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Investigation of factors influencing the recovery of muscle glycogen after exercise for the development of effective nutritional strategies

Research Project

Project/Area Number 19H04017
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59020:Sports sciences-related
Research InstitutionUniversity of Tsukuba (2020-2022)
National Agency for the Advancement of Sports and Health (2019)

Principal Investigator

Takahashi Hideyuki  筑波大学, 体育系, 教授 (00292540)

Co-Investigator(Kenkyū-buntansha) 亀井 明子  独立行政法人日本スポーツ振興センター国立スポーツ科学センター, スポーツメディカルセンター, 先任研究員 (10276636)
元永 恵子  独立行政法人日本スポーツ振興センター国立スポーツ科学センター, スポーツ研究部, 研究員 (20330516)
小島 千尋  独立行政法人日本スポーツ振興センター国立スポーツ科学センター, スポーツ研究部, 契約研究員 (00845878)
石橋 彩  東京大学, 大学院総合文化研究科, 特別研究員 (40756524)
下山 寛之  筑波大学, 体育系, 助教 (80760652)
近藤 衣美  筑波大学, 体育系, 特別研究員(PD) (50515707)
赤澤 暢彦  独立行政法人日本スポーツ振興センター国立スポーツ科学センター, スポーツ研究部, 契約研究員 (30713250)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2022: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2021: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2020: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Keywords筋グリコーゲン / 磁気共鳴分光法 / 骨格筋 / 炭水化物 / グリコーゲンローディング / 競技種目特性
Outline of Research at the Start

高強度・長時間運動のエネルギー源として骨格筋のグリコーゲン(Gly)は重要であり、筋Glyの減少は運動パフォーマンスの低下や筋疲労に繋がる。したがって、複数回あるいは連日続く試合や練習で良いパフォーマンスを発揮・維持するためには、減少した筋Glyを素早く回復させるための栄養摂取戦略が重要になる。しかしながら、そのような戦略策定に必要となる、筋Gly回復が身体の部位毎、競技種目毎そして個人毎にどのように異なるのか、その差異をもたらす要因は何なのかに関する知見は十分ではない。そこで本研究では、炭素磁気共鳴分光法による非侵襲的な筋Gly測定法を用いて、これらを明らかにすることを目的とする。

Outline of Final Research Achievements

We have newly developed detection coils for magnetic resonance spectroscopy, which enable the measurement of muscle glycogen in the upper arm and forearm regions. It has been shown that the aerobic capacity of muscles is a physiological factor that affects the rate of muscle glycogen recovery after high-intensity exercise. Examining the changes in muscle glycogen concentration through a three-day glycogen loading period, it has been found that the average increase in glycogen concentration is similar in the upper arm and thigh regions. However, the increase in each region within the same subject may not necessarily be equivalent. In experiments measuring muscle glycogen changes in different regions across various sport events, it has been demonstrated that the extent of muscle glycogen changes due to exercise or weight reduction varies depending on the sport event and body region.

Academic Significance and Societal Importance of the Research Achievements

運動による筋グリコーゲン(Gly)の減少はパフォーマンス低下や筋疲労に繋がるため、良いパフォーマンスを発揮・維持するためには、減少した筋Glyを素早く回復させる必要がある。また、同じ量の炭水化物を摂取したとしても、筋Gly濃度の変化には比較的大きな個人差がある。本研究の成果は、競技種目特性や個人特性に応じて、試合に向けたグリコーゲンローディングやトレーニングの計画立案、運動により減少した筋Gly濃度を素早く回復させるための栄養摂取・リカバリー戦略立案のため、そして、今後の基礎的および実践的Gly代謝研究・分野のさらなる発展のために役立つ、重要な基礎的知見になると考えられる。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (32 results)

All 2023 2022 2021 2020 2019

All Journal Article (15 results) (of which Peer Reviewed: 14 results,  Open Access: 5 results) Presentation (17 results) (of which Int'l Joint Research: 6 results,  Invited: 1 results)

  • [Journal Article] Preexercise high-fat meal following carbohydrate loading attenuates glycogen utilization during endurance exercise in male recreational runners2023

    • Author(s)
      Kaito Iwayama, Yoko Tanabe, Katsuhiko Yajima, Fumiya Tanji, Takahiro Onishi, Hideyuki Takahashi
    • Journal Title

      J. Strength Cond. Res.

      Volume: 37 Issue: 3 Pages: 661-668

    • DOI

      10.1519/jsc.0000000000004311

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of three type of muscle glycogen loading interventions using a very-high-carbohydrate diet in an elite male racewalker: a case report2023

    • Author(s)
      Emi Kondo, Eri Takai, Hiroyuki Sagayama, Hideyuki Takahashi
    • Journal Title

      Phys. Act. Nutr.

