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cancer gene therapy using non-invasive gene delivery with Bubble liposomes and ultrasound

Research Project

Project/Area Number 19700423
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Medical systems
Research InstitutionTeikyo University

Principal Investigator

SUZUKI Ryo  Teikyo University, 薬学部, 助教 (90384784)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
Keywords低侵襲治療システム / 超音波 / リポソーム / 遺伝子治療 / がん / がん遺伝子治療 / ソノポレーション / 組織特異的遺伝子導入 / 低侵襲
Research Abstract

バブルリポソームと超音波照射の併用による新たな遺伝子デリバリー技術の開発を行い、本技術ががん遺伝子治療における低侵襲的な遺伝子導入システムとして有用であることが明らかとなった。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (26 results)

All 2009 2008 2007

All Journal Article (11 results) (of which Peer Reviewed: 8 results) Presentation (15 results)

  • [Journal Article] Delivery of siRNA into the cytoplasm by liposomal bubbles and ultrasound2008

    • Author(s)
      Negishi Y, Endo Y, Fukuyama T, Suzuki R, Takizawa T, Omata D, Maruyama K, Aramaki Y
    • Journal Title

      J Control Release 132(2)

      Pages: 124-130

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Effective gene delivery with novel liposomal bubbles and ultrasonic destruction technology2008

    • Author(s)
      Suzuki R, Takizawa T, Negishi Y, Utoguchi N, Maruyama K.
    • Journal Title

      Int J Pharm 354(1-2)

      Pages: 49-55

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Accelerating effects of ultrasonic thrombolysis with bubble liposomes2008

    • Author(s)
      Zenitani T, Suzuki R, Maruyama K, Furuhata H
    • Journal Title

      J Med Ultrasonics 35

      Pages: 5-10

    • NAID

      10024142617

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] バブルリポソームと超音波によるDDS2008

    • Author(s)
      鈴木 亮、宇都口直樹、丸山一雄
    • Journal Title

      化学工業 59(4)

      Pages: 300-57

    • Related Report
      2008 Final Research Report
  • [Journal Article] Development of site specific gene delivery system with sonoporation,2008

    • Author(s)
      Suzuki R, Oda Y, Namai E, Takizawa T, Negishi Y, Utoguchi N, Tachibana K, Maruyama K.
    • Journal Title

      Yakugaku Zasshi 128(2)

      Pages: 187-192

    • NAID

      110006572172

    • Related Report
      2008 Final Research Report
  • [Journal Article] Tumor specific ultrasound enhanced gene transfer in vivo with novel lip osomal bubbles2008

    • Author(s)
      鈴木亮
    • Journal Title

      J. Control. Release 125

      Pages: 137-144

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effective gene delivery with novel liposomal bubbles and ultrasonic dest ruction technology2008

    • Author(s)
      鈴木亮
    • Journal Title

      Int. J. Pham 354

      Pages: 49-55

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor specific ultrasound enhanced gene transfer in vivo with novel liposomal bubbles.2008

    • Author(s)
      Ryo, Suzuki
    • Journal Title

      J. Control. Release 125

      Pages: 137-144

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of site specific gene delivery system with sonoporation2008

    • Author(s)
      Ryo, Suzuki
    • Journal Title

      Yakugaku Zasshi 128

      Pages: 187-192

    • NAID

      110006572172

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Gene delivery by combination of novel liposomal bubbles with perfluoro propane and ultrasound2007

    • Author(s)
      Ryo, Suzuki
    • Journal Title

      J. Control. Release 117

      Pages: 130-136

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effective gene delivery with liposomal bubbles and ultrasound as novel non-viral system2007

    • Author(s)
      Ryo, Suzuki
    • Journal Title

      J Drug Target. 15

      Pages: 531-537

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] リポソーム型微小気泡(バブルリポソーム)の開発とドラッグデリバリーへの応用2009

    • Author(s)
      鈴木亮
    • Organizer
      日本超音波医学会北海道地方会
    • Place of Presentation
      北海道
    • Year and Date
      2009-03-07
    • Related Report
      2008 Annual Research Report
  • [Presentation] リポソーム型微小気泡(バブルリポソーム)の開発とドラッグデリバリーへの応用2009

    • Author(s)
      鈴木亮
    • Organizer
      超音波とマイクロバブルの相互作用に関するシンポジウム
    • Place of Presentation
      名古屋
    • Year and Date
      2009-01-09
    • Related Report
      2008 Annual Research Report
  • [Presentation] リポソーム型微小気泡(バブルリポソーム)の開発とドラッグデリバリーへの応用 (招待講演)2009

