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Space making particle therapy for sarcoma and pediatric tumor

Research Project

Project/Area Number 19H03603
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionKobe University

Principal Investigator

SASAKI RYOHEI  神戸大学, 医学部附属病院, 教授 (30346267)

Co-Investigator(Kenkyū-buntansha) 赤坂 浩亮  神戸大学, 医学研究科, 非常勤講師 (20707161)
福本 巧  神戸大学, 医学研究科, 教授 (70379402)
宮脇 大輔  神戸大学, 医学部附属病院, 特命准教授 (30546502)
文野 誠久  京都府立医科大学, 医学(系)研究科(研究院), 助教 (40405254)
出水 祐介  神戸大学, 医学研究科, 客員准教授 (50452496)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2019: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywordsスペーサー / 小児腫瘍 / 陽子線治療 / 粒子線治療 / 骨軟部腫瘍 / 体内空間可変放射線治療 / 吸収性材料 / spacer / particle therapy / sarcoma / pediatric cancer
Outline of Research at the Start

本研究課題の概要は以下の4項目から構成され、① 切除不能骨軟部肉腫、小児悪性腫瘍に対する体内空間可変粒子線治療のPhase I/II 臨床試験を立案・実施し本治療法の有効性を明らかにする、② 吸収性スペーサーと生殖器の保護を目的とする被曝低減手術との融合治療の開発、③ 柔軟で低癒着な次世代の吸収性スペーサーの開発、④ 頻度の多い腹部悪性疾患への適応基準の明確化と定位放射線治療への適応拡大である。

Outline of Final Research Achievements

This study is to apply space-making therapy using absorptive spacer, which has been proved useful and safe in particle beam therapy. A Phase 1 clinical trial is planned to verify the consistent safety and efficacy of a series of treatment strategies from absorbable spacer placement in pediatric patients. The absorbable spacer was developed by our group and approved by the Pharmaceutical Affairs (Dec. 11, 2018), preparation of guidelines for proper use (May 2011-June), launch of the absorbable spacer (May 2011.06), and insurance adaptation for the absorbable spacer and its indwelling surgery (December 2019) Class IV medical devices have been clinically applied. The absorbable spacer has published the results of a first-in-human trial in particle beam therapy. Since then, its usefulness has attracted attention worldwide. Feasibility study in pediatic malignancies has been conducted.

Academic Significance and Societal Importance of the Research Achievements

外科用吸収糸を用いた不織布型の生体適応性の吸収性スペーサーを世界に先駆けて独自開発し、治療期間のみ腫瘍と正常組織を分離して根治的な粒子線治療を実現する体内空間可変粒子線治療を提唱した。薬事承認が得られた後、スペーサーとその留置術は保険収載されており、これまで根治的な手術、放射線治療が提供できなかった進行した腫瘍に対しても、保険診療で根治治療ができる道を切り開いた。稀少がんである骨軟部腫瘍や、小児腫瘍では成人とは異なった特徴もあるため慎重を要するが、臨床試験にてその安全性を確認できた。さらに次世代スペーサーの開発も手がけ、低侵襲な方法で留置が可能な圧縮型のスペーサーの仕様もほぼ確定できた。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (39 results)

All 2022 2021 2020 2019

All Journal Article (25 results) (of which Int'l Joint Research: 10 results,  Peer Reviewed: 25 results,  Open Access: 23 results) Presentation (13 results) (of which Int'l Joint Research: 8 results,  Invited: 1 results) Book (1 results)

  • [Journal Article] Reactive oxygen species-inducing titanium peroxide nanoparticles as promising radiosensitizers for eliminating pancreatic cancer stem cells2022

    • Author(s)
      Salah Mohammed、Akasaka Hiroaki、Shimizu Yasuyuki、Morita Kenta、Nishimura Yuya、Kubota Hikaru、Kawaguchi Hiroki、Sogawa Tomomi、Mukumoto Naritoshi、Ogino Chiaki、Sasaki Ryohei
    • Journal Title

