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Development of highly atom-economical synthetic methods based on catalytic cascade reactions

Research Project

Project/Area Number 19689001
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Chemical pharmacy
Research InstitutionKyoto University

Principal Investigator

OHNO Hiroaki  Kyoto University, 薬学研究科, 准教授 (30322192)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥23,400,000 (Direct Cost: ¥18,000,000、Indirect Cost: ¥5,400,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2008: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2007: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000)
Keywords有機化学 / 多成分反応 / 連続反応 / 銅 / パラジウム / 金 / インドール / イソキノリン / アミジン / β-カルボリン / Ergotアルカロイド / リゼルグ酸 / C-H活性化 / カルバゾール / アルケンイソスター
Research Abstract

The author investigated development of synthetic methods based on catalytic cascade of atom-economical reactions such as C-H bond activation and multi-component reactions. Consequently, several methods for construction of fused heterocycles such as indoles, isoquinolines, isoindoles, carbazoles, and quinazolines have been developed. Furthermore, total syntheses of ergot alkaloids and jaspine B, as well as efficient synthesis of trifluoromethylalkene dipeptide isosteres have been achieved. These results provide a preliminary model for efficient organic synthesis.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (110 results)

All 2010 2009 2008 2007 Other

All Journal Article (50 results) (of which Peer Reviewed: 49 results) Presentation (54 results) Remarks (4 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Direct Synthesis of Quinazolines through Copper-Catalyzed Reaction of Aniline-Derived Benzamidines.2010

    • Author(s)
      Y.Ohta, Y.Tokimizu, S.Oishi, N.Fujii, H.Ohno.
    • Journal Title

      Org.Lett 12(17)

      Pages: 3963-3965

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective Divergent Synthesis of Four Diastereomers of Pachastrissamine (Jaspine B).2010

    • Author(s)
      Y.Yoshimitsu, S.Inuki, S.Oishi, N.Fujii, H.Ohno.
    • Journal Title

      J.Org.Chem. 75(11)

      Pages: 3843-3846

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ring-Construction/Stereoselective Functionalization Cascade: Total Synthesis of Pachastrissamine (Jaspine B) through Palladium-Catalyzed Bis-cyclization of Propargyl Chlorides and Carbonates.2010

    • Author(s)
      S.Inuki, Y.Yoshimitsu, S.Oishi, N.Fujii, H.Ohno.
    • Journal Title

      J.Org.Chem. 75(11)

      Pages: 3831-3842

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Construction of Linked Nitrogen Heterocycles by Palladium(0)-Catalyzed Intramolecular Domino Cyclization of 2-Alkynylaziridines Bearing a 2-Aminoethyl Group via Ring Expansion with Isocyanate2010

    • Author(s)
      A.Okano, S.Oishi, T.Tanaka, N.Fujii, H.Ohno.
    • Journal Title

      J.Org.Chem. 75(10)

      Pages: 3396-3400

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Fused and Linked Bicyclic Nitrogen Heterocycles by Palladium-Catalyzed Domino Cyclization of Propargyl Bromide.2010

    • Author(s)
      A.Okano, K.Tsukamoto, S.Kosaka, H.Maeda, S.Oishi, T.Tanaka, N.Fujii, H.Ohno.
    • Journal Title

      Chem.Eur.J. 16(28)

      Pages: 8410-8418

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gold-Catalyzed Intramolecular Alkyne Cycloisomerization Cascade: Direct Synthesis of Aryl-Annulated[ a]carbazoles from Aniline-Substituted Diethynylarenes.2010

    • Author(s)
      K.Hirano, Y.Inaba, T.Watanabe, S.Oishi, N.Fujii, H.Ohno.
    • Journal Title

      Adv.Synth.Catal. 352(2)

      Pages: 368-372

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficient Synthesis of Pyrimido[1,2-c][1,3]- benzothiazin-6-imines and Related Tricyclic Heterocycles by SNAr-Type C-S, C-N, or C-O Bond Formation with Heterocumulenes.2010

    • Author(s)
      T.Mizuhara, S.Oishi, N.Fujii, H.Ohno.
    • Journal Title

      J.Org.Chem. 75(1)

      Pages: 265-268

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Efficient Synthesis of Pyrimido[1,2-c][1,3]benzothiazin-6-imines and Related Tricyclic Heterocycles by S_NAr-Type C-S, C-N, or C-O Bond Formation with Heterocumulenes2010

    • Author(s)
      Mizuhara, T., Ohno, H., et al.
    • Journal Title

      J.Org.Chem.

