Single-cell omics analysis to develop the therapy for heart failure via cardiomyocyte reprogramming

• Project/Area Number: 19H03649
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: The University of Tokyo
• Principal Investigator: Nomura Seitaro 東京大学, 医学部附属病院, 特任助教 (10722118)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000); Fiscal Year 2021: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000); Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
• Keywords: 心不全 / シングルセル解析 / 心筋リプログラミング / シングルセル生物学 / ゲノム編集

Outline of Research at the Start

心不全は、心臓の中心的な構成要素である心筋細胞の機能的な破綻により生じます。我々は、心臓の中に存在する全ての細胞のシングルセルレベルの全遺伝子発現を解析することで、心不全発症過程において心筋細胞でどのような遺伝子発現のダイナミクスが生じるかを明らかにすることに成功しました。本研究では、この遺伝子発現の情報を基にして、不全型の心筋細胞をリプログラミングして心不全の病態を改善する治療法の開発を目指します。

Outline of Final Research Achievements

By using single-cell RNA-seq analysis, we clarified that cardiomyocytes diverge into adaptive and failing cardiomyocytes in the onset of heart failure, and DNA damage and activation of p53 signaling are important in the induction of failing cardiomyocytes. Next, by extracting cell-cell interactions from single-cell data, we revealed that the interplay of TGF-beta signaling between cardiac fibroblasts and cardiomyocytes induces cardiomyocyte senescence. By integrating spatial transcriptome and single-cell RNA-seq of the post-myocardial infarction heart, we identified mechanosensing gene-positive cardiomyocytes that appear at the border zone of myocardial infarction, and revealed that they adaptively regulate the formation of cardiac remodeling.

Academic Significance and Societal Importance of the Research Achievements

心不全は、心臓のポンプ機能の低下によって全身に十分な量の血液を送れなくなる病態であり、がんと並んで世界中で多くの患者の命を脅かしています。これまで心不全がなぜ起こるのかわからない点が多かったのですが、我々は心臓を構成する細胞を取り出してそれぞれの細胞に含まれる全ての遺伝子を読み取る技術を確立してその疑問を明らかにすることができました。今後は、この研究で明らかになった心不全のメカニズムに基づいた新しい治療法を開発していきます。

Research Products

• [Journal Article] Novel AGL variants in a patient with glycogen storage disease type IIIb and pulmonary hypertension caused by pulmonary veno-occlusive disease: A case report (2023)
  • Author(s): Shindo Akito、Ueda Kazutaka、Minatsuki Shun、Nakayama Yukiteru、Hatsuse Satoshi、Fujita Kanna、Nomura Seitaro、Hatano Masaru、Takeda Norifumi、Akazawa Hiroshi、Komuro Issei
  • Journal Title: Frontiers in Genetics Volume: 14 Pages: 1148067-1148067
  • DOI: 10.3389/fgene.2023.1148067
  • Peer Reviewed / Open Access
• [Journal Article] Precision and genomic medicine for dilated and hypertrophic cardiomyopathy (2023)
  • Author(s): Nomura Seitaro、Ono Minoru
  • Journal Title: Frontiers in Cardiovascular Medicine Volume: 10 Pages: 1137498-1137498
  • DOI: 10.3389/fcvm.2023.1137498
  • Peer Reviewed / Open Access
• [Journal Article] LMNA Mutations and Right Heart Failure in Patients With Cardiomyopathy and With Left Ventricular Assist Devices (2023)
  • Author(s): Yamada T, Nomura S, Amiya E, Katoh M, Inoue S, Hatsuse S, Fujita K, Ito M, Fujita T, Bujo C, Tsuji M, Ishida J, Ko T, Yamada S, Katagiri M, Sassa T, Kinoshita O, Nawata K, Tobita T, Satoh M, Ishiwata J, Daimon M, Tatsuno K, Fukuda S, Kashimura T, Minamino T, Hatano M, Ono M, Aburatani H, Komuro I.
  • Journal Title: Journal of Cardiac Failure Volume: 29 Issue: 5 Pages: 855-857
  • DOI: 10.1016/j.cardfail.2023.01.011
  • Peer Reviewed / Open Access
• [Journal Article] Cross-ancestry genome-wide analysis of atrial fibrillation unveils disease biology and enables cardioembolic risk prediction (2023)
  • Author(s): Miyazawa Kazuo、Ito Kaoru、Ito Masamichi、Zou Zhaonan、Kubota Masayuki、Nomura Seitaro、Matsunaga Hiroshi、Koyama Satoshi、Ieki Hirotaka、et al.
