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Hypothesis of the second critical point of water and protein folding mechanism

Research Project

Project/Area Number 19750010
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Physical chemistry
Research InstitutionFukuoka University

Principal Investigator

YOSHIDA Koji  Fukuoka University, 理学部, 助教 (00309890)

Project Period (FY) 2007 – 2009
Project Status Completed (Fiscal Year 2009)
Budget Amount *help
¥4,020,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥720,000)
Fiscal Year 2009: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2008: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2007: ¥900,000 (Direct Cost: ¥900,000)
Keywords生物物理 / 中性子散乱 / タンパク質 / 水和 / 化学物理 / 液体
Research Abstract

Dynamics of hydration water around proteins and confined water in nano-porous materials (silica and dextran gel) was measured with X-ray and neutron scattering experiments. The temperature behaviors in the relaxation time of confined water molecules in the porous silica change from the Ahrrenus type to the non-Ahrrenus one at around 220 K (fragile-strong transition) where the atomic motion of hydrated proteins changes from a harmonic to anharmonic behavior. From these results, the role of water in protein folding was discussed.

Report

(4 results)
  • 2009 Annual Research Report   Final Research Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (23 results)

All 2010 2009 2008 2007

All Journal Article (14 results) (of which Peer Reviewed: 14 results) Presentation (9 results)

  • [Journal Article] A Study of alcohol-induced gelation of beta-lactoglobulin with small-angle neutron scattering, neutron spin echo, and dynamic light scattering measurements2010

    • Author(s)
      K. Yoshida, T. Yamaguchi, N. Osaka, H. Endo, M. Shibayama
    • Journal Title

      Phys. Chem. Chem. Phys. 12

      Pages: 3260-3269

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Ion hydration in aqueous solutions of lithium chloride, nickel chloride, and cesium chloride in ambient to supercritical water2010

    • Author(s)
      T. Yamaguchi, H. Ohzono, M. Yamagami, K. Yamanaka, K. Yoshida, H. Wakita
    • Journal Title

      Journal of Molecular Liquids 201(in press)

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] A Study of alcohol-induced gelation of beta-lactoglobulin with small-angle neutron scattering, neutron spin echo, and dynamic light scattering measurements2010

    • Author(s)
      K.Yoshida, T.Yamaguchi, N.Osaka, H.Endo, M.Shibayama
    • Journal Title

      Phys.Chem.Chem.Phys. 12

      Pages: 3260-3269

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ion hydration in aqueous solutions of lithium chloride, nickel chloride, and cesium chloride in ambient to supercritical water2010

    • Author(s)
      T.Yamaguchi, H.Ohzono, M.Yamagami, K.Yamanaka, K.Yoshida, H.Wakita
    • Journal Title

      Journal of Molecular Liquids (In press)

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thermodynamic, structural and dynamic properties of supercooled water confined in mesoporous MCM-41 studied with calorimetric, neutron diffraction, and neutron spin echo measurements2009

    • Author(s)
      K. Yoshida, T. Yamaguchi, S. Kittaka, M. -C. Bellissent-Funel, P. Fouquet
    • Journal Title

      J. Chem. Phys. 129

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] On the solvent role in alcohol-induced a-helix formation of chymotrypsin inhibitor-22009

    • Author(s)
      K. Yoshida, J. Kawaguchi, S. Lee, T. Yamaguchi
    • Journal Title

      Pure Appl. Chem. 80

      Pages: 1337-1347

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] 中性子スピンエコー法による過冷却状態における細孔水の動的挙動2008

    • Author(s)
      吉田亨次
    • Journal Title

      福岡大学理学集報 39

      Pages: 55-62

    • NAID

      110007039878

    • Related Report
      2009 Final Research Report 2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Thermodynamic, structural and dynamic properties of supercooled water confined in mesoporous MCM-41 studied with calorimetric, neutron diffraction, and neutron spin echo measurements2008

    • Author(s)
      K. Yoshida, T. Yamaguchi, S. Kittaka, M.-C. Bellissent-Funel, P. Fouquet
    • Journal Title

      J. Chem. Phys 129

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] On the solvent role in alcohol-induced α-helix formation ofchymotrypsin inhibitor-22008

    • Author(s)
      K. Yoshida, J. Kawaguchi, S. Lee, T. Yamaguchi
    • Journal Title

      Pure Appl. Chem 80

      Pages: 1337-1347

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] On the solvent role in alcohol-induced α-helix formation of chymotrypsin inhibitor-22008

    • Author(s)
      Koji Yoshida, Junko Kawaguchi, Sannum Lee, Toshio Yamaguchi
    • Journal Title

      Pure and Applied Chemistry (In press)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydration water in dynamics of a hydrated P-lactoglobulin2007

    • Author(s)
      K. Yoshida, T. Yamaguchi, M. -C. Belllissent-funel, S. Longeville
    • Journal Title

