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Development and application of chemical genomic platforms by use of synthetic organic chemistry

Research Project

Project/Area Number 19681023
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Living organism molecular science
Research InstitutionTohoku University

Principal Investigator

KANOH Naoki  Tohoku University, 大学院・薬学研究科, 准教授 (40317293)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥21,450,000 (Direct Cost: ¥16,500,000、Indirect Cost: ¥4,950,000)
Fiscal Year 2009: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2008: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2007: ¥12,610,000 (Direct Cost: ¥9,700,000、Indirect Cost: ¥2,910,000)
Keywordsマイクロアレイ / 有機化学 / ケミカルゲノミクス / 生物活性物質
Research Abstract

Small-molecule microarray and affinity matrix technologies have been developed. Firstly, by introducing a cleavable site in a photoactivatable linker, which is used to immobilize small molecules on an affinity matrix, validation of the immobilized small molecule on the affinity matrix became possible for the first time. The newly developed cleavable photoactivatable platform also permits the efficient detection of proteins covalently bound to the immobilized small molecule. Secondly, small-molecule microarray platforms that detect substrate specificity of cytochrome P450 have been developed.

Report

(5 results)
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (76 results)

All 2010 2009 2008 2007 Other

All Journal Article (23 results) (of which Peer Reviewed: 23 results) Presentation (39 results) Book (13 results) Remarks (1 results)

  • [Journal Article]2010

    • Author(s)
      N.Kanoh, H.Takayama, K.Honda, T.Moriya, T.Teruya, S.Simizu, H.Osada, Y.Iwabuchi
    • Journal Title

      Bioconjugate Chem. 21

      Pages: 182-186

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article]2010

    • Author(s)
      N. Kanoh, H. Takayama, K. Honda, T. Moriya, T. Teruya, S. Simizu, H. Osada, Y. Iwabuchi
    • Journal Title

      Bioconjugate Chemistry 21

      Pages: 182-182

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Cleavable linker for photo-cross-linked small-molecule affinity matrix2010

    • Author(s)
      N.Kanoh
    • Journal Title

      Bioconjugate Chemistry 21

      Pages: 182-186

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Syntheses and Biological Evaluation of Irciniastatin A and the C1-C2 Alkyne Analogue2010

    • Author(s)
      T.Watanabe
    • Journal Title

      Organic Letters 12

      Pages: 1040-1043

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure-activity relationship of C-5-curcuminoids and synthesis of their molecular probes thereof2010

    • Author(s)
      H.Yamakoshi
    • Journal Title

      Bioorganic & Medicinal Chemistry 18

      Pages: 1083-1092

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis and Determination of the Absolute Configuration of(-)-Idesolide2010

    • Author(s)
      H.Yamakoshi
    • Journal Title

      Organic Letters 12

      Pages: 980-983

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      I.Miyazaki, H.Okumura, S.Simizu, Y.Takahashi, N.Kanoh, Y.Muraoka, Y.Nonomura, H.Osada
    • Journal Title

      Chembiochem 10

      Pages: 845-852

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article]2009

    • Author(s)
      I. Miyazaki, H. Okumura, S. Simizu, Y. Takahashi, N. Kanoh, Y. Muraoka, Y. Nonomura, H. Osada
    • Journal Title

      Chembiochem 10

      Pages: 845-845

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Structure-Affinity Relationship Study of Bleomycins and Shble Protein by Use of a Chemical Array2009

    • Author(s)
      I.Miyazaki
    • Journal Title

      ChemBioChem 10

      Pages: 845-852

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An Expedient Route to a Potent Gastrin/CCK-B Receptor Antagonist(+)-AG-041R2009

    • Author(s)
      S.Sato
    • Journal Title

      Journal of Organic Chemistry 74

      Pages: 7522-7524

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Highly enantioselective intramolecular aza-spiroannulation onto indoles using chiral rhodium catalysis : Asymmetric entry to the spiro-beta-lactam core of chartellines2009

    • Author(s)
      S.Sato
    • Journal Title

      Chemical Communications

      Pages: 6264-6266

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Syntheses of naturally occurring cytotoxic[7.7]paracyclophanes, (-)-cylindrocyclophane A and its enantiomer, and implications for biological activity2009

    • Author(s)
      H.Yamakoshi
    • Journal Title

      Organic & Bioorganic Chemistry 7

      Pages: 3772-3781

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total synthesis of methyl sarcophytoate, a marine natural biscembra-noid2009