      Volume: 27 Issue: 1 Pages: 47-54

    • DOI

      10.20463/pan.2023.0006

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Different Carbohydrate Intakes within 24 Hours after Glycogen Depletion on Muscle Glycogen Recovery in Japanese Endurance Athletes2022

    • Author(s)
      Keiko Namma-Motonaga, Emi Kondo, Takuya Osawa, Keisuke Shiose, Akiko Kamei, Motoko Taguchi, Hideyuki Takahashi
    • Journal Title

      Nutrients

      Volume: 14 Issue: 7 Pages: 1430-1430

    • DOI

      10.3390/nu14071320

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Muscle Glycogen Assessment and Relationship with Body Hydration Status: A Narrative Review2022

    • Author(s)
      Keisuke Shiose, Hideyuki Takahashi and Yosuke Yamada
    • Journal Title

      Nutrients

      Volume: 15 Issue: 1 Pages: 155-155

    • DOI

      10.3390/nu15010155

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 筋グリコーゲンの新たな評価手法とその活用法2022

    • Author(s)
      石橋彩, 寺田新, 髙橋英幸
    • Journal Title

      Precision Medicine

      Volume: 5 Pages: 30-33

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Effects of an overnight high-carbohydrate meal on muscle glycogen after rapid weight loss in male collegiate wrestlers2021

    • Author(s)
      Kondo Emi、Shiose Keisuke、Osawa Takuya、Motonaga Keiko、Kamei Akiko、Nakajima Kohei、Sagayama Hiroyuki、Wada Takahiro、Nishiguchi Shigeki、Takahashi Hideyuki
    • Journal Title

      BMC Sports Science, Medicine and Rehabilitation

      Volume: 13 Issue: 1 Pages: 96-96

    • DOI

      10.1186/s13102-021-00325-w

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Muscle glycogen consumption and recovery kinetics using 13C magnetic resonance spectroscopy in semi-professional soccer players: A case study2021

    • Author(s)
      Daisuke Nakamura, Mariko Nakamura, Yoko Tanabe, Keisuke Shiose, Aya Ishibashi, Hideyuki Takahashi
    • Journal Title

      Football Sci.

      Volume: 18 Pages: 43-50

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Augmented muscle glycogen utilization following a single session of sprint training in hypoxia2021

    • Author(s)
      Kasai Nobukazu, Tanji Fumiya, Ishibashi Aya, Ohnuma Hayato, Takahashi Hideyuki, Goto Kazushige, Suzuki Yasuhiro
    • Journal Title

      Eur. J. Appl. Physiol.

      Volume: 121 Issue: 11 Pages: 2981-2991

    • DOI

      10.1007/s00421-021-04748-8

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diurnal variations in muscle and liver glycogen differ depending on the timing of exercise2021

    • Author(s)
      Iwayama Kaito, Tanabe Yoko, Tanji Fumiya, Ohnishi Takahiro, Takahashi Hideyuki
    • Journal Title

      J. Physiol. Sci.

      Volume: 71 Issue: 1 Pages: 35-35

    • DOI

      10.1186/s12576-021-00821-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of low energy availability during three consecutive days of endurance training on iron metabolism in male long distance runners2020

    • Author(s)
      Aya Ishibashi, Chihiro Kojima, Yoko Tanabe, Kaito Iwayama, Tsutomu Hiroyama, Toshiki Tsuji, Akiko Kamei, Kazushige Goto, Hideyuki Takahashi
    • Journal Title

      Physiol. Rep.

