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Research for the prediction of coronary artery complication associated with Kawasaki disease

Research Project

Project/Area Number 19H03904
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 58030:Hygiene and public health-related: excluding laboratory approach
Research InstitutionWakayama Medical University

Principal Investigator

Kitano Naomi  和歌山県立医科大学, 医学部, 准教授 (40316097)

Co-Investigator(Kenkyū-buntansha) 鈴木 崇之  和歌山県立医科大学, 医学部, 助教 (40816691)
末永 智浩  和歌山県立医科大学, 医学部, 講師 (70433365)
垣本 信幸  和歌山県立医科大学, 医学部, 助教 (90614412)
土橋 智弥  和歌山県立医科大学, 医学部, 助教 (20828488)
山野 貴司  和歌山県立医科大学, 医学部, 講師 (40624151)
鈴木 啓之  和歌山県立医科大学, 医学部, 博士研究員 (80196865)
武内 崇  和歌山県立医科大学, 医学部, 大学院研究生 (10246522)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2022: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2021: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2020: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Keywords川崎病 / 疫学 / 冠動脈瘤 / 血管炎 / 多施設共同研究 / 季節性 / 環境要因 / 宿主要因 / 季節 / 冠動脈 / 急性期治療 / 臨床疫学 / 冠動脈異常 / 治療抵抗性 / 時間集積性 / 地域集積性 / 多施設調査 / 乳児川崎病 / 後天性心疾患 / 危険因子
Outline of Research at the Start

川崎病は乳幼児に好発する急性の全身性血管炎で、日本で年間1万5千人余が罹患する。川崎病急性期に冠動脈瘤が発生する可能性があり、代表的な後天性心疾患である。病因は未解明だが、これまでの疫学研究によって、川崎病発症に時間集積性と地域集積性があることがわかっている。本研究では、発症の季節や患者年齢によって、発症に関わる環境因子が異なる可能性を仮定し、発症に関わった環境因子と宿主因子の相互作用によって、治療反応性や冠動脈病変の発生が異なると考えて研究計画を立てた。本研究では、川崎病冠動脈瘤発生防止のための治療戦略に役立てることを目標に、疫学研究の手法を用いて、冠動脈瘤発生予測モデルの開発を目指す。

Outline of Final Research Achievements

The etiology of Kawasaki disease (KD) is unknown, and the diagnosis is based on clinical symptoms and is considered a syndrome. The goal of acute treatment of KD is to prevent the development of coronary artery abnormalities (CAAs), and a treatment strategy that allows the optimal choice of treatment for each individual case is needed. We reported that the sex ratio differs according to the age group of patients with KD and that the distribution of the season in which KD occurred is characteristic. In this study, we identified an association between the proportion of patients with initial unresponsiveness to IVIG and increasing age. Differences in the risk factors were observed between initial unresponsiveness to IVIG and the deveropment of CAAs in infants with KD.
Also, we examined that the age of the affected patients and the coronary artery measurements at the time of diagnosis were important factors in predicting the occurrence of CAAs before the start of acute treatment.

Academic Significance and Societal Importance of the Research Achievements

本研究で川崎病罹患者の年齢層によって初期治療反応性と冠動脈異常発生との関係が異なることを明らかとした。このことは、急性期治療ガイドラインにおいて、冠動脈異常発生の事前予測(スコア等)の必要性と、罹患者の年齢層を加味した治療アルゴリズムの必要性を示唆するものである。

Report

(4 results)
  • 2023 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (31 results)

All 2022 2021 2020 Other

All Int'l Joint Research (2 results) Journal Article (7 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 7 results) Presentation (22 results) (of which Int'l Joint Research: 6 results,  Invited: 2 results)

  • [Int'l Joint Research] University of California San Diego(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University of California San Diego(米国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Status of treatment and outcome in Kawasaki disease in the Kinki area of Japan2022

    • Author(s)
      Tsuchihashi T, Kakimoto N, Kitano N, Suenaga T, Ikeda K, Izui M, Kobayashi N, Yoshimura K, Nakamura Y, Suzuki H; steering committee of the Society of Kinki Area Kawasaki Disease Research.
    • Journal Title

      Pediatr Int.

      Volume: 64(1) Issue: 1

    • DOI

      10.1111/ped.15391

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of Age, Sex, Lack of Response to Intravenous Immunoglobulin, and Development of Coronary Artery Abnormalities in Children With Kawasaki Disease in Japan2022

    • Author(s)
      Takekoshi N, Kitano N, Takeuchi T, Suenaga T, Kakimoto N, Suzuki T, Kada TT, Shibuta S, Tachibana S, Murayama Y, Yamaga H, Suzuki H.
    • Journal Title

      JAMA Netw Open.

