| Project/Area Number |
19791072
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Oita University |
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Principal Investigator |
HASEGAWA Akira Oita University, 医学部・麻酔科学講座, 助教 (90448548)
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| Project Period (FY) |
2007 – 2009
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| Project Status |
Completed (Fiscal Year 2009)
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| Budget Amount *help |
¥3,720,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥420,000)
Fiscal Year 2009: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2008: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2007: ¥1,900,000 (Direct Cost: ¥1,900,000)
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| Keywords | 人工呼吸 / 体温 / 温熱ストレス / 熱ショック蛋白質 / ムチン / 集中治療 |
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| Research Abstract |
Inflammation lets mucin in the respiratory duct increase,but does not understand whether expression of mucin comes under what kind of influence by abnormal body temperature. First of all, I clarified relations of inflammation and body temperature. It is known that we have cytoprotective protection effect for aggression in heat shock protein (HSP). I made a rat endotoxin shock model and examined protection effect when I induced HSP. As s result, it was recognized that HSP was induced by adding heat stress (42℃15minutes), and inhibited inflammation significantly, and improved the survival rate. I will push forward study about body temperature and relations with expression of mucin more in future.
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