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Elucidating the molecular mechanisms of neuronal polarity with genetic mosaic methods

Research Project

Project/Area Number 19687014
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Developmental biology
Research InstitutionThe University of Tokyo

Principal Investigator

CHIHARA Takahiro  The University of Tokyo, 大学院・薬学系研究科, 講師 (00431891)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥25,350,000 (Direct Cost: ¥19,500,000、Indirect Cost: ¥5,850,000)
Fiscal Year 2009: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2008: ¥8,190,000 (Direct Cost: ¥6,300,000、Indirect Cost: ¥1,890,000)
Fiscal Year 2007: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywords形態形成 / 神経極性 / 神経発生生物学 / モザイク解析 / ショウジョウバエ / 樹状突起 / 軸索
Research Abstract

To form functional neural circuits like brain, each neuron must possess extremely polarized cellular structures, dendrites and an axon. In this study, we utilized various Drosophila molecular genetic methods to elucidate the molecular mechanisms for neuronal polarization in vivo. Molecular genetic analyses of several mutants defective in neuronal polarization and circuit formation revealed the importance of sugar modification on cell surface proteins.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report

Research Products

(39 results)

All 2010 2009 2008 2007 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (30 results) Remarks (1 results)

  • [Journal Article] Histon deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero.2010

    • Author(s)
      Joy S.Tea, Takahiro Chihara, Liqun Luo.
    • Journal Title

      The Journal of Neuroscience. 30

      Pages: 9939-9946

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lineage-specific effects of Notch/Numb signaling in post-embryonic development of the Drosophila brain.2010

    • Author(s)
      Suewei Lin, Sen-Lin Lai, Huang-Hsiang Yu, Takahiro Chihara, Liqun Luo, Tzumin Lee.
    • Journal Title

      Development. 137

      Pages: 43-51

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Lineage-specific effects of Notch/Numb signaling in post-embryonic development of the Drosophila brain2010

    • Author(s)
      Suewei Lin, Sen-Lin Lai, Huang-Hsiang Yu, Takahiro Chihara, Liqun Luo, Tzumin Lee
    • Journal Title

      Development

      Volume: 137 Pages: 43-51

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histon deacetylase Rpd3 regulates olfactory projection neuron dendrite targeting via the transcription factor Prospero2010

    • Author(s)
      Joy S.Tea, Takahiro Chihara, Liqun Luo
    • Journal Title

      The Journal of Neuroscience

      Volume: 30 Pages: 9939-46

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Organelles in developing neurons : Essential regulators of neuronal morphogenesis and function.2009

    • Author(s)
      Sayaka Sekine, Masayuki Miura, Takahiro Chihara.
    • Journal Title

      The International Journal of Developmental Biology. 53

      Pages: 19-27

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Organelles in developing neurons : Essential regulators of neuronal morphogenesis and function2009

    • Author(s)
      Sayaka Sekine, Masayuki Miu ra and Takahiro Chihara
    • Journal Title

      The International Journal of Developmental Biology 53

      Pages: 19-27

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cytoplasmic and mitochondrial protein translation in axonal and dendritic terminal arborization.2007

    • Author(s)
      Takahiro Chihara, David Luginbuhl, Liqun Luo.
    • Journal Title

      Nature Neuroscience. 10

      Pages: 828-837

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Cytoplasmic and mitochondrial protein translation in axonal and dendritic terminal arborization2007

    • Author(s)
      Takahiro Chihara, David Luginbuhl and Liqun Luo
    • Journal Title

      Nature Neuroscience 10

      Pages: 828-837

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] メンター:研究人生における最強の味方2010

    • Author(s)
      Takahiro Chihara
    • Organizer
      The 43^<rd> Annual meeting for the Japanese society of developmental biologists
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2010-06-21
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neuronal wiring in the olfactory system requires a novel targeting molecule, Dogi.2010

    • Author(s)
      Chisako Ando, Liqun Luo, Masayuki Miura, Takahiro Chihara.
    • Organizer
      The 13^<th> European Drosophila neurobiology conference.
    • Place of Presentation
      Manchester, UK
    • Related Report
      2009 Final Research Report
  • [Presentation] Dendritic and axonal targeting along medial to lateral axis in the antennal lobe are regulated by Meigo, a putative UDP-sugar transporter.2010

    • Author(s)
      Sayaka Sekine, Liqun Luo, Masayuki Miura, Takahiro Chihara.
    • Organizer
      The 51^<st> Annual Drosophila Research Conference
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Dendritic and axonal targeting along medial to lateral axis in the antennal lobe are regulated by Meigo, a putative UDP-sugar transporter2010

    • Author(s)
      Sayaka Sekine, Liqun Luo, Masayuki Miura, Takahiro Chihara
    • Organizer
      The 51^<st> Annual Drosophila Research Conference
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2009 Annual Research Report
  • [Presentation] Neuronal wiring in the olfactory system requires a novel targeting molecule, Dogi2010

