|Budget Amount *help
¥20,670,000 (Direct Cost: ¥15,900,000、Indirect Cost: ¥4,770,000)
Fiscal Year 2010: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2009: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2008: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2007: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
This project was aimed to theoretically understand the evolutionary mechanism by which a genome acquires novel functional genes through gene duplication. The theoretical result should contribute to the developing algorithms to detect new genes from genomes. In the first half of the funded period (H19 and H20), I successfully developed theories on the pattern of DNA polymorphism and divergence in duplicated genes. This directly resulted in a new algorithm to scan a genome for evidence of newly arisen functional genes. The algorithm is simple enough to apply to any genome, from yeast to human. In the second half (H21 and H22), by using this algorithm, we identified a number of such new genes in yeasts and fruit flies, which gave insights into what kind of genes contributed the recent genome evolution of these species.