      Journal of Experimental & Clinical Cancer Research

      Volume: 41 Issue: 1 Pages: 146-146

    • DOI

      10.1186/s13046-022-02358-6

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fiducial marker position affects target volume in stereotactic lung irradiation2022

    • Author(s)
      Akasaka Hiroaki、Mizonobe Kazufusa、Oki Yuya、Uehara Kazuyuki、Nakayama Masao、Tamura Shuhei、Munetomo Yoshiki、Kawaguchi Haruna、Ishida Jun、Harada Aya、Ishihara Takeaki、Kubota Hikaru、Kawaguchi Hiroki、Sasaki Ryohei、Mayahara Hiroshi
    • Journal Title

      Journal of Applied Clinical Medical Physics

      Volume: ‐ Issue: 6 Pages: 1-10

    • DOI

      10.1002/acm2.13596

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blowing time ratio and high-resolution manometry to evaluate swallowing function of patients with oral and oropharyngeal cancer2022

    • Author(s)
      Komatsu Hirokazu、Furukawa Tatsuya、Iritani Keisuke、Tatehara Shun、Takahashi Miki、Iwaki Shinobu、Kakei Yasumasa、Hasegawa Takumi、Teshima Masanori、Shinomiya Hirotaka、Otsuki Naoki、Hashikawa Kazunobu、Kiyota Naomi、Sasaki Ryohei、Akashi Masaya、Nibu Ken-ichi
    • Journal Title

      Auris Nasus Larynx

      Volume: 49 Issue: 3 Pages: 477-483

    • DOI

      10.1016/j.anl.2021.10.013

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Roles of skull base surgery and particle radiotherapy for orbital malignant tumors involving the skull base2021

    • Author(s)
      Teshima Masanori、Shinomiya Hirotaka、Kimura Hidehito、Hashikawa Kazunobu、Kiyota Naomi、Miyawaki Daisuke、Sasaki Ryohei、Kohmura Eiji、Nibu Ken‐ichi
    • Journal Title

      Laryngoscope Investigative Otolaryngology

      Volume: 6 Issue: 6 Pages: 1347-1352

    • DOI

      10.1002/lio2.687

    • NAID

      120007179199

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Image contrast assessment of metal-based nanoparticles as applications for image-guided radiation therapy2021

    • Author(s)
      Nakayama Masao、Akasaka Hiroaki、Miyazaki Eiichi、Goto Yoshihiro、Oki Yuya、Kawate Yosuke、Morita Kenta、Sasaki Ryohei
    • Journal Title

      Physics and Imaging in Radiation Oncology

      Volume: 20 Pages: 94-97

    • DOI

      10.1016/j.phro.2021.11.003

    • NAID

      120007179179

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PET/MRI is useful for early detection of pelvic insufficiency fractures after radiotherapy for cervical cancer2021

    • Author(s)
      Azumi Maho、Matsumoto Masuyo、Suzuki Kaho、Sasaki Ryohei、Ueno Yoshiko、Nogami Munenobu、Terai Yoshito
    • Journal Title

      Oncology Letters

      Volume: 22 Issue: 5 Pages: 776-776

    • DOI

      10.3892/ol.2021.13037

    • NAID

      120007153052

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The feasibility of transcatheter arterial chemoembolization following radiation therapy for hepatocellular carcinoma2021

    • Author(s)
      Hamada Mostafa、Ueshima Eisuke、Ishihara Takeaki、Koide Yutaka、Okada Takuya、Horinouchi Hiroki、Ishida Jun、Mayahara Hiroshi、Sasaki Koji、Gentsu Tomoyuki、Sofue Keitaro、Yamaguchi Masato、Sasaki Ryohei、Sugimoto Koji、Murakami Takamichi
    • Journal Title