      Volume: 75 Pages: 265-268

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gold-Catalyzed Intramolecular Alkyne Cycloisomerization Cascade : Direct Synthesis of Aryl-Annulated[a]carbazoles from Aniline-Substituted Diethynylarenes2010

    • Author(s)
      Hirano, K., Ohno, H., et al.
    • Journal Title

      Adv.Synth.Catal.

      Volume: 352 Pages: 368-372

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Synthesis of Fused and Linked Bicyclic Nitrogen Heterocycles by Palladium-Catalyzed Domino Cyclization of Propargyl Bromides2010

    • Author(s)
      Okano, A., Ohno, H., et al.
    • Journal Title

      Chem.Eur.J.

      Volume: 16 Pages: 8410-8418

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of Linked Nitrogen Heterocycles by Palladium(0)-Catalyzed Intramolecular Domino Cyclization of 2-Alkynylaziridines Bearing a 2-Aminoethyl Group via Ring Expansion with Isocyanate2010

    • Author(s)
      Okano, A., Ohno, H., et al.
    • Journal Title

      J.Org.Chem.

      Volume: 75 Pages: 3396-3400

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ring-Construction/Stereoselective Functionalization Cascade : Total Synthesis of Pachastrissamine (Jaspine B) through Palladium-Catalyzed Bis-cyclization of Propargyl Chlorides and Carbonates2010

    • Author(s)
      Inuki, S., Ohno, H., et al.
    • Journal Title

      J.Org.Chem.

      Volume: 75 Pages: 3831-3842

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stereoselective Divergent Synthesis of Four Diastereomers of Pachastrissamine (Jaspine B)2010

    • Author(s)
      Yoshimitsu, Y., Ohno, H., et al.
    • Journal Title

      J.Org.Chem.

      Volume: 75 Pages: 3843-3846

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct Synthesis of Quinazolines through Copper-Catalyzed Domino Alkynylation and Cyclization of Aniline-Derived Benzamidines2010

    • Author(s)
      Ohta, Y., Ohno, H., et al.
    • Journal Title

      Org.Lett.

      Volume: 12 Pages: 3963-3965

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ring-Construction/Stereoselective Functionalization Cascade: Total Synthesis of Pachastrissamine (Jaspine B) through Palladium-Catalyzed Bis-cyclization of Bromoallenes.2009

    • Author(s)
      S.Inuki, Y.Yoshimitsu, S.Oishi, N.Fujii, H.Ohno.
    • Journal Title

      Org.Lett. 11(19)

      Pages: 4478-4481

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Construction of Nitrogen Heterocycles Bearing an Aminomethyl Group by Copper-Catalyzed Domino Three-Component Coupling-Cyclization2009

    • Author(s)
      Y.Ohta, H.Chiba, S.Oishi, N.Fujii, H.Ohno.
    • Journal Title

      J.Org.Chem. 74(18)

      Pages: 7052-7058

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid Access to 3-(Aminomethyl)isoquinoline-Fused Polycyclic Compounds by Copper-Catalyzed Four-Component Coupling, Cascade Cyclisation and Oxidation.2009

    • Author(s)
      Y.Ohta, Y.Kubota, T.Watabe, H.Chiba, S.Oishi, N.Fujii, H.Ohno.
    • Journal Title

      J.Org.Chem. 74(16)

      Pages: 6299-6302

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Palladium-Catalyzed Direct Synthesis of Carbazoles via One-Pot N-Arylation and Oxidative Biaryl Coupling: Synthesis and Mechanistic Study.2009

    • Author(s)
      T.Watanabe, S.Oishi, N.Fujii, H.Ohno.
    • Journal Title

      J.Org.Chem. 74(13)

      Pages: 4720-4726

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Facile Synthesis of 1,2,3,4-Tetrahydro-β-carbolines by One-Pot Domino Three-Component Indole Formation and Nucleophilic Cyclization.2009

    • Author(s)
      Y.Ohta, S.Oishi, N.Fujii, H.Ohno.
    • Journal Title

      Org.Lett. 11(9)

      Pages: 1979-1982

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Rapid Access to 3-(Aminomethyl)isoquinoline-Fused Polycyclic Compounds by Copper-Catalyzed Four-Component Coupling, Cascade Cyclisation and Oxidation2009

    • Author(s)
      Ohta, Y., Ohno, H., et al.
    • Journal Title

      J.Org.Chem.

