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Searching for effective drugs against ovarian clear cell carcinoma based on microarray analysis

Research Project

Project/Area Number 19890114
Research Category

Grant-in-Aid for Young Scientists (Start-up)

Allocation TypeSingle-year Grants
Research Field Obstetrics and gynecology
Research InstitutionKyoto University

Principal Investigator

MATSUMURA Noriomi  Kyoto University, 医学研究科, 助教 (20452336)

Project Period (FY) 2007 – 2008
Project Status Completed (Fiscal Year 2008)
Budget Amount *help
¥3,085,000 (Direct Cost: ¥2,680,000、Indirect Cost: ¥405,000)
Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000)
Fiscal Year 2007: ¥1,330,000 (Direct Cost: ¥1,330,000)
Keywords卵巣明細胞腺癌 / マイクロアレイ / バイオインフォマティックス / 分子標的薬 / 卵巣癌 / キナーゼ阻害剤 / チョコレートのう胞 / 薬剤抵抗性 / メチル化 / 組織型 / 明細胞腺癌 / Src / Oncogene
Research Abstract

卵巣癌細胞株のマイクロアレイ解析によって、明細胞腺癌を特徴づける遺伝子群を同定した。その結果、1) 卵巣明細胞腺癌を特徴づける遺伝子群には、チョコレートのう胞内の酸化ストレス環境によって上昇する遺伝子が多く含まれること、2) 明細胞腺癌は腎細胞癌と類似し、キナーゼ活性との関連が深いRas活性が高く、増殖能との関連が深いE2F活性が低いことを明らかにした。したがって、明細胞腺癌に対して、増殖をターゲットとする抗がん剤ではなく、キナーゼ活性を阻害する分子標的薬が有用と考えられた。

Report

(3 results)
  • 2008 Annual Research Report   Final Research Report ( PDF )
  • 2007 Annual Research Report
  • Research Products

    (36 results)

All 2009 2008 2007

All Journal Article (15 results) (of which Peer Reviewed: 15 results) Presentation (21 results)

  • [Journal Article] Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer : high expression of ULBP2 is an indicator of poor prognosis2009

    • Author(s)
      Li K, Mandai M, Hamanishi J, Matsumura N, Suzuki A, Yagi H, Yamaguchi K, Baba T, Fujii S, Konishi I.
    • Journal Title

      Cancer Immunol Immunother 58

      Pages: 641-52

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Classification using hierarchical clustering of tumor-infiltrating immune cells identifies poor prognostic ovarian cancers with high levels of COX expression2009

    • Author(s)
      Liu M, Matsumura N, Mandai M, Li K, Yagi H, Baba T, Suzuki A, Hamanishi J, Fukuhara K.
    • Journal Title

      Konishi I. Mod Pathol 22

      Pages: 373-84

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Yin yang 1 modulates taxane response in epithelial ovarian cancer2009

    • Author(s)
      Matsumura N, Huang Z, Baba T, Lee PS, Barnett JC, Mori S, Chang JT, Kuo WL, Gusberg AH, Whitaker RS, Gray JW, Fujii S, Berchuck A
    • Journal Title

      Murphy SK. Mol Cancer Res 7

      Pages: 210-20

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells2009

    • Author(s)
      Baba T, Convery PA, Matsumura N, Whitaker RS, Kondoh E, Perry T, Huang Z, Bentley RC, Mori S, Fujii S, Marks JR, Berchuck A
    • Journal Title

      Murphy SK. Oncogene 28

      Pages: 209-18

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Immunostimulatory effect of Fms-like tyrosine kinase 3 ligand on peripheral monocyte-derived dendritic cells and natural killer cells : utilization for ovarian cancer treatment2009

    • Author(s)
      Matsumura N, Mandai M, Hamanishi J, Yamaguchi K, Fukuhara K, Yagi H, Higuchi T, Takakura K
    • Journal Title

      Fujii S. Oncol Rep 19

      Pages: 505-15

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Yin yang 1 modulates taxaane response in epithelial ovarian cancer.2009

    • Author(s)
      Matsumura N, Huang Z, Baba T, Lee PS, Barnett JC, Mori S, Chang JT, Kuo WL, Gusberg AH, Whitaker RS, Gray JW, Fujii S, Berchuck A, Murphy SK.
    • Journal Title

      Molecular Cancer Research 7

      Pages: 210-220

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Classification using hierarchicl cclustering of tumor-infiltrating immune cells identifies poor prognostic ovarian cancers with high levels of COX expression.2009

