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Verification of diagnostic biomarker candidates for biliary and pancreatic carcinoma by SRM MS-based Multiple Assay

Research Project

Project/Area Number 19689028
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Digestive surgery
Research InstitutionTohoku University

Principal Investigator

ONOGAWA Tohru  東北大学, 病院, 助教 (50431557)

Project Period (FY) 2007 – 2010
Project Status Completed (Fiscal Year 2010)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2010: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2009: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2008: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2007: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywords薬物輸送体 / 抗癌剤感受性 / プロテオミクス / バイオマーカー / 質量分析 / トランスポーター / 癌細胞 / フォーカス / 薬物輸送 / 抗癌剤
Research Abstract

Cholangiocarcinoma (CC) is usually diagnosed in advanced stage and associated with a dismal prognosis. A proteomic analysis may help identify novel biomarkers for the eraly detection, prevention and treatment of CC. The purpose of this study was to identify proteins differentially overexpressed in CC and to validate these proteins as potential biomarkers. We conducted a retrospective global proteomic sthdy of formalin-fixed parafiin-embedded (FEPE) tissues by shotgun LC-MS/MS. We identified abouto 2000 proteins, and statistical comparison showed that 160 proteins were overexpressed in CC compared to noncancerous bile duct. We applied a targeted proteomics approach based on selected reaction monitoring (SRM) to quantify a subset of these proteins. SRM analysis suggested that some proteins would be useful as potential biomarkers. Expression of these proteins was cinfirmed by immunohistochemistry. Further validation using a large-scale sample set of FFPE tissues is now under way.

Report

(6 results)
  • 2010 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (63 results)

All 2011 2010 2009 2008 2007

All Journal Article (33 results) (of which Peer Reviewed: 33 results) Presentation (26 results) Book (3 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Computed tomography reflected endocrine function of the pancreas2011

    • Author(s)
      Sakata N, Egawa S, Rikiyama T, Yoshimatsu G, Masuda K, Ohtsuka H, Ottomo S, Nakagawa K, Hayashi H, Morikawa T, Onogawa T, Yamamoto K, Yoshida H, Akada M, Motoi F, Naitoh T, Katayose Y, Unno M
    • Journal Title

      J Gastrointest Surg.

      Volume: 15(3) Pages: 535-32

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Paclitaxel as second-line chemotherapy in patients with gemcitabine-refractory pancreatic cancer: a retrospective study2011

    • Author(s)
      Maeda S, Motoi F, Onogawa T, Morikawa T, Shigeru O, Sakata N, Takadate T, Naitoh T, Rikiyama T, Katayose Y, Egawa S, Unno M
    • Journal Title

      Int J Clin Oncol.

      Volume: (in Press)

    • NAID

      10030246872

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] The HMG-CaA reductase inhibitor prevastatin stimulates insulin secretion through organic anion transporter polypeptides2010

    • Author(s)
      Abe M, Toyohara T, Ishii A, Suzuki T, Noguchi N, Akiyama Y, Shiwaku HO, Nakagomi-Hagugara R, Zheng G, Shibata E, Souma T, Shindo T, Shima H, Takeuchi Y, Mishima E, Tanemoto M, Terasaki T, Onogawa T, Unno M, Ito S, Takasawa S, Abe T
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 25(3) Pages: 274-82

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of Frey procedures: Japanese experience2010

    • Author(s)
      Egawa S, Motoi F, Sakata N, Kitamura Y, Nakagawa K, Ohtsuka H, Hayashi H, Morikawa T, Omura N, Ottomo S, Yoshida H, Onogawa T, Yamamoto K, Akada M, Rikiyama T, Katayose Y, Matsuno S, Unno M
    • Journal Title

      J Hepatoviliary Pancreat Sci

      Volume: 17(6) Pages: 745-41

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of Frey procedures : Japanese experience2010