      Volume: 74 Pages: 6299-6302

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Construction of Nitrogen Heterocycles Bearing an Aminomethyl Group by Copper-Catalyzed Domino Three-Component Coupling-Cyclization2009

    • Author(s)
      Ohta, Y., Ohno, H., et al.
    • Journal Title

      J.Org.Chem.

      Volume: 74 Pages: 7052-7058

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ring-Construction/Stereoselective Functionalization Cascade : Total Synthesis of Pachastrissamine (Jaspine B) through Palladium-Catalyzed Bis-cyclization of Bromoallenes2009

    • Author(s)
      Inuki, S., Ohno, H., et al.
    • Journal Title

      Org.Lett.

      Volume: 11 Pages: 4478-4481

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Facile Synthesis of 1,2,3,4-Tetrahydro-β-carbolines by One-Pot Domino -Three-Component Indole Formation and Nucleophilic Cyclization2009

    • Author(s)
      Ohta Y. and Ohno H., et al.
    • Journal Title

      Org. Lett. 11

      Pages: 1979-1982

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Palladium-Catalyzed Direct Synthesis of Carbazoles via One-Pot N-Arylation and Oxidative Biaryl Coupling : Synthesis and Mechanistic Study2009

    • Author(s)
      Watanabe T. and Ohno H., et.al.
    • Journal Title

      J. Org. Chem. 74

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of (±)-Lysergic Acid, Lysergol, and Isolysergol by Palladium-Catalyzed Domino Cyclization of Amino Allenes Bearing a Bromoindolyl Group.2008

    • Author(s)
      S.Inuki, S.Oishi, N.Fujii, H.Ohno.
    • Journal Title

      Org.Lett 10(22)

      Pages: 5239-5242

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Concise Synthesis of Indole-Fused 1,4-Diazepines through Copper(I)-Catalyzed Domino Three-Component Coupling-Cyclization-N-Arylation under Microwave Irradiation.2008

    • Author(s)
      Y.Ohta, H.Chiba, S.Oishi, N.Fujii, H.Ohno.
    • Journal Title

      Org.Lett. 10(16)

      Pages: 3535-3538

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] N.Fujii.Palladium-Catalysed Biscyclisation of Allenic Bromoalkenes through Zipper-Mode Cascade.2008

    • Author(s)
      A.Okano, T.Mizutani, S.Oishi, T.Tanaka, H.Ohno
    • Journal Title

      Chem.Commun 30

      Pages: 3534-3536

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Palladium-Catalyzed sp^3 C-H Activation of Simple Alkyl Groups: Direct Preparation of Indoline Derivatives from N-Alkyl-2-bromoanilines.2008

    • Author(s)
      T.Watanabe, S.Oishi, N.Fujii, H.Ohno.
    • Journal Title

      Org.Lett 10(9)

      Pages: 1759-1762

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct Construction of Bicyclic Heterocycles by Palladium-Catalyzed Tandem Cyclization of Propargyl Bromides.2008

    • Author(s)
      H.Ohno, A.Okano, S.Kosaka, K.Tsukamoto, M.Ohata, K.Ishihara, H.Maeda, T.Tanaka, N.Fujii.
    • Journal Title

      Org.Lett 10(6)

      Pages: 1171-1174

    • NAID

      130006995906

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Facile Synthesis of 3-(Aminomethyl)isoquinoline by Copper-Catalysed Domino Four-Component Coupling and Cyclisation.2008

    • Author(s)
      Y.Ohta, S.Oishi, N.Fujii, H.Ohno.
    • Journal Title

      Chem.Commun 7

      Pages: 835-837

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure-Activity Relationship of Pyrazine-Based CK2 Inhibitors : Synthesis and Evaluation of 2,6-Disubstituted Pyrazines and 4,6-Disubstituted Pyrimidines2008

    • Author(s)
      Suzuki Y. and Ohno H., et.al.
    • Journal Title

      Arch. Pharm. 349

      Pages: 554-561

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Palladium-Catalyzed sp3 C-H Activation of Simple Alkyl Groups : Direct Preparation of Indoline Derivatives from N-Alkyl-2-bromoanilines2008

    • Author(s)
      Watanabe T. and Ohno H., et.al.
    • Journal Title

      Org. Lett. 10

      Pages: 1759-1762

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Palladium-Catalysed Biscyclisation of Allenic Bromoalkenes through Zipper-Mode Cascade2008

    • Author(s)
      Okano A. and Ohno H., et.al.
    • Journal Title

      Chem. Commun.

