Analysis of the tumor metastasis inhibited by Citrobacter rodentium infection and the investigation of bacterial anti-metastasis vaccine.

• Project/Area Number: 19790317
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Bacteriology (including Mycology)
• Research Institution: Keio University (2008); The University of Tokyo (2007)
• Principal Investigator: NAGAI Takeshi Keio University, 医学部, 助教 (60418655)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 細菌 / 感染症 / 癌 / 癌転移 / 細菌感染

Research Abstract

マウスに大腸炎を誘導するCitrobacter rodentiumと癌転移の相関関係について研究を行った。一度C. rodentiumに感染したマウスでは、その後の黒色腫細胞移入による肺への癌転移が有意に抑制された。この抑制作用は、C. rodentiumに対する何らかの抗体が、癌細胞の表面抗原に交差反応をして見られる現象であることを明らかにした。

Research Products

• [Journal Article] Differential roles of interleukin-17A and -17F in host defense against mucoepithelial bacterial infection and allergic responses (2009)
  • Author(s): Ishigame H, Kakuta S, Nagai T, Kadoki M, Nambu A, Komiyama Y, Fujikado N, Tanahashi Y, Akitsu A, Kotaki H, Sudo K, Nakae S, Sasakawa C, Iwakura Y
  • Journal Title: Immunity 30 Pages: 108-116
  • Peer Reviewed
• [Journal Article] Differential roles of interleukin-17A and-17F in host defense against mucoepithelial bacterial infection and allergic responses (2009)
  • Author(s): Ishigame, H., et.al.
  • Journal Title: Immunity 30 Pages: 108-116
  • Peer Reviewed
• [Journal Article] The enteropathogenic E. coli-effector EspB facilitates microvilli effacing and antiphagocytosis by inhibiting myosin function (2007)
  • Author(s): Iizumi, Y., Sagara H, Kabe Y, Azuma M, Kume K, Ogawa M, Nagai T, Gillespie PG, Sasakawa C, Handa H
  • Journal Title: Cell Host Microbe 2 Pages: 383-392
  • Peer Reviewed
• [Journal Article] Helicobacter pylori Dampens Gut Epithelial Self-Renewal by Inhibiting Apoptosis, a Bacterial Strategy to Enhance Colonization of the Stomach (2007)
  • Author(s): Mimuro H, Suzuki T, Nagai S, Rieder G, Suzuki M, Nagai T, Fujita Y, Nagamatsu K, Ishijima N, Koyasu S, Haas R, Sasakawa C
  • Journal Title: Cell Hostand and Microbe 4 Pages: 255-263
  • Peer Reviewed
• [Presentation] "Citrobacter rodentiumの感染によって癌の転移が抑制される (2008)
  • Author(s): 永井武、三室仁美、石亀晴道、角田茂、岩倉洋一郎、笹川千尋
  • Organizer: 第81回日本細菌学会総会
  • Place of Presentation: 京都
  • Year and Date: 2008-03-25
• [Presentation] Citrobacter rodentiumの感染によって癌の転移が抑制される (2008)
  • Author(s): 永井 武
  • Organizer: 第81回日本細菌学会総会
  • Place of Presentation: 国立京都国際会館
  • Year and Date: 2008-03-24