the wall. It was found that the area strain reached 1.81 at maximum, larger than the reported value at which a pore is formed in the lipid bilayer membrane. Those results suggested the possibility of estimating hemolysis by evaluating the area strain. In conclusion, the results address the necessity to consider deformation of RBCs for better evaluation of hemolysis and this model would be useful to build the RBC-based hemolysis simulator.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (35 results)

All 2010 2009 2008 2007 Other

All Journal Article (2 results) (of which Peer Reviewed: 1 results) Presentation (31 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Simulation of erythrocyte deformation in a high shear flow.2009

    • Author(s)
      Masanori Nakamura, Sadao Bessho, Shigeo Wada
    • Journal Title

      Conf Proc IEEE Eng Med Biol Soc. 2009

      Pages: 2358-2361

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 溶血シミュレータ構築に向けた赤血球変形挙動の数値解析と可視化2009

    • Author(s)
      中村匡徳, 別所貞雄, 和田成生
    • Journal Title

      可視化情報 29,114

      Pages: 27-32

    • NAID

      10025308328

    • Related Report
      2009 Final Research Report
  • [Presentation] 流動する赤血球の変形解析と面積ひずみに基づく溶血予測2010

    • Author(s)
      別所貞雄, 中村匡徳, 越山顕一朗, 和田成生
    • Organizer
      第85期定時総会講演会
    • Place of Presentation
      兵庫
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 溶血シミュレータ構築に向けた分岐管路内を流れる赤血球の変形解析2010

    • Author(s)
      中村匡徳, 別所貞雄, 和田成生
    • Organizer
      第22回バイオエンジアリング講演会
    • Place of Presentation
      岡山
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 赤血球変形能が微小循環血流に与える影響2009

    • Author(s)
      田中雄大, 別所貞雄, 中村匡徳, 宮崎浩, 越山顕一朗, 和田成生
    • Organizer
      関西学生会学生員卒業研究発表講演会
    • Place of Presentation
      大阪
    • Year and Date
      2009-03-15
    • Related Report
      2009 Final Research Report
  • [Presentation] Computational modeling of a red blood cell towards the development of hemolysis simulator2009

    • Author(s)
      Masanori Nakamura
    • Organizer
      Modeling and Simulation of Complex Systems
    • Place of Presentation
      Tokyo
    • Year and Date
      2009-02-18
    • Related Report
      2009 Final Research Report
  • [Presentation] Computational analysis on the deformation of a red blood cell in a branched pipe2009

    • Author(s)
      Sadao Bessho, Masanori Nakamura, Shigeo Wada
    • Organizer
      3rd East Asian Pacific Student Workshop on nano-Biomedical Engineering
    • Place of Presentation
      Singapore
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 壁に向かって高速流動する赤血球の変形解析2009

    • Author(s)
      別所貞雄, 中村匡徳, 和田成生
    • Organizer
      第20回バイオフロンティア講演会
    • Place of Presentation
      和歌山
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Multi-scale modeling of blood flow for the analysis of red blood cell behaviors in a micro-circulation2009

    • Author(s)
      Masanori Nakamura
    • Organizer
      XXXVI International Congress of Physiological Sciences
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Analysis of red blood cell deformation for the development of hemolysis simulator2009

    • Author(s)
      Masanori Nakamura, Sadao Bessho, Shigeo Wada
    • Organizer
      XXII Congress International Society of Biomechanics
    • Place of Presentation
      Cape Town
    • Related Report
      2009 Final Research Report
  • [Presentation] 溶血シミュレータ構築に向けた赤血球流動および変形解析2009

    • Author(s)
      中村匡徳, 別所貞雄, 田中雄大, 和田成生
    • Organizer
      第48回日本生体医工学会大会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] 個々の赤血球挙動に着目した溶血シミュレータ構築に向けて2009

    • Author(s)
      中村匡徳
    • Organizer
      日本機械学会第21回バイオエンジニアリング講演会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 流動する赤血球の変形解析とそれに基づく容血指標の提案2009

    • Author(s)
      別所貞雄, 中村匡徳, 和田成生
    • Organizer
      第21回バイオエンジニアリング講演会
    • Place of Presentation
      札幌
    • Related Report
      2009 Final Research Report
  • [Presentation] Simulation of erythrocyte deformation in a high shear flow2009

    • Author(s)
      Masanori Nakamura, Sadao Bessho, Shigeo Wada
    • Organizer
      31^<st> Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Minneapolis Minnesota, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Analysis of red blood cell deformation for the development of hemolysis simulator2009

    • Author(s)
      Masanori Nakamura, Sadao Bessho, Shigeo Wada
    • Organizer
      XXII Congress International Society of Biomechanics
    • Place of Presentation
      Cape Town, South Africa
    • Related Report
      2009 Annual Research Report
  • [Presentation] 溶血シミュレータ構築に向けた赤血球流動および変形解析"2009

    • Author(s)
      中村匡徳, 別所貞雄, 田中雄大, 和田成生
    • Organizer
      第48回日本生体医工学会大会
    • Place of Presentation
      東京
    • Related Report
      2009 Annual Research Report
  • [Presentation] 流動する赤血球の変形解析とそれに基づく溶血指標の提案2009

    • Author(s)
      別所貞雄, 中村匡徳, 和田成生
    • Organizer
      日本機械学会第21回バイオエンジニアリング講演会
    • Place of Presentation
      札幌
    • Related Report
      2008 Annual Research Report
  • [Presentation] 流動する赤血球変形挙動の数値解析~個々の赤血球変形を考慮した溶血シミュレータ構築へ向けた取り組み~2008