      Volume: 8 Issue: 12

    • DOI

      10.14814/phy2.14494

    • NAID

      120007159556

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Validity of Bioimpedance Spectroscopy in the Assessment of Total Body Water and Body Composition in Wrestlers and Untrained Subjects2020

    • Author(s)
      Shiose Keisuke、Kondo Emi、Takae Rie、Sagayama Hiroyuki、Motonaga Keiko、Yamada Yosuke、Uehara Yoshinari、Higaki Yasuki、Takahashi Hideyuki、Tanaka Hiroaki
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 17 Issue: 24 Pages: 9433-9433

    • DOI

      10.3390/ijerph17249433

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Urinary N-Terminal Fragment of Titin Reflects Muscle Damage After a Soccer Match in Male Collegiate Soccer Players2020

    • Author(s)
      Tanabe Yoko、Shimizu Kazuhiro、Kondo Emi、Yasumatsu Mikinobu、Nakamura Daisuke、Sagayama Hiroyuki、Takahashi Hideyuki
    • Journal Title

      Journal of Strength and Conditioning Research

      Volume: 35 Issue: 2 Pages: 360-365

    • DOI

      10.1519/jsc.0000000000003923

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Muscle glycogen content during endurance training under low energy availability2020

    • Author(s)
      Chihiro Kojima, Aya Ishibashi, Yoko Tanabe, Kaito Iwayama, Akiko Kamei, Hideyuki Takahashi, Kazushige Goto
    • Journal Title

      Med. Sci. Sports Exerc.

      Volume: 52 Issue: 1 Pages: 187-195

    • DOI

      10.1249/mss.0000000000002098

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Diurnal variation in the glycogen content of the human liver using 13C MRS2020

    • Author(s)
      Kaito Iwayama, Takahiro Onishi, Katsuya Maruyama, Hideyuki Takahashi
    • Journal Title

      NMR in Biomedicine

      Volume: 33 Issue: 6

    • DOI

      10.1002/nbm.4289

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of Thoracic Gas Volume Changes on Body Composition Assessed by Air Displacement Plethysmography after Rapid Weight Loss and Regain in Elite Collegiate Wrestlers2019

    • Author(s)
      Kondo Emi、Shiose Keisuke、Yamada Yosuke、Osawa Takuya、Sagayama Hiroyuki、Motonaga Keiko、Ouchi Shiori、Kamei Akiko、Nakajima Kohei、Takahashi Hideyuki、Okamura Koji
    • Journal Title

      Sports

      Volume: 7 Issue: 2 Pages: 48-48

    • DOI

      10.3390/sports7020048

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 運動を伴わないグリコーゲンローディング効果の部位差に関する研究2022

    • Author(s)
      小島千尋, 元永恵子, 亀井明子, 高橋祐美子, 石橋彩, 髙橋英幸
    • Organizer
      第77回日本体力医学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 運動前の多価不飽和脂肪酸摂取がグリコーゲン利用に及ぼす影響2022

    • Author(s)
      岩山海渡, 田名辺陽子, 矢島克彦, 丹治史弥, 大西貴弘, 髙橋英幸
    • Organizer
      第77回日本体力医学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 女子陸上中長距離選手の月経有無及び栄養状態の実態把握2022

    • Author(s)
      高井恵理, 石井美子, 近藤衣美, 中村真理子, 髙橋英幸, 能瀬さやか, 亀井明子
    • Organizer
      第33回日本臨床スポーツ医学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Effect of carbohydrate supplementation on endocrine and muscle glycogen contents in amenorrheic runners2022

    • Author(s)
      Akiko Kamei, Eri Takai, Yoshiko Ishii, Emi Kondo, Mariko Nakamura, Hideyuki Takahashi, Sayaka Nose-Ogura
    • Organizer
      International Sport + Exercise Nutrition Conference 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 男性エリート競歩選手におけるグリコーゲンローディングのための糖質摂取量の事例検討2021

    • Author(s)
      近藤衣美, 高井恵里, 髙橋英幸
    • Organizer
      日本スポーツ栄養学会第7回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Influence of the menstrual cycle on muscle glycogen utilization with high-intensity intermittent exercise until exhaustion in eumenorrheic women2021