    • Author(s)
      Egawa S, et al
    • Journal Title

      J Hepatobiliary Pancreat Sci

      Volume: 17(6) Pages: 745-751

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The HMG-CoA reductase inhibitor pravastatin stimulates insulin secretion through organic anion transporter polypeptides2010

    • Author(s)
      Abe M, et al
    • Journal Title

      Drug Metab Pharmacokinet

      Volume: 25(3) Pages: 274-282

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Computed tomography reflected endocrine function of the pancreas2010

    • Author(s)
      Sakata N, et al
    • Journal Title

      J Gastrointest Surg

      Volume: 15(3) Pages: 525-32

    • Related Report
      2010 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of adenovirus-mediated p27kip1 lacking the Jab1-binding region enhances cytotoxicity and inhibits xenografted human cholangiocarcinoma growth2009

    • Author(s)
      Shiraso S, Katayose Y, Yamamoto K, Muzuma M, Yabuuchi S, Oda A, Rikiyama T, Onogawa T, Yoshida H, Hayashi H, Ohtsuka H, Motoi F, Egawa S, Kato J, Unno M
    • Journal Title

      Anticancer Res.

      Volume: 29(6) Pages: 2015-24

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Clock gene mouse period2 overexpression inhibits growth ot fuman pancreatic cancer cells and has synergistic effect with cisplatin2009

    • Author(s)
      Oda A, Katayose Y, Yabuuchi S, Yamamoto K, Mizuma M, Shirasou S, Onogawa T, Ohtsuka H, Yoshida H, Hayashi H, Rikiyama T, Kim H, Choe Y, Kim K, Son H, Motoi F, Egawa S, Unno M
    • Journal Title

      Anticancer Res.

      Volume: 29(4) Pages: 1201-9

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] ZD1839 (IRESSA) stabilizes p27^<Kip1> and enhances radiosensitivity in cholangiocarcinoma cell lines2009

    • Author(s)
      Yabuuchi S, Katayoshi Y, Oda A, Mizuma M, Shirasou S, Sasaki T, Yamamoto K, Oikawa M, Rikiyama T, Onogawa T, Yoshida H, Ohtsuka H, Motoi F, Egawa S, Unno M
    • Journal Title

      Anticancer Res.

      Volume: 29(4) Pages: 1169-80

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Assessment of Frey procedures : Japanese experience2009

    • Author(s)
      Egawa S, et al.
    • Journal Title

      J Hepatobiliary Pancreat Surg

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Overexpression of adenovirus-mediated p27^<kip1> lacking the Jab1-binding region enhances cytotoxicity and inhibits xenografted human cholangiocarcinoma growth2009

    • Author(s)
      Shiraso S, et al.
    • Journal Title

      Anticancer Res. 29(6)

      Pages: 2015-2024

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clock gene mouse period2 overexpression inhibits growth of human pancreatic cancer cells and has synergistic effect with cisplatin2009

    • Author(s)
      Oda A, et al.
    • Journal Title

      Anticancer Res. 29(4)

      Pages: 1201-1209

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ZD1839(IRESSA)stabilizes p27Kip1 and enhances radiosensitivity in cholangio-carcinoma cell lines2009

    • Author(s)
      Yabuuchi S, et al.
    • Journal Title

      Anticancer Res. 29(4)

      Pages: 1169-1180

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clock gene mouse period2 overexpression inhibits growth of humanpancreatic cancer cells and has synergistic effect with Cisplatin2009

    • Author(s)
      Oda A, Katayose Y, Yabuuchi S, Yamamoto K, Mizuma M, Shirasou S, Onogawa T, Ohtsuka H, Yoshida H, Hayashi H, Rikiyama T, Kim H, Choe Y, Kim K, Son H, Motoi F, Egawa S, Unno M
    • Journal Title

      Anticancer Res. 29(4)

      Pages: 1201-1209

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ZD1839(IRESSA(R)) Stabilizes p27Kip1 and Enhances Radiosensitivity in Cholangiocarcinoma Cell Lines2009