    • Author(s)
      中村匡徳
    • Organizer
      日本機械学会関西支部第9回秋季技術交流フォーラム
    • Place of Presentation
      京都
    • Year and Date
      2008-10-11
    • Related Report
      2009 Final Research Report
  • [Presentation] 流動する赤血球変形挙動の数値解析〜個々の赤血球変形を考慮した溶血シミュレータ構築へ向けた取り組み〜2008

    • Author(s)
      中村匡徳
    • Organizer
      日本機械学会関西支部第9回秋季技術交流フォーラム
    • Place of Presentation
      京都
    • Year and Date
      2008-10-11
    • Related Report
      2008 Annual Research Report
  • [Presentation] Red Blood Cell Behavior in an Intra-Ventricular Flow2008

    • Author(s)
      Masanori Nakamura, Sadao Bessho, Shigeo Wada
    • Organizer
      Workshop on Multi-scale Modelling of the Heart
    • Place of Presentation
      Auckland, New Zealand
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] 定常・非定常せん断流における赤血球の変形動態の数値解析2008

    • Author(s)
      別所貞雄, 中村匡徳, 宮崎浩, 越山顕一朗, 和田成生
    • Organizer
      関西学生会平成19年度学生員卒業研究発表会
    • Place of Presentation
      大阪
    • Year and Date
      2008-03-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 定常・非定常平行流における赤血球の変形動態の解析2008

    • Author(s)
      別所貞雄, 中村匡徳, 和田成生
    • Organizer
      第20回 バイオエンジニアリング講演会
    • Place of Presentation
      東京
    • Year and Date
      2008-01-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] Multi-scale modeling of blood flow for the establishment of hemolysis simulator on the basis of the deformation analysis of an individual red blood cell2008

    • Author(s)
      Masanori Nakamura
    • Organizer
      The 3rd ME International Symposium, Physiome and Systems Biology for Integrated Life Sciences and Predictive Medicine
    • Place of Presentation
      San Francisco, CA, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] 流動する赤血球の変形動態の解析~変形量と既存の溶血指標との関係~2008

    • Author(s)
      中村匡徳, 別所貞雄, 和田成生
    • Organizer
      第21回計算力学講演会
    • Place of Presentation
      沖縄
    • Related Report
      2009 Final Research Report
  • [Presentation] Red blood cell deformation behavior in a high-shear flow2008

    • Author(s)
      Masanori Nakamura, Sadao Bessho, Shigeo Wada
    • Organizer
      International Congress of Theoretical and Applied Mechanics
    • Place of Presentation
      Adelaide, Australia
    • Related Report
      2009 Final Research Report
  • [Presentation] Dynamic deformation analysis of a red blood cell in a steady and unsteady shear flow2008

    • Author(s)
      Sadao Bessho, Masanori Nakamura, Kenichiro Koshiyama, Shigeo Wada
    • Organizer
      ASME 2008 Summer Bioengineering Conference
    • Place of Presentation
      Marco island, FL, USA
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] Red blood cell behavior in an intra-ventricular flow2008

    • Author(s)
      Masanori Nakamura, Sadao Bessho, Shigeo Wada
    • Organizer
      Workshop on Multi-scale Modelling of the Heart
    • Place of Presentation
      Auckland, New
    • Related Report
      2009 Final Research Report
  • [Presentation] 定常・非定常平行流における赤血球の変形動態の解析2008

    • Author(s)
      別所貞雄, 中村匡徳, 和田成生
    • Organizer
      第20回バイオエンジニアリング講演会
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] Multi-scale Modeling of Blood Flow for the Establishment of Hemolys is Simulator on the basis of the Deformation Analysis of an Individual Red Blood Cell2008

    • Author(s)
      Nakamura M
    • Organizer
      The 3rd ME International Symposium, Physiome and Systems Biology for Integrated Life Sciences and Predictive Medicine
    • Place of Presentation
      San Francisco, CA, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] 流動する赤血球の変形動態の解析〜変形量と既存の溶血指標との関係〜2008

    • Author(s)
      中村匡徳, 別所貞雄, 和田成生
    • Organizer
      日本機械学会第21回計算力学講演会
    • Place of Presentation
      沖縄
    • Related Report
      2008 Annual Research Report
  • [Presentation] Red Blood Cell Deformation Behavior in a High-Shear Flow2008

    • Author(s)
      Nakamura M, Bessho S, Wada S
    • Organizer
      International Congress of Theoretical and Applied Mechanics
    • Place of Presentation
      Adelaide,Australia
    • Related Report
      2008 Annual Research Report
  • [Presentation] Proposal of Mesoscopic Analysis Method of Blood Rheology2007

    • Author(s)
      Masanori Nakamura, Toshihiro Omori, Takami Yamaguchi, Shigeo Wada
    • Organizer
      Third Asian Pacific Conference on Biomechanics
    • Place of Presentation
      東京
    • Year and Date
      2007-11-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] 流動する赤血球の変形挙動2007

    • Author(s)
      別所貞雄, 中村匡徳, 和田成生
    • Organizer
      第20回計算力学講演会
    • Place of Presentation
      京都
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Book] Advances in Computational Vision and Medical Image Processing Methods and Applications 132009

    • Author(s)
      Lima, R, Nakamura M, Omori T, Ishikawa T, Wada S and Yamaguchi T
    • Total Pages
      17
    • Publisher
      Microscale Flow Dynamics of Red Blood Cells in Microchannels : An Experimental and Numerical Analysis
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.jamstec.go.jp/esc/publication/annual/annual2007/pdf/2project/chapter3/175sakaguchi.pdf

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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