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Fine Hybrid Bionics by Fabrication of Muscle Actuator Modules

Research Project

Project/Area Number 19H00751
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 20:Mechanical dynamics, robotics, and related fields
Research InstitutionMeijo University

Principal Investigator

Fukuda Toshio  名城大学, 理工学部, 教授 (70156785)

Co-Investigator(Kenkyū-buntansha) 竹内 大  名古屋大学, 工学研究科, 助教 (20713374)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥46,020,000 (Direct Cost: ¥35,400,000、Indirect Cost: ¥10,620,000)
Fiscal Year 2021: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2020: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Fiscal Year 2019: ¥21,710,000 (Direct Cost: ¥16,700,000、Indirect Cost: ¥5,010,000)
Keywords筋組織 / アクチュエータ / マイクロロボット / モジュール構造 / フレキシブルセンサ / フィードバック制御
Outline of Research at the Start

本研究では、申請者らが有する微細加工及び細胞組織構築技術を用いて、生体内の筋肉にある筋紡錘に相当するマイクロセンサを有する筋組織アクチュエータモジュール(SMAモジュール)を世界に先駆けて作製する。さらに、SMAモジュールを複数組み合わせることでフィードバックループを有する筋駆動マイクロロボットの実現を目指す。これにより筋制御機構の解明に寄与するファイン・ハイブリッド・バイオニクス(FH-Bio)を創生する。

Outline of Final Research Achievements

In this research, we developed modularized in vitro muscle actuators for precise control of muscle tissues outside of our body. Tendon structures were prepared at both ends of a muscle actuator to modularize the muscle tissue. The developed modularized muscle actuators can be stacked to increase the output force. Flexible sensors were also developed to measure the motion of the modularized muscle actuators. The sensor has liquid metal inside a soft silicon tube, and it was used to measure the motion of the modularized muscle actuators. The experimental results showed that the developed sensor showed the output change when 0 to 1 mN force was applied to the sensor. The sensing range of the developed sensor was matched to the output force of the modularized muscle actuators. The developed modularized muscle actuators will be used to actuate micro-robots.

Academic Significance and Societal Importance of the Research Achievements

バイオアクチュエータの従来研究では筋組織の収縮量をリアルタイムで計測し、収縮量に基づくフィードバック制御を行うシステムは未だ構築されていなかった。また、筋組織とロボット骨格との接合はほとんどが細胞接着性因子を用いた強固な接着を用いており、筋組織が機能しなくなった場合にはロボット骨格ごと破棄することが必要となっていた。本研究では筋組織アクチュエータをモジュール化しセンサを用いた収縮量のリアルタイム計測を実現することで、上記の課題を解決しマクロスケールにおける“ロボット”と同様、マイクロスケールにおいてもアクチュエータとセンサを統合しフィードバック制御システムを構築する礎を築いた。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Comments on the Screening Results   Annual Research Report
  • Research Products

    (25 results)

All 2021 2020 2019

All Journal Article (4 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 4 results,  Open Access: 2 results) Presentation (21 results) (of which Int'l Joint Research: 8 results)

  • [Journal Article] Development of Cultured Muscles with Tendon Structures for Modular Bio-Actuators2021

    • Author(s)
      Nomura Takuto、Takeuchi Masaru、Kim Eunhye、Huang Qiang、Hasegawa Yasuhisa、Fukuda Toshio
    • Journal Title

      Micromachines

      Volume: 12 Issue: 4 Pages: 379-379

    • DOI

      10.3390/mi12040379

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Magnetic self-assembly of toroidal hepatic microstructures for micro-tissue fabrication2020

    • Author(s)
      Masaru Takeuchi、Masaki Iriguchi、Mamoru Hattori、Eunhye Kim、Akihiko Ichikawa、Yasuhisa Hasegawa、Qiang Huang、Toshio Fukuda
    • Journal Title

      Biomedical Materials

      Volume: 15 Issue: 5 Pages: 055001-055001

    • DOI

      10.1088/1748-605x/ab8487

    • NAID

      120006941040

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Construction of Hepatic-Lobule-Like 3-D Vascular Network in Cellular Structure by Manipulating Magnetic Fibers2020

    • Author(s)
      Eunhye Kim, Masaru Takeuchi, Akiyuki Hasegawa, Akihiko Ichikawa, Yasuhisa Hasegawa, Qiang Huang, Toshio Fukuda
    • Journal Title

      IEEE/ASME Transactions on Mechatronics

      Volume: 25 Issue: 1 Pages: 477-486

    • DOI

      10.1109/tmech.2019.2957494

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] On-Chip Construction of Multilayered Hydrogel Microtubes for Engineered Vascular-Like Microstructures2019

    • Author(s)
      Tao Yue, Na Liu, Yuanyaun Liu, Yan Peng, Shaorong Xie, JunLuo, Qiang Huang, Masaru Takeuchi, Toshio Fukuda
    • Journal Title

      Micromachines

      Volume: 10 Issue: 12 Pages: 840-840

    • DOI

      10.3390/mi10120840

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Design of Soft Sensor for Feedback Control of Bio-Actuator Powered by Skeletal Muscle2021

    • Author(s)
      Eunhye Kim, Masaru Takeuchi, Ryosuke Ohira, Takuto Nomura, Yasuhisa Hasegawa, Qiang Huang, Toshio Fukuda
    • Organizer
      2021 IEEE International Conference on Robotics and Automation (ICRA)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] バイオアクチュエータのフィードバック制御のためのソフトセンサの作製2021

    • Author(s)
      金恩恵,竹内大,小栗巧暉,大平亮輔,野村匠永,福田敏男
    • Organizer
      ロボティクス・メカトロニクス講演会2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] Development of Multiple Connectable Bio-Actuator by Tendon Structures2021