    • Author(s)
      Fujii S, Takakura K, Matsumura N, Higcohi T, Yura S, Mandai M, Baba T, Yoshioka S.
    • Journal Title

      Modern Pathology 22

      Pages: 373-384

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of the NKG2D ligands, MICA/B and ULBP2 in ovarian cancer : high expression of ULBP2 is an indicator of poor prognosis.2009

    • Author(s)
      Li K, Mandai H, Hamanishi J, Matsumura N, Suzuki A, Yagi H, Yamaguchi K, Baba T, Fujii S, Konishi I.
    • Journal Title

      Cancer Immunology, Immunotherapy 58

      Pages: 641-652

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Epigenetic regulation of CD133 and tumorigenicity of CD133+ovvarian cancer cells.2009

    • Author(s)
      Baba T, Convery PA, Matsumura N, Whitaker RS, Kondoh E, Perry T, Huang Z, Bentley RC, Mori S, Fuji S, Marks JR, Berchuck A, Murphy SK.
    • Journal Title

      Oncogene. 15

      Pages: 209-118

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunostimulatory effect of Fms-like tyrosine kinase 3 ligand on peripheral monocyte-derived dendritic cells and antural killer cells: utilization for ovarian cancer treatment.2008

    • Author(s)
      Matsumura N, Mandai M, Hamanishi J, Yamaguchi K, Fukuhara K, Yagi H, Higuchi T, Takakura K, Fujii S.
    • Journal Title

      Oncology reports 19

      Pages: 505-515

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anatomic identification and functional outcomes of the nerve sparing Okabayashi radical hysterectomy2007

    • Author(s)
      Fujii S, Takakura K, Matsumura N, Higuchi T, Yura S, Mandai M, Baba T
    • Journal Title

      Yoshioka S. Gynecol Oncol 107

      Pages: 4-13

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Trophinin is a potent prognostic marker of ovarian cancer involved in platinum sensitivity2007

    • Author(s)
      Baba T, Mori S, Matsumura N, Kariya M, Murphy SK, Kondoh E, Kusakari T, Kuroda H, Mandai M, Higuchi T, Takakura K, Fukuda MN
    • Journal Title

      Fujii S. Biochem Biophys Res Commun 360

      Pages: 363-9

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Neuropilin-1 promotes unlimited growth of ovarian cancer by evading contact inhibition2007

    • Author(s)
      Baba T, Kariya M, Higuchi T, Mandai M, Matsumura N, Kondoh E, Miyanishi M, Fukuhara K, Takakura K
    • Journal Title

      Fujii S. Gynecol Oncol 105

      Pages: 703-11

    • Related Report
      2008 Final Research Report
    • Peer Reviewed
  • [Journal Article] Anatomic identification and functional outcomes of the nerve sparing Okabayashi radical hysterectomy.2007

    • Author(s)
      Fujii S, Takakura K, Matsumura N, Higuchi T, Yura S, Mandai M, Baba T, Yoshioka S.
    • Journal Title

      Gynecologic oncology 107

      Pages: 4-13

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Trophinin is a potent prognostic marker of ovarian cancer involved in platinum sensitivity.2007

    • Author(s)
      Baba T, Mori S, Matsumura N, Kariya M, Murphy SK, Kondoh E, Kusakari T, Kuroda H, Mandai M, Higuchi T, Takakura K, Fukuda MN, Fujii S.
    • Journal Title

      Biochemical and biophysical research communications 360

      Pages: 363-369

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] 卵巣癌腹膜播種の新生血管を標的として、ケモカインCCL19遺伝子導入胚性血管内皮細胞を用いて局所免疫賦活を目指した新規免疫療法開発の基礎的検討2009

    • Author(s)
      濱西潤三、万代昌紀、松村謙臣、馬場長、八木治彦、山口建、樋口壽宏、高倉賢二、小西郁生、藤井信吾
    • Organizer
      第61回日本産科婦人科学会学術集会高得点演題口演
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-04-05
    • Related Report
      2008 Final Research Report
  • [Presentation] 免疫細胞の浸潤パターンに基づく階層的クラスター解析により、COX高発現/予後不良の卵巣癌を同定できる2009

    • Author(s)
      吉岡弓子、松村謙臣、八木治彦、馬場長、鈴木彩子、濱西潤三、福原健、万代昌紀、小西郁生
    • Organizer
      第61回日本産科婦人科学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-04-05
    • Related Report
      2008 Final Research Report
  • [Presentation] 卵巣癌における化学療法感受性バイオマーカーの開発と組織型による分子標的の同定-治療個別化に向けたBioinformaticsの応用2009