      Volume: 1;5 (6) Issue: 6 Pages: e2216642-e2216642

    • DOI

      10.1001/jamanetworkopen.2022.16642

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Telecardiology in Rural Practice: Global Trends.2022

    • Author(s)
      Yamano T, Kotani K, Kitano N, Morimoto J, Emori H, Takahata M, Fujita S, Wada T, Ota S, Satogami K, Kashiwagi M, Shiono Y, Kuroi A, Tanimoto T, Tanaka A.
    • Journal Title

      nt J Environ Res Public Health

      Volume: 19(7) Issue: 7 Pages: 4335-4345

    • DOI

      10.3390/ijerph19074335

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Case Report: Ciclosporin A for Refractory Multisystem Inflammatory Syndrome in Children2022

    • Author(s)
      Suzuki T, Suenaga T, Sakai A, Sugiyama M, Mizokami M, Mizukami A, Takasago S, Hamada H, Kakimoto N, Takeuchi T, Ueda M, Komori Y, Tokuhara D, Suzuki H.
    • Journal Title

      Front Pediatr

      Volume: 31;10 Pages: 890755-890755

    • DOI

      10.3389/fped.2022.890755

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Seasonal Variation in Epidemiology of Kawasaki Disease-Related Coronary Artery Abnormalities in Japan, 1999–20172021

    • Author(s)
      Kitano Naomi, Takeuchi Takashi, Suenaga Tomohiro, Kakimoto Nobuyuki, Naka Akihiro, Shibuta Shoichi, Tachibana Shinya, Takekoshi Nobuhito, Suzuki Takayuki, Tsuchihashi Tomoya, Yamano Takashi, Akasaka Takashi, Suzuki Hiroyuki
    • Journal Title

      Journal of Epidemiology

      Volume: 31 Issue: 2 Pages: 132-138

    • DOI

      10.2188/jea.JE20190189

    • NAID

      130007981111

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2021-02-05
    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Z-score is a possible predictor of the risk of coronary artery lesion development in patients with Kawasaki disease in Japan2021

    • Author(s)
      Suzuki T, Kakimoto N, Tsuchihashi T, Suenaga T, Takeuchi T, Shibuta S, Kitano N, Suzuki H.
    • Journal Title

      Eur J Pediatr.

      Volume: 「-」 Issue: 9 Pages: 2797-2805

    • DOI

      10.1007/s00431-021-04006-1

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Temporal clustering of Kawasaki disease cases around the world.2021

    • Author(s)
      Burney JA, DeHaan LL, Shimizu C, Bainto EV, Newburger JW, DeBiasi RL, Dominguez SR, Portman MA., Melish M, Bratincsak A, Fabi M, Corinaldesi El, Yu JJ, Gee P, Kitano N, Tremoulet AH, Cayan DR, Burns JC; the Kawasaki Disease Climate Study Group
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 22584-22584

    • DOI

      10.1038/s41598-021-01961-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 川崎病急性期治療における新たな視点.2022

    • Author(s)
      鈴木啓之
    • Organizer
      第20回 九州川崎病研究会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 和歌山県における新型コロナウイルス感染症流行と川崎病罹患者の関連.2022

    • Author(s)
      垣本信幸, 村山友梨, 土橋智弥, 鈴木啓之, 末永智浩,徳原大介
    • Organizer
      第42回日本川崎病学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 川崎病性冠動脈瘤に合併する冠動脈石灰化症例における網羅的microRNA解析.2022

    • Author(s)
      鈴木崇之, 村山友梨, 土橋智弥, 垣本信幸, 末永智浩,武内崇,鈴木啓之,徳原大介
    • Organizer
      第42回日本川崎病学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 静脈機能不全様の症状を合併した小児多系統炎症性症候群の1例.2022

    • Author(s)
      末永智浩,土橋智弥,鈴木崇之,垣本信幸,鈴木啓之,武内崇,酒井愛子,杉山真也,溝上雅史,水上愛弓,高砂聡志
    • Organizer
      第125回日本小児科学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 当院で過去20年間に経験した川崎病巨大冠動脈瘤症例のまとめ.2022

    • Author(s)
      大星瑳希子, 伊藤恭平, 村山友梨, 土橋智弥, 鈴木啓之, 垣本信幸, 末永智浩, 武内崇, 鈴木啓之,徳原大介
    • Organizer
      第42回日本川崎病学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 新型コロナウイルス感染症と川崎病 ~和歌山からの報告~2022

    • Author(s)
      垣本信幸、村山友梨、土橋智弥、鈴木崇之、末永智浩、武内 崇、鈴木啓之
    • Organizer
      第46回近畿川崎病研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Seasonal variation in the onset of Kawasaki disease and related coronary artery abnormalities.2021

    • Author(s)
      Naomi Kitano、Takashi Takeuchi、Tomohiro Suenaga、Takashi Yamano、Takashi Akasaka、Hiroyuki Suzuki、 Wakayama Kawasaki disease Study (WKDS) group
    • Organizer
      The 85th Annual Scientific Meeting of the Japanese Circulation Society / World Congress of Cardiology 2021
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Discrepancy in risk factors between second-line treatment and developing coronary artery abnormalities among patients with Kawasaki disease in Japan.2021