      Acta Radiologica Open

      Volume: 10 Issue: 7 Pages: 20584-20584

    • DOI

      10.1177/20584601211034965

    • NAID

      120007153054

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Phase I trial of concurrent chemoradiotherapy with docetaxel, cisplatin and 5-fluorouracil (TPF-CRT) for locally advanced squamous cell carcinoma of the external auditory canal2021

    • Author(s)
      Shinomiya Hirotaka、Uehara Natsumi、Fujita Takeshi、Miyawaki Daisuke、Imamura Yoshinori、Teshima Masanori、Kakigi Akinobu、Kiyota Naomi、Sasaki Ryohei、Nibu Ken-ichi
    • Journal Title

      European Archives of Oto-Rhino-Laryngology

      Volume: - Issue: 6 Pages: 2805-2810

    • DOI

      10.1007/s00405-021-06974-4

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] New proposal to revise the classification for squamous cell carcinoma of the external auditory canal and middle ear2021

    • Author(s)
      Shinomiya H、Uehara N、Fujita T、Yoshida K、Imamura Y、Teshima M、Kimura H、Miyawaki D、Kakigi A、Kiyota N、Otsuki N、Sasaki R、Kohmura E、Nibu K
    • Journal Title

      The Journal of Laryngology & Otology

      Volume: 135 Issue: 4 Pages: 297-303

    • DOI

      10.1017/s002221512100089x

    • NAID

      120007041636

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Exosome-mediated radiosensitizing effect on neighboring cancer cells via increase in intracellular levels of reactive oxygen species2021

    • Author(s)
      Nakaoka Ai、Nakahana Makiko、Inubushi Sachiko、Akasaka Hiroaki、Salah Mohammed、Fujita Yoshiko、Kubota Hikaru、Hassan Mennaallah、Nishikawa Ryo、Mukumoto Naritoshi、Ishihara Takeaki、Miyawaki Daisuke、Sasayama Takashi、Sasaki Ryohei
    • Journal Title

      Oncology Reports

      Volume: 45 Issue: 4 Pages: 1-1

    • DOI

      10.3892/or.2021.7964

    • NAID

      120006975755

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy of Spacers in Radiation Therapy for Locally Advanced Pancreatic Cancer: A Planning Study2021

    • Author(s)
      KAWAGUCHI HIROKI、DEMIZU YUSUKE、MUKUMOTO NARITOSHI、ISHIHARA TAKEAKI、MIYAWAKI DAISUKE、KOMATSU SHOHEI、AKASAKA HIROAKI、SHINOTO MAKOTO、SHIOYAMA YOSHIYUKI、NAKAMURA KATSUMASA、FUKUMOTO TAKUMI、SASAKI RYOHEI
    • Journal Title

      Anticancer Research

      Volume: 41 Issue: 1 Pages: 503-508

    • DOI

      10.21873/anticanres.14801

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Surgical spacer placement for proton radiotherapy in locally advanced pancreatic body and tail cancers: initial clinical results2021

    • Author(s)
      Dongha Lee et al.
    • Journal Title

      Radiation Oncology

      Volume: 16 Issue: 1 Pages: 1-11

    • DOI

      10.1186/s13014-020-01731-z

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Risk factors for osteoradionecrosis of the jaw in patients with head and neck squamous cell carcinoma2021

    • Author(s)
      Kubota Hikaru、Miyawaki Daisuke、Mukumoto Naritoshi、Ishihara Takeaki、Matsumura Megumi、Hasegawa Takumi、Akashi Masaya、Kiyota Naomi、Shinomiya Hirotaka、Teshima Masanori、Nibu Ken-ichi、Sasaki Ryohei
    • Journal Title

      Radiation Oncology

      Volume: 16 Issue: 1 Pages: 1-1

    • DOI

      10.1186/s13014-020-01701-5

    • NAID

      120006954052

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The first pediatric case of sacral Ewing sarcoma treated with space‐making particle therapy2021