    • Author(s)
      松村謙臣
    • Organizer
      第61回日本産科婦人科学会学術集会シンポジウム口演
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-04-04
    • Related Report
      2008 Final Research Report
  • [Presentation] 卵巣癌大網転移におけるメチル化遺伝子群の発現とTGF-β活性の亢進2009

    • Author(s)
      山村省吾、松村謙臣、山口建、濱西潤三、馬場長、万代昌紀、小西郁生
    • Organizer
      第61回日本産科婦人科学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-04-04
    • Related Report
      2008 Final Research Report
  • [Presentation] 卵巣癌における化学療法感受性バイオマーカーの開発と組織型による分子標的の同定-治療個別化に向けたBioinformaticsの応用2009

    • Author(s)
      松村謙臣
    • Organizer
      第61回日本産婦人科学会シンポジウム
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-04-04
    • Related Report
      2008 Annual Research Report
  • [Presentation] 卵巣明細胞腺癌において、マイクロアレイ解析により特徴付けられる生物学的特性は特有の発癌環境を反映している2009

    • Author(s)
      山口建、万代昌紀、松村謙臣、山村省吾、濱西潤三、馬場長、藤井信吾、小西郁生
    • Organizer
      第61回日本産科婦人科学会学術集会婦人科腫瘍学部門優秀演題賞口演
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2009-04-03
    • Related Report
      2008 Final Research Report
  • [Presentation] Activated local immunity by chemokine CCL19-transduced embryonic encothelial progenitor cells suppresses lung metastasis of murine ovarian cancer2009

    • Author(s)
      J.Hamanishi, M.Mandai, N.Matsumura, T.Higuchi, K.Takakura, K.Yamaguchi, S.Fujii, I.Konishi
    • Organizer
      40th Annual Meeting of the Society of Gynecologic Oncologists
    • Place of Presentation
      San Antonio, TX
    • Related Report
      2008 Final Research Report
  • [Presentation] Gene signature specific for ovarian clear cell carcinoma is induced by the contents of endometriotic cysts2009

    • Author(s)
      K.Yamaguchi, M.Mandai, N.Matsumura, T.Baba, T.Oura, S.Matsui, S.K.Murphy, A.Berchuck, S.Fujii, I.Konishi
    • Organizer
      40th Annual Meeting of the Society of Gynecologic Oncologists
    • Place of Presentation
      San Antonio, TX
    • Related Report
      2008 Final Research Report
  • [Presentation] 7-hydroxystaurosporine(UCN-01)is effective in targeting ovarian cancer spheroids2009

    • Author(s)
      E.Kondoh, T.Baba, N.Matsumura, I.Konishi, S.Fujii, A.Berchuck, S.K.Murphy
    • Organizer
      40th Annual Meeting of the Society of Gynecologic Oncologists
    • Place of Presentation
      San Antonio, TX
    • Related Report
      2008 Final Research Report
  • [Presentation] BIGH3, target of methylation in ovarian cancer, is up-regulated in omental metastasis2008

    • Author(s)
      山村省吾、松村謙臣、万代昌紀、 馬場長、濱西潤三、山口建、小西郁生、Susan Murphy, Zhiqing Huang, Andrew Berchuck
    • Organizer
      第67回日本癌学会学術総会ワークショップ口演
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-29
    • Related Report
      2008 Final Research Report
  • [Presentation] Activated local immunity by CCL19-transfected embryonic endothelial progenitor cells suppresses lung metastasis2008

    • Author(s)
      濱西潤三、万代昌紀、松村謙臣、山口建、藤井信吾、小西郁生
    • Organizer
      第67回日本癌学会学術総会
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-29
    • Related Report
      2008 Final Research Report
  • [Presentation] The Characteristic Biology of Ovarian Clear Cell Ca. defined by Microarray Reflects the Specific Carcinogenetic Process2008

    • Author(s)
      山口建、万代昌紀、山村省吾、濱西潤三、馬場長、松村謙臣、豊國伸哉、藤井信吾、小西郁生
    • Organizer
      第67回日本癌学会学術総会ワークショップ口演
    • Place of Presentation
      名古屋国際会議場
    • Year and Date
      2008-10-28
    • Related Report
      2008 Final Research Report
  • [Presentation] 卵巣癌におけるNKG2Dリガンド発現の臨床的意義2008

