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Inhibitory effect of food factors on cytotoxic ozone-induced inflammation

Research Project

Project/Area Number 19700592
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Eating habits, studies on eating habits
Research InstitutionUniversity of Shizuoka

Principal Investigator

MIYOSHI Noriyuki  University of Shizuoka, 食品栄養科学部, 助教 (70438191)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,660,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywords健康と食生活 / 生活習慣病 / 酸化ストレス / 分析化学 / 細胞・組織
Research Abstract

本研究では、動脈硬化病巣やアルツハイマー脳患者から検出されたオゾン酸化コレステロール(athgeronal-AおよびB)の生物化学的解析を行い、atheronalsが有する強力な細胞毒性活性を明らかにした。また培養細胞、試験管内反応よりatheornals生成分子機構における食品成分の抑制効果について検討を行った。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (28 results)

All 2009 2008 2007 Other

All Journal Article (4 results) (of which Peer Reviewed: 2 results) Presentation (19 results) Book (4 results) Remarks (1 results)

  • [Journal Article] Formation of cholesterol ozonolysis products through an ozone-free mechanismmediated by themyeloperoxidase-H(2)O(2)-chloride system.2009

    • Author(s)
      Tomono S, Miyoshi N, Sato K,Ohba Y, Ohshima H.
    • Journal Title

      Biochem. Biophys. Res. Commun (in press)

    • Related Report
      2008 Final Research Report
  • [Journal Article] Formation of cholesterol ozonolysis products through an ozone-free mechanism mediated by the myeloperoxidase-H(2)O(2)-chloride system.2009

    • Author(s)
      Tomono S, Miyoshi N, Sato K, Ohba Y, Ohshima H.
    • Journal Title

      Biochem. Biophys. Res. Commun. (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ATP depletion alters the mode of cell death induced by benzyl isothiocyanate.2008

    • Author(s)
      Miyoshi N, Watanabe E, Osawa T, Okuhira M, Murata Y, Ohshima H, Nakamura Y
    • Journal Title

      Biochim. Biophys. Acta 1782

      Pages: 566-573

    • Related Report
      2008 Final Research Report
  • [Journal Article] ATP depletion alters the mode of cell death induced by benzyl isothio cyanate.2008

    • Author(s)
      Miyoshi N, Watanabe E, Osawa T, Okuhira M, Murata Y, Ohs hima H, Nakamura Y.
    • Journal Title

      Biochim. Biophys. Acta. 1782

      Pages: 566-73

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Presentation] 活性化好中球が産生するオゾン様活性酸素による酸化コレステロールの生成2008

    • Author(s)
      伴野勧、塩川秀美、三好規之、望月和樹、合田敏尚、大島寛史
    • Organizer
      第81回日本生化学会大会
    • Place of Presentation
      神戸
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] アセトアルデヒド曝露マーカーとしてのタンパク質中のNε-エチルリジンのNCI-GC/MSによる分析:ヒトロ腔内剥離細胞における検出2008

    • Author(s)
      馬渕良太、栗田亜矢、三好規之、菅敏幸、雨谷敬史、大島寛史
    • Organizer
      日本環境変異原学会第37回大会
    • Place of Presentation
      沖縄
    • Related Report
      2008 Final Research Report
  • [Presentation] AGEs由来アルギニン誘導体によるアルギニン代謝に関与する酵素活性に及ぼす影響2008

    • Author(s)
      頼盈伶、青山沙絵、永井竜児、三好規之、大島寛史
    • Organizer
      第18回日本メイラード学会
    • Place of Presentation
      東京
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Inhibitory effects of advanced glycation end products-related arginine derivatives on enzymatic activities of arginine-metabolizing enzymes.2008

    • Author(s)
      Lai Y-L, Aoyama S, Nagai R, Miyoshi N, Ohshima H
    • Organizer
      The International Symposium on Lipid Peroxidation 2008
    • Place of Presentation
      Karuizawa, Nagano, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Cytotoxic effects of cholesterol ozonolysis products on HL-60 cells2008

    • Author(s)
      Tomono S,Miyoshi N, Ohshima H.
    • Organizer
      The International Symposium on Lipid Peroxidation 2008.
    • Place of Presentation
      Karuizawa, Nagano, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Foemation of cholesterol ozonolysis products by differentiated neutrophil-like HL-60cells activated with phorbol myristate acetate.2008

    • Author(s)
      Tomono S, Shiokawa H, Miyoshi N,Ohshima H
    • Organizer
      The International Symposium on Lipid Peroxidation 2008.
    • Place of Presentation
      Karuizawa, Nagano, Japan
    • Related Report
      2008 Final Research Report
  • [Presentation] Increased expression and enzymatic activities of dimethylarginine dimethylaminohydrorase in cultured human cancerous and non-cancerous cells2008

    • Author(s)
      Aoyama S, Lai Y-L, Miyoshi N, Ohshima H
    • Organizer
      International Conference Biology, Chemistry and Therapeutic Applications ofNitric Oxide
    • Place of Presentation
      Bregenz, Austria
    • Related Report
      2008 Final Research Report
  • [Presentation] Inhibitory effects of advanced glycation end products-related arginine derivatives on enzymatic activities of three isoforms of nitric oxide synthase.2008

    • Author(s)
      Lai Y-L, Aoyama S, Nagai R, Miyoshi N, Ohshima, H
    • Organizer
      Fifth International Conference Biology, Chemistry and Therapeutic Applications ofNitric Oxide
    • Place of Presentation
      Bregenz, Austria
    • Related Report
      2008 Final Research Report
  • [Presentation] 好中球様分化HL-60細胞におけるオゾン酸化コレステロールの生成2008

