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Robust inference and its application to genome data

Research Project

Project/Area Number 19700270
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Statistical science
Research InstitutionThe Institute of Statistical Mathematics

Principal Investigator

FUJISAWA Hironori  The Institute of Statistical Mathematics, 数理・推論研究系, 准教授 (00301177)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥2,260,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥360,000)
Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2007: ¥700,000 (Direct Cost: ¥700,000)
Keywordsロバスト推測 / 遺伝子発現データ / 一塩基多型 / ロバスト観測
Research Abstract

When outliers are present, many statistical methods lose the validity of the result for analyzing the data. The statistical method which gives the valid result even if outliers are present is called the robust inference. In particular, it is important to make a latent bias small even when outliers are present. I have discussed robust inference and applied the method to genome data.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (36 results)

All 2010 2009 2008 2007 Other

All Journal Article (8 results) (of which Peer Reviewed: 8 results) Presentation (26 results) Remarks (2 results)

  • [Journal Article] SNEP: Simultaneous detection of nucleotide and expression polymorphisms using Affymetrix GeneChip.2009

    • Author(s)
      Fujisawa, H., Horiuchi, Y., Harushima, Y., Takada, T., Eguchi, S., Mochizuki, T., Sakaguchi, T., Shiroishi, T., Kurata, N.
    • Journal Title

      BMC Bioinformatics Vol.10,No.131

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] SNEP : Simultaneous detection of nucleotide and expression polymorphisms using Affymetrix GeneChip2009

    • Author(s)
      Fujisawa, Hironori
    • Journal Title

      BMC Bioinformatics 10

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Robust parameter estimation with a small bias against heavy contamination.2008

    • Author(s)
      Fujisawa, H., Eguchi, S.
    • Journal Title

      Journal of Multivariate Analysis Vol.99

      Pages: 2053-2081

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Robust parameter estimation with a small bias against heavy contamination2008

    • Author(s)
      Fujisawa, H.
    • Journal Title

      Journal of Multivariate Analysis 99

      Pages: 2053-2081

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identifying haplotype block structure by using ancestor-derived model.2007

    • Author(s)
      Fujisawa, H., Isomura, M., Eguchi, S., Ushijima, M., Miyata, S., Miki, Y., Matsuura, M.
    • Journal Title

      Journal of Human Genetics Vol.52

      Pages: 738-746

    • NAID

      10019812610

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A conservative test for multiple comparison based on highly correlated test statistics.2007

    • Author(s)
      Ninomiya, Y., Fujisawa, H.
    • Journal Title

      Biometrics Vol.63

      Pages: 1135-1142

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A conservative test for multiple comparison based on highly correlated test statistics.2007

    • Author(s)
      Ninomiya, Y.
    • Journal Title

      Biometrics 63

      Pages: 1135-1142

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Identifying haplotype block structure by using ancestor-derived model.2007

    • Author(s)
      Fujisawa, H.
    • Journal Title

      Journal of Human Genetics 52

      Pages: 738-746

    • NAID

      10019812610

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Affymetrix GeneChipを利用した塩基多型と発現多型の同時同定2010

    • Author(s)
      藤澤洋徳
    • Organizer
      統計的推測法の発展と応用
    • Place of Presentation
      広島
    • Year and Date
      2010-03-17
    • Related Report
      2009 Final Research Report
  • [Presentation] Affymetrix GeneChip を利用した塩基多型と発現多型の同時同定2010

    • Author(s)
      藤澤洋徳
    • Organizer
      統計的推測法の発展と応用
    • Place of Presentation
      広島
    • Year and Date
      2010-03-17
    • Related Report
      2009 Annual Research Report
  • [Presentation] SNEP: Simultaneous detection of nucleotide and expression polymorphisms using Affymetrix GeneChip2010

    • Author(s)
      藤澤洋徳
    • Organizer
      統計科学セミナー
    • Place of Presentation
      福岡
    • Year and Date
      2010-01-08
    • Related Report
      2009 Final Research Report
  • [Presentation] SNEP : Simultaneous detection of nucleotide and expression polymorphisms using Affymetrix GeneChip2010

    • Author(s)
      藤澤洋徳
    • Organizer
      統計科学セミナー
    • Place of Presentation
      福岡
    • Year and Date
      2010-01-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] Statistical Analysis of Affymetrix GeneChip Data2009

    • Author(s)
      Fujisawa, Hironori
    • Organizer
      2nd joint research meeting of ISI, ISM and ISSAS
    • Place of Presentation
      Mishima, Japan
    • Year and Date
      2009-10-12
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] A simple selection of smoothing parameter in penalized spline regression2009

    • Author(s)
      Fujisawa, Hironori
    • Organizer
      Joint Statistical Meting 2009
    • Place of Presentation
      Washington, D.C., USA
    • Year and Date
      2009-08-04
    • Related Report
      2009 Annual Research Report 2009 Final Research Report
  • [Presentation] Multiplicity adjustments in detecting reproductive barriers caused by Loci interactions2009

    • Author(s)
      Kuriki, Satoshi
    • Organizer
      BIRS Workshop 09w5040 Random Fields and Stochastic Geometry
    • Place of Presentation
      Banff, Canada
    • Year and Date
      2009-02-26
    • Related Report
      2009 Final Research Report
  • [Presentation] Robust parameter estimation with a small bias against heavy contamination2009

    • Author(s)
      Fujisawa, Hironori
    • Organizer
      Statistical Science's colloquium series at Cornell University
    • Place of Presentation
      New York, USA
    • Year and Date
      2009-02-25
    • Related Report
      2009 Final Research Report
  • [Presentation] Robust parameter estimation with a small bias against heavy contamination2009

