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Drug addiction as unregulated learning : the role of dopamine in the prefrontal cortex

Research Project

Project/Area Number 19700309
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neuroscience in general
Research InstitutionThe Institute of Physical and Chemical Research

Principal Investigator

WEITEMIER Adam  The Institute of Physical and Chemical Research, Murphy研究ユニット, 研究員 (70419878)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥1,810,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥210,000)
Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2007: ¥900,000 (Direct Cost: ¥900,000)
Keywordsnucleus accumbens / prefrontal cortex / dopamine / classical conditioning / microdialysis / drug abuse / reward / ドーパミン / セロトニン / マイクロダイアリシス / 鎮静剤 / 報酬 / マウス / 側座核 / 側坐核 / 先頭前野 / 古典的条件付け / マイクロダイアイリシス / 薬物乱用
Research Abstract

本研究ではマイクロダイアリシス法を用いてモルヒネ場所嗜好性(もしくはナロキソン場所嫌悪性)試験中の脳内での神経化学的な活動をモニターした。その結果、条件付け中のモルヒネ反復投与によるドーパミン活動の亢進と条件付け後の場所嗜好性強度の間に関係性があることが明らかとなった。 予想に反して、条件付け後のモルヒネ場所嗜好の発現中にはドーパミン活動の上昇は認められず、逆にドーパミン活動と場所嗜好性強度の間に負の相関関係が認められた。それに対して、ナロキソン場所嫌悪の発現中にはドーパミン活動が上昇しており、ドーパミンとセロトニンのバランスが場所嫌悪に関係があることを明らかとした。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (9 results)

All 2009 2008 2007

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (7 results)

  • [Journal Article] Accumbal dopamine and serotonin activity throughout acquisition and expression of place conditioning : correlative relationships with preference and aversion2009

    • Author(s)
      Adam Z. Weitemier, Niall P. Murphy
    • Journal Title

      European Journal of Neuroscience 29, 5

      Pages: 1015-26

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accumbal dopamine and serotonin activity throughout acquisition and expression of place conditioning: correlative relationships with preference and aversion2009

    • Author(s)
      Adam Z. Weitemier, Niall P. Murphy
    • Journal Title

      European Journal of Neuroscience (In press)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Mesolimbic dopamine and serotonin in drug conditioned place preference and aversion : correlations with voluntary behavior2008

    • Author(s)
      Adam Weitemier
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      Washington D.C. Convention Center
    • Year and Date
      2008-11-07
    • Related Report
      2008 Final Research Report
  • [Presentation] Mesolimbic dopamine and serotonin in drug conditioned place preference and aversion: correlations with voluntary behavior2008

    • Author(s)
      Adam Weitemier
    • Organizer
      Society for Neuroscience Annual Meeting
    • Place of Presentation
      Washington D.C. Convention Center
    • Year and Date
      2008-11-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mesolimbic dopamine and serotonin in drug conditioned place preference and aversion2008

    • Author(s)
      Adam Weitemier
    • Organizer
      correlations with voluntary behavior Workshop on Mechanism of Brain and Mind
    • Place of Presentation
      Wel City Sapporo, Hokkaido
    • Year and Date
      2008-08-09
    • Related Report
      2008 Final Research Report
  • [Presentation] Mesolimbic dopamine and serotonin in drug conditioned place preference and aversion: correlations with voluntary behavior2008

    • Author(s)
      Adam Weitemier
    • Organizer
      Workshop on Mechanism of Brain and Mind
    • Place of Presentation
      Wel City Sapporo, Hokkaido
    • Year and Date
      2008-08-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] Simultaneous measurement of behavior and catecholamine levels by microdialysis in the mouse brain over a three-day drug conditioning procedure.2007

    • Author(s)
      Adam Weitemier, Niall Murphy
    • Organizer
      第18回マイクロダイアリシス研究会
    • Place of Presentation
      昭和女子大学
    • Year and Date
      2007-12-03
    • Related Report
      2007 Annual Research Report
  • [Presentation] Mesolimbic dopamine activity during acquisition and expression of conditioned place preference and aversion2007

    • Author(s)
      Adam Weitemier, Niall Murphy
    • Organizer
      Mesolimbic dopamine activity during acquisition and expression of conditioned place preference and aversion
    • Place of Presentation
      Oregon Health & Science University, Oregon, USA
    • Year and Date
      2007-10-31
    • Related Report
      2007 Annual Research Report
  • [Presentation] Catecholamine activity during acquisition and expression of conditioned place preference and aversion.2007

    • Author(s)
      Adam Weitemier, Niall Murphy
    • Organizer
      Neuro2007
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2007-09-11
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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