    • Author(s)
      Takahiro Ichige
    • Journal Title

      Journal of Organic Chemistry 74

      Pages: 230-243

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthetic, studies on daphnicyclidin A : Enantiocontrolled construction of the BCD ring system2009

    • Author(s)
      Shuhei Ikeda
    • Journal Title

      Organic Letters 11

      Pages: 1833-1836

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article]2008

    • Author(s)
      M.Kawatani, H.Okumura, K.Honda, N.Kanoh, M.Muroi, N.Dohmae, M.Takami, M.Kitagawa, Y.Futamura, M.Imoto, H.Osada
    • Journal Title

      Proc.Natl.Acad.Sci.U.S.A. 105

      Pages: 11691-11696

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article]2008

    • Author(s)
      N.Kanoh, T.Nakamura, K.Honda, H.Yamakoshi, Y.Iwabuchi, H.Osada
    • Journal Title

      Tetrahedron 64

      Pages: 5692-5698

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article]2008

    • Author(s)
      M. Kawatani, H. Okumura, K. Honda, N. Kanoh, M. Muroi, N. Dohmae, M. Takami, M. Kitagawa, Y. Futamura, M. Imoto, H. Osada
    • Journal Title

      P Natl Acad Sci USA 105

      Pages: 11691-11691

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article]2008

    • Author(s)
      N. Kanoh, T. Nakamura, K. Honda, H. Yamakoshi, Y. Iwabuchi, H. Osada
    • Journal Title

      Tetrahedron 64

      Pages: 5692-5692

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Efficient entry to the pyrroloquinoline core of martinella alkaloids vianovel base-catalyzed Mukaiyama-Mannich reaction2008

    • Author(s)
      Shuhei Ikeda
    • Journal Title

      Chemistry Letters 37

      Pages: 962-963

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distribution of phto-cross-linked products from 3-ary-3-trifluoromethyl-diazirines and alcohols2008

    • Author(s)
      Naoki Kanoh
    • Journal Title

      Tetrahedron 64

      Pages: 5692-5698

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis and biological activities of reveromycin A and spirofungin A derivatives2008

    • Author(s)
      Tadashi Shimizu
    • Journal Title

      Bioorganic & Medicinal Chemistry Letters 18

      Pages: 3756-3760

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of Methyl Sarcophytoate2007

    • Author(s)
      Takahiro Ichige
    • Journal Title

      Journal of the American Chemical Society 129

      Pages: 9862-9863

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of an Enantiomeric DNA Oligomer and Its T-Hg (II)-T Base-Pair Formation2007

    • Author(s)
      Kaichiro Haruta
    • Journal Title

      Nucleic Acids Symposium Series

      Pages: 187-188

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 特異的切断サイトを有する新規光親和型小分子アフィニティービーズの開発2010

    • Author(s)
      守谷崇
    • Organizer
      日本化学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-29
    • Related Report
      2009 Annual Research Report
  • [Presentation] 抗腫瘍活性天然物ビセニスタチンの合成と構造活性相関2010

    • Author(s)
      中村織依菜
    • Organizer
      日本化学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 有機分子触媒を用いた分子内不斉アルドール反応によるキラルビシクロ環構築法の開発研究2010

    • Author(s)
      村崎広太
    • Organizer
      日本化学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 8-オキサビシクロ[3.2.1]型キラル合成素子の開発研究2010

    • Author(s)
      川住宗生
    • Organizer
      日本化学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] 蛋白質-小分子リガンド間相互作用検出のための有機化学2009

    • Author(s)
      叶直樹
    • Organizer
      有機合成化学協会東北支部青森地区講演会
    • Place of Presentation
      弘前
    • Year and Date
      2009-12-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] 有機合成化学を基盤とした天然有機化合物のケミカルバイオロジー2009

    • Author(s)
      叶直樹
    • Organizer
      第3回万有財団若手交流セミナー
    • Place of Presentation
      唐津ビューホテル
    • Year and Date
      2009-11-22
    • Related Report
      2009 Final Research Report
  • [Presentation] 有機合成化学を基盤とした天然有機化合物のケミカルバイオロジー2009

    • Author(s)
      叶直樹
    • Organizer
      第3回万有財団若手交流セミナー
    • Place of Presentation
      唐津
    • Year and Date
      2009-11-22
    • Related Report
      2009 Annual Research Report
  • [Presentation] 構造活性相関を志向した抗腫瘍活性天然物ビセニスタチンの合成研究2009

    • Author(s)
      福田隼
    • Organizer
      第35回 反応と合成の進歩シンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      2009-11-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 抗腫瘍性マクロライドFD-891の合成研究2009

    • Author(s)
      宮崎雄太
    • Organizer
      第48回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 8-オキシビシクロ[3.2.1]型キラル合成素子の開発研究2009

    • Author(s)
      川住宗生
    • Organizer
      第48回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 有機分子触媒を用いた分子内アルドール反応によるキラルビシクロ環構築法の開発研究2009

    • Author(s)
      村崎広太
    • Organizer
      第48回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 抗腫瘍活性食用植物成分 curcumin をリードとする創薬化学研究2009

    • Author(s)
      山越博幸
    • Organizer
      第48回日本薬学会東北支部大会
    • Place of Presentation
      仙台
    • Year and Date
      2009-10-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] 抗腫瘍活性天然物(+)-irciniastatin A/psymberin の全合成2009

    • Author(s)
      渡辺翼
    • Organizer
      第51回天然有機化合物討論会
    • Place of Presentation
      名古屋
    • Year and Date
      2009-10-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] タンパク質-小分子リガンド間相互作用検出のための有機化学2009

    • Author(s)
      叶直樹
    • Organizer
      化学系学術協会東北大会平成
    • Place of Presentation
      日本大学工学部
    • Year and Date
      2009-09-20
    • Related Report
      2009 Final Research Report
  • [Presentation] 蛋白質-小分子リガンド間相互作用検出のための有機化学2009

    • Author(s)
      叶直樹
    • Organizer
      化学系学術協会東北大会
    • Place of Presentation
      郡山
    • Year and Date
      2009-09-20
    • Related Report
      2009 Annual Research Report
  • [Presentation] 有機合成化学を基盤とした天然有機化合物のケミカルバイオロジー2009

    • Author(s)
      叶直樹
    • Organizer
      第26回 有機合成化学セミナー
    • Place of Presentation
      前橋
    • Year and Date
      2009-09-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Development of Photo-Cross-Linked Small-Molecule Microarrays and Affinity Matrix as Chemical Genetic Screening Platforms2009

    • Author(s)
      N.Kanoh
    • Organizer
      CSI Singapore, NUS, and Tohoku University G-COE Loint Symposium
    • Place of Presentation
      Genome Institute of Singapore
    • Year and Date
      2009-09-09
    • Related Report
      2009 Final Research Report
  • [Presentation] Development of Photo-Cross-Linked Small-Molecule Microarray and Affinity Matrix as Chemical Genetic Screening Platforms2009

    • Author(s)
      N.Kanoh
    • Organizer
      CSI Singapore, NUS-Tohoku University GCOE Joint Symposium
    • Place of Presentation
      Genome Institute of Singapore, Sigapore
    • Year and Date
      2009-09-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] リガンド反応性分子標的を検出・同定する開裂型 photoaffinity beads2009

    • Author(s)
      高山浩
    • Organizer
      仙台万有シンポジウム
    • Place of Presentation
      仙台
    • Year and Date
      2009-06-13
    • Related Report
      2009 Annual Research Report
  • [Presentation] 有機合成化学を基板とした天然有機化合物のケミカルバイオロジー2009

    • Author(s)
      叶直樹
    • Organizer
      新規素材探索研究会第8回セミナー
    • Place of Presentation
      新横浜富士ビューホテル
    • Year and Date
      2009-06-05
    • Related Report
      2009 Final Research Report
  • [Presentation] 有機合成化学を基板とした天然有機化合物のケミカルバイオロジー2009

    • Author(s)
      叶直樹
    • Organizer
      新規素材探索研究会第8回セミナー
    • Place of Presentation
      新横浜
    • Year and Date
      2009-06-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 低分子化合物のターゲット探索に用いる開裂型photoaffinity beadsの開発2009

    • Author(s)
      高山浩、叶直樹、本田香織、守谷崇、照屋貴之、清水史郎、長田裕之、岩渕好治
    • Organizer
      日本ケミカルバイオロジー学会第4回年会
    • Place of Presentation
      神戸市産業振興センター
    • Year and Date
      2009-05-18
    • Related Report
      2009 Final Research Report
  • [Presentation] 低分子化合物のターゲット探索に用いる開裂型 photoaffinity beads の開発2009