    • Author(s)
      Yabuuchi S, Katayose Y, Oda A, Mizuma M, Shirasou S, Sasaki T, Yamamoto K, Oikawa M, Rikiyama T, Onogawa T, Yoshida H, Ohtuska H, Motoi F, Egawa S, Unno M
    • Journal Title

      Anticancer Res. 29(4)

      Pages: 1169-1180

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulated p27Kip1 reduces matrix metalloproteinase-9 and inhibits invasion of human breast cancer cells2008

    • Author(s)
      Mizuma M, Katayose Y, Yamamoto K, Shirano S, Sasaki T, Yabuuchi S, Oda A, Masuda K, Rikiyama T, Yabuuchi S, Oda A, Masuda K, Rikiyama T, Onogawa T, Ohtsuka H, Motoi F, Egawa S, Unno M
    • Journal Title

      Anticancer Res.

      Volume: 28(5A) Pages: 2669-77

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Advanced bile duct carcinoma in a 15-year-old patient with pancreaticobiliary maljunction and congenital biliary cystic disease2008

    • Author(s)
      Nakamura H, Katayose Y, Rikiyama T, Onogawa T, Yamamoto K, Yoshida H, Hayashi H, Ohtsuka H, Hayashi Y, Egawa S, Unno M
    • Journal Title

      J Hepatobiliary Pancreat Surg

      Volume: 15(5) Pages: 554-9

    • NAID

      10024306069

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Bile acids repress E-cadherin through the induction of Snail and increase cancer invasiveness in human hepatobiliary carcinoma2008

    • Author(s)
      Fukase K, Ohtsuka H, Onogawa T, Oshio H, Ii T, Mutoh M, Katayose Y, Rikiyama T, Oikawa M, Motoi F, Egawa S, Abe T, Unno M
    • Journal Title

      Cancer Sci.

      Volume: 99(9) Pages: 1785-92

    • NAID

      10024010945

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Peroxisome proliferator -activated receptor alpha activates cyclooxygenase-2 gene transcription through bile acid transport in human colorectal cancer cell lines2008

    • Author(s)
      Oshio H, Abe T, Onogawa T, Ohtsuka H, Sato T, Ii T, Fukase K, Muto M, Katayose Y, Oikawa M, Rikiyama T, Egawa S, Unno M
    • Journal Title

      J Gastroenterol

      Volume: 43(7) Pages: 538-49

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Up-regulated p27Kip1 reduces matrix metalloproteinase-9 and inhibits invasion of human breast cancer cells.2008

    • Author(s)
      Mizuma M, Katayose Y, Yamamoto K, Shiraso S, Sasaki T, Yabuuchi S, Oda A, Masuda K, Rikiyama T, Onogawa T, Ohtsuka H, Motoi F, Egawa S, Unno M.
    • Journal Title

      Anticancer Res. 28(5A)

      Pages: 2669-2677

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Bile acids repress E-cadherin through the induction of Snail and increase cancer invasiveness in human hepatobiliary carcinoma.2008

    • Author(s)
      Fukase K, Ohtsuka H, Onogawa T, Oshio H, Ii T, Mutoh M, Katayose Y, Rikiyama T, Oikawa M, Motoi F, Egawa S, Abe T, Unno M.
    • Journal Title

      Cancer Sci. 99(9)

      Pages: 1785-1792

    • NAID

      10024010945

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Peroxisome proliferator-activated receptor alpha activates cyclooxygenase-2 gene transcription through bile acid transport in human colorectal cancer cell lines.2008

    • Author(s)
      Oshio H, Abe T, Onogawa T, Ohtsuka H, Sato T, Ii T, Fukase K, Muto M, Katayose Y, Oikawa M, Rikiyama T, Egawa S, Unno M.
    • Journal Title

      J Gastroenterol. 43(7)

