• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Role of internal feedback neural pathway in functional recovery from spinal cord injuries

Research Project

Project/Area Number 19H03975
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59010:Rehabilitation science-related
Research InstitutionTamagawa University (2021-2023)
Kyoto University (2019-2020)

Principal Investigator

TAKEI Tomohiko  玉川大学, 脳科学研究所, 准教授 (50527950)

Co-Investigator(Kenkyū-buntansha) 伊佐 正  京都大学, 医学研究科, 教授 (20212805)
Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2023: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2022: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2021: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2020: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2019: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Keywords運動制御 / 遠心性コピー / 化学遺伝学 / 皮質電位記録 / 感覚フィードバック / 運動障害 / 霊長類 / 随意運動 / 機能回復 / 感覚予測 / 予測 / 皮質電位 / 上肢 / 脊髄損傷
Outline of Research at the Start

脊髄損傷による運動機能障害から回復する場合、失われた神経連絡や神経機能の「復元」を目指す一方で、患者自身が「思い通りに動かない身体」を受容し、それに対して適切に行動を適応させていくことが重要である。本研究では、1)ウィルスベクターを用いた新しい神経回路操作技術の確立、2)ロボットアームを用いた詳細な行動解析、3)運動制御理論にもとづくシミュレーションを行うことで、脊髄損傷後に1)どのような神経回路によって(where)、2)どのような運動機能が(what)、3)どのようなメカニズムによって(how)、再獲得されているのかを体系的に明らかにする。

Outline of Final Research Achievements

To determine the contribution of the ‘efference copy’ of motor commands to motor control in normal conditions and during motor disorders, we aimed to establish techniques for recording and manipulating the ' efference copy' pathways in non-human primates. First, we attempted to inhibit the neural pathway transmitting 'efference copy' from the corticospinal tract to the lateral reticular nucleus with the chemogenetic tools but failed to show significant behavioural and electrophysiological changes. Therefore, we further recorded the neural activity in the motor-related areas that are the source of motor commands and conducted a detailed behavioural analysis using torque perturbation, which showed neural activity related to preparation for motor responses. These findings have promoted further research to clarify the cortico-cerebellar interaction and their function with regard to 'efference copy' for the preparation of motor responses.

Academic Significance and Societal Importance of the Research Achievements

従来の脊髄損傷に関する研究では、いかに元々の神経連絡や運動機能を「復元」するかということに主眼が置かれてきた。しかし、現段階の技術では完全な神経再生は難しく、また他の神経経路による機能代償も限定的である。そのため、このような不完全な神経回路のもとでは患者自身が「思い通りに動かない身体」を受容してそれに対して自分の行動を適応させること、すなわち運動機能の「復元」ではなく「再獲得」を目指していくことが重要である。本研究成果は、自分の身体状態の把握と考えられる「遠心性コピー」の神経メカニズムの理解を前進させた。この知見を元にさらなる研究により運動障害の神経機構が明らかになると期待される。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (9 results)

All 2024 2023 2022 2021 2020 2019

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 4 results,  Open Access: 5 results) Presentation (4 results) (of which Invited: 2 results)

  • [Journal Article] Neural Network Models for Spinal Implementation of Muscle Synergies2022

    • Author(s)
      Song Yunqing、Hirashima Masaya、Takei Tomohiko
    • Journal Title

      Frontiers in Systems Neuroscience

      Volume: 16

    • DOI

      10.3389/fnsys.2022.800628

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Modeling of hyper-adaptability: from motor coordination to rehabilitation2021

    • Author(s)
      Eberle Harry、Hayashi Yoshikatsu、Kurazume Ryo、Takei Tomohiko、An Qi
    • Journal Title

      Advanced Robotics

      Volume: 35 Issue: 13-14 Pages: 802-817

    • DOI

      10.1080/01691864.2021.1943710

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Distinct sensorimotor feedback loops for dynamic and static control of primate precision grip2020

    • Author(s)
      Tomomichi Oya, Tomohiko Takei, and Kazuhiko Seki
    • Journal Title

      Communications Biology

      Volume: 3 Issue: 1 Pages: 156-156

    • DOI

      10.1038/s42003-020-0861-0

    • NAID

      120006823945

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Forelimb force direction and magnitude independently controlled by spinal modules in the macaque2020

    • Author(s)
      Yaron Amit、Kowalski David、Yaguchi Hiroaki、Takei Tomohiko、Seki Kazuhiko
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 117 Issue: 44 Pages: 27655-27666

    • DOI

      10.1073/pnas.1919253117

    • NAID

      120006892060

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Distinct sensorimotor feedback loops for dynamic and static control of primate precision grip2019

    • Author(s)
      Oya Tomomichi、Takei Tomohiko、Seki Kazuhiko
    • Journal Title

      bioRxiv

      Volume: - Pages: 1-29

    • DOI

      10.1101/640201

    • NAID

      120006823945

    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Presentation] Neural dynamics of macaque ECoG signals during adaptive feedback motor control2024

    • Author(s)
      Akihiro Masaoka, Yosuke Kuroki, Sadataka Fukui,Ryota Masui,Tomohiko Takei
    • Organizer
      玉川大学脳科学ワークショップ2023
    • Related Report
      2023 Annual Research Report
  • [Presentation] Neural dynamics for adaptive feedback motor control2023

    • Author(s)
      武井智彦
    • Organizer
      第46回日本神経科学大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 手の運動制御における筋シナジーの神経基盤2023

    • Author(s)
      武井智彦
    • Organizer
      第9回嚥下シミュレーション研究会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 身体の時間遅れを克服する中枢神経メカニズム2023

    • Author(s)
      武井智彦
    • Organizer
      第14回スポーツ視覚研究会
    • Related Report
      2023 Annual Research Report
    • Invited

URL: 

Published: 2019-04-18   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi