Elucidating the molecular mechanisms of neuronal polarity with genetic mosaic methods
| Project/Area Number |
19687014
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Developmental biology
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| Research Institution | The University of Tokyo |
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Principal Investigator |
CHIHARA Takahiro The University of Tokyo, 大学院・薬学系研究科, 講師 (00431891)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2009: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2007: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
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| Keywords | 形態形成 / 神経極性 / 神経発生生物学 / モザイク解析 / ショウジョウバエ / 樹状突起 / 軸索 |
|---|
| Research Abstract |
To form functional neural circuits like brain, each neuron must possess extremely polarized cellular structures, dendrites and an axon. In this study, we utilized various Drosophila molecular genetic methods to elucidate the molecular mechanisms for neuronal polarization in vivo. Molecular genetic analyses of several mutants defective in neuronal polarization and circuit formation revealed the importance of sugar modification on cell surface proteins.
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Report
(4 results)
Research Products
(39 results)
