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Estimation of cognitive error risk by using neurofeedback driven dynamic functional connectivity

Research Project

Project/Area Number 19H04025
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 59030:Physical education, and physical and health education-related
Research InstitutionOsaka University

Principal Investigator

Nakai Toshiharu  大阪大学, 歯学研究科, 招へい教授 (30344170)

Co-Investigator(Kenkyū-buntansha) Bagarinao E.  名古屋大学, 医学系研究科(保健), 准教授 (00443218)
加藤 昇平  名古屋工業大学, 工学(系)研究科(研究院), 教授 (70311032)
鈴木 敦命  東京大学, 大学院人文社会系研究科(文学部), 准教授 (80547498)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
Keywordsニューロフィードバック / fMRI / BMI / 運動処方 / 加齢 / 運動認知訓練 / 脳機能計測 / 神経機能動態結合 / 動的神経結合 / 神経フィードバック / 認知機能予備能力 / 運動・認知訓練
Outline of Research at the Start

加齢により認知機能の予備能力(CR)が減少すると普段は明確な支障が無くても強い認知負荷が加わると急に認知過誤が発生して適切な対応ができず、予期せぬ事故や問題を引き起こしうる。本研究では高齢者に対する神経リハビリを最適化するために、神経回路の可塑的変化を非侵襲脳機能計測と行動データに基づいて定量化する手法を開発する。運動・認知機能の個人差が大きい高齢者のCRを推定する方法として神経フィードバック制御型の神経結合動態計測法を開発する。加速度計を使った日常動作記録や神経心理検査との相関を機械学習(AI分析)により明らかにし、指標の連続的拡張性を確保する。

Outline of Final Research Achievements

Real-time functional magnetic resonance imaging, coupled with machine learning to operate a small humanoid robot to give visual feedback of body coordinate representation, has enabled real-time classification of brain activation patterns that could represent performance of motor imagery. It was suggested that such neurofeedback (NF) training could be characterized by dynamic changes of activation patterns as the training progressed to estimate cognitive reserve (CR) in older adults. By employing updating of the used classifier every after feedback-scan to account for its temporal change, and combining with two-dimensional expansion of the classifier, 4 classes separation of the imagery movements (right/left, hand/foot) could be successfully demonstrated in both age groups. Detection and accuracy rate of imagery assignment in older subjects suggested that NF trainings are valid to evaluate CR for risk assessments in their daily life.

Academic Significance and Societal Importance of the Research Achievements

NF計測に基づく学習過程で観測される脳活動の時間軸変化と行動データの相関觧析から得られる諸指標は運動学習を通した認知機能の予備能力(cognitive reserve)を推定する指標として応用が期待される。近年、高齢者を対象とした健康増進事業が盛んであるが、今後個人の認知機能の状態を考慮しながら運動処方を最適化し、日常生活リスクを推定する上で參考指標のひとつとなろう。また、身体座標感覚に近似させた、より直感的なBMI操作の実現に寄与すると期待される。国際ワークショップ(BrainConnects)の運営を通してASEAN諸国との共同研究と人事交流をより一層推進出来た。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (44 results)

All 2022 2021 2020 2019 Other

All Int'l Joint Research (14 results) Journal Article (14 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 14 results,  Open Access: 10 results) Presentation (13 results) (of which Int'l Joint Research: 12 results,  Invited: 3 results) Book (1 results) Funded Workshop (2 results)

  • [Int'l Joint Research] 南洋理工大学(シンガポール)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] 國立精華大學(台湾)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Vietnam National Uni., Ho Chi Minh City(ベトナム)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] University of the Philippines Diliman(フィリピン)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] The Chinese University of Hong Kong(Hong Kong)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Nanyang Technological University/National Institute of Education(シンガポール)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] University of California San Diego(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] 南洋理工大学(シンガポール)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] 國立精華大學(台湾)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] University of the Philippines Dilman(フィリピン)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Vietnam National Uni., Ho Chi Minh City(ベトナム)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Universiti Teknologi PETRONAS(マレーシア)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Evaluation of the Effects of Magnetic Field Exposure on Body Sway2022