    • Author(s)
      Chisako Ando, Liqun Luo, Masayuki Miura, Takahiro Chihara
    • Organizer
      The 13^<th> European Drosophila neurobiology conference
    • Place of Presentation
      Manchester, UK
    • Related Report
      2009 Annual Research Report
  • [Presentation] 脳内単一脳細胞モザイク解析法を用いて神経回路形成を理解する2009

    • Author(s)
      Takahiro Chihara.
    • Organizer
      Symposium on "Biological Sciences" at Kumamoto University.
    • Place of Presentation
      Kumamoto, Japan
    • Year and Date
      2009-10-16
    • Related Report
      2009 Final Research Report
  • [Presentation] 脳内単一脳細胞モザイク解析法を用いて神経回路形成を理解する2009

    • Author(s)
      Takahiro Chihara
    • Organizer
      Symposium on "Biological Sciences" at Kumamoto University
    • Place of Presentation
      Kumamoto, Japan
    • Year and Date
      2009-10-16
    • Related Report
      2009 Annual Research Report
  • [Presentation] Meigo, a putative sugar transporter, regulates dendritic but not axonal targeting in Drosophila olfactory projection neurons2009

    • Author(s)
      Sayaka Sekine, Liqun Luo, Masayuki Miura, Takahiro Chihara
    • Organizer
      The 42^<nd> Annual meeting for the Japanese society of Developmental biologists
    • Place of Presentation
      Niigata, Japan
    • Year and Date
      2009-05-30
    • Related Report
      2009 Annual Research Report
  • [Presentation] ショウジョウバエ脳内の樹状突起ターゲティングを支える分子基盤国立遺伝学研究所研究会2009

    • Author(s)
      千原崇裕
    • Organizer
      モデル生物における神経系の遺伝学 -発生から行動まで-
    • Place of Presentation
      三島・静岡県
    • Year and Date
      2009-03-27
    • Related Report
      2009 Final Research Report
  • [Presentation] ショウジョウバエ脳内の樹状突起ターゲティングを支える分子基盤2009

    • Author(s)
      千原崇裕
    • Organizer
      国立遺伝学研究所研究会「モデル生物における神経系の遺伝学-発生から行動まで-」
    • Place of Presentation
      三島、静岡県
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Evolutionarily conserved protein, Dogi regulates dendritic targeting and axonal guidance of Drosophila olfactory projection neurons.2009

    • Author(s)
      Chisako Ando, Liqun Luo, Masayuki Miura, Takahiro Chihara.
    • Organizer
      50^<th> Annual Drosophila Research Conference.
    • Place of Presentation
      Chicago, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Dogi : an evolutionarily conserved protein is cell-autonomously required for dendritic targeting and axonal guidance of Drosophila olfactory projection neurons2009

    • Author(s)
      Chisako Ando, Liqun Luo, Masayuki Miura, Takahiro Chihara
    • Organizer
      The 42^<nd> Annual meeting for the Japanese society of Developmental biologists
    • Place of Presentation
      Niigata, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Meigo, a putative UDP-sugar transporter, regulaters dendritic but not axonal targeting of the olfactgory projection neuron2009

    • Author(s)
      Sayaka Sekine, Liqun Luo, Masayuki Miura, Takahiro Chihara
    • Organizer
      The 9^<th> Japanese Drosophila research conference
    • Place of Presentation
      Kakegawa, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Evolutionarily conserved protein, Dogi regulates dendritic targeting and axonal guidance of Drosophila olfactory projection neurons2009

    • Author(s)
      Chisako Ando, Liqun Luo, Masayuki Miura, Takahiro Chihara
    • Organizer
      The 9^<th> Japanese Drosophila research conference
    • Place of Presentation
      Kakegawa, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Identifying neurons with caspase activity in Drosophila adult brain2009

    • Author(s)
      Aki Kitabayashi, Takahiro Chihara, Masayuki Miura
    • Organizer
      The 9^<th> Japanese Drosophila research conference
    • Place of Presentation
      Kakegawa, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Caspase activation in developing neurons : evaluation of PARP-Venus, a genetically encoded probe for caspase activation2009

    • Author(s)
      Michie Morimoto, Takahiro Chihara, Masayuki Miura
    • Organizer
      The 9^<th> Japanese Drosophila research conference
    • Place of Presentation
      Kakegawa, Japan
    • Related Report
      2009 Annual Research Report
  • [Presentation] Evolutionarily conserved protein, Dogi regulates dendritic targeting and axonal guidance of Drosophila olfactory projection neurons2009

    • Author(s)
      Chisako Ando, Liqun Luo, Masayuki Miura and Takahiro Chihara
    • Organizer
      50^<th> Annual Drosophila Research Conference
    • Place of Presentation
      Chicago, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] 嗅覚系二次神経の軸索・樹状突起ガイダンスを制御する分子機構 金沢大学革新脳科学COEシンポジウム2008