  • Journal Title: Nature Genetics Volume: 55 Issue: 2 Pages: 187-197
  • DOI: 10.1038/s41588-022-01284-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Dysregulation of DNA Methylation in the Aryl-Hydrocarbon Receptor Repressor (<i>AHRR</i>) Gene (2022)
  • Author(s): Nomura S, Morita H.
  • Journal Title: Circulation Journal Volume: 86 Issue: 6 Pages: 993-994
  • DOI: 10.1253/circj.CJ-22-0111
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2022-05-25
  • Peer Reviewed / Open Access
• [Journal Article] Functional Evaluation of Human Bioengineered Cardiac Tissue Using iPS Cells Derived from a Patient with Lamin Variant Dilated Cardiomyopathy (2022)
  • Author(s): Miura K, Matsuura K, Yamasaki Itoyama Y, Sasaki D, Takada T, Furutani Y, Hayama E, Ito M, Nomura S, Morita H, Toyoda M, Umezawa A, Onoue K, Saito Y, Aburatani H, Nakanishi T, Hagiwara N, Komuro I, Shimizu T.
  • Journal Title: International Heart Journal Volume: 63 Issue: 2 Pages: 338-346
  • DOI: 10.1536/ihj.21-790
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2022-03-30
  • Peer Reviewed / Open Access
• [Journal Article] Endoplasmic reticulum stress-activated nuclear factor-kappa B signaling pathway induces the upregulation of cardiomyocyte dopamine D1 receptor in heart failure (2022)
  • Author(s): Shun Nakamura, Genri Numata, Toshihiro Yamaguchi, Hiroyuki Tokiwa, Yasutomi Higashikuni, Seitaro Nomura, Tetsuo Sasano, Eiki Takimoto, Issei Komuro
  • Journal Title: Biochemical and Biophysical Research Communications Volume: 637 Pages: 247-253
  • DOI: 10.1016/j.bbrc.2022.11.031
  • Peer Reviewed / Open Access
• [Journal Article] Beiging of perivascular adipose tissue regulates its inflammation and vascular remodeling (2022)
  • Author(s): Adachi Yusuke、Ueda Kazutaka、Nomura Seitaro、Ito Kaoru、Katoh Manami、Katagiri Mikako、Yamada Shintaro、Hashimoto Masaki、Zhai Bowen、Numata Genri、Otani Akira、Hinata Munetoshi、Hiraike Yuta、Waki Hironori、Takeda Norifumi、Morita Hiroyuki、Ushiku Tetsuo、Yamauchi Toshimasa、Takimoto Eiki、Komuro Issei
  • Journal Title: Nature Communications Volume: 13 Issue: 1 Pages: 5117-5117
  • DOI: 10.1038/s41467-022-32658-6
  • Peer Reviewed / Open Access
• [Journal Article] Manipulating Cardiomyocyte Plasticity for Heart Regeneration (2022)
  • Author(s): Ko Toshiyuki、Nomura Seitaro
  • Journal Title: Frontiers in Cell and Developmental Biology Volume: 10 Pages: 929256-929256
  • DOI: 10.3389/fcell.2022.929256
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac fibroblasts regulate the development of heart failure via Htra3-TGF-β-IGFBP7 axis (2022)
  • Author(s): Ko Toshiyuki、Nomura Seitaro、Yamada Shintaro、Fujita Kanna、Fujita Takanori、Satoh Masahiro、Oka Chio、Katoh Manami、Ito Masamichi、Amiya Eisuke、Hatano Masaru、Kinoshita Osamu、Nawata Kan、Abe Hiroyuki、Ushiku Tetsuo、Ono Minoru、Ikeuchi Masashi、Morita Hiroyuki、Aburatani Hiroyuki、Komuro Issei
  • Journal Title: Nature Communications Volume: 13 Issue: 1 Pages: 3275-3275
  • DOI: 10.1038/s41467-022-30630-y
  • Peer Reviewed / Open Access
• [Journal Article] New Vision, Mission, and Values of the Japanese Circulation Society (2021)
  • Author(s): Ishida M, Matsumoto C, Kida K, Fukuda M, Kagiyama N, Kusunose K, Matsumoto S, Nomura S, Okumura T, Shiono Y, Taniguchi T, Mizuno A, Kishi T, Node K, Komuro I, Hirata KI; Directors of the Japanese Circulation Society.
