| Co-Investigator(Renkei-kenkyūsha) |
MINEGISHI Naoko 東北大学, 大学院・医学系研究科, 准教授 (40271895)
MOTOHASHI Hozumi 東北大学, 大学院・医学系研究科, 准教授 (00282351)
KUROKAWA Hirofumi 東北大学, 大学院・医学系研究科, 講師 (80359546)
SUZUKI Norio 東北大学, 大学院・医学系研究科, 講師 (20447254)
MORIGUCHI Takashi 東北大学, 大学院・医学系研究科, 講師 (10447253)
SUZUKI Takafumi 東北大学, 大学院・医学系研究科, 助教 (70508308)
TAGUCHI Keiko 東北大学, 大学院・医学系研究科, 助教 (20466527)
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| Budget Amount *help |
¥518,570,000 (Direct Cost: ¥398,900,000、Indirect Cost: ¥119,670,000)
Fiscal Year 2011: ¥104,780,000 (Direct Cost: ¥80,600,000、Indirect Cost: ¥24,180,000)
Fiscal Year 2010: ¥116,350,000 (Direct Cost: ¥89,500,000、Indirect Cost: ¥26,850,000)
Fiscal Year 2009: ¥116,350,000 (Direct Cost: ¥89,500,000、Indirect Cost: ¥26,850,000)
Fiscal Year 2008: ¥111,280,000 (Direct Cost: ¥85,600,000、Indirect Cost: ¥25,680,000)
Fiscal Year 2007: ¥69,810,000 (Direct Cost: ¥53,700,000、Indirect Cost: ¥16,110,000)
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| Research Abstract |
Environmental stress response system allows organisms to keep cellular homeostasis. In this study, weexamined Keap1-Nrf2-mediated oxidative and xenobiotic defense system, and identified novel molecular mechanisms for stress-sensing system and their association with diseases. We alsoidentified diverse and elaborate gene regulatory mechanisms in response to hypoxic stressthrough the comprehensive analysis of erythropoietin gene regulatory regions.
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