    • Author(s)
      Takuto Nomura, Masaru Takeuchi, Eunhye Kim, Toshio Fukuda, Yasuhisa Hasegawa
    • Organizer
      2021 IEEE Workshop on Advanced Robotics and its Social Impact (ARSO)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ソフトセンサを用いたモジュラーバイオアクチュ エータの微小力計測2021

    • Author(s)
      金恩恵,竹内大,石山瑛祐,野村匠永,福田敏男
    • Organizer
      第39 回日本ロボット学会学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 立体培養における遠心力による高細胞密度培養筋の作製2021

    • Author(s)
      野村匠永,竹内大,金恩恵,福田敏男,長谷川泰久
    • Organizer
      第39 回日本ロボット学会学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Development of Cultured Muscles with High Cell Density by Centrifugal Force in Three-dimensional Cell Culture2021

    • Author(s)
      Takuto Nomura, Masaru Takeuchi, Eunhye Kim, Toshio Fukuda, Yasuhisa Hasegawa
    • Organizer
      32nd 2021 International Symposium on Micro-NanoMechatronics and Human Science (MHS)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 培養筋圧縮によるバイオアクチュエータの単位断面積あたりの収縮力向上2021

    • Author(s)
      野村匠永,竹内大,金恩恵,福田敏男,長谷川泰久
    • Organizer
      第22回計測自動制御学会システムインテグレーション部門講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 90.Construction of Multiple Hepatic Lobule like 3D Vascular Networks by Manipulating Magnetic Tweezers toward Tissue Engineering2020

    • Author(s)
      Eunhye Kim, Masaru Takeuchi, Taro Kozuka, Takuto Nomura, Akihiko Ichikawa, Yasuhisa Hasegawa, Qiang Huang, Toshio Fukuda
    • Organizer
      2020 IEEE International Conference on Intelligent Robots and Systems
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] モジュラーバイオアクチュエータの積層による培養筋出力の制御2020

    • Author(s)
      野村匠永、市川明彦、竹内大、金恩恵、福田敏男
    • Organizer
      ロボティクス・メカトロニクス 講演会 2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] 生分解性材料を用いたマイクロ構造体作製の研究2020

    • Author(s)
      小塚太郎、竹内大、市川明彦、福田敏男
    • Organizer
      ロボティクス・メカトロニクス 講演会 2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] 骨格筋アクチュエータのフィードバック制御2020

    • Author(s)
      金恩恵、竹内大、小栗巧暉、大平亮輔、野村匠永、市川明彦、福田敏男
    • Organizer
      第38回日本ロボット学会学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] スキャフォールドゲル削減による高細胞密度の培養筋の作製2020

    • Author(s)
      野村匠永、竹内大、金恩恵、長谷川泰久、福田敏男
    • Organizer
      第21回計測自動制御学会システムインテグレーション部門講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 筋組織アクチュエータのフィードバック制御のための液体金属を用いたソフトセンサの構築2020

    • Author(s)
      金恩恵、竹内大、小栗巧暉、大平亮輔、野村匠永、福田敏男
    • Organizer
      第21回計測自動制御学会システムインテグレーション部門講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Assembly of Multilayered Hepatic Lobule-like Vascular Network by using Heptapole Magnetic Tweezer2019

    • Author(s)
      Eunhye Kim, Masaru Takeuchi, Taro Kozuka, Takuto Nomura, Akiyuki Hasegawa, Akihiko Ichikawa, Qiang Huang, Toshio Fukuda
    • Organizer
      2019 International Conference on Robotics and Automation
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Making Micro Structure with Biodegradable Materials2019

    • Author(s)
      Taro Kozuka, Masaru Takeuchi, Akihiko Ichikawa, Toshio Fukuda
    • Organizer
      2019 International Symposium on Micro-NanoMechatronics and Human Science
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of Modular Bio Actuators Used Artificial Tendon Structure2019

    • Author(s)
      Takuto Nomura, Masaru Takeuchi, Akihiko Ichikawa, Eunhye Kim, Toshio Fukuda
    • Organizer
      2019 International Symposium on Micro-NanoMechatronics and Human Science
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Assembly of Magnetic Fibers to Form Perfusable Vascular Network with a Three-dimensional Tissue2019

    • Author(s)
      Eunhye Kim, Masaru Takeuchi, Ryohei Sakurai, Taro Kozuka, Takuto Nomura, Akiyuki Hasegawa, Akihiko Ichikawa, Toshio Fukuda
    • Organizer
      2019 International Symposium on Micro-NanoMechatronics and Human Science
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生分解性材料を用いたマイクロ構造体作製の研究2019

    • Author(s)
      小塚太郎、竹内大、長谷川明之、市川明彦、福田敏男
    • Organizer
      ロボティクス・メカトロニクス講演会2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 磁力による自己組織化を用いた細胞3次元肝臓モデルの構築の研究2019

    • Author(s)
      市川明彦、櫻井陵平、金恩恵、長谷川明之、竹内大、福田敏男
    • Organizer
      ロボティクス・メカトロニクス講演会2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 3Dプリント腱構造を持った培養筋の作製2019

    • Author(s)
      野村匠永、市川明彦、竹内大、、金恩恵、長谷川明之、福田敏男
    • Organizer
      ロボティクス・メカトロニクス講演会2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 人工腱を用いたモジュラーバイオアクチュエータの作製2019

    • Author(s)
      野村匠永、市川明彦、竹内大、金恩恵、福田敏男
    • Organizer
      第20回計測自動制御学会システムインテグレーション部門講演会
    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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