    • Author(s)
      千原崇裕
    • Organizer
      Neurobiology of Drosophila
    • Place of Presentation
      金沢・石川県
    • Year and Date
      2008-08-21
    • Related Report
      2009 Final Research Report
  • [Presentation] 嗅覚系二次神経の軸索・樹状突起ガイダンスを制御する分子機構2008

    • Author(s)
      千原崇裕層
    • Organizer
      金沢大学革新脳科学COEシンポジウム Neurobiology of Drosophila
    • Place of Presentation
      金沢、石川県
    • Year and Date
      2008-08-21
    • Related Report
      2008 Annual Research Report
  • [Presentation] Histone deacetylase 1 (Rpd3) in dendritic targeting of Drosophila olfactory projection neurons.2008

    • Author(s)
      Takahiro Chihara, Joy S.Wu, Liqun Luo.
    • Organizer
      49^<th> Annual Drosophila Research Conference.
    • Place of Presentation
      San Diego, USA
    • Related Report
      2009 Final Research Report
  • [Presentation] Histone deacetylase 1 (Rpd3)in dendritic targeting of Drosophila olfactory projection neurons2008

    • Author(s)
      Takahiro Chihara, Joy S. Wu and Liqun Luo
    • Organizer
      49^<th> Annual Drosophila Research Conference
    • Place of Presentation
      San Diego, USA
    • Related Report
      2008 Annual Research Report
  • [Presentation] Secretory pathway contributes to dendrite-specific targeting in Drosophila olfactory projection neurons2008

    • Author(s)
      Sayaka Sekine, Liqun Luo, Masayuki Miura and Takahiro Chihara
    • Organizer
      Neuroscience 2008
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Genetic mosaic analysis of dendritic guidance in Drosophilaolfactory projection neurons2008

    • Author(s)
      Takahiro Chihara, Chisako. Ando, Liqun Luo and Masayuki Miura
    • Organizer
      Neuroscience 2008
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Identifying neurons with caspase activation in Drosophila central nervous system2008

    • Author(s)
      Aki Kitabayashi, Michie Morimoto, Takahiro Chihara and Masayuki Miura
    • Organizer
      The 15^<th> Takeda Science Foundation Symposium on Bioscience : Cell Death
    • Place of Presentation
      Tokyo, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] ショウジョウバエ嗅覚系投射神経における樹状突起ガイダンスの遺伝学的モザイク解析2008

    • Author(s)
      安東知佐子、千原崇裕、Liqu nLuo、三浦正幸
    • Organizer
      BMB2008(第31回・日本分子生物学会年会・第81回日本生化学会大会・合同大会)
    • Place of Presentation
      神戸、兵庫県
    • Related Report
      2008 Annual Research Report
  • [Presentation] Genetic mosaic analysis in Drosophila brain reveals specialized functions of house-keeping genes in neuronal morphogenesis.2007

    • Author(s)
      Takahiro Chihara, Joy S.Wu, David Luginbuhl, Masayuki Miura, Liqun Luo.
    • Organizer
      BMB2007(第30回日本分子生物学会年会・第80回日本生化学会大会・合同大会)
    • Place of Presentation
      パシフィコ横浜・神奈川県
    • Related Report
      2009 Final Research Report
  • [Presentation] Genetic analysis of dendritic morphogenesis : Neuronal polarity, targeting and maintenance.2007

    • Author(s)
      Takahiro Chihara, David Luginbuhl, Liqun Luo.
    • Organizer
      The 8^<th> Japanese Drosophila Research Conference.
    • Place of Presentation
      Awaji Yumebutai International Conference Center, Hyogo, Japan
    • Related Report
      2009 Final Research Report
  • [Presentation] Genetic analysis of dendritic morphogenesis: Neuronal polarity, targeting and maintenance2007

    • Author(s)
      Takahiro Chihara, David Luginbuhl and Liqun Luo
    • Organizer
      The 8th Japanese Drosophila Research Conference
    • Place of Presentation
      Awaji Yumebutai International Conference Center, Hyogo, Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] Phenotypic analysis of a mutant defective in dendritic but not axonal targeting of Drosophila olfactory projection neuron2007

    • Author(s)
      Sayaka Sekine, Liqun Luo, Masayuki Miura and Takahiro Chihara
    • Organizer
      The 8th Japanese Drosophila Research Conference
    • Place of Presentation
      Awaji Yumebutai International Conference Center, Hyogo, Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] Genetic mosaic analysis in Drosophila brain reveals specialized functions of house-keeping genes in neuronal morphogenesis2007

    • Author(s)
      Takahiro Chihara, Joy S. Wu, David Luginbuhl, Masayuki Miura and Liqun Luo
    • Organizer
      BMB2007(第30回日本分子生物学会年会・第80回日本生化学会大会・合同大会)
    • Place of Presentation
      パシフィコ横浜、神奈川県
    • Related Report
      2007 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.f.u-tokyo.ac.jp/~genetics/index.html

    • Related Report
      2009 Final Research Report

URL: 

Published: 2007-03-31   Modified: 2016-04-21  

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