  • Journal Title: Circulation Journal Volume: 85 Issue: 12 Pages: 2248-2251
  • DOI: 10.1253/circj.CJ-21-0822
  • NAID: 130008119954
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2021-11-25
  • Peer Reviewed / Open Access
• [Journal Article] Recent Progress in Cardiovascular Research Involving Single-Cell Omics Approaches. (2021)
  • Author(s): Dai Z, Nomura S.
  • Journal Title: Front Cardiovasc Med. Volume: 8 Pages: 783398-783398
  • DOI: 10.3389/fcvm.2021.783398
  • Peer Reviewed / Open Access
• [Journal Article] Recent Findings Related to Cardiomyopathy and Genetics. (2021)
  • Author(s): Yamada T, Nomura S.
  • Journal Title: Int J Mol Sci. Volume: 22 Issue: 22 Pages: 12522-12522
  • DOI: 10.3390/ijms222212522
  • Peer Reviewed / Open Access
• [Journal Article] Single-Cell Analysis Revealed the Role of CD8+ Effector T Cells in Preventing Cardioprotective Macrophage Differentiation in the Early Phase of Heart Failure (2021)
  • Author(s): Komai Kyoko、Ito Minako、Nomura Seitaro、Shichino Shigeyuki、Katoh Manami、Yamada Shintaro、Ko Toshiyuki、Iizuka-Koga Mana、Nakatsukasa Hiroko、Yoshimura Akihiko
  • Journal Title: Frontiers in Immunology Volume: 12 Pages: 763647-763647
  • DOI: 10.3389/fimmu.2021.763647
  • Peer Reviewed / Open Access
• [Journal Article] Three-Dimensional Visualization of Hypoxia-Induced Pulmonary Vascular Remodeling in Mice (2021)
  • Author(s): Fujiwara Takayuki、Takeda Norifumi、Hara Hironori、Ishii Satoshi、Numata Genri、Tokiwa Hiroyuki、Maemura Sonoko、Suzuki Takaaki、Takiguchi Hiroshi、Kubota Yoshiaki、Seo Kinya、Sakata Asuka、Nomura Seitaro、Hatano Masaru、Ueda Kazutaka、Komuro Issei
  • Journal Title: Circulation Volume: 144 Issue: 17 Pages: 1452-1455
  • DOI: 10.1161/circulationaha.121.056219
  • Peer Reviewed / Open Access
• [Journal Article] Single-Cardiomyocyte RNA Sequencing to Dissect the Molecular Pathophysiology of the Heart. (2021)
  • Author(s): Katoh M, Nomura S, Yamada S, Aburatani H, Komuro I.
  • Journal Title: Methods Mol Biol. Volume: 2320 Pages: 183-192
  • DOI: 10.1007/978-1-0716-1484-6_18
  • ISBN: 9781071614839, 9781071614846
  • Peer Reviewed / Open Access
• [Journal Article] Activation of Sympathetic Signaling in Macrophages Blocks Systemic Inflammation and Protects against Renal Ischemia-Reperfusion Injury (2021)
  • Author(s): Hasegawa S, Inoue T, Nakamura Y, Fukaya D, Uni R, Wu CH, Fujii R, Peerapanyasut W, Taguchi A, Kohro T, Yamada S, Katagiri M, Ko T, Nomura S, Nakanishi Ozeki A, Susaki EA, Ueda HR, Akimitsu N, Wada Y, Komuro I, Nangaku M, Inagi R.
  • Journal Title: J Am Soc Nephrol. Volume: - Issue: 7 Pages: 1599-1615
  • DOI: 10.1681/asn.2020121723
  • NAID: 120007174517
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prediction of single-cell mechanisms for disease progression in hypertrophic remodelling by a trans-omics approach (2021)
  • Author(s): Hamano M, Nomura S, Iida M, Komuro I, Yamanishi Y.
  • Journal Title: Sci Rep. Volume: 11 Issue: 1 Pages: 8112-8112
  • DOI: 10.1038/s41598-021-86821-y
  • Peer Reviewed / Open Access
• [Journal Article] CXCR7 ameliorates myocardial infarction as a β arrestin-biased receptor (2021)
  • Author(s): Ishizuka et al.