    • Author(s)
      濱西潤三、李奎、万代昌紀、樋口壽宏、松村謙臣、八木治彦、福原健、劉敏、山口建、高倉賢二、藤井信吾
    • Organizer
      第60回日本産科婦人科学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-04-15
    • Related Report
      2008 Final Research Report
  • [Presentation] 卵巣癌におけるメチル化は予後不良と相関し、TGFb 経路の抑制をもたらす2008

    • Author(s)
      松村謙臣、Susan Murphy、万代昌紀、福原健、鈴木彩子、樋口壽宏、高倉賢二、藤井信吾
    • Organizer
      第60回日本産科婦人科学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-04-13
    • Related Report
      2008 Final Research Report
  • [Presentation] 卵巣癌の組織型によって特徴づけられる癌遺伝子シグナル伝達経路のマイクロアレイを用いた解析2008

    • Author(s)
      山口建、万代昌紀、松村謙臣、濱西潤三、鈴木彩子、八木治彦、福原健、高尾由美、巽啓司、樋口壽宏、高倉賢二、藤井信吾
    • Organizer
      第60回日本産科婦人科学会学術集会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2008-04-13
    • Related Report
      2008 Final Research Report
  • [Presentation] Targeting dormant ovarian cancer cells2008

    • Author(s)
      E.Kondoh, T.Baba, N.Matsumura, S.Fujii, A.Berchuck, S.K.Murphy
    • Organizer
      39th Annual Meeting of the Society of Gynecologic Oncologists. Focused Plenary Session
    • Place of Presentation
      Tampa, FL
    • Year and Date
      2008-03-10
    • Related Report
      2008 Final Research Report
  • [Presentation] Transcriptome analysis of DNA methylation status in ovarian cancer-Correlation of aggressiveness and TGFb pathway2008

    • Author(s)
      N.Matsumura, Z.Huang, T.Perry, D.Kroyer, T.Baba, S.Mori, M.Mandai, I.Konishi, S.Fujii, A.Berchuck, S.K. Murphy
    • Organizer
      39th Annual Meeting of the Society of Gynecologic Oncologists
    • Place of Presentation
      Tampa, FL
    • Related Report
      2008 Final Research Report
  • [Presentation] Gene signature-based oncogene pathway analysis in ovarian cancer ; difference by hisotologic subtypes2008

    • Author(s)
      K.Yamaguchi, M.Mandai, N.Matsumura, J.Hamanishi, T.Higuchi, K.Takakura, I.Konishi
    • Organizer
      39th Annual Meeting of the Society of Gynecologic Oncologists
    • Place of Presentation
      Tampa, FL
    • Related Report
      2008 Final Research Report
  • [Presentation] Microarray analysis identifies NSC668814 as a potentially active chemotherapeutic agent for platinum-resistant ovarian cancer cells with TP53 mutations2008

    • Author(s)
      T.Baba, S.Mori, N.Matsumura, M.Bernardini, S.Fujii, A.Berchuck, S.K.Murphy
    • Organizer
      39th Annual Meeting of the Society of Gynecologic Oncologists
    • Place of Presentation
      Tampa, FL
    • Related Report
      2008 Final Research Report
  • [Presentation] Stem cell marker CD133 (PROMININ-1) is epigenetically regulated in ovarian cancer2008

    • Author(s)
      T.Baba, P.A.Convery, N.Matsumura, R.S.Whitaker, T.Perry, Z.Huang, S.Mori, E.Kondoh, R.C.Bentley, S.Fujii, J.R.Marks, A.Berchuck, S.K.Murphy
    • Organizer
      39th Annual Meeting of the Society of Gynecologic Oncologists
    • Place of Presentation
      Tampa, FL
    • Related Report
      2008 Final Research Report
  • [Presentation] Transcriptome analysis of DNA methylation status in ovarian cancer-Correlation of aggressiveness and TGFb pathway2008

    • Author(s)
      Noriomi Matsumura, Zhiqing Huang, Tiffany Perry, Darby Kroyer, Tsukasa Baba, Seiichi Mori, Masaki Mandai, Ikuo Konishi, Shing Fujii
    • Organizer
      SGO 39th Annual Meeting on Women's Cancer
    • Place of Presentation
      Tampa, FL, USA
    • Related Report
      2007 Annual Research Report

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Published: 2007-04-01   Modified: 2016-04-21  

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