The function of the homeobox gene Hex in chondrogenesis

• Project/Area Number: 19790073
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Biological pharmacy
• Research Institution: Teikyo University
• Principal Investigator: MORIMOTO Riyo Teikyo University, 薬学部, 助教 (00439564)
• Project Period (FY): 2007 – 2009
• Project Status: Completed (Fiscal Year 2009)
• Budget Amount: ¥3,820,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥420,000); Fiscal Year 2009: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2008: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: Hex / 軟骨 / 細胞分化 / ホメオボックス遺伝子 / 軟骨細胞 / 細胞死 / 軟骨形成 / 発生 / 器官形成

Research Abstract

We revealed that the expression and a part of physiological function of Hex in cartilage. Hex mRNA is increased differentiation-dependently in chondrocytes. Hex protein in chondrocyte involved in the nucleocytoplasmic transport. Exogenous Hex induced the cell death in the chondroprogenitor cells. We will elucidate the question whether these cell death is induced during chondrogenesis under physiological conditions.

Research Products

• [Journal Article] miRNAによる軟骨形成制御機構 (2009)
  • Author(s): 森本理代
  • Journal Title: ファルマシア 45(1) Pages: 63-34
• [Presentation] Homeoprotein Hex moves between cytoplasm and nucleus during chondrocyte maturation. (2009)
  • Author(s): 森本理代
  • Organizer: 第82回生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] Homeoprotein Hex moves between cytoplasm and nucleus during chondrocyte maturation. (2009)
  • Author(s): 森本理代
  • Organizer: 第回生化学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2009-10-23
• [Presentation] Divergent type homeobox gene Hex regurates chondrocyte differentiation. (2009)
  • Author(s): 森本理代
  • Organizer: 第61回細胞生物学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-06-02
• [Presentation] Divergent type homeobox gene Hex regurateschondrocyte differentiation. (2009)
  • Author(s): 森本理代
  • Organizer: 第61回細胞生物学会大会
  • Place of Presentation: 名古屋
  • Year and Date: 2009-06-02
• [Presentation] Divergent type homeobox gene Hex regulates chondrocyte differentiation. (2008)
  • Author(s): 森本理代
  • Organizer: 第31回分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] Divergent type homeobox gene Hex regulates chondrocyte differentiation (2008)
  • Author(s): 森本理代
  • Organizer: 第31回分子生物学会年会・第81回日本生化学会大会合同大会
  • Place of Presentation: 神戸
  • Year and Date: 2008-12-09
• [Presentation] Secretion of L-Glutamate from osteoclasts through transcytosis. (2007)
  • Author(s): 森本理代
  • Organizer: 第40回発生学会・第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡
  • Year and Date: 2007-05-29
• [Presentation] Stecretion of L-Glutamate from osteoclasts through transcytosis. (2007)
  • Author(s): 森本 理代
  • Organizer: 第40回発生学会・第59回日本細胞生物学会合同大会
  • Place of Presentation: 福岡国際会議場
  • Year and Date: 2007-05-29
• [Remarks]
  • URL: http://www.pharm.teikyo-u.ac.jp/lab/seiri-k2/index.html