| Budget Amount *help |
¥6,199,813 (Direct Cost: ¥5,253,703、Indirect Cost: ¥946,110)
Fiscal Year 2009: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2008: ¥2,409,813 (Direct Cost: ¥1,853,703、Indirect Cost: ¥556,110)
Fiscal Year 2007: ¥2,100,000 (Direct Cost: ¥2,100,000)
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| Research Abstract |
In this study, I found that the protein products of two postplasmic/PEM RNA genes Ci-PEM (Ci-pem-1) and Ci-TDRD7 (Ci-pem-11) have crucial roles in germline formation of Ciona intestinalis respectively. The protein product of Ci-PEM was distributed in the nucleus in the germline blastomeres as well as the postplasm in the cleavage stage and required for the repression of somatic gene expression in the germline. Ci-TDRD7 protein formed a complex with CiVH, a homolog of the conserved germ cell marker Vasa, in the germline cells, and it was involved in the formation of the peri-nuclear CiVH granules in the primordial germ cells (PGCs) after gastrulation.
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