      Pages: 3534-3536

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Concise Synthesis of Indole-Fused 1,4-Diazepines through Copper(I)-Catalyzed Domino Three-Component Coupling-Cyclization-N-Arylation2008

    • Author(s)
      Ohta Y. and Ohno H., et.al.
    • Journal Title

      Org. Lett 10

      Pages: 3535-3538

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Samarium(II)-Mediated Spirocyclization by Intramolecular Aryl Radical Addition onto an Aromatic Ring2008

    • Author(s)
      Inuki S. and Ohno H,., et.al.
    • Journal Title

      J.Org.Chem. 10

      Pages: 7145-7152

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Total Synthesis of(±)-Lysergic Acid, Lysergol, and Isolysergol Palladium-Catalyzed Domino Cyclization of Amino Allenes Bearing a Bromoindolyl Group2008

    • Author(s)
      Inuki S. and Ohno H., et.al.
    • Journal Title

      Org. Lett. 10

      Pages: 5239-5242

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Facile synthesis of 3-(aminomethyl)isoquinolines by copper-catalysed domino four-component coupling and cyclisation2008

    • Author(s)
      Ohno H., et al.
    • Journal Title

      Chem. Commun. 7

      Pages: 835-837

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct construction of bicyclic heterocycles by palladium-catalyzed domino cyclization of propargyl bromides2008

    • Author(s)
      Ohno H., et al.
    • Journal Title

      Org. Lett. 10

      Pages: 1171-1174

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diastereoselective synthesis of highly functionalized fluoroalkene dipeptide isosteres and its application to fmoc-based solid phase synthesis of a cyclic pentapeptide mimetic2008

    • Author(s)
      Ohno H., et al.
    • Journal Title

      Tetrahedron 64

      Pages: 4332-4346

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficient synthesis of trifluoromethyl and related trisubstituted alkene dipeptide isosteres by palladium-catalyzed carbonylation of amino acid-derived allylic carbonates2008

    • Author(s)
      Ohno H., et al.
    • Journal Title

      J. Org. Chem. 73

      Pages: 3942-3945

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Palladium-catalyzed sp^3 C-H activation of simple alkyl groups : direct preparation of indoline derivatives from N-alkyl-2-bromoanilines2008

    • Author(s)
      Ohno H., et al.
    • Journal Title

      Org. Lett. 10

      Pages: 1759-1762

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gold-Catalyzed Hydroarylation of Allenes: A Highly Regioselective Carbon-Carbon Bond Formation Producing Six-Membered Rings.2007

    • Author(s)
      T.Watanabe, S.Oishi, N.Fujii, H.Ohno.
    • Journal Title

      Org.Lett 9(23)

      Pages: 4821-4824

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Zipper-Mode Double C-H Activation: Palladium-Catalyzed Direct Construction of Highly-Fused Heterocyclic Systems.2007

    • Author(s)
      H.Ohno, M.Iuchi, N.Fujii, T.Tanaka.
    • Journal Title

      Org.Lett 9(23)

      Pages: 4813-4815

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] One-Pot Synthesis of Carbazoles by Palladium-Catalyzed N-Arylation and Oxidative Coupling.2007

    • Author(s)
      T.Watanabe, S.Ueda, S.Inuki, S.Oishi, N.Fujii, H.Ohno.
    • Journal Title

      Chem.Commun. 43

      Pages: 4516-4518

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heck-Type Cyclization of Oxime Ethers: Stereoselective Carbon-Carbon Bond Formation with Aryl Halides to Produce Heterocyclic Oximes2007

    • Author(s)
      H.Ohno, A.Aso, Y.Kadoh, N.Fujii, T.Tanaka
    • Journal Title

      Angew.Chem.Int.Ed. 46(33)

      Pages: 6325-6328

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Heck-type cyclization of oxime ethers : stereoselective carbon-carbon bond formation with aryl halides to produce heterocvclic oximes2007

    • Author(s)
      Ohno H., et al.
    • Journal Title

      Angew. Chem. Int. Ed. 46

      Pages: 6325-6328

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Facile synthesis of fluoroalkenes by palladium-catalyzed reductive defluorination of allylic gem-difluorides2007

    • Author(s)
      Ohno H., et al.
    • Journal Title

      Org. Lett. 9

      Pages: 3465-3468

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-pot synthesis of carbazoles by palladium-catalyzed N-arylation and oxidative coupling2007

    • Author(s)
      Ohno H., et al.
    • Journal Title

      Chem. Commun. 43

      Pages: 4516-4518

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Zipper-mode double C-H activation : palladium-catalyzed direct construction of highly-fused heterocyclic systems2007

    • Author(s)
      Ohno H., et al.
    • Journal Title

      Org. Lett. 9

      Pages: 4813-4815

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] N.Fujii.Efficient Synthesis of Trifluoromethyl and Related Trisubstituted Alkene Dipeptide Isosteres by Palladium-catalyzed Carbonylation of Amino Acid-derived Allylic Carbonates.