      Pages: 538-549

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Up-regulated p27Kip1 reduces matrix metalloproteinase-9 and inhibits invasion of human breast cancer cells2008

    • Author(s)
      Mizuma M, Katayose Y, Yamamoto K, Shiraso S, Sasaki T, Yabuuchi S, Oda A, Masuda K, Rikiyama T, Onogawa T, Ohtsuka H, Motoi F, Egawa S, Unno M
    • Journal Title

      Anticancer Res. 28(5A)

      Pages: 2669-2677

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Advanced bile duct carcinoma in a 15-year-old patient with pancreaticobiliary maijunction and congenital biliary cystic disease2008

    • Author(s)
      Nakamura H, Katayose Y, Rikiyama T, Onogawa T, Yamamoto K, Yoshida H, Hayashi H, Ohtsuka H, Hayashi Y, Egawa S, Unno M
    • Journal Title

      J Hepatobiliary Pancreat Surg. 15(5)

      Pages: 554-559

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Bile acids repress E-cadherin through the induction of Snail and increasecancer invasiveness in human hepatobiliary carcinoma2008

    • Author(s)
      Fukase K, Ohtsuka H, Onogawa T, Oshio H, li T, Mutoh M, Katayose Y, Rikiyama T, Oikawa M, Motoi F, Egawa S, Abe T, Unno M
    • Journal Title

      Cancer Sci. 99(9)

      Pages: 1785-1792

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Peroxisome proliferator-activated receptor alpha activates cyclooxygenase-2 gene transcription through bile acid transport in human colorectal cancer cell lines2008

    • Author(s)
      Oshio H, Abe T, Onogawa T, Ohtsuka H, Sato T, li T, Fukase K, Muto M, Katayose Y, Oikawa M, Rikiyama T, Egawa S, Unno M
    • Journal Title

      J Gastroenterol. 43(7)

      Pages: 538-549

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Adenovirus expressing mutant p27kip1 enhanced apoptosis and inhibited the growth of xenografted human breast cancer2007

    • Author(s)
      Sakai T, Katayose Y, Yamamoto K, Mizuma M, Shiraso S, Yabuuchi S, Oda A, Rikiyama T, Oikawa M, Onogawa T, Suzuki M, Lee CT, Unno M
    • Journal Title

      Surg Today

      Volume: 37(12) Pages: 1073-82

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma2007

    • Author(s)
      Onogawa T, Muto M, Suzuki T, Ishida T, Rikiyama T, Katayose Y, Ohuchi N, Sasano H, Abe T, Unno M
    • Journal Title

      Cancer Sci.

      Volume: 98(10) Pages: 1570-6

    • NAID

      10019997421

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Expression of organic cation transporter SLC22A16 in human epithelial ovarian cancer: a possible role of the adriamycin importer2007

    • Author(s)
      Ota K, Ito K, Akahira H, Sato N, Onogawa T, Moriya T, Unno M, Abe T, Niikura H, Takano T, Yaegashi N
    • Journal Title

      Int J Gynecol Pathol

      Volume: 26(3) Pages: 334-40

    • Related Report
      2010 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human liver-specific organic anion transporter-2 is a potent prognostic factor for human breast carcinoma.2007

    • Author(s)
      Onogawa T, Muto M, Suzuki T, Ishida T, Rikiyama T, Katayose Y, Ohuchi N, Sasano H, Abe T, Unno M.
    • Journal Title

      Cancer Sci. 98(10)

      Pages: 1570-1576

    • NAID

      10019997421

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] Expression of organic cation transporter SLC22A16 in human epithelial ovarian cancer: a possible role of the adriamycin importer.2007

    • Author(s)
      Ota K, Ito K, Akahira J, Sato N, Onogawa T, Moriya T, Unno M, Abe T, Niikura H, Takano T, Yaegashi N.
    • Journal Title

      Int J Gynecol Pathol. 26(3)

