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Regulation of bone remodeling

Research Project

Project/Area Number 19689036
Research Category

Grant-in-Aid for Young Scientists (A)

Allocation TypeSingle-year Grants
Research Field Functional basic dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

NAKASHIMA Tomoki  Tokyo Medical and Dental University, 大学院・医歯学総合研究科, 助教 (00346959)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥27,040,000 (Direct Cost: ¥20,800,000、Indirect Cost: ¥6,240,000)
Fiscal Year 2009: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2008: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2007: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Keywords口腔生化学 / 骨代謝学 / 骨リモデリング / 破骨細胞 / 骨細胞 / トランスクリプトーム / 骨芽細胞 / コンデッショナル遺伝子改変マウス
Research Abstract

Bone remodeling optimizes bone strength and mineral metabolism. Control of bone remodeling requires a tightly orchestrated interplay among osteoblasts (bone forming cells), osteoclasts (bone resorbing cells) in bone surface and osteocytes, which embedded into bone. To identify the regulation factor of bone remodeling, we performed a genome-wide screening of these bone cells and in vivo analysis of gene targeting mice.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (51 results)

All 2010 2009 2008 2007 Other

All Journal Article (23 results) (of which Peer Reviewed: 14 results) Presentation (24 results) Remarks (4 results)

  • [Journal Article] Inhibitory NK receptor, Ly49Q, positively regulates osteoclast differentiation.2010

    • Author(s)
      Hayashi M, Nakashima T, Toyama-Sorimachi, N Takayanagi H.
    • Journal Title

      Biochem Biophys Res Commun 393

      Pages: 432-438

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Blimp1-mediated repression of negative regulators is required for osteoclast differentiation.2010

    • Author(s)
      Nishikawa K, Nakashima T, Hayashi M, Fukunaga T, Kato S, Kodama T, Takahashi S, Calame K, Takayanagi H.
    • Journal Title

      Proc Natl Acad Sci USA 107

      Pages: 3117-3122

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of IL-6 and PTHrP in osteoclast formation associated with oral cancers : The significance of IL-6 synthesized by stromal cells in response to cancer cells2010

    • Author(s)
      Kayamori K, Sakamoto K, Nakashima T, Takayanagi H, Morita K, Nguyen ST, Omura K, Miki Y, Akashi T, Ogata E, Yamaguchi A
    • Journal Title

      Am J Pathol 176

      Pages: 968-980

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Roles of IL-6 and PTHrP in osteoclast formation associated with oral cancers : The significance of IL-6 synthesized by stromal cells in response to cancer cells2010

    • Author(s)
      Kayamori K, Sakamoto K, Nakashima T, et al
    • Journal Title

      Am J Pathol. 176

      Pages: 968-980

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Blimp1-mediated repression of negative regulators is required for osteoclast differentiation2010

    • Author(s)
      Nishikawa K, Nakashima T, et al
    • Journal Title

      The Proceedings of the National Academy of Sciences USA (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Inhibitory NK receptor, Ly49Q, positively regulates osteoclast differentiation2010

    • Author(s)
      Hayashi M, Nakashima T, et al
    • Journal Title

      Biochemical and Biophysical Research Communications (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Osteoimmunology : Crosstalk Between the Immune and Bone Systems.2009

    • Author(s)
      Nakashima T, Takayanagi T
    • Journal Title

      J Clin Immunol 29

      Pages: 555-567

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Osteoclasts and the immune system.2009

    • Author(s)
      Nakashima T, Takayanagi T
    • Journal Title

      J Bone and Mineral Metab 27

      Pages: 519-29

    • NAID

      10027205348

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] RANKL/RANK/OPGと骨疾患2009

    • Author(s)
      中島友紀
    • Journal Title

      THE BONE 23

      Pages: 37-46

    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Journal Article] 骨破壊制御の新たなアプローチ.2009

    • Author(s)
      中島友紀、高柳広
    • Journal Title

      医薬ジャーナル 45

      Pages: 87-92

    • Related Report
      2009 Final Research Report
  • [Journal Article] Osteoimmunology : Crosstalk Between the Immune and Bone Systems2009

    • Author(s)
      中島友紀, et al
    • Journal Title

      J Clin Immunol 29

      Pages: 555-567

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] osteoclasts and the immune system2009

    • Author(s)
      中島友紀, et al
    • Journal Title

      J Bone and Mineral Metab 27

      Pages: 519-529

    • NAID

      10027205348

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨破壊制御の新たなアプローチ2009

    • Author(s)
      中島友紀
    • Journal Title

      医薬ジャーナル 45

      Pages: 87-92

    • Related Report
      2009 Annual Research Report
  • [Journal Article] The dynamic interplay between osteoclasts and the immune system2008

    • Author(s)
      Nakashima T, Takayanagi T
    • Journal Title

      Arch Biochem Biophys 473

      Pages: 166-171

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 骨免疫学の最先端.2008

    • Author(s)
      中島友紀、高柳広
    • Journal Title

      Mebio 25

      Pages: 24-35

    • Related Report
      2009 Final Research Report
  • [Journal Article] 免疫と骨:骨免疫学Osteoimmunologyの幕開け.2008

