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Peptide drugs derived from food material for periodontal disease preventing flail and AMR

Research Project

Project/Area Number 19H03829
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 57030:Conservative dentistry-related
Research InstitutionNiigata University

Principal Investigator

Koichi Tabeta  新潟大学, 医歯学系, 教授 (20401763)

Co-Investigator(Kenkyū-buntansha) 野中 由香莉  新潟大学, 医歯学総合病院, 講師 (40710520)
寺尾 豊  新潟大学, 医歯学系, 教授 (50397717)
藤本 啓二  慶應義塾大学, 理工学部(矢上), 教授 (70229045)
高橋 直紀  新潟大学, 医歯学系, 准教授 (80722842)
谷口 正之  新潟大学, 自然科学系, 教授 (00163634)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2022: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2021: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2020: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Keywords歯周炎 / ペプチド / 抗菌活性 / バイオフィルム / ペプチド医薬 / 歯周治療学 / 歯周病医薬 / 機能ペプチド / 歯周病原細菌 / アミノ酸置換
Outline of Research at the Start

口腔細菌の抗菌薬でのコントロールは,歯周病の予防・治療に有効なアプローチである。しかし,薬剤耐性菌の増加により,世界規模で抗菌薬の使用制限が課せられている。そこで本研究では,コメ及び大豆由来機能性ペプチドに着目し,特異的に口腔細菌のコントロールを行うペプチド群をスクリーニングする。その結果選出した食品機能ペプチドに対し,アミノ酸置換によりペプチド機能強化とナノカプセル化を行い,安全な次世代歯周病ペプチド医薬の開発を試みる。狭域スペクトルを特徴とする選択的バイオナノ医薬の開発による個別化医療を目指し,口腔領域におけるペプチド創薬研究を開拓する。

Outline of Final Research Achievements

Antimicrobial control of oral bacteria is an effective approach to the prevention and treatment of periodontal disease. However, due to the increase in drug-resistant bacteria, the use of antimicrobial agents has been restricted on a global scale. In this project, we focused on functional peptides derived from rice and soybeans to create new personalized periodontal peptide drugs that specifically control oral bacteria and analyzed their functions. As a result, several food functional peptide materials with antimicrobial activity and amino acid substitutions with enhanced function were selected for the prevention and treatment of periodontal disease. The library of functional peptides provides a basis for the development of next-generation periodontal peptide medicines that are safe alternatives to existing antimicrobial agents.

Academic Significance and Societal Importance of the Research Achievements

既存抗生物質と異なる作用機序を有し,歯周病細菌群に対して狭域スペクトルを持つペプチド医薬開発の発展性と学術的独自性を持つ。また,アミノ酸置換によるペプチド機能強化は,ペプチドの特異性と多様性の向上を可能とした。これらの機能ペプチドコレクションは検査・診断,症状・病期・細菌叢に対応するパーソナライズド歯周病医薬開発へつながり,国民に提供する新たな個別化医療の創造性を有する。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (18 results)

All 2022 2021 2020 2019

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 1 results) Presentation (15 results) (of which Int'l Joint Research: 3 results)

  • [Journal Article] Soybean peptide inhibits the biofilm of periodontopathic bacteria via bactericidal activity2022

    • Author(s)
      Hnin Yu Lwin, Yukari Aoki-Nonaka, Aoi Matsugishi, Naoki Takahashi, Takumi Hiyoshi, Koichi Tabeta
    • Journal Title

      Archives of Oral Biology

      Volume: 142 Pages: 105497-105497

    • DOI

      10.1016/j.archoralbio.2022.105497

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rice peptide with amino acid substitution inhibits biofilm formation by Porphyromonas gingivalis and Fusobacterium nucleatum2021

    • Author(s)
      Matsugishi Aoi、Aoki-Nonaka Yukari、Yokoji-Takeuchi Mai、Yamada-Hara Miki、Mikami Yoshikazu、Hayatsu Manabu、Terao Yutaka、Domon Hisanori、Taniguchi Masayuki、Takahashi Naoki、Yamazaki Kazuhisa、Tabeta Koichi
    • Journal Title

      Archives of Oral Biology

      Volume: 121 Pages: 104956-104956

    • DOI

      10.1016/j.archoralbio.2020.104956

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The AmyI‐1‐18 peptide derived from rice inhibits alveolar bone resorption via suppression of inflammatory cytokine production induced by lipopolysaccharide and interleukin‐1β in mice2019

    • Author(s)
      Aoki‐Nonaka Yukari、Tabeta Koichi、Yokoji Mai、Matsugishi Aoi、Matsuda Yumi、Takahashi Naoki、Sulijaya Benso、Domon Hisanori、Terao Yutaka、Taniguchi Masayuki、Yamazaki Kazuhisa
    • Journal Title