      Pages: 334-340

    • Related Report
      2009 Self-evaluation Report
    • Peer Reviewed
  • [Journal Article] 肝内結石症における肝内胆管癌の特徴と治療成績2007

    • Author(s)
      小野川 徹
    • Journal Title

      消化器画像 28(7)

      Pages: 533-537

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Discovery Proteomics using Formalin-Fixed Paraffin-Embedded Tissues of Cholangiocarcinoma2010

    • Author(s)
      前田晋平, 小野川徹, ら
    • Organizer
      第69回日本癌学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2010-09-22
    • Related Report
      2010 Annual Research Report
  • [Presentation] ホルマリン固定パラフィン包埋(FFPE)組織切片の臨床プロテオーム解析における基礎パラメータの検討2010

    • Author(s)
      小野川徹, ら
    • Organizer
      日本プロテオーム学会2010年会・第6回日本臨床プロテオーム研究会連合大会
    • Place of Presentation
      浦安
    • Year and Date
      2010-07-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胆道癌FFPE組織を用いた網羅的プロテオーム解析による新規バイオマーカーの探索と検証2010

    • Author(s)
      前田晋平, 小野川徹, ら
    • Organizer
      日本プロテオーム学会2010年会・第6回日本臨床プロテオーム研究会連合大会
    • Place of Presentation
      浦安
    • Year and Date
      2010-07-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] FFPE組織を用いたレトロスペクティブプロテオミクスによる膵癌新規予後予測マーカーの探索2010

    • Author(s)
      高舘達之, 小野川徹, ら
    • Organizer
      日本プロテオーム学会2010年会・第6回日本臨床プロテオーム研究会連合大会
    • Place of Presentation
      浦安
    • Year and Date
      2010-07-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] ホルマリン固定パラフィン包理(FFPE)組織切片の臨床プロテオーム解析における基礎パラメータの検討2010

    • Author(s)
      小野川徹ら(15名中1番目)
    • Organizer
      日本ヒトプロテオーム機構第8回大会・第6回日本臨床プロテオーム研究会連合大会
    • Place of Presentation
      浦安
    • Year and Date
      2010-07-26
    • Related Report
      2010 Final Research Report
  • [Presentation] 胆道癌FFPE組織を用いた網羅的プロテオーム解析による新規バイオマーカーの探索と検証2010

    • Author(s)
      前田晋平, 小野川徹ら
    • Organizer
      日本ヒトプロテオーム機構第8回大会・第6回日本臨床プロテオーム研究会連合大会
    • Place of Presentation
      浦安
    • Year and Date
      2010-07-26
    • Related Report
      2010 Final Research Report
  • [Presentation] FFPEを用いた網羅的プロテオーム解析による膵癌新規予後予測マーカーの探索2010

    • Author(s)
      高舘達之, 小野川徹ら
    • Organizer
      日本ヒトプロテオーム機構第8回大会・第6回日本臨床プロテオーム研究会連合大会
    • Place of Presentation
      浦安
    • Year and Date
      2010-07-26
    • Related Report
      2010 Final Research Report
  • [Presentation] The effectiveness of paclitaxel for gemcitabine-refractory pancreatic cancer2010

    • Author(s)
      S.Maeda, F.Motoi, et al
    • Organizer
      Joint Meeting of IAP and JPS 2010
    • Place of Presentation
      Fukuoka
    • Year and Date
      2010-07-13
    • Related Report
      2010 Annual Research Report
  • [Presentation] Discoverty of Prognostic Factor using Proteomic Analysis with Formalin-Fixed Paraffin-Embedded Tissues of Pancreatic Cancer2010

    • Author(s)
      Takadate T, Onogawa T, et al.
    • Organizer
      the Joint Meeting of the International Association of Pancreatology and the Japan Pancreas Society
    • Place of Presentation
      Fukuoka
    • Year and Date
      2010-07-11
    • Related Report
      2010 Final Research Report
  • [Presentation] Discovery of Prognostic Factor using Proteomic Analysis with Formalin-Fixed Paraffin-Embedded Tissues of Pancreatic Cancer2010