    • Author(s)
      林幹人、中島友紀、高柳広
    • Journal Title

      臨床検査 52

      Pages: 556-560

    • Related Report
      2009 Final Research Report
  • [Journal Article] The dynamic interplay between osteoclasts and the immune system2008

    • Author(s)
      Nakashima T
    • Journal Title

      Archives of Biochemistry and Biophysics 473

      Pages: 166-171

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 骨免疫学の最先端2008

    • Author(s)
      中島友紀
    • Journal Title

      Mebio 25

      Pages: 24-35

    • Related Report
      2008 Annual Research Report
  • [Journal Article] 免疫と骨 : 骨免疫学Osteoimmunologyの幕開け2008

    • Author(s)
      林幹人、中島友紀
    • Journal Title

      臨床検査 52

      Pages: 556-560

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes.2007

    • Author(s)
      Pospisilik JA, Knauf C, Joza N, Benit P, Orthofer M, Cani PD, Ebersberger I, Nakashima T, Sarao R, Neely G, Esterbauer H, Kozlov A, Kroemer G, Kahn CR, Rustin P, Burcelin R, Penninger JM
    • Journal Title

      Cell 131

      Pages: 467-491

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Scientific basis for the efficacy of combined use of antirheumatic drugs against bone destruction in rheumatoid arthritis.2007

    • Author(s)
      Suematsu A, Tajiri Y, Nakashima T, Taka J, Ochi S, Oda H, Nakamura K, Tanaka S, Hiroshi Takayanagi
    • Journal Title

      Mod. Rheumatol. 17

      Pages: 17-23

    • NAID

      10018733776

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Osteoimmunology-破骨細胞の誘導と炎症.2007

    • Author(s)
      中島友紀、高柳広
    • Journal Title

      整形外科 58

      Pages: 1615-1624

    • Related Report
      2009 Final Research Report
  • [Journal Article] 破骨細胞と免疫系.2007

    • Author(s)
      中島友紀、高柳広
    • Journal Title

      生体と科学 58

      Pages: 196-204

    • Related Report
      2009 Final Research Report
  • [Presentation] Identification of novel genes regulated by NFATc1 in osteoclastogenesis.2009

    • Author(s)
      Nakashima T, Hayashi M, Takayanagi H.
    • Organizer
      The 26th Naito Conference on "Osteobiology"
    • Place of Presentation
      Awaji
    • Year and Date
      2009-11-05
    • Related Report
      2009 Final Research Report
  • [Presentation] Identification of novel genes regulated by NFATc1 in osteoclasto genesis2009

    • Author(s)
      中島友紀, et al
    • Organizer
      The 26th Naito Conference on Osteobiology
    • Place of Presentation
      Awaji Japan
    • Year and Date
      2009-11-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨の恒常性を司る骨リモデリングシステムの解明2009

    • Author(s)
      中島友紀
    • Organizer
      第22回長崎骨粗鬆症研究会
    • Place of Presentation
      長崎(招待講演)
    • Year and Date
      2009-10-06
    • Related Report
      2009 Final Research Report
  • [Presentation] 骨の恒常性を司る骨リモデリングシステムの解明2009

    • Author(s)
      中島友紀
    • Organizer
      第22回長崎骨粗鬆症研究会
    • Place of Presentation
      長崎
    • Year and Date
      2009-10-06
    • Related Report
      2009 Annual Research Report
  • [Presentation] Meet the Expert 6 Bone cell biology2009

    • Author(s)
      中島友紀
    • Organizer
      第27回日本骨代謝学会
    • Place of Presentation
      大阪(教育講演)
    • Year and Date
      2009-07-25
    • Related Report
      2009 Final Research Report
  • [Presentation] Meet the Expert 6 Bone cell biology2009

    • Author(s)
      中島友紀
    • Organizer
      第27回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2009-07-25
    • Related Report
      2009 Annual Research Report
  • [Presentation] 骨の恒常性を司る骨リモデリングシステムの解明2009

    • Author(s)
      中島友紀
    • Organizer
      Skeletal Research Meeting
    • Place of Presentation
      京都(招待講演)
    • Year and Date
      2009-06-27
    • Related Report
      2009 Final Research Report
  • [Presentation] 骨の恒常性を司る骨リモデリングシステムの解明2009

    • Author(s)
      中島友紀
    • Organizer
      第3回 Skeletal Research Meeting
    • Place of Presentation
      京都
    • Year and Date
      2009-06-27
    • Related Report
      2009 Annual Research Report
  • [Presentation] 破骨細胞の分化機構2009

    • Author(s)
      中島友紀
    • Organizer
      昭和大学大学院セミナー
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2009-02-06
    • Related Report
      2009 Final Research Report
  • [Presentation] 破骨細胞の分化ステージ特異的なNFATc1の機能解析2008

    • Author(s)
      中島友紀(シンポニスト)
    • Organizer
      第26回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2008-10-29
    • Related Report
      2008 Annual Research Report
  • [Presentation] The crucial role of RANKL in bone loss and cancer metastasis.2008