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 3426-3426
  • DOI: 10.1038/s41598-021-83022-5
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Precision medicine for heart failure based on molecular mechanisms: The 2019 ISHR Research Achievement Award Lecture (2021)
  • Author(s): Nomura S, Komuro I.
  • Journal Title: J Mol Cell Cardiol. Volume: 152 Pages: 29-39
  • DOI: 10.1016/j.yjmcc.2020.11.010
  • Peer Reviewed / Open Access
• [Journal Article] Single-cell genomics to understand disease pathogenesis (2021)
  • Author(s): Nomura S.
  • Journal Title: J Hum Genet. Volume: 66 Issue: 1 Pages: 75-84
  • DOI: 10.1038/s10038-020-00844-3
  • Peer Reviewed / Open Access
• [Journal Article] Review of Single-Cell RNA Sequencing in the Heart (2020)
  • Author(s): Yamada S, Nomura S.
  • Journal Title: Int J Mol Sci. Volume: 21 Issue: 21 Pages: 8345-8345
  • DOI: 10.3390/ijms21218345
  • Peer Reviewed / Open Access
• [Journal Article] Trends and Limitations in the Assessment of the Contractile Properties of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes From Patients With Dilated Cardiomyopathy (2020)
  • Author(s): Ito M, Nomura S, Morita H, Komuro I.
  • Journal Title: Front Cardiovasc Med. Volume: 7 Pages: 154-154
  • DOI: 10.3389/fcvm.2020.00154
  • Peer Reviewed / Open Access
• [Journal Article] Population-specific and trans-ancestry genome-wide analyses identify distinct and shared genetic risk loci for coronary artery disease (2020)
  • Author(s): 2.Koyama S, Ito K, Terao C, Akiyama M, Horikoshi M, Momozawa Y, Matsunaga H, Ieki H, Ozaki K, Onouchi Y, Takahashi A, Nomura S, Morita H, Akazawa H, Kim C, Seo JS, Higasa K, Iwasaki M, Yamaji T, et al.
  • Journal Title: Nature Genetics Volume: 52 Issue: 11 Pages: 1169-1177
  • DOI: 10.1038/s41588-020-0705-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure (2020)
  • Author(s): Yamaguchi Toshihiro、Sumida Tomokazu S.、Nomura Seitaro、Satoh Masahiro、Higo Tomoaki、Ito Masamichi、Ko Toshiyuki、Fujita Kanna、Sweet Mary E.、Sanbe Atsushi、Yoshimi Kenji、Manabe Ichiro、Sasaoka Toshikuni、Taylor Matthew R. G.、Toko Haruhiro、Takimoto Eiki、Naito Atsuhiko T.、Komuro Issei
  • Journal Title: Nature Communications Volume: 11 Issue: 1 Pages: 4364-4364
  • DOI: 10.1038/s41467-020-18128-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Transethnic Meta-Analysis of Genome-Wide Association Studies Identifies Three New Loci and Characterizes Population-Specific Differences for Coronary Artery Disease (2020)
  • Author(s): Matsunaga Hiroshi, ... Ogishima Soichi et al.
  • Journal Title: Circulation: Genomic and Precision Medicine Volume: 13 Issue: 3
  • DOI: 10.1161/circgen.119.002670
  • Peer Reviewed / Open Access
• [Journal Article] Genetic and Non-Genetic Determinants of Clinical Phenotypes in Cardiomyopathy (2019)
  • Author(s): Nomura S.
  • Journal Title: J Cardiol. Volume: 73 Issue: 3 Pages: 187-190
  • DOI: 10.1016/j.jjcc.2018.11.001
  • NAID: 40021821824
  • Peer Reviewed / Open Access
• [Journal Article] High-throughput single-molecule RNA imaging analysis reveals heterogeneous responses of cardiomyocytes to hemodynamic overload (2019)
  • Author(s): Satoh M、Nomura S、Harada M、Yamaguchi T、Ko T、Sumida T、Toko H、Naito AT.、Takeda N、Tobita T、Fujita T、Ito M、Fujita K、Ishizuka M、Kariya T、Akazawa H、Kobayashi Y、Morita H、Takimoto E、Aburatani H、Komuro I
  • Journal Title: Journal of Molecular and Cellular Cardiology Volume: 128 Pages: 77-89
  • DOI: 10.1016/j.yjmcc.2018.12.018
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quantification of DNA Damage in Heart Tissue as a Novel Prediction Tool for Therapeutic Prognosis of Patients With Dilated Cardiomyopathy. (2019)
  • Author(s): Ko T, Fujita K, Nomura S, Uemura Y, Yamada S, Tobita T, Katoh M, Satoh M, Ito M, Domoto Y, Hosoya Y, Amiya E, Hatano M, Morita H, Fukayama M, Aburatani H, Komuro I.
