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The role of BDNF/trkB signaling in the transition to postherpetic neuralgia

Research Project

Project/Area Number 19700337
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurochemistry/Neuropharmacology
Research InstitutionUniversity of Toyama

Principal Investigator

TAKASAKI Ichiro  University of Toyama, 生命科学先端研究センター, 助教 (00397176)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,520,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
Keywords帯状疱疹痛 / 帯状疱疹後神経痛 / 神経栄養因子
Research Abstract

帯状疱疹から帯状疱疹後神経痛への発症機序は明らかでない。本研究は脳由来神経栄養因子(BDNF)とその受容体trkBに注目し、帯状疱疹後神経痛への移行における脊髄BDNF/trkBシグナリングの役割について解析した。帯状疱疹痛マウスの脊髄においてBDNF産生量が増加し、抗体等でBDNFのはたらきをブロックすると、帯状疱疹痛を抑制し、帯状疱疹後神経痛への移行も抑制された。本研究の成果により、帯状疱疹後神経痛への移行におけるBDNF/trkB受容体の関与が明らかとなった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (17 results)

All 2008 2007

All Journal Article (12 results) (of which Peer Reviewed: 12 results) Presentation (5 results)

  • [Journal Article] Extracellular Adenosine 5'-Triphosphate Elicits the Expression of Brain- Derived Neurotrophic Factor Exon IV mRNA in Rat Astrocytes2008

    • Author(s)
      Takasaki I, Takarada S, Tatsumi S, Azegami A, Yasuda M, Fukuchi M, Tabuchi A, Kondo T, Tabuchi Y, and Tsuda M
    • Journal Title

      GLIA 56

      Pages: 1369-1379

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Morphine inhibits herpetic allodynia through mu-opioid receptors in Abeta-fiber neurons2008

    • Author(s)
      Sasaki A, Nakashima Y, Takasaki I, Andoh T, Shiraki K, Kuraishi Y
    • Journal Title

      Neuroreport 19

      Pages: 975-979

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice2008

    • Author(s)
      Sasaki A, Takasaki I, Andoh T, Shiraki K, Takeshima H, Takahata H, and Kuraishi Y
    • Journal Title

      Neuroreport 19

      Pages: 83-86

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Extracellular Adenosine 5-Triphosphate Elicits the Expression of Brain-Derived Neurotrophic Factor Exon IV mRNA in Rat Astrocytes2008

    • Author(s)
      Takasaki, et.al.
    • Journal Title

      GLIA 56

      Pages: 1369-1379

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nociceptin-receptor deficiency prevents postherpetic pain without effects on acute herpetic pain in mice2008

    • Author(s)
      Sasaki, et.al.
    • Journal Title

      NeuroReport 19

      Pages: 83-86

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Morphine inhibits herpetic allodynia through mu-opioid receptors in Abe to-fiber neurons2008

    • Author(s)
      Sasaki, et.al.
    • Journal Title

      NeuroReport 19

      Pages: 975-979

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different roles of nitric oxide synthase -1 and -2 between herpetic and postherpetic allodynia in mice2007

    • Author(s)
      Sasaki A, Mabuchi T, Serizawa K, Takasaki I, Andoh T, Shiraki K, Ito S, and Kuraishi Y
    • Journal Title

      Neuroscience 150

      Pages: 459-66

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Loperamide on Mechanical Allodynia Induced by Herpes Simplex Virus Type-1 in Mice2007

    • Author(s)
      Sasaki A, Nakashima Y, Takasaki I, Andoh T, Shiraki K and Kuraishi Y
    • Journal Title

      J. Pharmacol. Sci 104

      Pages: 218-224

    • NAID

      10024314645

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of genetic networks involved in the cell growth arrest and differentiation of a rat astrocyte cell line RCG-122007

    • Author(s)
      Takasaki I, Takarada S, Fukuchi M, Yasuda M, Tsuda M and Tabuchi Y
    • Journal Title

      J. Cell. Biochem 102

      Pages: 1472-1485

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of genetic networks involved in the cell growth arrest and differentiation of a rat astrocyte cell line RCG-12.2007

    • Author(s)
      Takasaki, et. al.
    • Journal Title

      J Cell. Biochem. 102

      Pages: 1472-1485

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Loperamide on Mechanical Allodynia Induced by Herpes Simplex Virus Type-1 in Mice.2007

    • Author(s)
      Sasaki, et. al.
    • Journal Title

      J. Pharmacol. Sci. 104

      Pages: 218-224

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Different roles of nitric oxide synthase-1 and -2 between herpetic and postherpetic allodynia in mice.2007

    • Author(s)
      Sasaki, et. al.
    • Journal Title

      Neuroscience 150

      Pages: 459-466

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Extracellular ATP elicits the expression of BDNF exon IV mRNA in rat astrocytes and astrocyte cell line RCG-122008

    • Author(s)
      Takasaki I, Takarada S, Tatsumi S, Azegami A, Yasuda M, Fukuchi M, Tabuchi A, Kondo T, Tabuchi Y, and Tsuda M
    • Organizer
      The 38th Annual Meeting of the Society for Neuroscience (Neuroscience 2008)
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2008 Final Research Report
  • [Presentation] アストロサイトにおけるATP誘導性BDNF遺伝子発現上昇メカニズムの解析2007

    • Author(s)
      立見沙織, 高崎一朗, 宝田聡子, 田渕圭章, 津田正明
    • Organizer
      日本薬学会北陸支部第117回例会
    • Place of Presentation
      金沢
    • Year and Date
      2007-11-11
    • Related Report
      2008 Final Research Report
  • [Presentation] 帯状疱疹痛と帯状疱疹後神経痛のモデルマウス2007

    • Author(s)
      高崎一朗, 佐々木淳, 安東嗣修, 白木公康, 倉石泰
    • Organizer
      北陸実験動物研究会
    • Place of Presentation
      富山
    • Year and Date
      2007-09-15
    • Related Report
      2008 Final Research Report
  • [Presentation] 網羅的遺伝子発現解析に基づいた帯状疱疹痛発症機序の解明2007

    • Author(s)
      高崎一朗, 倉石泰
    • Organizer
      第24回麻酔メカニズム研究会
    • Place of Presentation
      大阪
    • Year and Date
      2007-07-21
    • Related Report
      2008 Final Research Report
  • [Presentation] 帯状疱疹痛モデルマウスの疼痛発症における脊髄galectin-3の関与2007

    • Author(s)
      高崎一朗, 小松史明, 谷口佳奈, 佐々木淳, 安東 嗣修, 加藤一郎, 平賀紘一, 白木公康, 倉石泰
    • Organizer
      日本薬学会第127年会
    • Place of Presentation
      富山
    • Related Report
      2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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