    • Author(s)
      鈴木 亮、小田雄介、宇都口直樹、丸山一雄
    • Organizer
      超音波とマイクロバブルの相互作用に関するシンポジウム
    • Place of Presentation
      名古屋
    • Related Report
      2008 Final Research Report
  • [Presentation] 超音波感受性微小気泡を利用した薬物・遺伝子デリバリー (招待講演)2009

    • Author(s)
      鈴木 亮、丸山一雄
    • Organizer
      第36回日本超音波医学会 北海道地方会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] バブルリポソームと超音波の併用による肝臓特異的遺伝子導入法の開発 (口頭発表)2008

    • Author(s)
      鈴木 亮、生井栄佑、小田雄介、平裕一郎、根岸洋一、宇都口直樹、立花克郎、丸山一雄
    • Organizer
      日本超音波医学会第81回学術集会
    • Place of Presentation
      神戸
    • Related Report
      2008 Final Research Report
  • [Presentation] リポソーム型微小気泡(バブルリポソーム)を利用したin vivo超音波遺伝子導入に関する検討 (口頭発表)2008

    • Author(s)
      鈴木 亮、生井栄佑、小田雄介、宇都口直樹、根岸洋一、立花克郎、丸山一雄
    • Organizer
      第2回超音波分子診断治療研究会
    • Place of Presentation
      札幌
    • Related Report
      2008 Final Research Report
  • [Presentation] リポソームテクノロジーを基盤とするDDSと免疫療法の構築 (招待講演)2008

    • Author(s)
      鈴木 亮、丸山一雄
    • Organizer
      日本油化学会第47年会 オレオナノサイエンス部会
    • Place of Presentation
      東京
    • Related Report
      2008 Final Research Report
  • [Presentation] 超音波エネルギーを利用した新規遺伝子導入法の開発 (ポスター発表)2008

    • Author(s)
      鈴木 亮、生井栄佑、小田雄介、西家功人、宇都口直樹、根岸洋一、丸山一雄
    • Organizer
      日本バイオイメージング学会
    • Place of Presentation
      千葉
    • Related Report
      2008 Final Research Report
  • [Presentation] In vivo gene delivery by sonoporation with liposomal bubbles2007

    • Author(s)
      Ryo, Suzuki
    • Organizer
      ISSS 2007
    • Place of Presentation
      京都府 (京都)
    • Year and Date
      2007-12-15
    • Related Report
      2007 Annual Research Report
  • [Presentation] Gene delivery into tumor tissue with novel liposomal bubbles and ultra sound2007

    • Author(s)
      Ryo, Suzuki
    • Organizer
      日本癌学会
    • Place of Presentation
      神奈川県 (横浜)
    • Year and Date
      2007-10-04
    • Related Report
      2007 Annual Research Report
  • [Presentation] TISSUE SPECIFIC GENE DELIVERY WITH LIPOSOMAL BUBBLES AND ULTRASOUND2007

    • Author(s)
      Ryo, Suzuki
    • Organizer
      日本遺伝子治療学会
    • Place of Presentation
      愛知県 (名古屋)
    • Year and Date
      2007-06-30
    • Related Report
      2007 Annual Research Report
  • [Presentation] Ultrasound enhanced tumor tissue specific gene delivery with liposomal bubbles2007

    • Author(s)
      Ryo, Suzuki
    • Organizer
      ISTU2007
    • Place of Presentation
      韓国 (ソウル)
    • Year and Date
      2007-06-13
    • Related Report
      2007 Annual Research Report
  • [Presentation] Development of minimally invasive and tissue specific gene delivery with novel liposomal bubbles2007

    • Author(s)
      Ryo, Suzuki
    • Organizer
      10th Annual Meeting of the American Society of Gene Therapy
    • Place of Presentation
      米国 (シアトル)
    • Year and Date
      2007-06-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] 超音波を利用した薬物送達におけるリポソーム技術の新展開2007

    • Author(s)
      鈴木 亮
    • Organizer
      日本超音波医学会
    • Place of Presentation
      鹿児島県 (鹿児島)
    • Year and Date
      2007-05-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] リポソーム型バブルと超音波の併用による組織特異的遺伝子導入法の開発2007

    • Author(s)
      鈴木 亮
    • Organizer
      日本生体医工学会
    • Place of Presentation
      宮城県 (仙台)
    • Year and Date
      2007-04-26
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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