The Study of Relationship between Blood Sialoproteins and Pathological Condition -Proposal for Pathological Sialoproteome-

Research Project

Project/Area Number	19790397
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Single-year Grants
Research Field	Laboratory medicine
Research Institution	Kyushu University
Principal Investigator	AOKI Yoshimasa Kyushu University, 大学病院, 主任臨床検査技師 (80419514)
Project Period (FY)	2007 – 2009
Project Status	Completed (Fiscal Year 2009)
Budget Amount *help	¥3,490,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥390,000) Fiscal Year 2009: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000) Fiscal Year 2008: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000) Fiscal Year 2007: ¥1,800,000 (Direct Cost: ¥1,800,000)
Keywords	血中シアロ糖タンパク / シアル酸 / ノイラミニダーゼ / プロテオミクス / 二次元電気泳動 / 質量分析
Research Abstract	To explore novel pathological marker proteins, blood sialoproteins in a number of healthy subjects were analyzed by the two dimensional electrophoresis. Several proteins that were able to become the candidates were found. Hereafter, when these proteins are compared with the various group of disease and analyzed the sugar chain modification in detail, new clinical significance may be found. Thus, as for this study, utility is very high.