    • Author(s)
      Tomoka Matsuda, Hideyuki Takahashi, Mariko Nakamura, Moe Kanno, Hazuki Ogata, Akira Ishikawa, Mizuki Yamada, Akiko Funaki, Hyunjun Gam, Nodoka Ikegami, Mikako Sakamaki-Sunaga
    • Organizer
      26th Annual Congress of the European College of Sport Science
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Evaluation of muscle damage by urinary N-terminal fragment of titin after a soccer match in male collegiate soccer players2021

    • Author(s)
      Yoko Tanabe, Kazuhiro Shimizu, Emi Kondo, Mikinobu Yasumatsu, Daisuke Nakamura, Hiroyuki Sagayama, Hideyuki Takahashi
    • Organizer
      ARIHHP Human High Performance Forum 2021
    • Related Report
      2020 Annual Research Report
  • [Presentation] 月経周期が長時間の高強度間欠的運動時の筋グリコーゲン濃度に及ぼす影響2020

    • Author(s)
      松田知華, 緒方はづき, 菅野萌, 石川明良, 山田満月, 亀本佳世子, 甘賢俊, 小泉和史, 中村真理子, 髙橋英幸, 須永美歌子
    • Organizer
      第75回日本体力医学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 大学生自転車選手における自転車スプリントパフォーマンスと殿筋の筋量の関係2020

    • Author(s)
      石井泰光, 山口大貴, 黒川剛, 髙橋英幸
    • Organizer
      第75回日本体力医学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Proton, phosphorous, and carbon magnetic resonance spectroscopy technique (MRS) for monitoring of training and performance in athletes2019

    • Author(s)
      Hideyuki Takahashi
    • Organizer
      24th Annual Congress of the European College of Sport Science
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Pre-match muscle glycogen levels of three matches in 1 week based on high carbohydrate intake2019

    • Author(s)
      Daisuke Nakamura, Mikinori Yasumatsu, Akinori Tobita, Mariko Nakamura, Yoko Tanabe, Kaito Iwayama, Keisuke Shiose, Aya Ishibashi, Hideyuki Takahashi
    • Organizer
      24th Annual Congress of the European College of Sport Science
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of high-carbohydrate meal on muscle glycogen and physical performance after rapid weight loss in elite collegiate wrestlers2019

    • Author(s)
      Emi Kondo, Keisuke Shiose, Hiroyuki Sagayama, Keiko Motonaga, Mio Nishimaki, Daichi Yamashita, Akiko Kamei, Kohei Nakajima, Shigeki Nishiguchi, Hideyuki Takahashi
    • Organizer
      24th Annual Congress of the European College of Sport Science
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of hypoxia on power outputs and muscle glycogen utilization during repeated sprints2019

    • Author(s)
      Takuya Osawa, Emi Kondo, Hideyuki Takahashi
    • Organizer
      24th Annual Congress of the European College of Sport Science
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] スキー・コンバインドナショナルチーム選手における運動後の異なる炭水化物の摂取量が翌朝の骨格筋グリコーゲンの回復に及ぼす影響2019

    • Author(s)
      石橋彩, 谷中拓哉, 山辺芳, 久保貴寛, 河野孝典, 亀井明子, 石毛勇介, 髙橋英幸
    • Organizer
      日本スポーツ栄養学会第6回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 運動後の筋グリコーゲン回復速度に筋の有酸素性能力が影響を及ぼす2019

    • Author(s)
      髙橋英幸, 塩瀬圭佑, 岩山海渡, 下山寛之, 元永恵子, 丸山克也
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 運動するタイミングの違いが骨格筋および肝臓グリコーゲン濃度の変動に及ぼす影響2019

    • Author(s)
      岩山海渡, 田名辺陽子, 丹治史弥, 大西貴弘, 丸山克也, 髙橋英幸
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] レスリング選手の試合前日の高糖質食摂取が試合当日の筋グリコーゲン濃度に及ぼす影響2019

    • Author(s)
      近藤衣美, 下山寛之, 石井泰光, 山下大地, 西牧未央, 岩山海渡, 元永恵子, 亀井明子, 和田貴広, 朝倉利夫, 富山英明, 西口茂樹, 中嶋耕平, 髙橋英幸
    • Organizer
      第74回日本体力医学会大会
    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2024-01-30  

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