    • Author(s)
      Takagi Daisuke、Morikawa Yuri、Kamei Michi、Ogino Hiroyuki、Iwata Hiromitsu、Maeda Naoko、Akita Nobuhiro、Fukumoto Takumi、Sasaki Ryohei、Kondo Satoshi
    • Journal Title

      Pediatric Blood & Cancer

      Volume: 68 Issue: 5

    • DOI

      10.1002/pbc.28842

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Titanium oxide nano-radiosensitizers for hydrogen peroxide delivery into cancer cells2021

    • Author(s)
      Morita Kenta、Nishimura Yuya、Nakamura Satoko、Arai Yuki、Numako Chiya、Sato Kazuyoshi、Nakayama Masao、Akasaka Hiroaki、Sasaki Ryohei、Ogino Chiaki、Kondo Akihiko
    • Journal Title

      Colloids and Surfaces B: Biointerfaces

      Volume: 198 Pages: 111451-111451

    • DOI

      10.1016/j.colsurfb.2020.111451

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Surgical outcomes of metastatic bone tumors in the extremities (Surgical outcomes of bone metastases)2021

    • Author(s)
      Hara H、Sakai Y、Kawamoto T、Fukase N、Kawakami Y、Takemori T、Fujiwara S、Kitayama K、Yahiro S、Miyamoto T、Kakutani K、Niikura T、Miyawaki D、Okada T、Sakashita A、Imamura Y、Sasaki R、Kizawa Y、Minami H、Matsumoto T、Matsushita T、Kuroda R、Akisue T
    • Journal Title

      Journal of Bone Oncology

      Volume: 27 Pages: 100352-100352

    • DOI

      10.1016/j.jbo.2021.100352

    • NAID

      120007038644

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Space-making particle therapy for sarcomas derived from the abdominopelvic region2020

    • Author(s)
      Komatsu Shohei、Demizu Yusuke、Sulaiman Nor Shazrina、Terashima Kazuki、Suga Masaki、Kido Masahiro、Toyama Hirochika、Tokumaru Sunao、Okimoto Tomoaki、Sasaki Ryohei、Fukumoto Takumi
    • Journal Title

      Radiotherapy and Oncology

      Volume: 146 Pages: 194-199

    • DOI

      10.1016/j.radonc.2020.02.021

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Stereotactic body radiotherapy in patients with lung tumors composed of mainly ground-glass opacity2020

    • Author(s)
      Onishi H、Shioyama Y、Matsumoto Y、Shibamoto Y、Miyakawa A、Suzuki G、Nishimura Y、Sasaki R、Miyawaki D、Kuriyama K、Komiyama T、Marino K、Aoki S、Saito R、Araya M、Maehata Y、Nonaka H、Tominaga L、Saito M、Sano N、Yamada S
    • Journal Title

      Journal of Radiation Research

      Volume: 61 Issue: 3 Pages: 426-430

    • DOI

      10.1093/jrr/rraa015

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Real‐time in vivo dosimetry system based on an optical fiber‐coupled microsized photostimulable phosphor for stereotactic body radiation therapy2020

    • Author(s)
      Yada Ryuichi、Maenaka Kazusuke、Miyamoto Shuji、Okada Go、Sasakura Aki、Ashida Motoi、Adachi Masashi、Sato Tatsuhiko、Wang Tianyuan、Akasaka Hiroaki、Mukumoto Naritoshi、Shimizu Yasuyuki、Sasaki Ryohei
    • Journal Title

      Medical Physics

      Volume: 47 Issue: 10 Pages: 5235-5249

    • DOI

      10.1002/mp.14383

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel artifact‐robust and highly visible zinc solid fiducial marker for kilovoltage x‐ray image‐guided radiation therapy2020