    • Author(s)
      E.Inokuchi, T.Narumi, A.Niida, K.Kobayashi, K.Tomita, S.Oishi, H.Ohno
    • Journal Title

      J.Org.Chem.

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Presentation] 金触媒を用いたアニリン誘導体の分子内連続環化反応による芳香環縮環型カルバゾール誘導体の合成2010

    • Author(s)
      稲葉祐介、大野浩章、他
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] パラジウム触媒とイソシアネートを用いたエチニルアジリジンの環拡大-連続的環化反応による連結型複素環の構築2010

    • Author(s)
      岡野晃典、大野浩章, 他
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] Jaspine Bおよびその誘導体の立体選択的合成研究2010

    • Author(s)
      吉光佑二、大野浩章, 他
    • Organizer
      日本薬学会第130年会
    • Place of Presentation
      岡山
    • Year and Date
      2010-03-28
    • Related Report
      2009 Annual Research Report
  • [Presentation] パラジウム触媒とイソシアネートを用いたエチニルアジリジンの環拡大-連続的環化反応による連結型複素環の構築2009

    • Author(s)
      岡野晃典、大野浩章, 他
    • Organizer
      第29回有機合成若手セミナー
    • Place of Presentation
      神戸
    • Year and Date
      2009-11-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 銅触媒によるテトラヒドロピリミジンを配位性置換基とした酸化的分子間オルトC-H官能基化反応2009

    • Author(s)
      水原司、大野浩章, 他
    • Organizer
      第35回反応と合成の進歩シンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      2009-11-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] 銅触媒による多成分カップリング反応を用いたワンポット含窒素多環式複素環骨格構築法の開発2009

    • Author(s)
      太田悠介、大野浩章、他
    • Organizer
      第35回反応と合成の進歩シンポジウム
    • Place of Presentation
      金沢
    • Year and Date
      2009-11-16
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] 銅触媒によるテトラヒドロピリミジンを配位性置換基とした酸化的分子間オルトC-H官能基化反応2009

    • Author(s)
      水原司、大野浩章, 他
    • Organizer
      第59回日本薬学会近畿支部総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] Jaspine Bおよびその誘導体の立体選択的合成2009

    • Author(s)
      吉光佑二、大野浩章, 他
    • Organizer
      第59回日本薬学会近畿支部総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 銅触媒による多成分カップリング反応を用いた多環式インドールのワンポット構築法の開発2009

    • Author(s)
      太田悠介、大野浩章, 他
    • Organizer
      第59回日本薬学会近畿支部総会
    • Place of Presentation
      大阪
    • Year and Date
      2009-10-24
    • Related Report
      2009 Annual Research Report
  • [Presentation] 多成分カップリング・連続環化反応によるピロロインドール誘導体及びジピロロピリジン誘導体の合成研究2009

    • Author(s)
      鈴木大和、大野浩章、他
    • Organizer
      第7回次世代を担う有機化学シンポジウム
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-24
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] カルバゾール骨格を有する新規Eg5阻害剤のデザインと合成2009

    • Author(s)
      渡部敏明、大野浩章, 他
    • Organizer
      日本ケミカルバイオロジー研究会第4回年会
    • Place of Presentation
      神戸
    • Year and Date
      2009-05-19
    • Related Report
      2009 Annual Research Report
  • [Presentation] ピラジンを母核とするCK2阻害剤の構造活性相関研究2009

    • Author(s)
      鈴木大和、大野浩章, 他
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] パラジウム触媒を用いたsp3 C-H活性化によるインドリンの合成2009

    • Author(s)
      渡部敏明、大野浩章, 他
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-28
    • Related Report
      2008 Annual Research Report
  • [Presentation] 銅触媒を用いた連続三成分結合形成反応による2-(アミノメチル)インドール骨格およびインドール縮環型多環式骨格構築法の開発2009

    • Author(s)
      太田悠介、大野浩章, 他
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2009-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] Pd触媒によるアレン連続環化反応を利用したErgotAlkaloid骨格の一挙構築法開発と応用2008

