Relationship between radiation induced membrane response and low dose hyper-radiosensitivity
| Project/Area Number |
19710054
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | Kitasato University |
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Principal Investigator |
WADA Seiichi Kitasato University, 獣医学部・獣医学科, 講師 (50370490)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,950,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥750,000)
Fiscal Year 2009: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥700,000 (Direct Cost: ¥700,000)
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| Keywords | 放射線 / 細胞死 / 細胞膜 / スフィンゴミエリナーゼ / DNA修復 / 低線量 / 亜鉛元素 / バイスタンダー効果 / スフィンゴメエリナーゼ / 活性酸素 / アポトーシス / イオンビーム / 局所損傷 |
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| Research Abstract |
Cellular response by low dose irradiation was calculated from response by high dose irradiation. Recently hyper-radiosensitivity response, that did not fitted to data calculated from response by high dose irradiation, was discovered. It was considered that hyper-radiosensitivity was due to bystander effect or biological dysfunction, however, it was not elucidated in detail.
In this study, it was elucidated that radiation-induced membrane resoponse was trigger of hyper-radiosensitivity, signal molecular mediated by membrane rasponse was extracellularly transmitted and dysfunction of DNA repair mediated by this signal molecular induced cell death.
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Report
(4 results)
Research Products
(12 results)