    • Author(s)
      伴野勧、三好規之、石井剛志、大島寛史
    • Organizer
      第61回日本酸化ストレス学会学術集会
    • Place of Presentation
      京都
    • Related Report
      2008 Annual Research Report 2008 Final Research Report
  • [Presentation] Alpha-tocopherol induces procaspase-3 expression mediated by the transcriptional factor Spl.2008

    • Author(s)
      Miyoshi N, Nakamura Y, Ohshima H
    • Organizer
      Experimental Biology
    • Place of Presentation
      San Diego, CA, USA.
    • Related Report
      2008 Final Research Report
  • [Presentation] Alpha-tocopherol induces procaspase-3 expression mediated by the tran scriptional factor Spl2008

    • Author(s)
      Miyoshi N, Nakamura Y, Ohshima H.
    • Organizer
      Experimental Biology
    • Place of Presentation
      San Diego, CA, USA.
    • Related Report
      2008 Annual Research Report
  • [Presentation] Inhibitory effects of advanced glycation end products-related arginine derivatives on enzymatic activities of three isoforms of nitric oxide sy nthase2008

    • Author(s)
      Lai Y-L, Aoyama S, Nagai R, Miyoshi N, Ohshima, H.
    • Organizer
      Fifth International Conference Biology, Chemistry and Theraneutic Applications of Nitric Oxide
    • Place of Presentation
      Bregenz, Austria.
    • Related Report
      2008 Annual Research Report
  • [Presentation] Increased expression and enzymatic activities of dimethylarginine dimet hylaminohydrorase in cultured human cancerous and non-cancerous cell2008

    • Author(s)
      Aoyama S, Lai Y-L, Miyoshi N, Ohshima H.
    • Organizer
      Fifth International Conference Biology, Chemistry and Theraneutic Annlications of Nitric Oxide
    • Place of Presentation
      Bregenz, Austria.
    • Related Report
      2008 Annual Research Report
  • [Presentation] Foemation of cholesterol ozonolysis products by differentiated neutroph it-like HL-60 cells activated with nhorbol mvristate acetate2008

    • Author(s)
      Tomono S, Shiokawa H, Miyoshi N, Ohshima H.
    • Organizer
      The International Symposium on Lipid Peroxidati on 2008
    • Place of Presentation
      Karuizawa, Nagano, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cytotoxic effects of cholesterol ozonolysis products on HL-60 cells2008

    • Author(s)
      Tomono S, Miyoshi N, Ohshima H.
    • Organizer
      The International Symposium on Lipid Peroxidati on 2008
    • Place of Presentation
      Karuizawa, Nagano, Japan
    • Related Report
      2008 Annual Research Report
  • [Presentation] Inhibitory effects of advanced glycation end products-related arginine derivatives on enzymatic activities of arginine-metabolizing enzymes2008

    • Author(s)
      Lai Y-L, Aoyama S, Nagai R Mivoshi N. Ohshima H.
    • Organizer
      The International Symposium on Lipid Peroxidati on 2008
    • Place of Presentation
      Karuizawa, Nagano, Japan.
    • Related Report
      2008 Annual Research Report
  • [Presentation] アセトアルデヒド曝露マーカーとしてのタンパク質中のN^5-エチルリジンのNCI-GC/MSによる分析 : ヒトロ腔内剥離細胞における検出2008

    • Author(s)
      馬渕良太、栗田亜矢、三好規之、菅敏幸、雨谷敬史、大島寛史
    • Organizer
      日本環境変異原学会第37回大会
    • Place of Presentation
      沖縄
    • Related Report
      2008 Annual Research Report
  • [Presentation] Cholesterol ozonolysis products as a possible biomarker for metabolic syndrome2008

    • Author(s)
      Tomono S., Iwabuchi T., Yasue Y., Niizuma S., Miyoshi M., Ohshima H.
    • Organizer
      International symposium on Biomarkers of Oxidative Stress in Health and Diseases
    • Place of Presentation
      Osaka,Japan
    • Related Report
      2007 Annual Research Report
  • [Presentation] オゾン酸化コレステロールによるHL-60細胞の細胞傷害分子機構2007

    • Author(s)
      伴野 勧、新妻 聖子、岩渕 智恵、安江 祐佳墨、三好 規之、大島 寛史
    • Organizer
      第80回日本生化学会大会(Biochemistry and Molecular Biology 2007)
    • Place of Presentation
      横浜市(パシフィコ横浜)
    • Related Report
      2007 Annual Research Report
  • [Book] Chemoprevention of Cancer and DNA Damage by Dietary Factors2009

    • Author(s)
      Ohshima H, Tomono S, Lai Y-L,Miyoshi N
    • Publisher
      WILEY-BLACKWELL
    • Related Report
      2008 Final Research Report
  • [Book] Chemoprevention of Cancer and DNA Damage by Dietary Factors2009

    • Author(s)
      Ohshima H, Tomono S, Lai Y-L, Miyoshin(分担)
    • Total Pages
      787
    • Publisher
      WILEY-BLACKWELL
    • Related Report
      2008 Annual Research Report
  • [Book] 酸化ストレスの医学2008

    • Author(s)
      大島寛史、三好規之
    • Publisher
      診断と治療社
    • Related Report
      2008 Final Research Report
  • [Book] がん予防『酸化ストレスの医学』2008

    • Author(s)
      大島寛史、三好規之(分担)
    • Total Pages
      384
    • Publisher
      診断と治療社
    • Related Report
      2008 Annual Research Report
  • [Remarks]

    • URL

      http://sfns.u-shizuoka-ken.ac.jp/cellbioc/

    • Related Report
      2008 Annual Research Report

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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