    • Author(s)
      Wang Tianyuan、Inubushi Sachiko、Ikeo Naoko、Mukai Toshiji、Okumura Keisuke、Akasaka Hiroaki、Yada Ryuichi、Yoshida Kenji、Miyawaki Daisuke、Ishihara Takeaki、Nakaoka Ai、Sasaki Ryohei
    • Journal Title

      Medical Physics

      Volume: 47 Issue: 10 Pages: 4703-4710

    • DOI

      10.1002/mp.14412

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Comparative Assessment of Mechanisms and Effectiveness of Radiosensitization by Titanium Peroxide and Gold Nanoparticles2020

    • Author(s)
      Hassan Mennaallah、Nakayama Masao、Salah Mohammed、Akasaka Hiroaki、Kubota Hikaru、Nakahana Makiko、Tagawa Tatsuichiro、Morita Kenta、Nakaoka Ai、Ishihara Takeaki、Miyawaki Daisuke、Yoshida Kenji、Nishimura Yuya、Ogino Chiaki、Sasaki Ryohei
    • Journal Title

      Nanomaterials

      Volume: 10 Issue: 6 Pages: 1125-1125

    • DOI

      10.3390/nano10061125

    • NAID

      120006878579

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Space-Making Particle Therapy with Surgical Spacer Placement in Patients with Sacral Chordoma2020

    • Author(s)
      Tsugawa Daisuke、Komatsu Shohei、Demizu Yusuke、Sulaiman Nor Shazrina、Suga Masaki、Kido Masahiro、Toyama Hirochika、Okimoto Tomoaki、Sasaki Ryohei、Fukumoto Takumi
    • Journal Title

      Journal of the American College of Surgeons

      Volume: 230 Issue: 2 Pages: 207-215

    • DOI

      10.1016/j.jamcollsurg.2019.11.007

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of salvage therapies for isolated para-aortic lymph node recurrence in patients with uterine cervical cancer after definitive treatment2019

    • Author(s)
      Kubota Hikaru、Tsujino Kayoko、Sulaiman Nor Shazrina、Sekii Shuhei、Matsumoto Yoko、Ota Yosuke、Soejima Toshinori、Yamaguchi Satoshi、Sasaki Ryohei
    • Journal Title

      Radiation Oncology

      Volume: 14 Issue: 1 Pages: 236-244

    • DOI

      10.1186/s13014-019-1442-6

    • NAID

      120006796523

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] First-In-Human Phase 1 Study of a Nonwoven Fabric Bioabsorbable Spacer for Particle Therapy: Space-Making Particle Therapy (SMPT)2019

    • Author(s)
      Sasaki Ryohei、Demizu Yusuke、Yamashita Tomohiro、Komatsu Shohei、Akasaka Hiroaki、Miyawaki Daisuke、Yoshida Kenji、Wang Tianyuan、Okimoto Tomoaki、Fukumoto Takumi
    • Journal Title

      Advances in Radiation Oncology

      Volume: 4 Issue: 4 Pages: 729-737

    • DOI

      10.1016/j.adro.2019.05.002

    • NAID

      120006796509

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Validation of combination treatment with surgical spacer placement and subsequent particle radiotherapy for unresectable hepatocellular carcinoma2019

    • Author(s)
      Komatsu Shohei、Terashima Kazuki、Matsuo Yoshiro、Takahashi Daiki、Suga Masaki、Nishimura Naoko、Lee Dongha、Tai Kentaro、Kido Masahiro、Toyama Hirochika、Demizu Yusuke、Tokumaru Sunao、Okimoto Tomoaki、Sasaki Ryohei、Fukumoto Takumi
    • Journal Title

      Journal of Surgical Oncology

      Volume: 120(2) Issue: 2 Pages: 214-222

    • DOI

      10.1002/jso.25495

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] 粒子線治療用吸収性スペーサーにおけるガス発生パターンの検討2021

