Role for mechanical stress in lung and airway remodeling
| Project/Area Number |
19689017
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| Research Category |
Grant-in-Aid for Young Scientists (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Nagoya University |
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Principal Investigator |
ITO Satoru Nagoya University, 医学部・附属病院, 助教 (60378073)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥13,910,000 (Direct Cost: ¥10,700,000、Indirect Cost: ¥3,210,000)
Fiscal Year 2009: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2008: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2007: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000)
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| Keywords | 気管支喘息 / リモデリング / メカニカルストレス / ARDS / TRP / カルシウムイオン / 気道平滑筋 / メカノトランスダクション / IL-8 / 肺微小血管内皮 / 呼吸生理 / メンソール / エンドセリン |
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| Research Abstract |
We demonstrated that mechanical stretch activates Ca^<2+> influx via stretch-activated channels and induces production of cytokine/chemokines (IL-6, IL-8, and MCP-1) in human airway smooth muscle cells and pulmonary microvascular endothelial cells. Thus, excessive mechanical strain would contribute to the pathogenesis of lung and airway remodeling via altering cellular properties of pulmonary cells.
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Report
(4 results)
Research Products
(45 results)
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[Journal Article] Mechanical stretch enhances IL-8 production in pulmonary microvascular endothelial cells.2009
Author(s)
Iwaki M, Ito S, Morioka M, Iwata S, Numaguchi Y, Ishii M, Kondo M, Kume H, Naruse K, Sokabe M, Hasegawa Y.
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Journal Title
Biochem Biophys Res Commun 389
Pages: 531-536
Related Report
Peer Reviewed
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