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Development of integrated dose evaluation system in accelerator-based BNCT treatment

Research Project

Project/Area Number 19H03594
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionHokkaido University

Principal Investigator

Ishikawa Masayori  北海道大学, 保健科学研究院, 教授 (80314772)

Co-Investigator(Kenkyū-buntansha) 小川原 亮  京都大学, 化学研究所, 助教 (00807729)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2022: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2021: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2019: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
KeywordsSOF検出器 / PQD法 / DOI-PET / BNCT / 中性子計測
Outline of Research at the Start

加速器BNCTでは、熱外中性子を主たる成分として照射することから、異なる中性子増感物質を含むシンチレータを組み合わせたマルチプローブ型SOF検出器を開発し、熱中性子量、熱外中性子量、ガンマ線量を同時に評価できるシステムの構築を目指す。また、BNCTでは患部におけるホウ素(10B)濃度を推定するために、18F-BPA PET撮像中に血中ホウ素濃度を測定可能な腕部装着可能な小型PET装置を開発する。

Outline of Final Research Achievements

We have developed a new SOF detector that can simultaneously evaluate thermal, epithermal, and gamma-ray doses by improving the SOF detector to measure thermal neutron fluence in real-time and combine scintillators containing different neutron sensitizers. In addition, we aimed to develop a small PET device that can be worn on the arm for simultaneous measurement of blood boron concentration during 18F-BPA PET imaging as a direct evaluation method of blood boron concentration. We developed a new DOI detector using the PQD method developed in our laboratory. We confirmed that the position-sensitive photomultiplier tube has sufficient depth discrimination capability at any position in an experiment using four layers of scintillators in actual measurements.

Academic Significance and Societal Importance of the Research Achievements

加速器BNCTでは、熱外中性子を主たる成分として照射することから、熱外中性子照射量をモニタできる検出器の開発が望まれている。本研究で開発を試みたマルチコア型SOF検出器では、熱外中性子量のみならず、熱中性子量、γ線量も同時に評価可能であることから、腫瘍への適切な線量投与量を把握するのみならず、正常組織への被ばく量も同時に推定可能となることから、臨床上非常に有益である。
また、本研究で開発を試みた腕部装着型PET装置では、18F-BPAを用いた PET撮像の際に腫瘍組織と正常組織の薬剤取込比率を直接評価することで、治療効果予測の精度を飛躍的に向上できると期待している。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (13 results)

All 2022 2021 2019

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results) Presentation (10 results) (of which Int'l Joint Research: 6 results)

  • [Journal Article] Improvement and benchmarking of the deterministic transport calculation code CBZ to design beam shaping assembly for BNCT2022

    • Author(s)
      Go Chiba, Hikaru Handa, Masayori Ishikawa
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 190 Pages: 110465-110465

    • DOI

      10.1016/j.apradiso.2022.110465

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A simulation-based study on water radiolysis species for 1H+, 4He2+, and 12C6+ ion beams with multiple ionization using Geant4-DNA2021

    • Author(s)
      Kentaro Baba, Tamon Kusumoto, Shogo Okada, Masayori Ishikawa
    • Journal Title

      Journal of Applied Physics

      Volume: 129 Issue: 24

    • DOI

      10.1063/5.0054665

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative estimation of track segment yields of water radiolysis species under heavy ions around Bragg peak energies using Geant4-DNA2021

    • Author(s)
      92.Baba K, Kusumoto T, Okada S, Ogawara R, Kodaira S, Raffy Q, Barillon R, Ludwig N, Galindo C, Peaupardin P, Ishikawa M.
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 1524-1524

    • DOI

      10.1038/s41598-021-81215-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Feasibility study on quenching effect correction in organic scintillator for high-LET particles2022

    • Author(s)
      M. Ishikawa, K. Baba, R. Ogawara, T. Kusumoto, T. Hamano
    • Organizer
      2022 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a Peak-to-Charge-Discrimination-based Depth-of-Interaction detector for the Positron emission tomography2022

    • Author(s)
      Kento Miyata, M. Ishikawa
    • Organizer
      2022 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Feasibility study on energy-dependent neutron flux monitor using multi-core SOF detector2021

    • Author(s)
      M. Ishikawa, R. Ogawara, K. Baba, S. Ishiguri, H. Handa
    • Organizer
      19th International Congress of Neutron Capture Therapy
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Feasibility study on optimization of beam shaping assembly for accelerator-based neutron source for BNCT using deterministic particle transport calculation code2021

    • Author(s)
      H. Handa, G. Chiba, M. Ishikawa
    • Organizer
      19th International Congress of Neutron Capture Therapy
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SOF検出器によるエネルギー領域別中性子束モニタ開発の基礎検討2019

    • Author(s)
      石川 正純、馬場 健太郎、小川原 亮、清水 尚音、櫻井 良憲
    • Organizer
      第16回日本中性子捕捉療法学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 多芯型SOF検出器開発に向けた中性子エネルギー成分別照射量評価手法の検討2019

    • Author(s)
      馬場健太郎、飯田光、石川正純
    • Organizer
      第16回日本中性子捕捉療法学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Scintillator with Optical Fiber (SOF)検出器と水ファントムを用いた中性子エネルギースペクトル推定手法の検討2019

    • Author(s)
      馬場健太郎、石川正純
    • Organizer
      第16回日本中性子捕捉療法学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Feasibility study on energy-dependent neutron flux monitor using multi-core SOF detector2019

    • Author(s)
      M. Ishikawa, K. Baba, R. Ogawara, N. Shimizu, Y. Sakurai
    • Organizer
      2019 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Activity estimation during accelerator-based BNCT treatment2019

    • Author(s)
      M. Ishikawa, H. Tanaka, H. Kumada
    • Organizer
      5th International Symposium on the System of Radiological Protection
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 要望演題5 BNCT:マルチコアSOF検出器を用いたエネルギー領域別中性子束モニタの検討2019

    • Author(s)
      石川 正純
    • Organizer
      日本放射線腫瘍学会第32回学術大会
    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2024-01-30  

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