Development of Drug Delivery System for Fibrosis Treatment Based on Scrap And Build Mechanism

• Project/Area Number: 19700405
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Hyogo University of Health Sciences (2008); Kyoto University (2007)
• Principal Investigator: UEDA Hiroki Hyogo University of Health Sciences, 薬学部, 講師 (70432325)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥2,990,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥1,300,000 (Direct Cost: ¥1,300,000)
• Keywords: 再生医工学材料 / 薬物伝達システム / 線維症 / スクラップアンドビルド / 肺 / スクラップアンドビルト

Research Abstract

肺線維症は、不可逆的な肺へのコラーゲン性組織の過形成による肺胞構造の破壊に帰する重篤な呼吸器疾患である。本疾患からの正常組織再構築には、コラーゲン性組織形成の抑制のみならず、組織の線維化の解除が必要であると考えられてきた。そこで、本研究では、2つの異なる薬物キャリア構造を化学結合した、微粒子型、ならびに分子型の複合化薬物キャリアを開発し、コラーゲン性細胞外マトリックスの酵素分解と組織線維化抑制に機能する細胞増殖因子・遺伝子の局所徐放を併用した、新規な線維症治療方法の開発を試みた。

Research Products

• [Journal Article] Dose Effect of Dual Delivery of Vascular Endotherial Growth Factor and Bone Morphogenetic Protein-2 on Bone Regeneration in a Rat Critical-Size Deffect Model. Tissue Engineering (2009)
  • Author(s): Simon Young, Zarana S. Patel, James D. Kretlow, Matthew B. Murphy, Paschalia M. Mountziaris, L. Scott Baggett, Hiroki Ueda, Yasuhiko Tabata, John A. Jansen, Mark Wong, Antonios G. Mikos
  • Journal Title: Part A 15
  • Peer Reviewed
• [Journal Article] Dose Effect of Dual Delivery of Vascular Endotherial Growth Factor and Bone Morphogenetic Protein-2 on Bone Regeneration in a Rat Critical-Size Deffect Model (2009)
  • Author(s): S. Young, Z. S. Patel, H. Ueda, Y. Tabata, J. A. Jansen, M. Wong, A. G. Mikos, et.al.
  • Journal Title: Tissue Engineering Part A
  • Peer Reviewed
• [Journal Article] In vitro and in vivo release of vascular endotherial growth factor from gelatin microparticles and biodegradable composite scaffolds (2008)
  • Author(s): Zarana S. Patel, Masaya Yamamoto, Hiroki Ueda, Yasuhiko Tabata, Antonios G. Mikos
  • Journal Title: Pharmaceutical Research Vol. 25, No.10 Pages: 2370-2378
  • Peer Reviewed
• [Journal Article] Replacement of the left main bronchus with a tissue-engineered prosthesis in a canine model (2008)
  • Author(s): Toshihiko Sato, Hiroyuki Tao, Masato Araki, Hiroki Ueda, Koichi Omori, Tatsuo Nakamura
  • Journal Title: The Annals of Thoracic Surgery 86(2) Pages: 422-428
  • Peer Reviewed
• [Journal Article] In vitro and in vivo release of vascular endotherial growth factor from gelat in microparticles and bioderadable composite scaffolds (2008)
  • Author(s): Z. S. Patel, M. Yamamoto, H. Ue da, Y. Tabata, A. G. Mikos
  • Journal Title: Pharmaceutical Research 25(10) Pages: 2370-2378
  • Peer Reviewed
• [Journal Article] Replacement of the left main bronchus with a tissue-engineered prosthesis in a canine model (2008)
  • Author(s): T. Sato, H. Tao, M. Araki, H. Ueda, K. Omori, T. Nakamura
  • Journal Title: The Annals of Thoracic Surgery 86(2) Pages: 422-428
  • Peer Reviewed
• [Presentation] In Vitro Evaluation of TGF-beta1 Interaction with Collagen Sponges Dehydrothermally Crosslinked (2007)
  • Author(s): Hiroki UEDA and Yasuhiko TABATA
  • Organizer: The 9th US-Japan Symposium on Drug Delivery Systems
  • Place of Presentation: Hawaii
  • Year and Date: 20071216-20
• [Presentation] IN VITRO EVALUATION OF TGF-BETA1 INTERACTION WITH COLLAGEN SPONGES DEHYDROTHERMALLY CROSSLINKED (2007)
  • Author(s): Hiroki Ueda
  • Organizer: 9th US-JAPAN SYMPOSIUM ON DRUG DELIVERY SYSTEMS
  • Place of Presentation: Lahaina, Maui, Hawaii, USA
  • Year and Date: 20071216-20