    • Author(s)
      高山浩
    • Organizer
      日本ケミカルバイオロジー学会第4回年会
    • Place of Presentation
      神戸
    • Year and Date
      2009-05-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] KSRP特異的リガンドGO-Y0862009

    • Author(s)
      叶直樹
    • Organizer
      日本ケミカルバイオロジー学会第4回年会
    • Place of Presentation
      神戸
    • Year and Date
      2009-05-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Cytochrome P450による基質構造変化を検出する化合物アレイ型プラットフォームの開発2009

    • Author(s)
      高山浩
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都国際会議場、京都
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Chemosite non-selective organic reaction in natural product-based chemical genetics2008

    • Author(s)
      N.Kanoh
    • Organizer
      8^<th> Tateshina Conference on Organic Chemistry
    • Place of Presentation
      蓼科フォーラム
    • Year and Date
      2008-11-07
    • Related Report
      2009 Final Research Report
  • [Presentation] 有機合成化学を基盤とした天然有機化合物のケミカルバイオロジー2008

    • Author(s)
      叶直樹
    • Organizer
      第26回有機合成化学セミナー
    • Place of Presentation
      前橋市中央公民館
    • Year and Date
      2008-09-16
    • Related Report
      2009 Final Research Report
  • [Presentation] Photo-generated carbene as a chemical handle for functionalizing small molecules2008

    • Author(s)
      Naoki Kanoh
    • Organizer
      IUPAC International Conference on Biodiversity and Natural Products ICOB-6 & ISCNP-26
    • Place of Presentation
      Delta Prince Edward, Charlottetown, PEI, Canada
    • Year and Date
      2008-07-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] Photo-generated carbene as a possible universal chemical handle for functionalizing small molecules2008

    • Author(s)
      N.Kanoh
    • Organizer
      IUPAC International Conference on Biodiversity and Natural Products ICOB-6 & ISCNP-26
    • Place of Presentation
      Prince Edward Island, Canada
    • Year and Date
      2008-07-05
    • Related Report
      2009 Final Research Report
  • [Presentation] 酸化酵素cytochrome P450の基質と阻害剤を検出する化合物アレイ型プラットフォームの開発2008

    • Author(s)
      叶直樹
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      学術総合センター、東京
    • Year and Date
      2008-05-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] Photo-generated carbene as a possible universal chemical handle for functionalizing small molecules2008

    • Author(s)
      Naoki Kanoh
    • Organizer
      The 12th Japan-Korea Joint Symposium on Drug Design and Development
    • Place of Presentation
      仙台市戦災復興記念館
    • Year and Date
      2008-05-15
    • Related Report
      2008 Annual Research Report
  • [Presentation] 生理活性物質の固相単体への官能基非選択的導入法は化学遺伝学研究のパラダイムシフトとなり得るか?2008

    • Author(s)
      叶 直樹
    • Organizer
      日本薬学会第128年会一般シンポジウム
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2008-03-28
    • Related Report
      2007 Annual Research Report
  • [Presentation] SPRイメージング法を用いたp38 MAP kinaseとp62の結合部位の同定2008

    • Author(s)
      齊藤 安貴子
    • Organizer
      日本農芸化学会2008年度大会
    • Place of Presentation
      名城大学天白キャンパス(愛知県名古屋市)
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] 生理活性物質の固相単体への官能基非選択的導入法は化学遺伝学研究のパラダイムシフトとなり得るか?2008

    • Author(s)
      叶 直樹
    • Organizer
      第4回理研ケミカルバイオロジーシンポジウム
    • Place of Presentation
      熱海金城館(静岡県熱海市)
    • Year and Date
      2008-02-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] Chemosite Non-selective Organic Reaction in Natural Product-Based Chemical Genetics2008

    • Author(s)
      Naoki Kanoh
    • Organizer
      8^<th> Tateshina conference on Organic Chemistry
    • Place of Presentation
      蓼科フォーラム、長野県茅野市
    • Related Report
      2008 Annual Research Report
  • [Presentation] The identification of a novel inhibitor of osteoclastogenesis that acts via inhibition of glyoxalase I2007

    • Author(s)
      川谷 誠
    • Organizer
      AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
    • Place of Presentation
      Moscone Convention Center West, San Francisco, CA
    • Year and Date
      2007-10-22
    • Related Report
      2007 Annual Research Report
  • [Presentation] Development of A Photo-Cross-Linked Natural Product Microarray Platform for Screening Lysate of Human Cells2007