  • Journal Title: JACC Basic Transl Sci. Volume: 4 Issue: 6 Pages: 670-680
  • DOI: 10.1016/j.jacbts.2019.05.010
  • Peer Reviewed / Open Access
• [Journal Article] Cooperation of PU.1 with IRF8 and NFATc1 defines chromatin landscapes during RANKL‐induced osteoclastogenesis (2019)
  • Author(s): Izawa Naohiro、Kurotaki Daisuke、Nomura Seitaro、Fujita Takanori、Omata Yasunori、Yasui Tetsuro、Hirose Jun、Matsumoto Takumi、Saito Taku、Kadono Yuho、Okada Hiroyuki、Miyamoto Takeshi、Tamura Tomohiko、Aburatani Hiroyuki、Tanaka Sakae
  • Journal Title: Journal of Bone and Mineral Research Volume: なし Issue: 6 Pages: 1143-1154
  • DOI: 10.1002/jbmr.3689
  • Peer Reviewed / Open Access
• [Journal Article] Characterization of a small molecule that promotes cell cycle activation of human induced pluripotent stem cell-derived cardiomyocytes (2019)
  • Author(s): Ito Masamichi、Hara Hironori、Takeda Norifumi、Naito Atsuhiko T.、Nomura Seitaro、Kondo Masaki、Hata Yutaka、Uchiyama Masanobu、Morita Hiroyuki、Komuro Issei
  • Journal Title: Journal of Molecular and Cellular Cardiology Volume: 128 Pages: 90-95
  • DOI: 10.1016/j.yjmcc.2019.01.020
  • Peer Reviewed / Open Access
• [Presentation] Multiomics analysis to develop precision medicine in heart failure (2021)
  • Author(s): 野村征太郎
  • Organizer: 日本循環器学会
  • Invited
• [Presentation] 心筋梗塞の心臓リモデリングを制御する空間的なメカノセンシング機構 (2021)
  • Author(s): 野村征太郎
  • Organizer: 日本循環器学会
  • Invited
• [Presentation] Molecular Mechanisms of Heart Failure (2021)
  • Author(s): Seitaro Nomura
  • Organizer: Asian Pacific Society of Cardiology Congress (APSC2022)
  • Int'l Joint Research / Invited
• [Presentation] 拡張型心筋症の発症機序 (2021)
  • Author(s): 野村征太郎
  • Organizer: 日本循環器学会
  • Invited
• [Presentation] 統合的シングルセル解析による循環器疾患システム構造の理解と精密医療の発展 (2021)
  • Author(s): 野村征太郎
  • Organizer: 第263回日本循環器学会関東甲信越地方会 教育セッションⅠ 循環器病克服のための基礎研究のすすめ
  • Invited
• [Presentation] 循環器疾患システム構造の理解を目指した統合的シングルセル解析 (2021)
  • Author(s): 野村征太郎
  • Organizer: 第25回日本心血管内分泌代謝学会学術総会若手主宰シンポジウム「心血管内分泌研究の最前線」
  • Invited
• [Presentation] Integrated single-cell analysis to understand the system architecture of cardiovascular disease (2021)
  • Author(s): Seitaro Nomura
  • Organizer: 第44回日本分子生物学会
  • Invited
• [Presentation] Spatial transcriptomics of cardiovascular diseases (2021)
  • Author(s): Seitaro Nomura
  • Organizer: 2021 Asia Pacific Spatial Biology Summit
  • Int'l Joint Research / Invited
• [Presentation] ゲノムからみた心筋症の精密医療 (2021)
  • Author(s): 野村征太郎
  • Organizer: 第25回日本心不全学会学術集会
  • Invited
• [Presentation] 心不全における心筋細胞の分子生物学的考察と臨床応用（心不全のシステム循環器学） (2021)
  • Author(s): 野村征太郎
  • Organizer: 第69回日本心臓病学会学術集会
  • Invited
• [Presentation] DNA damage leading to heart failure (2021)
  • Author(s): Seitaro Nomura
  • Organizer: European Society of Cardiology
  • Int'l Joint Research / Invited
• [Presentation] Single-cell Analysis Dissects the Biology of Heart Failure (2021)
