Pharmacological evaluation of experimental pancreatic arterial infusion chemotherapy with the unification of the blood supply

• Project/Area Number: 19790893
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Radiation science
• Research Institution: Nara Medical University
• Principal Investigator: TOSHIHIRO Tanaka Nara Medical University, 医学部, 助教 (70326338)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,780,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥480,000); Fiscal Year 2008: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2007: ¥1,700,000 (Direct Cost: ¥1,700,000)
• Keywords: 膵癌 / 動注 / VR / IVR / 十二指腸閉塞 / ステント

Research Abstract

膵癌に対する血流改変を用いた5-FU膵動注療法の薬理学的有利性をブタを用いた動物実験で証明した。また、臨床研究として血管造影下CTを用いて本手法の実行可能性を評価した。

Research Products

• [Journal Article] A novel interventional radiology technique for arterial infusion chemotherapy against advanced pancreatic cance (2009)
  • Author(s): Tanaka T, et al
  • Journal Title: Am J Roentgenol (in press)
• [Journal Article] Pharmacological evaluation of experimental pancreatic arterial infusion chemotherapy with the unification of the blood supply (2009)
  • Author(s): Tanaka T, et al
  • Journal Title: J Vasc Interv Radiol (submitted)
• [Journal Article] A novel interventional radiology technique for arterial infusion chemotherapy against advanced pancreatic cancer (2009)
  • Author(s): Toshihiro Tanaka, et.al.
  • Journal Title: American Journal Roentgenology 192 Pages: 168-187
  • Peer Reviewed
• [Journal Article] Arterial infusion of 5-fluorouracil combined with concurrent radiotherapy for unresectable pancreatic cancer : results from a pilot study (2007)
  • Author(s): Tanaka T, et al
  • Journal Title: Am J Roentgenol 189 Pages: 421-428
• [Journal Article] Arterial Infusion of 5-Fluorouracil Combined with Concurrent Radiotherapy for Unresectable Pancreatic Cancer:Results from a Pilot Study (2007)
  • Author(s): Toshihiro Tanaka, et. al.
  • Journal Title: American Journal Roentgenology 189 Pages: 421-428
  • Peer Reviewed
• [Presentation] 血流改変術を併用した5-FU膵動注化学療法の実験的検討 (2009)
  • Author(s): 田中利洋 他
  • Organizer: 日本IVR学会総会
  • Place of Presentation: 大阪
• [Presentation] Hepatic arterial infusion of 5-fluorouracil through port-catheter system for liver metastases from pancreatic cancer (2008)
  • Author(s): 田中利洋
  • Organizer: CIRSE2008
  • Place of Presentation: コペンハーゲン
  • Year and Date: 2008-09-17
• [Presentation] A phase I study of arterial infusion with 5-FU combined with systemic gemcitabine for unresectable pancreatic cancer(S73) (2008)
  • Author(s): Tanaka T
  • Organizer: SIR
  • Place of Presentation: in Washington D.C
• [Presentation] Alteration of pancreatic blood supply in arterial infusion chemotherapy for advanced pancreatic cancer(188) (2008)
  • Author(s): Tanaka T.
  • Organizer: ISIR&JSIR
  • Place of Presentation: in Karuizawa, Japan
• [Presentation] Hepatic arterial infusion of 5-fluorouracil through port-catheter system for liver metastases from pancreatic cancer (2008)
  • Author(s): Tanaka T.
  • Organizer: CIRSE
  • Place of Presentation: in Copenhagen
• [Presentation] A phase l study of arterial infusion with 5・FU combined withsystemic gemcitabine for unresectable pancreatic cancer (2008)
  • Author(s): 田中 利洋
  • Organizer: SIR2008
  • Place of Presentation: ワシントンDC