    • Author(s)
      Fujisawa, Hironori
    • Organizer
      Statistical Science's colloquium series at Cornell University
    • Place of Presentation
      Ithaca, USA
    • Year and Date
      2009-02-25
    • Related Report
      2008 Annual Research Report
  • [Presentation] 罰則付スプライン回帰におけるスムージングパラメータの簡単な選択法2008

    • Author(s)
      藤澤洋徳
    • Organizer
      統計関連学会連合大会
    • Place of Presentation
      神戸
    • Year and Date
      2008-09-08
    • Related Report
      2009 Final Research Report
  • [Presentation] 罰則付スプライン回帰におけるスムージングパラメータの簡単な選択法2008

    • Author(s)
      藤澤洋徳
    • Organizer
      統計関連学会連合大会
    • Place of Presentation
      横浜
    • Year and Date
      2008-09-08
    • Related Report
      2008 Annual Research Report
  • [Presentation] A sequential selection of smoothing parameter in penalized spline regression2008

    • Author(s)
      Fujisawa, Hironori
    • Organizer
      2008 Joint Meeting of ISI, ISM and ISSAS
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2008-06-19
    • Related Report
      2009 Final Research Report
  • [Presentation] A sequential selection of smoothing parameter in penalized spline regression2008

    • Author(s)
      Fujisawa, Hironori
    • Organizer
      2nd joint research meeting of ISI, ISM and ISSAS
    • Place of Presentation
      Taipei, Taiwan
    • Year and Date
      2008-06-19
    • Related Report
      2008 Annual Research Report
  • [Presentation] SNPを考慮に入れた遺伝子発現データ解析2008

    • Author(s)
      藤澤洋徳
    • Organizer
      シンポジウム「バイオインフォマティックスおよび経時観察データの解析」
    • Place of Presentation
      廿日市
    • Year and Date
      2008-02-08
    • Related Report
      2009 Final Research Report
  • [Presentation] SNPを考慮に入れた遺伝子発現データ解析2008

    • Author(s)
      藤澤 洋徳
    • Organizer
      バイオインフォマティックスおよび経時観察データの解析
    • Place of Presentation
      広島
    • Year and Date
      2008-02-08
    • Related Report
      2007 Annual Research Report
  • [Presentation] A unified method for detecting single feature polymorphisms and gene expression level differences2008

    • Author(s)
      Fujisawa, Hironori
    • Organizer
      Pasific Symposium on Biocomputing
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2008-01-06
    • Related Report
      2009 Final Research Report
  • [Presentation] A unified method for detecting single feature polymorphisms and gene expression level differences2008

    • Author(s)
      Fujisawa, Hironori
    • Organizer
      Pacific Symposium on Biocomputing
    • Place of Presentation
      Hawaii, USA
    • Year and Date
      2008-01-06
    • Related Report
      2007 Annual Research Report
  • [Presentation] A unified method for detecting single feature polymorphisms and gene expression level differences2007

    • Author(s)
      Fujisawa, Hironori
    • Organizer
      1st joint research meeting of ISM and ISSAS (on Bioinfomatics)
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2007-11-30
    • Related Report
      2009 Final Research Report
  • [Presentation] A unified method for detecting single feature polymorphisms and gene expression level differences2007

    • Author(s)
      Fujisawa, Hironori
    • Organizer
      1st joint research meeting of ISM and ISSAS(on Bioinfomatics)
    • Place of Presentation
      東京
    • Year and Date
      2007-11-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] 異分野コミュニケーション~円滑にするコツは?~2007

    • Author(s)
      藤澤洋徳
    • Organizer
      情報・システム研究機構若手クロストーク研究会
    • Place of Presentation
      三島
    • Year and Date
      2007-11-26
    • Related Report
      2009 Final Research Report
  • [Presentation] 遺伝子座間の相互作用による生殖的隔離障壁の検出と多重性調整2007

    • Author(s)
      栗木哲
    • Organizer
      統計関連学会連合大会
    • Place of Presentation
      神戸
    • Year and Date
      2007-09-07
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] SNPを考慮した遺伝子発現データ解析2007

    • Author(s)
      藤澤洋徳
    • Organizer
      統計関連学会連合大会
    • Place of Presentation
      神戸
    • Year and Date
      2007-09-07
    • Related Report
      2009 Final Research Report 2007 Annual Research Report
  • [Presentation] 数理統計学とデータ解析, 統計数理研究所2007

    • Author(s)
      藤澤洋徳
    • Organizer
      統計数理研究所外部評価シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-08-13
    • Related Report
      2009 Final Research Report
  • [Presentation] 数理統計学とデータ解析2007

    • Author(s)
      藤澤 洋徳
    • Organizer
      外部評価シンポジウム
    • Place of Presentation
      東京
    • Year and Date
      2007-08-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] SNPを考慮した遺伝子発現データ解析2007

    • Author(s)
      藤澤洋徳
    • Organizer
      統計若手サマーセミナー
    • Place of Presentation
      指宿
    • Year and Date
      2007-08-07
    • Related Report
      2009 Final Research Report
  • [Presentation] SNPを考慮した遺伝子発現データ解析2007

    • Author(s)
      藤澤 洋徳
    • Organizer
      統計サマーセミナー
    • Place of Presentation
      鹿児島
    • Year and Date
      2007-08-07
    • Related Report
      2007 Annual Research Report
  • [Remarks] Fujisawa et al. (2009, BMC Bioinformatics)で開発したソフトウェア「SNEP」のホームページ

    • URL

      http://www.ism.ac.jp/~fujisawa/SNEP/

    • Related Report
      2009 Final Research Report
  • [Remarks]

    • URL

      http://www.ism.ac.jp/~fujisawa/SNEP/

    • Related Report
      2009 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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