  • Author(s): 野村征太郎
  • Organizer: 日本循環器学会
  • Invited
• [Presentation] Multi-omics Analysis Dissects the Biology of Heart Failure (2021)
  • Author(s): 野村征太郎
  • Organizer: 日本循環器学会
  • Invited
• [Presentation] 心不全患者におけるDNA傷害指標の病期評価能を検証する他施設前向き観察研究 (2021)
  • Author(s): 野村征太郎
  • Organizer: 日本循環器学会
  • Invited
• [Presentation] 分子生物学と未来の心不全診療 (2020)
  • Author(s): 野村征太郎
  • Organizer: 日本循環器学会関東甲信越地方会
  • Invited
• [Presentation] Elucidation of mechanism involved in the development and progression of heart failure using single-cell RNA-Seq (2020)
  • Author(s): 野村征太郎
  • Organizer: 日本循環器学会
  • Invited
• [Presentation] Omics Studies of Dilated Cardiomyopathy -拡張型心筋症のオミックス解析- (2020)
  • Author(s): 野村征太郎
  • Organizer: 日本循環器学会
  • Invited
• [Presentation] 心不全ゲノム診療近未来予想図 (2020)
  • Author(s): 野村征太郎
  • Organizer: 日本循環器学会
  • Invited
• [Presentation] Disease Modeling of Dilated Cardiomyopathy -Application of iPSC and Single-cell Omics Technology (2020)
  • Author(s): 野村征太郎
  • Organizer: 日本循環器学会
  • Invited
• [Presentation] AIによるprecision medicine (2020)
  • Author(s): 野村征太郎
  • Organizer: 日本循環器学会
  • Invited
• [Presentation] ゲノム分子病理解析による心筋症の病態解明と精密医療 (2020)
  • Author(s): 野村征太郎
  • Organizer: 日本循環器学会関東甲信越地方会
  • Invited
• [Presentation] ntegrative single-cell analysis to dissect heart failure biology (2019)
  • Author(s): Seitaro Nomura
  • Organizer: Cold Spring Harbor Laboratory meeting
  • Int'l Joint Research
• [Presentation] Multi-omics dissection of heart failure for the development of precision cardiovascular medicine (2019)
  • Author(s): Seitaro Nomura
  • Organizer: Gordon Research Conference
  • Int'l Joint Research
• [Presentation] Multi-omics dissection of heart failure for precision cardiovascular medicine (2019)
  • Author(s): Seitaro Nomura
  • Organizer: Annual Meeting of Taiwan Society of Cardiology
  • Int'l Joint Research / Invited
• [Presentation] Multi-omics dissection of heart failure for cardiovascular precision medicine (2019)
  • Author(s): Seitaro Nomura
  • Organizer: Cell Symposia Gene regulation
  • Int'l Joint Research
• [Presentation] Genetic architecture of cardiomyopathy (2019)
  • Author(s): Seitaro Nomura
  • Organizer: European Society of Cardiology
  • Int'l Joint Research / Invited
• [Presentation] Cardiomyocyte gene programs encoding morphological and functional signatures in cardiac hypertrophy and failure (2019)
  • Author(s): Seitaro Nomura
  • Organizer: Cell Symposia: Single Cell meeting
  • Int'l Joint Research
• [Presentation] 永井良三賞受賞講演「シングルセルシステム循環器学による循環器疾患システム構造の全貌解明」 (2019)
  • Author(s): 野村征太郎
  • Organizer: 第23回日本心血管内分泌代謝学会学術総会
  • Invited
• [Presentation] 心臓疾患における細胞・分子挙動の網羅的理解 (2019)
  • Author(s): 野村征太郎
  • Organizer: 第23回日本心血管内分泌代謝学会学術総会
  • Invited
• [Presentation] Systems biology for the integrative understanding of cardiac system (2019)
  • Author(s): 野村征太郎