    • Author(s)
      出水祐介、美馬正幸、福光延吉、鈴木毅、福本巧、佐々木良平、副島俊典
    • Organizer
      第17回日本粒子線治療臨床研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Proton therapy with a bio-absorbable spacer for Ewing sarcoma: the world's first pediatric case of space-making proton therapy2021

    • Author(s)
      Iwata H, Kamei M, Takagi D, Naoko M, Ito Y, Mitsuhiro K, Hiroyuki O, Shibamoto Y, Fukumoto T, SAsaki R
    • Organizer
      PTCOG
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Efficacy of space-making radiotherapy (SMRT) using bioabsorbable spacer for locally advanced unresectable pancreatic cancer in a planning study2021

    • Author(s)
      Hiroki Kawaguchi
    • Organizer
      The 4 th International Cancer Research Symposium a Training for Oncology Professionals
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Titanium peroxide nanoparticle enhance the efficacy of immuno-radiotherapy via activated CD8+ T cell dependent antitumor effect in vivo2020

    • Author(s)
      Hikaru Kubota
    • Organizer
      American Society for Radiation Oncology 62nd Annual Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel biocompatible artifact-robust and highly visible fiducial marker for image-guided radiotherapy2020

    • Author(s)
      Tianyuan Wang
    • Organizer
      European Society for Radiation Oncology 2020 Congress
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Toxicity and outcomes of re-irradiation for intra-thoracic recurrence using stereotactic body radiation therapy (SBRT)2020

    • Author(s)
      Kazuma Iwashita
    • Organizer
      American Society for Radiation Oncology 62nd Annual Meeting
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 当院における限局性前立腺癌に対するIMRTの治療成績2020

    • Author(s)
      石原武明
    • Organizer
      第33回日本放射線腫瘍学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 3D-CRT から IMRT へと変遷する中での放射線療法の課題2020

    • Author(s)
      佐々木 良平
    • Organizer
      第44回日本頭頸部癌学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 小児腫瘍に対する吸収性スペーサーの臨床応用、適応と留置手技に関して2020

    • Author(s)
      佐々木 良平
    • Organizer
      第56回日本小児外科学会近畿地方会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] First-in-human phase I study of the bioabsorbable PGA spacer for particle therapy: Space-modulated particle therapy (SMPT)2019

    • Author(s)
      Ryohei Sasaki, Yusuke Demizu, Tomohiro Yamashita, Shohei Komatsu, Hiroaki Akasaka, Daisuke Miyawaki, Kenji Yoshida, Tianyuan Wang,Tomoaki Okimoto,Takumi Fukumoto,
    • Organizer
      The 7th Japan-Taiwan Radiation Oncology Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] First-in-human phase I study of the bioabsorbable PGA spacer for particle therapy: Space-modulated particle therapy (SMPT)2019

    • Author(s)
      Ryohei Sasaki, Y. Demizu, T. Yamashita, S. Komatsu, H. Akasaka, D. Miyawaki, K. Yoshida, T. Wang, T. Okimoto, and T. Fukumoto
    • Organizer
      2019 ASTRO annual meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 吸収性スペーサ【ネスキープ】の臨床応用-適応とその留置手術について-「本治療法の粒子線治療の中での活用」2019

    • Author(s)
      佐々木 良平
    • Organizer
      日本放射線腫瘍学会第32回学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] First-in-human phase I study of space modulated particle therapy using bioabsorbable spacer2019

    • Author(s)
      Yusuke Demizu, Ryohei Sasaki, Tomohiro Yamashita, Tomoaki Okimoto, Hiroaki Akasaka, Daisuke Miyawaki, Kenji Yoshida, Tianyuan Wang, Shohei Komatsu, and Takumi Fukumoto
    • Organizer
      The 58th Annual Conference of the Particle Therapy Co-Operative Group
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Book] Exosomes in Cancer Diagnosis and Radiation Therapy2021

    • Author(s)
      Monash K
    • Total Pages
      300
    • Publisher
      Intech
    • Related Report
      2021 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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