    • Author(s)
      井貫晋輔、大野浩章、他
    • Organizer
      第34回反応と合成の進歩シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2008-11-24
    • Related Report
      2009 Final Research Report
  • [Presentation] 銅触媒-マイクロ波照射を用いた連続三成分カップリング-環化-N-アリール化反応によるインドール縮環型1.4-ジアゼピン合成法2008

    • Author(s)
      太田悠介、大野浩章, 他
    • Organizer
      第34回反応と合成の進歩シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2008-11-14
    • Related Report
      2008 Annual Research Report
  • [Presentation] 連続三成分カップリングー環化-N-アリール化反応による銅触媒一マイクロ波照射を用いたインドール縮環型1, 4-ジアゼピン合成法の開発2008

    • Author(s)
      太田悠介、大野浩章, 他
    • Organizer
      第28回有機合成若手セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] パラジウム触媒を用いたプロモエンアレンの連続的閉環反応による多環式複素環の一挙構築2008

    • Author(s)
      岡野晃典、大野浩章, 他
    • Organizer
      第28回有機合成若手セミナー
    • Place of Presentation
      大阪
    • Year and Date
      2008-11-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] パラジウム触媒を用いたプロモエンアレンの連続環化反応による多環式複素環の一挙構築2008

    • Author(s)
      岡野晃典、大野浩章, 他
    • Organizer
      第34回反応と合成の進歩シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2008-11-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] 銅触媒-マイクロ波照射を用いた連続三成分カップリング-環化-N-アリール化反応によるインドール縮環型1,4-ジアゼピン合成法開発2008

    • Author(s)
      太田悠介、大野浩章、他
    • Organizer
      第34回反応と合成の進歩シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2008-11-04
    • Related Report
      2009 Final Research Report
  • [Presentation] Pd触媒によるアレン連続環化反応を利用したErgot Alkaloid骨格の一挙構築法開発と応用2008

    • Author(s)
      井貫晋輔、大野浩章, 他
    • Organizer
      第34回反応と合成の進歩シンポジウム
    • Place of Presentation
      京都
    • Year and Date
      2008-11-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] 求核的CF3化反応による立体選択的トリフルオロメチルアルケン型ジペプチドイソスターの合成研究2008

    • Author(s)
      小林数也、大野浩章, 他
    • Organizer
      第58回日本薬学会近畿支部総会
    • Place of Presentation
      神戸
    • Year and Date
      2008-10-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] キナーゼ阻害剤テンプレートを指向した三環性芳香環構築反応の開発2008

    • Author(s)
      鈴木大和、大野浩章, 他
    • Organizer
      第58回日本薬学会近畿支部総会
    • Place of Presentation
      神戸
    • Year and Date
      2008-10-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] 触媒的連続結合形成反応の開発とErgotアルカロイド全合成への応用2008

    • Author(s)
      大野浩章
    • Organizer
      第43回天然物化学討論会
    • Place of Presentation
      大阪
    • Year and Date
      2008-07-10
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] パラジウム触媒を用いたアレン連続環化反応を利用したErgot Alkaloid 骨格の一挙構築法開発と応用2008

    • Author(s)
      井貫晋輔、大野浩章、他
    • Organizer
      第6回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-05-30
    • Related Report
      2009 Final Research Report
  • [Presentation] Pd触媒によるアレン連続環化反応を利用したErgotAlkaloid骨格の一挙構築法開発と応用2008

    • Author(s)
      井貫晋輔、大野浩章、他
    • Organizer
      第6回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-05-30
    • Related Report
      2009 Final Research Report
  • [Presentation] パラジウム触媒を用いたアレン連続環化反応を利用したErgot Alkaloid骨格の一挙構築法開発と応用2008

    • Author(s)
      井貫晋輔、大野浩章, 他
    • Organizer
      第6回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-05-30
    • Related Report
      2008 Annual Research Report
  • [Presentation] pd触媒によるアレン連続環化反応を利用したErgot Alkaloid骨格の一挙構築法開発と応用2008

    • Author(s)
      井貫晋輔, et al.
    • Organizer
      第6回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2008-05-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 新規三環性ヘテロ芳香環構築反応の開発とキナーゼ阻害剤テンプレートへの応用2008

    • Author(s)
      鈴木大和、大野浩章, 他
    • Organizer
      日本薬学会第129年会
    • Place of Presentation
      京都
    • Year and Date
      2008-03-27
    • Related Report
      2008 Annual Research Report
  • [Presentation] ピラジンを母核とするCK2阻害剤の構造活性相関研究2008