      Journal of Periodontology

      Volume: . Issue: 10 Pages: 1160-1169

    • DOI

      10.1002/jper.18-0630

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Presentation] 大豆由来ペプチドの抗バイオフィルム効果の検討2022

    • Author(s)
      Hnin Yu Lwin,野中由香莉,松岸葵,多部田康一
    • Organizer
      第65回春季日本歯周病学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Ferulic acid inhibits the biofilm formation of Porphyromonas gingivalis2022

    • Author(s)
      Hnin Yu Lwin,野中由香莉,松岸 葵,日吉 巧,湊裕佳子,多部田康一
    • Organizer
      第65回秋季日本歯周病学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 抗菌性ペプチドN3Lによる歯周病原細菌由来バイオフィルム制御能の検討2022

    • Author(s)
      松岸 葵,野中由香莉,Hnin Yu Lwin,多部田康一
    • Organizer
      日本歯科保存学会2022年度秋季学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Soybean peptide inhibits biofilm of periodontopathic bacteria via bactericidal activity2021

    • Author(s)
      Hnin Yu Lwin, Aoki-Nonaka Y, Matsugishi A, Tabeta K
    • Organizer
      99th General Session of the IADR
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 大豆ペプチドはFusobacterium nucleatumのバイオフィルム形成を阻害する2021

    • Author(s)
      松岸 葵,野中由香莉,Hnin Yu Lwin,多部田康一
    • Organizer
      第64回春季日本歯周病学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 大豆ペプチドは Porphyromonas gingivalis およびFusobacterium nucleatumの バイオフィルム形成を阻害する2021

    • Author(s)
      Hnin Yu Lwin,野中由香莉,松岸葵,多部田康一
    • Organizer
      第154回日本歯科保存学会2021年度春季学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 大豆ペプチドはFusobacterium nucleatumのバイオフィルム形成を阻害する2021

    • Author(s)
      松岸葵 野中由香莉 Hnin Yu Lwin 多部田康一
    • Organizer
      第64回春季日本歯周病学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 大豆ペプチドは Porphyromonas gingivalis およびFusobacterium nucleatumの バイオフィルム形成を阻害する2021

    • Author(s)
      Hnin Yu Lwin,野中 由香莉,松岸 葵,多部田 康一
    • Organizer
      日本歯科保存学会2021年度春季学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Soybean Peptide Inhibits Biofilm of Periodontopathic Bacteria via Bactericidal Activity2021

    • Author(s)
      Hnin Yu Lwin, Yukari Aoki-Nonaka, Aoi Matsugishi, Koichi Tabeta
    • Organizer
      The 2021 IADR/AADR/CADR General Session
    • Related Report
      2020 Annual Research Report
  • [Presentation] コメペプチドとそのアミノ酸置換体はPorphyromonas gingivalis,Fusobacterium nucleatumのバイオフィルム形成を阻害する.2020

    • Author(s)
      松岸 葵,野中由香莉,竹内麻衣,原 実生,早津 学,三上剛和,牛木辰男,土門久哲,山崎和久,多部田康一
    • Organizer
      第63回春季日本歯周病学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] コメ由来ペプチドのアミノ酸置換体による歯周病原細菌のバイオフィルム阻害作用の解析2020

    • Author(s)
      松岸 葵,野中由香莉,竹内麻衣,原 実生,土門久哲,寺尾 豊,山崎和久,多部田康一
    • Organizer
      令和2年度新潟歯学会第1回例会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Rice peptide with amino acid substitution inhibits biofilm formation of periodontopathic bacteria.2020

    • Author(s)
      13) Matsugishi A, Aoki-Nonaka Y, Yokoji-Takeuchi M, Yamada-Hara M, Domon H, Yamazaki K, Tabeta K
    • Organizer
      International Collaborative Symposium on Development of Human Resources in Practical Oral Health and Treatment.
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Rice Peptide and Amino Acid Substitutions Inhibit Porphyromonas gingivalis Biofilm.2019

    • Author(s)
      5) Matsugishi A, Aoki-Nonaka Y, Yokoji M, Yamada-Hara M, Domon H, Yamazaki K, Tabeta K
    • Organizer
      97th General Session of the IADR
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] コメ由来ペプチドAmyI-1-18,アミノ酸置換体がPorphyromonas gingivalis バイオフィルムに及ぼす影響.2019

    • Author(s)
      28) 松岸 葵,野中由香莉,竹内麻衣,原 実生,土門久晢,山崎和久,多部田康一
    • Organizer
      第62回春季日本歯周病学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] コメ由来ペプチドAmyⅠ-1-18およびアミノ酸置換体はPorphyromonas gingivalis バイオフィルム形成を阻害する.2019

    • Author(s)
      42) 松岸 葵,野中由香莉,竹内麻衣,原 実生,土門久哲,山崎和久,多部田康一
    • Organizer
      日本歯科保存学会2019年度秋季学術大会(第151回)
    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2024-01-30  

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