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Construction of a fluorescent probe for cyclic ADP-ribose, an intracellular signaling molecule

Research Project

Project/Area Number 19750135
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Chemistry related to living body
Research InstitutionNara Medical University (2008)
Tohoku University (2007)

Principal Investigator

YAMAUCHI Akiyo  Nara Medical University, 医学部, 助教 (70361110)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000)
Fiscal Year 2008: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
Keywords生体認識 / 機能化学 / 蛍光プローブ / サイクリックADPリボース / π-π相互作用
Research Abstract

細胞内のカルシウム(Ca2+)濃度を調節する重要な情報伝達物質であるサイクリックADPリボース(cADPR)に対して,水溶液中で相互作用して蛍光強度変化を示す,初の蛍光プローブを構築した.このプローブはcADPRのアデニン環と相互作用する芳香環と,cADPRのリボースと結合するフェニルボロン酸をもち,これらの官能基がcADPRを挟み込むような構造をしている.このプローブは,より高性能なcADPR蛍光プローブを開発するための分子設計指針を与えるものである.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (2 results)

All 2007

All Journal Article (2 results) (of which Peer Reviewed: 2 results)

  • [Journal Article] Fluorescence Response Mechanism of D-Glucose Selectivity for Supramolecular Probes Composed of Phenylboronic-acid-modified β-Cyclodextrin and Styrylpyridinium Dyes2007

    • Author(s)
      Iwao Suzuki, Akiyo Yamauchi, Y. Sakashita, K. Hirose, T. Miura, T. Hayashita
    • Journal Title

      Analytical Sciences 23

      Pages: 1167-1171

    • NAID

      10019826508

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Fluorescence Response Mechanism of D-Glucose Selectivity for Supramolecular Probes Composed of Phenylboronic-acid-modified β-Cyclodextrin and Styrylpyridinium Dyes2007

    • Author(s)
      I. Suzuki, A. Yamauchi, Y. Sakashita, K. Hirose, T. Miura, T. Hayashita
    • Journal Title

      Analytical Sciences 23

      Pages: 1167-1171

    • NAID

      10019826508

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2007-04-01   Modified: 2016-04-21  

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