      Eur. Phys. J. Special Topics 141

      Pages: 223-226

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structure and dynamic properties of liquids confined in MCM-41 mesopores2007

    • Author(s)
      T. Yamaguchi, K. Yoshida, P. Smirnov, T. Takamuku, S. Kittaka, S. Takahara, Y. Kuroda, M. -C. Bellissent-Funel
    • Journal Title

      Eur. Phys. J. Special Topics 141

      Pages: 19-27

    • Related Report
      2009 Final Research Report
    • Peer Reviewed
  • [Journal Article] Hydration water in dynamics of a hydrated β-lactoglobulin2007

    • Author(s)
      K. Yoshida, T. Yamaguchi, M.-C. Belllissent-funel, S. Longeville
    • Journal Title

      Eur. Phys. J. Special Topics 141

      Pages: 223-226

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Structure and dynamic properties of liquids confined in MCM-41 mesopores2007

    • Author(s)
      T. Yamaguchi, K. Yoshida, P. Smimov, T. Takamuku, S. Kittaka, S. Takahara, Y. Kuroda, M.-C. Bellissent-Funel
    • Journal Title

      Eur. Phys. J. Special Topics 141

      Pages: 19-27

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 中性子スピンエコー法による多孔性シリカ中の低温水のダイナミクス2009

    • Author(s)
      吉田亨次, 山口, 橘高, M.C. Bellissent-Funel, P. Fouquet
    • Organizer
      第32回溶液化学シンポジウム
    • Place of Presentation
      新潟市
    • Year and Date
      2009-11-18
    • Related Report
      2009 Final Research Report
  • [Presentation] 中性子スピンエコー法による多孔性シリカ中の低温水のダイナミクス2009

    • Author(s)
      吉田, 山口, 橘高, M.C.Bellissent-Funel, P.Fouquet
    • Organizer
      第32回溶液化学シンポジウム
    • Place of Presentation
      新潟大学
    • Year and Date
      2009-11-18
    • Related Report
      2009 Annual Research Report
  • [Presentation] Collective Dynamics of Hydrated Protein by Inelastic X-ray Scattering2009

    • Author(s)
      K. Yoshida, T. Yamaguchi, S. Hosokawa, A.Q.R. Baron
    • Organizer
      European Molecular Liquid Group Meeting 2009
    • Place of Presentation
      Salzburg (Austria)
    • Year and Date
      2009-09-08
    • Related Report
      2009 Final Research Report
  • [Presentation] Collective Dynamics of Hydrated Protein by Inelastic X-ray Scattering2009

    • Author(s)
      K.Yoshida, T.Yamaguchi, S.Hosokawa, A.Q.R.Baron
    • Organizer
      European Molecular Liquid Group Meeting 2009
    • Place of Presentation
      Salzburg(オーストリア)
    • Year and Date
      2009-09-08
    • Related Report
      2009 Annual Research Report
  • [Presentation] 中性子散乱および動的光散乱によるβ-ラクトグロブリンの構造と運動に対するアルコールの影響2008

    • Author(s)
      吉田亨次・山口敏男・遠藤仁・柴山充弘
    • Organizer
      第2回分子科学討論会
    • Place of Presentation
      福岡市
    • Year and Date
      2008-09-24
    • Related Report
      2009 Final Research Report 2008 Annual Research Report
  • [Presentation] 二次元NMRおよびレプリカ交換MDによるモデルペプチドのアルコール変性機構の研究2007

    • Author(s)
      吉田亨次、KRISHTAL、藤永、李、根本、金澤、山口
    • Organizer
      第1回分子科学討論会
    • Place of Presentation
      仙台市
    • Year and Date
      2007-09-19
    • Related Report
      2009 Final Research Report
  • [Presentation] 二次元NMRおよびレプリカ交換MDによるモデルペプチドのアルコール変性機構の研究2007

    • Author(s)
      吉田、KRISHTAL、藤永、李、根本、金渾、山口
    • Organizer
      第1回分子科学討論会
    • Place of Presentation
      東北大学
    • Year and Date
      2007-09-19
    • Related Report
      2007 Annual Research Report
  • [Presentation] 中性子散乱法によるナノ細孔中の水の構造とダイナミクス"2007

    • Author(s)
      吉田亨次
    • Organizer
      第68回分析化学討論会若手企画シンポジウム
    • Place of Presentation
      宇都宮市
    • Year and Date
      2007-05-20
    • Related Report
      2009 Final Research Report
  • [Presentation] 中性子散乱法によるナノ細孔中の水の構造とダイナミクス2007

    • Author(s)
      吉田亨次
    • Organizer
      第68回分析化学討論会若手企画シンポジウム
    • Place of Presentation
      宇都宮大学
    • Year and Date
      2007-05-20
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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