    • Author(s)
      Yamaguchi‐Sekino Sachiko、Iwakiri Kazuyuki、Sekino Masaki、Nakai Toshiharu
    • Journal Title

      IEEJ Transactions on Electrical and Electronic Engineering

      Volume: Trans 2022 Issue: 7 Pages: 1-5

    • DOI

      10.1002/tee.23587

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Verbal Training Induces Enhanced Functional Connectivity in Japanese Healthy Elderly Population2022

    • Author(s)
      Yang Fan-Pei Gloria、Liu Tzu-Yu、Liu Chih-Hsuan、Murakami Shumei、Nakai Toshiharu
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 16 Pages: 1-10

    • DOI

      10.3389/fnhum.2022.786853

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Aging patterns of Japanese auditory semantic processing: an fMRI study2022

    • Author(s)
      Liu Hengshuang、Miyakoshi Makoto、Nakai Toshiharu、Annabel Chen Shen-Hsing
    • Journal Title

      Aging, Neuropsychology, and Cognition

      Volume: 29 Issue: 2 Pages: 213-236

    • DOI

      10.1080/13825585.2020.1861202

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Reserve and Maintenance in the Aging Brain: A Longitudinal Study of Healthy Older Adults2022

    • Author(s)
      Bagarinao Epifanio、Watanabe Hirohisa、Maesawa Satoshi、Kawabata Kazuya、Hara Kazuhiro、Ohdake Reiko et al.
    • Journal Title

      eneuro

      Volume: 9 Issue: 1 Pages: 1-10

    • DOI

      10.1523/eneuro.0455-21.2022

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Resting State Networks Related to the Maintenance of Good Cognitive Performance During Healthy Aging2021

    • Author(s)
      Maesawa Satoshi、Mizuno Satomi、Bagarinao Epifanio、Watanabe Hirohisa、Kawabata Kazuya、Hara Kazuhiro、Ohdake Reiko、Ogura Aya、Mori Daisuke、Nakatsubo Daisuke、Isoda Haruo、Hoshiyama Minoru、Katsuno Masahisa、Saito Ryuta、Ozaki Norio、Sobue Gen
    • Journal Title

      Frontiers in Human Neuroscience

      Volume: 15 Pages: 1-10

    • DOI

      10.3389/fnhum.2021.753836

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bridging large-scale cortical networks: Integrative and function-specific hubs in the thalamus2021

    • Author(s)
      Kawabata Kazuya、Bagarinao Epifanio、Watanabe Hirohisa、Maesawa Satoshi、Mori Daisuke、Hara Kazuhiro、Ohdake Reiko、Masuda Michihito、Ogura Aya、Kato Toshiyasu、Koyama Shuji、Katsuno Masahisa、Wakabayashi Toshihiko、Kuzuya Masafumi、Hoshiyama Minoru、Isoda Haruo、Naganawa Shinji、Ozaki Norio、Sobue Gen
    • Journal Title

      iScience

      Volume: 24 Issue: 10 Pages: 103106-103106

    • DOI

      10.1016/j.isci.2021.103106

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Characteristics of Neural Network Changes in Normal Aging and Early Dementia2021

    • Author(s)
      Watanabe Hirohisa、Bagarinao Epifanio、Maesawa Satoshi、Hara Kazuhiro、Kawabata Kazuya、Ogura Aya、Ohdake Reiko、Shima Sayuri、Mizutani Yasuaki、Ueda Akihiro、Ito Mizuki、Katsuno Masahisa、Sobue Gen
    • Journal Title

      Frontiers in Aging Neuroscience

      Volume: 13 Pages: 1-10

    • DOI

      10.3389/fnagi.2021.747359

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fiber‐specific white matter analysis reflects upper motor neuron impairment in amyotrophic lateral sclerosis2021