    • Author(s)
      鈴木大和, et al.
    • Organizer
      日本薬学会第128年会(2008)
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] 求核的CF_3化反応による立体選択的トリフルオロメチルアルケン型ジペプチドイソスターの合成2008

    • Author(s)
      小林数也, et al.
    • Organizer
      日本薬学会第128年会(2008)
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] パラジウム触媒を用いたアレンの連続環化反応によるErgot Alkaloid骨格の一挙構築2008

    • Author(s)
      井貫晋輔, et al.
    • Organizer
      日本薬学会第128年会(2008)
    • Place of Presentation
      横浜
    • Year and Date
      2008-03-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Synthesis of Nitrogen Heterocycles by Palladium-Catalyzed sp^3 C-H Activation2008

    • Author(s)
      Toshiaki Watanabe, et al.
    • Organizer
      The 9th Youngnam-Kinki Joint Symposium on Organometallic Chemistry
    • Place of Presentation
      Kyoto
    • Year and Date
      2008-01-25
    • Related Report
      2007 Annual Research Report
  • [Presentation] ピラジンを母核とするCK2阻害剤の構造活性相関研究2008

    • Author(s)
      鈴木大和, et al.
    • Organizer
      日本ケミカルバイオロジー研究会第3回年会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] パラジウム触媒を用いたアレンの連続環化反応によるErgot Alkaloid骨格の一挙構築2007

    • Author(s)
      井貫晋輔, et al.
    • Organizer
      第27回有機合成若手セミナー
    • Place of Presentation
      京都
    • Year and Date
      2007-11-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] パラジウム触媒カルボニル化反応を用いたトリフルオロメチルアルケンジペプチドイソスター及び類縁体の新規合成法の開発2007

    • Author(s)
      井ノ口恵利子, et al.
    • Organizer
      第27回有機合成若手セミナー
    • Place of Presentation
      京都
    • Year and Date
      2007-11-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] ペプチド結合ミメティックスとしてのフルオロアルケン骨格の展望2007

    • Author(s)
      鳴海哲夫, et al.
    • Organizer
      第44回ペプチド討論会
    • Place of Presentation
      富山
    • Year and Date
      2007-11-07
    • Related Report
      2007 Annual Research Report
  • [Presentation] 連続結合形成反応による縮環型芳香族化合物の一挙合成法の開発2007

    • Author(s)
      大野浩章、他
    • Organizer
      第33回反応と合成の進歩シンポジウム
    • Place of Presentation
      長崎
    • Year and Date
      2007-11-06
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] パラジウム触媒によるカルボニル化反応を用いたトリフルオロメチルアルケン型ジペプチドイソスター及び類縁体の新規合成法の開発2007

    • Author(s)
      井ノ口恵利子, et al.
    • Organizer
      第33回反応と合成の進歩シンポジウム
    • Place of Presentation
      長崎
    • Year and Date
      2007-11-05
    • Related Report
      2007 Annual Research Report
  • [Presentation] 有機金属による炭素-フッ素結合切断を伴うフルオロアルケン骨格の合成:多価官能基を有するフルオロアルケン型ジペプチドイソスターの高立体選択的合成への展開2007

    • Author(s)
      鳴海哲夫
    • Organizer
      第57回日本薬学会近畿支部大会
    • Place of Presentation
      大阪
    • Year and Date
      2007-10-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] パラジウム触媒を用いたアレンの連続環化反応によるErgot Alkaloid骨格の一挙構築2007

    • Author(s)
      井貫晋輔, et al.
    • Organizer
      第57回日本薬学会近畿支部大会
    • Place of Presentation
      大阪
    • Year and Date
      2007-10-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] パラジウム触媒によるカルボニル化反応を用いたトリフルオロメチルアルケン型ジペプチドイソスター及び類縁体の新規合成法の開発2007

    • Author(s)
      井ノ口恵利子, et al.
    • Organizer
      第57回日本薬学会近畿支部大会
    • Place of Presentation
      大阪
    • Year and Date
      2007-10-27
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pd触媒を用いたタンデム型N-アリール化-C-H 活性化によるカルバゾールの合成と反応機構の考察2007

    • Author(s)
      渡部敏明、大野浩章、他
    • Organizer
      第5回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2009 Final Research Report
  • [Presentation] Synthesis and application of carbazoles by palladium-catalyzed tandem N-arylation and oxidative C-H activation2007

