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Cloning of Aβ-binding membrane protein in microglia by using SST-REX method

Research Project

Project/Area Number 19700340
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Neurochemistry/Neuropharmacology
Research InstitutionNagoya University

Principal Investigator

ITO Sachiko  Nagoya University, 大学院・医学系研究科, COE特任教授 (70447845)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,550,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥450,000)
Fiscal Year 2008: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2007: ¥1,600,000 (Direct Cost: ¥1,600,000)
Keywords神経生物学 / ミクログリア / アミロイドβ / シグナル伝達 / 神経科学
Research Abstract

アルツハイマー病(AD)の主な病因物質であるアミロイドβ(Aβ)が、ADの発症または制御に関与していると考えられているミクログリアに作用する機序を解明する為に、Aβと結合するミクログリア膜表面蛋白質について解析した。膜蛋白質選択的に分離できるという特徴をもつSST-REX法を用いて、ミクログリア膜蛋白質を発現する細胞群を作製し、その中から、Aβと結合する細胞を単離し、ミクログリア細胞表面のAβ結合膜蛋白質を同定、解析した。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (5 results)

All 2009 2008

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (1 results)

  • [Journal Article] Age-related decline of immune function and age-related diseases2009

    • Author(s)
      Ken-ichi Isobe, Naomi Nishio, Sachiko Ito
    • Journal Title

      Nihon Rinsyo in press

    • NAID

      40016709041

    • Related Report
      2008 Final Research Report
  • [Journal Article] Age-related decline of immune function and age-related diseases2009

    • Author(s)
      Isobe Ken-ichi
    • Journal Title

      Nihon Rinsyo

    • Related Report
      2008 Annual Research Report
  • [Journal Article] Inhibition of reactive oxygen species down-regulates protein synthesis in RAW 264.7.2008

    • Author(s)
      Kimura K, Ito S, Nagino M, Isobe K
    • Journal Title

      Biochem Biophys Res Commun 372(1)

      Pages: 272-275

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Inhibition of reactive oxygen species down-regulates protein synthesis in RAW 264.72008

    • Author(s)
      Kimura Kenya
    • Journal Title

      Biochem Biophys Res Commun. 372

      Pages: 272-275

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] Amyloid-β刺激によるミクログリア活性化と炎症性物質の産生2008

    • Author(s)
      伊藤佐知子、磯部健一
    • Organizer
      第31回日本基礎老化学会
    • Place of Presentation
      松本、日本
    • Year and Date
      2008-06-13
    • Related Report
      2008 Annual Research Report 2008 Final Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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