    • Author(s)
      Naomi Kitano、Nobuhito Takekoshi、Takashi Takeuchi、Nobuyuki Kakimoto、Takayuki Suzuki、Tomoya Tsuchihashi、Shinya Tachibana、 Shoichi Shibuta、 Hiroyuki Suzuki、 Tomohiro Suenaga、 Wakayama Kawasaki disease Study (WKDS) group
    • Organizer
      The 13th International Kawasaki Disease Symposium
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Z-score is a possible predictor of the risk of coronary artery lesion development in patients with Kawasaki disease in Japan.2021

    • Author(s)
      Takayuki Suzuki, Nobuyuki Kakimoto, Tomoya Tsuchihashi, Tomohiro Suenaga, Takashi Takeuchi, Shoichi Shibuta, Naomi Kitano, Hiroyuki Suzuki
    • Organizer
      The 13th International Kawasaki Disease Symposium
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Intimal thickening and disruption of the media occur in the arterial walls of CA not associated with CAL in patients with KD.2021

    • Author(s)
      Tomoya Tsuchihashi, Nobuyuki Kakimoto, Takashi Takeuchi, Tomohiro Suenaga, Takayuki Suzuki, Hiroyuki Suzuki, Yasushi Ino, Takashi Kubo, Takashi Akasaka, Shoichi Shibuta
    • Organizer
      The 13th International Kawasaki Disease Symposium
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A case of multisystem inflammatory syndrome in children (MIS-C) with venous dysfunction-like symptoms.2021

    • Author(s)
      Suenaga T, Murayama Y, Tsuchihashi T, Suzuki T, Kakimoto N, Takeuchi T, Suzuki H
    • Organizer
      The 13th International Kawasaki Disease Symposium
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The utility of information and communication technology for arrhythmia treatment to overcome geographical accessibility2021

    • Author(s)
      山野貴司、寺田幸誠、柏木 学、黒井章央、北野尚美、久保隆史、田中 篤、穂積健之、赤阪隆史
    • Organizer
      第85回日本循環期学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 川崎病急性期の冠動脈Z-scoreによる冠動脈病変発症予測の試み2021

    • Author(s)
      鈴木崇之, 土橋智弥, 垣本信幸,末永智浩, 武内 崇, 渋田昌一, 北野尚美, 鈴木啓之
    • Organizer
      第41回日本川崎病学会・学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 静脈機能不全様の症状を合併した小児多系統炎症性症候群の1例2021

    • Author(s)
      末永智浩、土橋智弥、鈴木崇之、垣本信幸、武内 崇、鈴木啓之
    • Organizer
      第41回日本川崎病学会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 川崎病急性期治療成績に関する後ろ向き観察研究2021

    • Author(s)
      土橋智弥、池田和幸、泉井雅史、小林奈歩、吉村 健、北野尚美、鈴木啓之、中村好一
    • Organizer
      第45回近畿川崎病研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Seasonal variation in the onset of Kawasaki disease and related coronary artery abnormalities2021

    • Author(s)
      Kitano N, Takeuchi T, Suenaga T, Yamano T, Akasaka T and Suzuki H
    • Organizer
      The 85th Annual Scientific Meeting of the Japanese Circulation Society / World Congress of Cardiology 2021
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 近畿川崎病研究会における川崎病急性期治療成績に関する後ろ向き観察研究2021

    • Author(s)
      土橋智弥、池田和幸、泉井雅史、小林奈歩、 吉村健、垣本信幸、北野尚美、鈴木啓之、関係各病院担当医師、中村好一
    • Organizer
      第45回近畿川崎病研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 川崎病罹患者の性別と年齢を考慮した治療反応性の検討2020

    • Author(s)
      竹腰信人、北野尚美、武内 崇、末永智浩、垣本信幸、鈴木崇之、土橋智弥、渋田昌一、立花伸也、鈴木啓之
    • Organizer
      第40回日本川崎病学会学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 川崎病患者の年齢と性別を考慮した治療反応性の検討2020

    • Author(s)
      竹腰信人、北野尚美、武内 崇、末永智浩、垣本信幸、鈴木崇之、土橋智弥、渋田昌一、立花伸也、鈴木啓之
    • Organizer
      第56回日本小児循環器学会総会・学術集会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 川崎病罹患者の性別と年齢を考慮した治療反応性の検討2020

    • Author(s)
      竹腰信人、北野尚美、武内 崇、末永智浩、垣本信幸、鈴木崇之、土橋智弥、渋田昌一、立花伸也、鈴木啓之
    • Organizer
      第56回日本小児循環器学会総会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 和歌山県内における川崎病の初期治療に対する抵抗性と冠動脈病変に関する検討2020

    • Author(s)
      竹腰信人、北野尚美、武内 崇、末永智浩、垣本信幸、鈴木崇之、土橋智弥、渋田昌一、立花伸也、鈴木啓之
    • Organizer
      第40回日本川崎病学会・学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 難治性川崎病症例にシクロスポリンAを導入した第1例目とその後の展開2020

    • Author(s)
      鈴木啓之
    • Organizer
      第40回日本川崎病学会・学術集会
    • Related Report
      2019 Annual Research Report
    • Invited

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Published: 2019-04-18   Modified: 2025-01-30  

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