    • Author(s)
      Nakashima T.
    • Organizer
      The 13th Congress of the Asia Pacific League of Associations for Rheumatology (APLAR 2008)
    • Place of Presentation
      Yokohama(招待講演)
    • Year and Date
      2008-09-26
    • Related Report
      2009 Final Research Report
  • [Presentation] The crucial role of RANKL in bone loss and cancer metastasis2008

    • Author(s)
      Nakashima T(シンポニスト)
    • Organizer
      The 13th Congress of the Asia Pacific League of Associations for Rheumatology 2008
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] NFATc1-dependent programme of osteoclast differentiation and function2008

    • Author(s)
      Hayashi M, Nakashima T
    • Organizer
      The 13th Congress of the Asia Pacific League of Associations for Rheumatology 2008
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of combined use of anti-rheumatic drugs on osteoclast differentiation2008

    • Author(s)
      Suematsu A, Nakashima T
    • Organizer
      The 13th Congress of the Asia Pacific League of Associations for Rheumatology 2008
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-26
    • Related Report
      2008 Annual Research Report
  • [Presentation] Effect of combined use of anti-rheumatic drugs on osteoclast differentiation.2008

    • Author(s)
      Suematsu A, Tajiri Y, Nakashima T, Ochi S, Oda H, Nakamura K, Tanaka S, Takayanagi H.
    • Organizer
      The 13th Congress of the Asia Pacific League of Associations for Rheumatology (APLAR 2008)
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-24
    • Related Report
      2009 Final Research Report
  • [Presentation] NFATc1-dependent programme of osteoclast differentiation and function.2008

    • Author(s)
      Hayashi M, Nakashima T, Takayanagi H.
    • Organizer
      The 13th Congress of the Asia Pacific League of Associations for Rheumatology (APLAR 2008)
    • Place of Presentation
      Yokohama
    • Year and Date
      2008-09-24
    • Related Report
      2009 Final Research Report
  • [Presentation] Novel Screening System for Bone Matrix Proteins That Control Bone Mineralization.2008

    • Author(s)
      Inoue H, Nakashima T, Iwamatsu A, Suematsu A, Yamaguchi A, Takayanagi H.
    • Organizer
      The 30th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Montreal
    • Year and Date
      2008-09-12
    • Related Report
      2009 Final Research Report
  • [Presentation] Novel Screening System for Bone Matrix Proteins That Control Bone Mineralization2008

    • Author(s)
      Inoue H, Nakashima T, et.al.
    • Organizer
      The 30th Annual Meeting of the American Society for Bone and Mineral Research
    • Place of Presentation
      Montreal
    • Year and Date
      2008-09-12
    • Related Report
      2008 Annual Research Report
  • [Presentation] 破骨細胞分化の分子機構2007

    • Author(s)
      中島友紀
    • Organizer
      第49回歯科基礎医学会学術大会
    • Place of Presentation
      札幌(招待講演)
    • Year and Date
      2007-08-29
    • Related Report
      2009 Final Research Report
  • [Presentation] CaMK/CREB経路による破骨細胞制御メカニズム2007

    • Author(s)
      末松綾子、佐藤浩二郎、中島友紀、青木和広、大谷啓一、山口朗、高柳広
    • Organizer
      第25回日本骨代謝学会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-19
    • Related Report
      2009 Final Research Report
  • [Presentation] RANKLの役割2007

    • Author(s)
      中島友紀
    • Organizer
      第25回内分泌・代謝学サマーセミナー
    • Place of Presentation
      兵庫(招待講演)
    • Year and Date
      2007-07-17
    • Related Report
      2009 Final Research Report
  • [Presentation] 抗リウマチ薬の併用による破骨細胞分化抑制作用の増強2007

    • Author(s)
      末松綾子、田尻康人、中島友紀、越智小枝、織田弘美、中村耕三、田中栄、高柳広
    • Organizer
      第51回日本リウマチ学会
    • Place of Presentation
      東京
    • Year and Date
      2007-04-26
    • Related Report
      2009 Final Research Report
  • [Presentation] 癌転移を制御する新規ターゲットとしてRANKL2007

    • Author(s)
      中島友紀
    • Organizer
      第1回Bone Research Seminar
    • Place of Presentation
      東京(招待講演)
    • Year and Date
      2007-03-24
    • Related Report
      2009 Final Research Report
  • [Presentation] 癌転移を制御する新規ターゲットとしてRANKL2007

    • Author(s)
      中島友紀
    • Organizer
      第5回口腔医科学フロンティア
    • Place of Presentation
      仙台(招待講演)
    • Year and Date
      2007-02-03
    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://homepage.mac.com/osteoimmunology/

    • Related Report
      2009 Final Research Report
  • [Remarks] 所属研究機関ホームページ

    • URL

      http://homepage.mac.com/osteoimmunology/

    • Related Report
      2009 Annual Research Report
  • [Remarks]

    • URL

      http://homepage.mac.com/osteoimmunology/

    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://homepage.mac.com/osteoimmunology/

    • Related Report
      2007 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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