    • Author(s)
      宮崎 功
    • Organizer
      The 2nd International Workshop on Approaches to Single-Cell Analysis
    • Place of Presentation
      早稲田大学早稲田キャンパス(東京都新宿区)
    • Year and Date
      2007-09-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] 蛋白質-低分子間相互作用検出法の開発2007

    • Author(s)
      叶 直樹
    • Organizer
      日本薬学会東北支部学術講演会
    • Place of Presentation
      東北薬科大学(宮城県仙台市)
    • Year and Date
      2007-05-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] 低分子リガンドの網羅的スクリーニングを目指したSPRイメージングの高感度化2007

    • Author(s)
      高山 浩
    • Organizer
      第2回ケミカルバイオロジー研究会年会
    • Place of Presentation
      京都大学時計台記念(京都府京都市)
    • Year and Date
      2007-05-10
    • Related Report
      2007 Annual Research Report
  • [Book] Small Molecule Microarrays : Methods and Protocols(M.Uttamchandani, S.Q.Yao, Eds)2010

    • Author(s)
      N.Kanoh
    • Publisher
      Humana Press
    • Related Report
      2009 Final Research Report
  • [Book] バイオチップ実用化ハンドブック(金子周一、堀池靖浩 監修)2010

    • Author(s)
      叶直樹
    • Publisher
      NTS Inc.
    • Related Report
      2009 Final Research Report
  • [Book] Small Molecule Microarrays: Methods and Protocols2010

    • Author(s)
      N. Kanoh
    • Publisher
      Humana Press(in press)
    • Related Report
      2009 Self-evaluation Report
  • [Book] バイオチップ実用化ハンドブック2010

    • Author(s)
      叶直樹
    • Publisher
      株式会社エヌ・ティー・エス(印刷中)
    • Related Report
      2009 Annual Research Report
  • [Book] Small Molecule Microarrays : Methods and Protocols2010

    • Author(s)
      N.Kanoh
    • Publisher
      Humana Press(印刷中)
    • Related Report
      2009 Annual Research Report
  • [Book] Protein Targeting with Small Molecules : Chemical Biology Techniques and Applications(H.Osada, Ed.)2009

    • Author(s)
      N.Kanoh, H.Osada
    • Publisher
      Wiley
    • Related Report
      2009 Final Research Report
  • [Book] Protein Targeting with Small Molecules: Chemical BIology Techniques and Applications2009

    • Author(s)
      N. Kanoh, H. Osada
    • Total Pages
      57
    • Publisher
      Wiley
    • Related Report
      2009 Self-evaluation Report
  • [Book] Protein Targeting with Small Molecules : Chemical Biology Techniques and Applications2009

    • Author(s)
      N.Kanoh
    • Publisher
      John Wiley & Sons, Inc.
    • Related Report
      2009 Annual Research Report
  • [Book] ナノバイオ計測の実際(三原久和、小畠英理、馬場嘉信 編)2007

    • Author(s)
      叶直樹
    • Publisher
      講談社サイエンティフィク
    • Related Report
      2009 Final Research Report
  • [Book] マイクロアレイ・バイオチップの最新技術(伊藤嘉浩 監修)2007

    • Author(s)
      清水史郎、宮崎功、近藤恭光、叶直樹、長田裕之
    • Publisher
      CMC Press
    • Related Report
      2009 Final Research Report
  • [Book] 分子間相互作用解析ハンドブック(礒辺俊明、中山敬一、伊藤隆司 編)2007

    • Author(s)
      齋藤亜貴子、叶直樹、長田裕之
    • Publisher
      羊土社
    • Related Report
      2009 Final Research Report
  • [Book] マイクロアレイ・バイオチップの最新技術2007

    • Author(s)
      清水史郎
    • Total Pages
      305
    • Publisher
      シーエムシー出版
    • Related Report
      2007 Annual Research Report
  • [Book] 分子間相互作用解析ハンドブック(光親和型低分子マイクロアレイを用いた低分子-蛋白質相互作用の検出)2007

    • Author(s)
      齊藤 安貴子
    • Total Pages
      287
    • Publisher
      (株)羊土社
    • Related Report
      2007 Annual Research Report
  • [Remarks] ホームページ等

    • Related Report
      2009 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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