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Mechanisms of the extrapyramidal symptoms caused by methylmercury chloride

Research Project

Project/Area Number 19700334
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Nerve anatomy/Neuropathology
Research InstitutionNational Institute for Minamata Disease

Principal Investigator

MARUMOTO Masumi  国立水俣病総合研究センター, 基礎研究部, 主任研究員 (00335506)

Project Period (FY) 2007 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥6,373,279 (Direct Cost: ¥5,110,215、Indirect Cost: ¥1,263,064)
Fiscal Year 2011: ¥1,183,279 (Direct Cost: ¥910,215、Indirect Cost: ¥273,064)
Fiscal Year 2010: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2007: ¥900,000 (Direct Cost: ¥900,000)
Keywordsメチル水銀 / 水俣病 / マウス / 線条体 / 小型神経細胞 / 錐体外路 / 無機水銀 / 局在 / 神経細胞 / ミクログリア / アストログリア / 可視化 / 自発運動量 / 錐体外路障害
Research Abstract

The patients who had severe symptom of Minamata disease and, in the case that an extrapyramidal sign was observed clinically, showed pathological changes in the extrapyramidal tract nuclei. In addition, pathological changes were observed in the extrapyramidal tract nuclei in the case that whole brain was damaged severely. The methylmercury treated mice displayed locomotor hyperactivity. Histopathological examination showed significant decrease in the number of neurons with proliferation of astroglias in the bilateral caudate putamen in the methylmercury treated mice.

Report

(4 results)
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (2 results)

All 2007

All Presentation (2 results)

  • [Presentation] MethyImercury exposure induces hyperactivity and neuronal loss in thecaudate putamen in mice.2007

    • Author(s)
      Masumi Sawada
    • Organizer
      Twenty-fourth International Neurotoxicology Conference
    • Place of Presentation
      San Antonio,Texas,USA.
    • Year and Date
      2007-11-12
    • Related Report
      2007 Annual Research Report
  • [Presentation] Methylmercury exposure induces hyperactivity and neuronal loss in the caudate putamen in mice2007

    • Author(s)
      Sawada M, Fujimura M, Yasutake A.
    • Organizer
      Twenty-fourth international neurotoxicology conference
    • Place of Presentation
      Holiday Inn Riverwalk(San Antonio, Texas, USA)
    • Related Report
      2011 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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