  • Organizer: 第23回日本心血管内分泌代謝学会学術総会
  • Invited
• [Presentation] Multi-omics dissection of heart failure for cardiovascular precision medicine (2019)
  • Author(s): 野村征太郎
  • Organizer: 第23回日本心不全学会学術集会
  • Invited
• [Presentation] マルチオミックス連関による心筋症における精密医療の実現 (2019)
  • Author(s): 野村征太郎
  • Organizer: 第23回日本心不全学会学術集会
  • Invited
• [Presentation] ゲノム分子病理解析による心筋症における精密医療の実現 (2019)
  • Author(s): 野村征太郎
  • Organizer: 第23回日本心不全学会学術集会
  • Invited
• [Presentation] Heart Cell Atlas for understanding the pathophysiology of the Heart and for the development of precision cardiovascular medicine (2019)
  • Author(s): 野村征太郎
  • Organizer: 第3回日本循環器学会基礎研究フォーラム
  • Invited
• [Presentation] シングルセル解析による循環器疾患の病態解明と臨床応用 (2019)
  • Author(s): 野村征太郎
  • Organizer: シングルセル研究会
  • Invited
• [Presentation] 循環器疾患のシングルセルオミクス解析 (2019)
  • Author(s): 野村征太郎
  • Organizer: 日本学術会議 公開シンポジウム「ゲノムビックデータ解析の新潮流」
  • Invited
• [Book] 循環器疾患最新の治療2022-2023 (2022)
  • Author(s): 野村征太郎・小室一成
  • Total Pages: 520
  • Publisher: 南江堂
  • ISBN: 9784524229956
• [Book] もっとよくわかる！循環器学と精密医療 (2020)
  • Author(s): 野村征太郎
  • Total Pages: 204
  • Publisher: 羊土社
  • ISBN: 9784758122085
• [Book] 心不全治療薬の考え方，使い方「心筋ミオシン活性化薬」 (2019)
  • Author(s): 野村征太郎
  • Total Pages: 298
  • Publisher: 中外医学社
  • ISBN: 9784498136588
• [Book] 実験医学増刊 Vol.37 No.20 シングルセルゲノミクス 組織の機能、病態が1細胞レベルで見えてきた！「心筋シングルセル解析による病態解明から臨床応用」 (2019)
  • Author(s): 野村征太郎、油谷浩幸
  • Total Pages: 219
  • Publisher: 羊土社
  • ISBN: 9784758103831
• [Book] 循環器ジャーナル 2020年01月号 (通常号) ( Vol.68 No.1) 特集 U40世代が描く心不全診療の現状と未来－基礎研究を識り，臨床を素心深考する「がん治療関連性心血管障害の予後予測因子はありますか？ゲノム研究はどこまで進んでいるの？」 (2019)
  • Author(s): 野村征太郎
  • Total Pages: 184
  • Publisher: 医学書院
  • ISBN: 9784260029605
• [Book] Heart View 2019年12月号 Vol.23 No.13 心筋症のいまを識る！「遺伝子検査を心筋症・循環器診療にどう活かすか？」 (2019)
  • Author(s): 野村征太郎
  • Total Pages: 120
  • Publisher: 文光堂
• [Book] 循環器内科 第86巻第6号「心筋症の遺伝子治療」 (2019)
  • Author(s): 野村征太郎
  • Total Pages: 150
  • Publisher: 科学評論社
• [Patent(Industrial Property Rights)] 心筋梗塞・心不全の治療標的としての心保護因子Htra3の同定 (2021)
  • Inventor(s): 野村征太郎、候聡志、油谷浩幸、小室一成
  • Industrial Property Rights Holder: 国立大学法人東京大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2021
  • Overseas
• [Patent(Industrial Property Rights)] 虚血性心疾患のリスク判定方法及びリスク判定システム (2020)
  • Inventor(s): 伊藤薫・小山智史・鎌谷洋一郎・野村征太郎・小室一成・油谷浩幸
  • Industrial Property Rights Holder: 国立研究開発法人理化学研究所・国立大学法人東京大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2020
  • Overseas
• [Patent(Industrial Property Rights)] 心不全患者の心機能回復可能性の評価方法 (2019)
  • Inventor(s): 野村征太郎、候聡志、油谷浩幸、小室一成
  • Industrial Property Rights Holder: 野村征太郎、候聡志、油谷浩幸、小室一成
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019
  • Overseas
• [Patent(Industrial Property Rights)] 虚血性心疾患発症と予後を予測するゲノムリスクスコア (2019)
  • Inventor(s): 伊藤薫、野村征太郎、赤澤宏、小室一成
  • Industrial Property Rights Holder: 伊藤薫、野村征太郎、赤澤宏、小室一成
  • Industrial Property Rights Type: 特許
  • Filing Date: 2019