Searching for effective drugs against ovarian clear cell carcinoma based on microarray analysis
Project/Area Number |
19890114
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Research Category |
Grant-in-Aid for Young Scientists (Start-up)
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Allocation Type | Single-year Grants |
Research Field |
Obstetrics and gynecology
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Research Institution | Kyoto University |
Principal Investigator |
MATSUMURA Noriomi Kyoto University, 医学研究科, 助教 (20452336)
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Project Period (FY) |
2007 – 2008
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Project Status |
Completed (Fiscal Year 2008)
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Budget Amount *help |
¥3,085,000 (Direct Cost: ¥2,680,000、Indirect Cost: ¥405,000)
Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000)
Fiscal Year 2007: ¥1,330,000 (Direct Cost: ¥1,330,000)
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Keywords | 卵巣明細胞腺癌 / マイクロアレイ / バイオインフォマティックス / 分子標的薬 / 卵巣癌 / キナーゼ阻害剤 / チョコレートのう胞 / 薬剤抵抗性 / メチル化 / 組織型 / 明細胞腺癌 / Src / Oncogene |
Research Abstract |
卵巣癌細胞株のマイクロアレイ解析によって、明細胞腺癌を特徴づける遺伝子群を同定した。その結果、1) 卵巣明細胞腺癌を特徴づける遺伝子群には、チョコレートのう胞内の酸化ストレス環境によって上昇する遺伝子が多く含まれること、2) 明細胞腺癌は腎細胞癌と類似し、キナーゼ活性との関連が深いRas活性が高く、増殖能との関連が深いE2F活性が低いことを明らかにした。したがって、明細胞腺癌に対して、増殖をターゲットとする抗がん剤ではなく、キナーゼ活性を阻害する分子標的薬が有用と考えられた。
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Report
(3 results)
Research Products
(36 results)
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[Journal Article] Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer : high expression of ULBP2 is an indicator of poor prognosis2009
Author(s)
Li K, Mandai M, Hamanishi J, Matsumura N, Suzuki A, Yagi H, Yamaguchi K, Baba T, Fujii S, Konishi I.
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Journal Title
Cancer Immunol Immunother 58
Pages: 641-52
Related Report
Peer Reviewed
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[Journal Article] Yin yang 1 modulates taxane response in epithelial ovarian cancer2009
Author(s)
Matsumura N, Huang Z, Baba T, Lee PS, Barnett JC, Mori S, Chang JT, Kuo WL, Gusberg AH, Whitaker RS, Gray JW, Fujii S, Berchuck A
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Journal Title
Murphy SK. Mol Cancer Res 7
Pages: 210-20
Related Report
Peer Reviewed
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[Journal Article] Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells2009
Author(s)
Baba T, Convery PA, Matsumura N, Whitaker RS, Kondoh E, Perry T, Huang Z, Bentley RC, Mori S, Fujii S, Marks JR, Berchuck A
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Journal Title
Murphy SK. Oncogene 28
Pages: 209-18
Related Report
Peer Reviewed
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[Journal Article] Yin yang 1 modulates taxaane response in epithelial ovarian cancer.2009
Author(s)
Matsumura N, Huang Z, Baba T, Lee PS, Barnett JC, Mori S, Chang JT, Kuo WL, Gusberg AH, Whitaker RS, Gray JW, Fujii S, Berchuck A, Murphy SK.
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Journal Title
Molecular Cancer Research 7
Pages: 210-220
Related Report
Peer Reviewed
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[Journal Article] Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer : high expression of ULBP2 is an indicator of poor prognosis.2009
Author(s)
Li K, Mandai H, Hamanishi J, Matsumura N, Suzuki A, Yagi H, Yamaguchi K, Baba T, Fujii S, Konishi I.
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Journal Title
Cancer Immunology, Immunotherapy 58
Pages: 641-652
Related Report
Peer Reviewed
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[Journal Article] Epigenetic regulation of CD133 and tumorigenicity of CD133+ovvarian cancer cells.2009
Author(s)
Baba T, Convery PA, Matsumura N, Whitaker RS, Kondoh E, Perry T, Huang Z, Bentley RC, Mori S, Fuji S, Marks JR, Berchuck A, Murphy SK.
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Journal Title
Oncogene. 15
Pages: 209-118
Related Report
Peer Reviewed
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[Journal Article] Trophinin is a potent prognostic marker of ovarian cancer involved in platinum sensitivity2007
Author(s)
Baba T, Mori S, Matsumura N, Kariya M, Murphy SK, Kondoh E, Kusakari T, Kuroda H, Mandai M, Higuchi T, Takakura K, Fukuda MN
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Journal Title
Fujii S. Biochem Biophys Res Commun 360
Pages: 363-9
Related Report
Peer Reviewed
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[Journal Article] Trophinin is a potent prognostic marker of ovarian cancer involved in platinum sensitivity.2007
Author(s)
Baba T, Mori S, Matsumura N, Kariya M, Murphy SK, Kondoh E, Kusakari T, Kuroda H, Mandai M, Higuchi T, Takakura K, Fukuda MN, Fujii S.
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Journal Title
Biochemical and biophysical research communications 360
Pages: 363-369
Related Report
Peer Reviewed
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[Presentation] Gene signature specific for ovarian clear cell carcinoma is induced by the contents of endometriotic cysts2009
Author(s)
K.Yamaguchi, M.Mandai, N.Matsumura, T.Baba, T.Oura, S.Matsui, S.K.Murphy, A.Berchuck, S.Fujii, I.Konishi
Organizer
40th Annual Meeting of the Society of Gynecologic Oncologists
Place of Presentation
San Antonio, TX
Related Report
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[Presentation] Targeting dormant ovarian cancer cells2008
Author(s)
E.Kondoh, T.Baba, N.Matsumura, S.Fujii, A.Berchuck, S.K.Murphy
Organizer
39th Annual Meeting of the Society of Gynecologic Oncologists. Focused Plenary Session
Place of Presentation
Tampa, FL
Year and Date
2008-03-10
Related Report
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[Presentation] Transcriptome analysis of DNA methylation status in ovarian cancer-Correlation of aggressiveness and TGFb pathway2008
Author(s)
N.Matsumura, Z.Huang, T.Perry, D.Kroyer, T.Baba, S.Mori, M.Mandai, I.Konishi, S.Fujii, A.Berchuck, S.K. Murphy
Organizer
39th Annual Meeting of the Society of Gynecologic Oncologists
Place of Presentation
Tampa, FL
Related Report
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[Presentation] Stem cell marker CD133 (PROMININ-1) is epigenetically regulated in ovarian cancer2008
Author(s)
T.Baba, P.A.Convery, N.Matsumura, R.S.Whitaker, T.Perry, Z.Huang, S.Mori, E.Kondoh, R.C.Bentley, S.Fujii, J.R.Marks, A.Berchuck, S.K.Murphy
Organizer
39th Annual Meeting of the Society of Gynecologic Oncologists
Place of Presentation
Tampa, FL
Related Report
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[Presentation] Transcriptome analysis of DNA methylation status in ovarian cancer-Correlation of aggressiveness and TGFb pathway2008
Author(s)
Noriomi Matsumura, Zhiqing Huang, Tiffany Perry, Darby Kroyer, Tsukasa Baba, Seiichi Mori, Masaki Mandai, Ikuo Konishi, Shing Fujii
Organizer
SGO 39th Annual Meeting on Women's Cancer
Place of Presentation
Tampa, FL, USA
Related Report