    • Author(s)
      Takadate T, Onogawa T, et al
    • Organizer
      Joint Meeting of IAP and JPS 2010
    • Place of Presentation
      Fukuoka
    • Year and Date
      2010-07-11
    • Related Report
      2010 Annual Research Report
  • [Presentation] 病院保管のホルマリン固定組織からプロテオーム解析はどこまでできるか?2010

    • Author(s)
      小野川徹ら(21名中1番目)
    • Organizer
      第22回日本肝胆膵外科学会総会
    • Place of Presentation
      仙台
    • Year and Date
      2010-06-28
    • Related Report
      2010 Final Research Report
  • [Presentation] 病院保管のホルマリン固定化永久組織からプロテオーム解析はどこまでできるか?~ナノテクノロジーによるTissue to serum & bile strategy~2010

    • Author(s)
      小野川徹, ら
    • Organizer
      第22回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] ホルマリン固定パラフィン包埋組織を用いた臨床プロテオミクスによる膵癌新規バイオマーカーの探索2010

    • Author(s)
      高舘達之, 小野川徹, ら
    • Organizer
      第22回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-27
    • Related Report
      2010 Annual Research Report
  • [Presentation] FFPE組織を用いた網羅的プロテオーム解析による胆道癌新規バイオマーカーの探索2010

    • Author(s)
      前田晋平, 小野川徹, ら
    • Organizer
      第22回日本肝胆膵外科学会・学術集会
    • Place of Presentation
      仙台
    • Year and Date
      2010-05-26
    • Related Report
      2010 Annual Research Report
  • [Presentation] 胆道癌ホルマリン固定パラフィン包理切片からのディスカバリープロテオミクス2009

    • Author(s)
      小野川徹ら(21名中1番目)
    • Organizer
      日本ヒトプロテオーム機構第7回大会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-27
    • Related Report
      2010 Final Research Report
  • [Presentation] 胆道癌ホルマリン固定パラフィン包埋切片からのディスカバリープロテオミクス2009

    • Author(s)
      小野川徹, ら(21名中1番目)
    • Organizer
      日本ヒトプロテオーム機構第7回大会
    • Place of Presentation
      東京
    • Year and Date
      2009-07-27
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 胆道癌ホルマリン固定パラフィン包埋切片からのディスカバリープロテオミクス2009

    • Author(s)
      小野川徹, ら
    • Organizer
      日本ヒトプロテオーム機構(JHUPO)第7回大会
    • Place of Presentation
      東京・北里大学薬学部
    • Year and Date
      2009-07-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 胆道癌におけるディスカバリープロテオミクス~当院の病理組織と自科臨床データからオリジナルな成果を! ~2009

    • Author(s)
      小野川徹, ら
    • Organizer
      東北大学医学系グローバルCOE Network Medicine 創生拠点 第2回シンポジウム
    • Place of Presentation
      仙台・東北大学医学部
    • Year and Date
      2009-07-11
    • Related Report
      2009 Annual Research Report
  • [Presentation] ホルマリン固定パラフィン包埋組織切片からのクリニカルディスカバリープロテオミクスによる胆道癌新規バイオマーカー探索2009

    • Author(s)
      小野川徹, ら
    • Organizer
      独立行政法人 物質・材料研究機構 第3回ナノテクノロジー融合センターセミナー
    • Place of Presentation
      つくば・独立行政法人物質・材料研究機構
    • Year and Date
      2009-05-23
    • Related Report
      2009 Annual Research Report
  • [Presentation] 胆道癌ホルマリン固定パラフィン包理組織からのディスカバリープロテオミクス2009

    • Author(s)
      小野川徹ら(21名中1番目)
    • Organizer
      第5回日本臨床プロテオーム研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-09
    • Related Report
      2010 Final Research Report
  • [Presentation] 胆道癌ホルマリン固定パラフィン包埋組織からのディスカバリープロテオミクス2009