    • Author(s)
      Toshiaki Watanabe, Hiroaki Ohno, et al.
    • Organizer
      Eighth Tetrahedron Symposium
    • Place of Presentation
      ベルリン
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] Construction of 2-(aminomethyl)indole motif by Cu-catalyzed multi-component reaction2007

    • Author(s)
      Yusuke Ohta, Hiroaki Ohno, et al.
    • Organizer
      14th IUPAC Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
    • Place of Presentation
      奈良
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] Synthesis and application of carbazoles by palladium-catalyzed tandem N-arylation of carbazoles by palladium-catalyzed tandem N-arylation and oxidative C-H activation2007

    • Author(s)
      Toshiaki Watanabe, Hiroaki Ohno, et al.
    • Organizer
      14th IUPAC Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
    • Place of Presentation
      奈良
    • Related Report
      2009 Final Research Report
  • [Presentation] Construction of 2-(aminomethyl)indole motif by Cu-catalyzed multicomponent reaction2007

    • Author(s)
      Yusuke Ohta, Hiroaki Ohno, et al.
    • Organizer
      234th ACS meeting & exposition
    • Place of Presentation
      ボストン
    • Related Report
      2009 Final Research Report
  • [Presentation] パラジウム触媒を用いたプロパルギルブロミドの連続的閉環反応による二環性複素環の一挙構築2007

    • Author(s)
      岡野晃典、大野浩章、他
    • Organizer
      第33回反応と合成の進歩シンポジウム
    • Place of Presentation
      長崎
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] Pd触媒を用いたタンデム型N-アリール化-C-H活性化によるカルバゾールの合成と反応機構の考察2007

    • Author(s)
      渡部敏明, et al.
    • Organizer
      第5回次世代を担う有機化学シンポジウム
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] One-pot synthesis of carbazoles by palladium-catalyzed N-arylation and oxidative coupling2007

    • Author(s)
      Toshiaki Watanabe, et al.
    • Organizer
      6th AFMC International Medicinal Chemistry Symposium
    • Place of Presentation
      イスタンブール
    • Related Report
      2007 Annual Research Report
  • [Presentation] Synthesis and application of carbazoles by palladium-catalyzed tandem N-arylation and oxidative C-H activation2007

    • Author(s)
      Toshiaki Watanabe, et al.
    • Organizer
      14th IUPAC Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
    • Place of Presentation
      奈良
    • Related Report
      2007 Annual Research Report
  • [Presentation] Pd-Catalyzed carbonylation of CF_3-containing allylic carbonate : application to the synthesis of (Z)-trifluoromethylalkene dipeptide isosteres2007

    • Author(s)
      Eriko Inokuchi, et al.
    • Organizer
      14th IUPAC Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
    • Place of Presentation
      奈良
    • Related Report
      2007 Annual Research Report
  • [Presentation] Construction of 2-(aminomethyl)indole motif by Cu-catalyzed multi-component reaction2007

    • Author(s)
      Yusuke Ohta, et al.
    • Organizer
      234th ACS meeting & exposition
    • Place of Presentation
      ボストン
    • Related Report
      2007 Annual Research Report
  • [Presentation] Diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres : Lys-Lys and Glu-Glu type FADIs2007

    • Author(s)
      Tetsuo Narumi, et al.
    • Organizer
      234th ACS meeting & exposition
    • Place of Presentation
      ボストン
    • Related Report
      2007 Annual Research Report
  • [Remarks] ホームページ等

    • URL

      http://www.pharm.kyoto-u.ac.jp/seizo/home.htm

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.pharm.kyoto-u.ac.jp/seizo/home.htm

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://www.pharm.kyoto-u.acjp/seizo/home.htm

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://www.pharm.kyoto-u.ac.jp/seizo/home.htm

    • Related Report
      2007 Annual Research Report
  • [Patent(Industrial Property Rights)] Eg5阻害剤2008

    • Inventor(s)
      藤井信孝、大石真也、大野浩章、他
    • Industrial Property Rights Holder
      京都大学・ファルマIP
    • Industrial Property Number
      2008-331963
    • Filing Date
      2008-12-26
    • Related Report
      2009 Final Research Report
  • [Patent(Industrial Property Rights)] Eg5阻害剤2008

    • Inventor(s)
      藤井、大石, 他
    • Industrial Property Rights Holder
      京都大学・ファルマIP
    • Industrial Property Number
      2008-331963
    • Filing Date
      2008-12-26
    • Related Report
      2008 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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