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Actin Cytoskeletal Mechanics on Mechanosensory Mechanism of Osteocyte

Research Project

Project/Area Number 19760064
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeSingle-year Grants
Research Field Materials/Mechanics of materials
Research InstitutionKanazawa Institute of Technology

Principal Investigator

TANAKA Mototsugu  Kanazawa Institute of Technology, 工学部, 講師 (30346085)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,660,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥360,000)
Fiscal Year 2008: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2007: ¥2,100,000 (Direct Cost: ¥2,100,000)
Keywords骨細胞 / メカノセンシング / カルシウム応答 / 細胞バイオメカニクス / リモデリング
Research Abstract

骨細胞に対する局所力学刺激付与方法,変形量の測定方法,および細胞応答のその場観察方法を確立し,骨細胞においては,細胞体よりも細胞突起の力学応答特性が顕著に高いことを明らかにした.また,骨組織内部の骨細胞と周囲組織の力学刺激付与による変位量の測定方法と,内部骨細胞と周囲組織の変形および細胞応答をその場観察するシステムを構築し,生骨組織に対する変形付与によって内部骨細胞がカルシウム応答を示した瞬間の,内部骨細胞および周囲組織のひずみ量を評価できた.

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (17 results)

All 2008 2007 Other

All Journal Article (5 results) (of which Peer Reviewed: 4 results) Presentation (12 results)

  • [Journal Article] Mechanosensitivity of A Single Osteocyte: Difference in Cell Process and Cell Body2007

    • Author(s)
      AONUMA YUKI, ADACHI TAIJI, TANAKA MOTOTSUGU, HOJO MASAKI, TAKANO-YAMAMOTO TERUKO, KAMIOKA HIROSHI
    • Journal Title

      Journal of Biomechanical Science and Engineering Vol.2, Supp1.1

      Pages: 165-165

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Mechanosensitivity of A Single Osteocyte: Difference in Cell Process and Cell Body2007

    • Author(s)
      Yuki Aonuma et. al.
    • Journal Title

      Journal of Biomechanical Science and Engineering Vol.2, Suppl.1

    • Related Report
      2007 Annual Research Report
  • [Journal Article] Calcium Response in Single Osteocytes to Locally Applied Mechanical Stimulus : Differences in Cell Process and Cell Body

    • Author(s)
      ADACHI TAIJI, AONUMA YUKI, TANAKA MOTOTSUGU, HOJO MASAKI, TAKANO-YAMAMOTO TERUKO, KAMIOKA HIROSHI
    • Journal Title

      Journal of Biomechanics (in print)

    • NAID

      120001596913

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Calcium Response in Single Osteocytes to Locally Applied Mechanical Stimulus : Differences in Cell Process and Cell Body

    • Author(s)
      Yuki Aonuma, et.al.
    • Journal Title

      Journal of Biomechanics (印刷中)

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Calcium Response in Single Osteocytes to Locally Applied Mechanical Stimulus: Differences in Cell Process and Cell Body

    • Author(s)
      Yuki Aonuma et. al.
    • Journal Title

      Journal of Bone and Mineral Research (投稿中)

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Site-Dependence of Mechanosensitivity in Isolated Osteocytes2008

    • Author(s)
      Yuki Aonuma
    • Organizer
      The 13th International Conference on Biomedical Engineering
    • Place of Presentation
      Singapore
    • Year and Date
      2008-12-03
    • Related Report
      2008 Annual Research Report
  • [Presentation] Mechanosensitivity to Localized Mechanical Stimulus in Isolated Osteocytes2008

    • Author(s)
      Taiji Adachi
    • Organizer
      第31回日本バイオレオロジー学会年会
    • Place of Presentation
      東京
    • Year and Date
      2008-06-05
    • Related Report
      2008 Annual Research Report
  • [Presentation] Site-Dependence of Mechanosensitivity in Isolated Osteocytes2008

    • Author(s)
      AONUMA YUKI, ADACHI TAIJI, TANAKA MOTOTSUGU, HOJO MASAKI, TAKANO-YAMAMOTO TERUKO, KAMIOKA HIROSHI
    • Organizer
      The 13th International Conference of Biomedical Engineering
    • Place of Presentation
      Singapore
    • Related Report
      2008 Final Research Report
  • [Presentation] 骨マトリクスの変形に対する骨細胞のカルシウム応答観察2008

    • Author(s)
      青沼有紀,安達泰治,田中基嗣,北條正樹,山本照子,上岡寛
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2008 Final Research Report
  • [Presentation] Mechanical Stimulusin Isolated Osteocytes2008

    • Author(s)
      ADACHI TAUT, AONUMA YUKI, TANAKA MOTOTSUGU, HOJO MASAKI, TAKANO-YAMAMOTO TERUKO, KAMIOKA HIROSHI
    • Organizer
      第31回日本バイオレオロジー学会年会
    • Place of Presentation
      東京大学小柴ホール
    • Related Report
      2008 Final Research Report
  • [Presentation] 骨基質の変形にともなう骨細胞の変形およびカルシウム応答の観察2008

    • Author(s)
      青沼有紀,安達泰治,田中基嗣,北條正樹,山本照子,上岡寛
    • Organizer
      日本機械学会バイオエンジニアリング部門第20回バイオエンジニアリング講演会
    • Place of Presentation
      芝浦工業大学豊洲キャンパス
    • Related Report
      2008 Final Research Report
  • [Presentation] 骨マトリクスの変形に対する骨細胞のカルシウム応答観察2008

    • Author(s)
      青沼有紀
    • Organizer
      第26回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2008 Annual Research Report
  • [Presentation] 骨基質の変形にともなう骨細胞の変形およびカルシウム応答の観察2008

    • Author(s)
      青沼有紀
    • Organizer
      日本機械学会バイオエンジニアリング部門第20回バイオエンジニアリング講演会
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] Mechanosensitivity of A Single Osteocyte : Difference in Cell Process and Cell Body2007

    • Author(s)
      AONUMA YUKI, ADACHI TAIJI, TANAKA MOTOTSUGU, HOJO MASAKI, TAKANO-YAMAMOTO TERUKO, KAMIOKA HIROSHI
    • Organizer
      The 3rd Asian Pacific Conference on Biomechanics
    • Place of Presentation
      東京大学生産技術研究所
    • Related Report
      2008 Final Research Report
  • [Presentation] 単離骨細胞の細胞突起/細胞体の力学的刺激に対するカルシウム応答の違い2007

    • Author(s)
      青沼有紀,安達泰治,田中基嗣,北條正樹,山本照子,上岡寛
    • Organizer
      第25回日本骨代謝学会学術集会
    • Place of Presentation
      大阪国際会議場
    • Related Report
      2008 Final Research Report
  • [Presentation] Mechanosensitivity of A Single Osteocyte: Difference in Cell Process and Cell Body2007

    • Author(s)
      Yuki Aonuma
    • Organizer
      Third Asian Pacific Conference on Biomechanics
    • Place of Presentation
      東京
    • Related Report
      2007 Annual Research Report
  • [Presentation] 単離骨細胞の細胞突起/細胞体の力学的刺激に対するカルシウム応答の違い2007

    • Author(s)
      青沼有紀
    • Organizer
      第25回日本骨代謝学会学術集会
    • Place of Presentation
      大阪
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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