Analysis of the adhesion molecule which is important for ovarian cancer dissemination

• Project/Area Number: 19890124
• Research Category: Grant-in-Aid for Young Scientists (Start-up)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Osaka University
• Principal Investigator: SAWADA Kenjiro Osaka University, 医学部・附属病院, 助教 (00452392)
• Project Period (FY): 2007 – 2008
• Project Status: Completed (Fiscal Year 2008)
• Budget Amount: ¥3,085,000 (Direct Cost: ¥2,680,000、Indirect Cost: ¥405,000); Fiscal Year 2008: ¥1,755,000 (Direct Cost: ¥1,350,000、Indirect Cost: ¥405,000); Fiscal Year 2007: ¥1,330,000 (Direct Cost: ¥1,330,000)
• Keywords: 卵巣癌 / 腹膜播種 / インテグリン / カドヘリン / 分子標的治療 / E-Cadherin / Integrin α5 / Fibronectin

Research Abstract

卵巣癌腹膜播種には、上皮細胞間の接着因子であるE-cadherinの発現抑制によって誘導されるIntegrin α5が重要な役割を果たしており、Integrin α5の分子標的治療は卵巣癌腹膜播種の抑制に有用である可能性を証明した。
また、妊娠初期において絨毛細胞が母体子宮筋層内に浸潤する際に、低酸素刺激によるE-Cadherinの発現消失から誘導されるIntegrin α5の発現が重要な役割を果たしていることを臨床胎盤検体のデータを併せて証明した。

Research Products

• [Journal Article] In vitro and in vivo assays to analyze the contribution of Rho kinase in angiogenesis (2008)
  • Author(s): Sawada, K., et al.
  • Journal Title: Method Enzymol 439 Pages: 395-412
• [Journal Article] Loss of E-cadherin promotes ovarian cancer metastasis via α5-integrin which is a therapeutic target (2008)
  • Author(s): Sawada, K., et al.
  • Journal Title: Cancer Res 68 Pages: 2329-2339
• [Journal Article] Thrombin induces tumor invasion through the induction and association of matrix metalloproteinase-9 and β 1-integrin on the cell surface (2008)
  • Author(s): Radjabi, A.R. Sawada, K., et al.
  • Journal Title: J Biol Chem 283 Pages: 2822-2834
• [Journal Article] In vitro and in vivo assays to analyze the contribution of Rho kinase in angiogenesis. (2008)
  • Author(s): Sawada, K., et al
  • Journal Title: Method Enzymol 439 Pages: 395-412
  • Peer Reviewed
• [Journal Article] Loss of E-cadher in promotes ovarian cancer metastasisvia α5-integrin which is a therapeutic target. (2008)
  • Author(s): Sawada, K., et al
  • Journal Title: Cancer Res 68 Pages: 2329-2339
  • Peer Reviewed
• [Journal Article] Thrombin induces tumor invasion through the induction and assoc iat ion of matrix metalloproteiiiase-9 andβ1-integrin on the cell surface. (2008)
  • Author(s): Radjabi, A. R. Sawada, K., et al
  • Journal Title: J Biol Chem 283 Pages: 2822-2834
  • Peer Reviewed
• [Journal Article] Thrombin induces tumor invasion through the unduction and association of matrix metalloproteinase-9 and β1-integrin on the cell surface (2008)
  • Author(s): Radjabi AR, Sawada K, et. al.
  • Journal Title: J Bio Chem 283 Pages: 2282-2834
  • Peer Reviewed
• [Journal Article] Peripheral quantitative computed tomography (pQCT) is useful for monitoring bone mineral bensity of the patients who receive hormone replacement therapy (2007)
  • Author(s): Sawada K, et. al.
  • Journal Title: Maturitas 56 Pages: 343-349
  • Peer Reviewed
• [Journal Article] Loss of E-cadherin promotes ovarian cancer metastasis via α5-integrin which is a therapeutic targets
  • Author(s): Sawada K, et. al.
  • Journal Title: Cancer Res (in press)
  • Peer Reviewed
• [Presentation] Metal transcriptional factor (MTF-1) is involved in hypoxic regulation of Placenta Growth Factor(PIGF) in Trophoblast cells (2008)
  • Author(s): Sakata, M. Nishimoto, F. Minekawa, R. Okamoto, M. Sawada, K., et al.
  • Organizer: Endocrine Society
  • Place of Presentation: San Francisco USA
  • Year and Date: 2008-06-16