Mechanism and protection against noise-induced hearing loss

• Project/Area Number: 19791235
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Single-year Grants
• Research Field: Otorhinolaryngology
• Research Institution: Keio University
• Principal Investigator: YAMASHITA Daisuke Keio University, 医学部, 助教 (60306785)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,690,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥390,000); Fiscal Year 2008: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2007: ¥2,000,000 (Direct Cost: ¥2,000,000)
• Keywords: 耳鼻咽喉学 / 感音難聴 / アポトーシス / 内耳再生 / アボトーシス / 再生

Research Abstract

はじめに強大音響に曝露されることにより、難聴になる動物モデルを作製した。次にその難聴モデル動物において、内耳有毛細胞(聴覚を司る神経細胞)の細胞死(アポトーシス)に至るメカニズムを詳細に解明した。最後にその結果に基づき、難聴を治療する方法を種々のアプローチで検討し、聴覚機能・内耳形態の両面において難聴を治す可能性のある結果が得られた。

Research Products

• [Journal Article] Neuroprotective effects of T-817MA against noise-induced hearing loss (2008)
  • Author(s): Yamashita D, Shiotani A. Kanzaki S, Nakagawa M, Ogawa K
  • Journal Title: Neuroscience Res 61(1) Pages: 38-42
• [Journal Article] Bcl-2 genes regulate noise-induced hearing loss (2008)
  • Author(s): Yamashita D, Minami SB, Kanzaki S, Ogawa K, Miller JM
  • Journal Title: J. Neuroscience. Res 86(4) Pages: 920-928
• [Journal Article] 感音難聴への治療戦略 (2008)
  • Author(s): 山下大介
  • Journal Title: 慶應医学 85(1) Pages: 39-45
  • NAID: 10024168745
• [Journal Article] 騒音性難聴 (2008)
  • Author(s): 山下大介
  • Journal Title: 図説医療 62(3) Pages: 170-173
• [Journal Article] Bc1-2 genes regulate noise-induced hearing loss (2008)
  • Author(s): Yamashita D., et.al.
  • Journal Title: J. Neurosci. Res 86(4) Pages: 920-928
  • Peer Reviewed
• [Journal Article] Neuroprotective effects of T-817MA against noise-induced hearing loss (2008)
  • Author(s): Yamashita D., et.al.
  • Journal Title: Neuroscience Res 61(1) Pages: 38-42
  • Peer Reviewed
• [Journal Article] 騒音性難聴 (2008)
  • Author(s): 山下大介
  • Journal Title: 医療 62(3) Pages: 170-173
  • Peer Reviewed
• [Journal Article] Bcl-2 genes regulate noise-induced hearing loss (2008)
  • Author(s): Yamashita D., et. al.
  • Journal Title: J. Neurosci. Res. 86(4) Pages: 920-928
  • Peer Reviewed
• [Journal Article] Neuroprotective effects ofT-817MA against noise-induced hearing loss (2008)
  • Author(s): Yamashita D., et. al.
  • Journal Title: Neurosdence Res. 61(1) Pages: 38-42
  • Peer Reviewed
• [Journal Article] 騒音性難聴 (2008)
  • Author(s): 山下 大介
  • Journal Title: 医療 62(3) Pages: 170-173
  • Peer Reviewed
• [Journal Article] 感音難聴への治療戦略 (2008)
  • Author(s): 山下 大介
  • Journal Title: 慶應医学 85(1) Pages: 39-45
  • NAID: 10024168745
  • Peer Reviewed
• [Journal Article] Creatine and Tempol attenuate noise-induced hearing loss (2007)
  • Author(s): Minami SB, Yamashita D, Ogawa K, Schacht J, Miller JM
  • Journal Title: Brain Res 1148 Pages: 83-89
• [Journal Article] Mechanism of noise-induced hearing loss indicate multiple methods of prevention (2007)
  • Author(s): Le Prell CG, Yamashita D, Minami SB, Yamasoba T, Miller JM
  • Journal Title: Hearing Res 226(1-2) Pages: 22-43
• [Journal Article] Creatine and Tempol attenuate noise-induced hearing loss (2007)
  • Author(s): Minami SB, Yamashita D., et. al.
  • Journal Title: Brain Res. 1148 Pages: 83-89
  • Peer Reviewed
• [Journal Article] Mechanisms of noise-induced hearing loss indicate mviltiple methods ofprevention (2007)
  • Author(s): Le PreU CG, Yamashita D., et. al.
  • Journal Title: Hearing Res. 226(1-2) Pages: 22-43
  • Peer Reviewed
• [Presentation] 音響外傷性難聴に対するSA4503の内耳神経保護効果 (2008)
  • Author(s): 山下大介、孫こうい、神崎晶、松永達雄、小川郁
  • Organizer: 日本耳科学会(18回)
  • Place of Presentation: 神戸
  • Year and Date: 2008-10-26
• [Presentation] 音響外傷性難聴に対するSA4503の内耳神経保護効果 (2008)
  • Author(s): 山下大介、神崎晶, 等
  • Organizer: 日本耳科学会(第18回)
  • Place of Presentation: 神戸(日本)
  • Year and Date: 2008-10-16
• [Presentation] Detection system for transplanted bone marrow stem cells in inner ear by SPIO (2008)
  • Author(s): Yamashita D. Watada Y. Kanzaki S. Toyoda M. Tanimoto N. Kobayashi M. Ogawa K. Umezawa A
  • Organizer: 日本神経科学会(第31回)
  • Place of Presentation: 東京
  • Year and Date: 2008-07-11
• [Presentation] Detection system for transplanted bone marrow stem cells in inner ear by SPIO (2008)
  • Author(s): Yamashita D., et.al.
  • Organizer: 日本神経科学会(第31回)
  • Place of Presentation: 東京(日本)
  • Year and Date: 2008-07-11
• [Presentation] 内耳におけるOgg1ノックアウトマウスの機能解析 (2008)
  • Author(s): 山下大介、和多田有紀子、神崎晶、小川郁
  • Organizer: 日本耳鼻咽喉科学会総会(109回)
  • Place of Presentation: 大阪
  • Year and Date: 2008-05-19
• [Presentation] 内耳におけるOgg1ノックアウトマウスの機能解析 (2008)
  • Author(s): 山下大介、神崎晶, 等
  • Organizer: 日本耳鼻咽喉科学会総会(第109回)
  • Place of Presentation: 大阪(日本)
  • Year and Date: 2008-05-19
• [Presentation] Neuroprotective effects of T817MA against noise-induced hearing loss (2008)
  • Author(s): Yamashita D. Shiotani A. Kanzaki S. Ogawa K
  • Organizer: ARO(31回)
  • Place of Presentation: アリゾナ(アメリカ)
  • Year and Date: 2008-02-19
• [Presentation] Neuroprotective effects of T-817MA against noise-induced hearing loss (2008)
  • Author(s): Yaniasliita D., et. al.
  • Organizer: Association for Research in Otolarjmgology
  • Place of Presentation: アリゾナ(アメリカ)
  • Year and Date: 2008-02-19
• [Presentation] 超常磁性体酸化鉄による内耳移植細胞の生体内検出システム (2007)
  • Author(s): 山下大介、神崎晶、松永達雄、藤井正人、小川郁
  • Organizer: 第17回日本耳科学会
  • Place of Presentation: 福岡
  • Year and Date: 2007-10-18
• [Presentation] 超常磁性体酸化鉄による内耳移植細胞の生体内検出システム (2007)
  • Author(s): 山下 大介、神崎 晶等
  • Organizer: 日本耳科学会
  • Place of Presentation: 福岡
  • Year and Date: 2007-10-18