    • Author(s)
      小野川徹, ら(21名中1番目)
    • Organizer
      第5回日本臨床プロテオーム研究会
    • Place of Presentation
      東京
    • Year and Date
      2009-05-09
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 胆道癌ホルマリン固定パラフィン包埋組織からのディスカバリープロテオミクス2009

    • Author(s)
      小野川徹, ら
    • Organizer
      第5回日本臨床プロテオーム研究会(JSCP)2009
    • Place of Presentation
      東京・京王プラザホテル
    • Year and Date
      2009-05-09
    • Related Report
      2009 Annual Research Report
  • [Presentation] 新規乳癌独立予後規定因子LST-2/SLC01B3の癌細胞特異的発現とその主要生物学的意義2008

    • Author(s)
      小野川徹ら(8名中1番目)
    • Organizer
      第3回トランスポーター研究会年会
    • Place of Presentation
      京都
    • Year and Date
      2008-06-07
    • Related Report
      2010 Final Research Report
  • [Presentation] 新規乳癌独立予後規定因子LST-2/SLCO1B3の癌細胞特異的発現とその腫瘍生物学的意義2008

    • Author(s)
      小野川徹, ら(8名中1番目)
    • Organizer
      第3回トランスポーター研究会年会
    • Place of Presentation
      京都
    • Year and Date
      2008-06-07
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] 検体微量ペプチド試料からの薬物輸送体及び代謝酵素蛋白群の網羅的同時絶対定量解析と抗癌剤感受性予測2008

    • Author(s)
      小野川徹ら(18名中1番目)
    • Organizer
      第108回日本外科学会定期学術集会
    • Place of Presentation
      長崎
    • Year and Date
      2008-05-15
    • Related Report
      2010 Final Research Report 2009 Self-evaluation Report
  • [Presentation] 高度進行胆管癌に対するネオアジュバント放射線化学療法2007

    • Author(s)
      小野川 徹
    • Organizer
      第182回日本消化器病学会東北支部例会
    • Place of Presentation
      仙台
    • Year and Date
      2007-02-10
    • Related Report
      2007 Annual Research Report
  • [Book] Deseases of the Pancreas -Current Surgical Therapy-(共著書) (Beger HG, Matsuno S, Cameron JL Eds.), Section 10 : Congenital Anomalies of the Pancreas, Chapter 82 : Biliopancreatic Maljunction: Classification, Diagnosis, and Treatment2008

    • Author(s)
      Onogawa T, Rikiyama T, Unno M, Matsuno S.
    • Publisher
      Springer-Verlag Berlin Heidelberg
    • Related Report
      2010 Final Research Report
  • [Book] Diseases of the Pancreas -Current Surgical Therapy2008

    • Author(s)
      Beger HG, Matsuno S, Cameron JL Eds.
    • Publisher
      Springer-Verlag
    • Related Report
      2009 Self-evaluation Report
  • [Book] Diseases of the Pancreas -Current Surgical Therapy-Section 10 : Congenital Anomalies of the Pancreas, Chapter 82 : Biliopancreatic Maliunction : Classification, Diaanosis, and Treatment2008

    • Author(s)
      (Beger HG, Matsuno S, Cameron JL Eds.) Onogawa T, Rikiyama T, Unno M, Matsuno S
    • Publisher
      Springer-Verlag Berlin Heidelberg 2008, Printed in Germany
    • Related Report
      2008 Annual Research Report
  • [Patent(Industrial Property Rights)] 胆道がん診断用新規バイオマーカー群2011

    • Inventor(s)
      小野川徹, 海野倫明, 前田晋平
    • Industrial Property Rights Holder
      国立大学法人東北大学
    • Industrial Property Number
      2011-107624
    • Filing Date
      2011-05-12
    • Related Report
      2010 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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