    • Author(s)
      Ogura Aya、Kawabata Kazuya、Watanabe Hirohisa、Choy Shao Wei、Bagarinao Epifanio、Kato Toshiyasu、Imai Kazunori、Masuda Michihito、Ohdake Reiko、Hara Kazuhiro、Nakamura Ryoichi、Atsuta Naoki、Nakamura Tomohiko、Katsuno Masahisa、Sobue Gen
    • Journal Title

      European Journal of Neurology

      Volume: 29 Issue: 2 Pages: 432-440

    • DOI

      10.1111/ene.15136

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Do individual differences in face recognition ability moderate the other ethnicity effect?2021

    • Author(s)
      Childs Michael Jeanne、Jones Alex、Thwaites Peter、Zdravkovic Suncica、Thorley Craig、Suzuki Atsunobu、Shen Rachel、Ding Qi、Burns Edwin、Xu Hong、Tree Jeremy J.
    • Journal Title

      Journal of Experimental Psychology: Human Perception and Performance

      Volume: 47 Issue: 7 Pages: 893-907

    • DOI

      10.1037/xhp0000762

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Improving Real-Time Brain State Classification of Motor Imagery Tasks During Neurofeedback Training2020

    • Author(s)
      Bagarinao Epifanio、Yoshida Akihiro、Terabe Kazunori、Kato Shohei、Nakai Toshiharu
    • Journal Title

      Frontiers in Neuroscience

      Volume: 14

    • DOI

      10.3389/fnins.2020.00623

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of screening tool as subjective measure to identify older adults at risk of dependency in Japan: Multivariate regression analysis between objective and subjective measures2020

    • Author(s)
      Tanakka Ayuko , Nakai Toshiharu
    • Journal Title

      International Journal of Gerontology

      Volume: 14 Pages: 99-103

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aging Patterns of Japanese Auditory Semantic Processing: An fMRI Study2020

    • Author(s)
      Liu HengSheng, Miyakoshi Makoto, Nakai Toshiharu, Chen SH Annabel
    • Journal Title

      Aging, Neuropsychology and Cognition

      Volume: 28 Pages: 1-24

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Trust2020

    • Author(s)
      Chen S.H. Annabel、Suzuki Atsunobu
    • Journal Title

      Encyclopedia of behavioural neuroscience

      Volume: 2 Eds Pages: 532-539

    • DOI

      10.1016/b978-0-12-819641-0.00064-5

    • ISBN
      9780128216361
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Reorganization of brain networks and its association with general cognitive performance over the adult lifespan.2019

    • Author(s)
      Epifanio Bagarinao, Hirohisa Watanabe, Satoshi Maesawa, Daisuke Mori, Kazuhiro Hara, Kazuya Kawabata, Noritaka Yoneyama, Reiko Ohdake,…他 Haruo Isoda, Shinji Naganawa, Gen Sobue
    • Journal Title

      Sci Rep.

      Volume: 9(1) Issue: 1 Pages: 11352-11352

    • DOI

      10.1038/s41598-019-47922-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Bias towards trusting others is associated with insular activity before distrusting others2021

    • Author(s)
      uzuki A, Ueno M, Ishikawa K, Kobayashi A, Okubo M, Nakai T
    • Organizer
      The 62nd annual meeting of Psychonomic Society
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Age Related Change of Brain Activation during NF-fMRI Training Using a Small Humanoid Robot Agent2020

    • Author(s)
      Nakai T, Yoshida A, Ueno M, Kato S, Bagarinao E
    • Organizer
      Human Brain Mapping 2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Perception and learning of others’ trustworthiness in healthy older adults.2020

    • Author(s)
      Suzuki A
    • Organizer
      Online Workshop 2020 on Sustainable Development, Karolinska Institutet, KTH Royal Institute of Technology, and Stockholm University
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Improving SVM’s Classification Performance during Real-Time Neurofeedback Training2019

    • Author(s)
      Bagarinao E, Yoshida Y, Terabe K, Kato S, Nakai T
    • Organizer
      Real-time Functional Imaging and Neurofeedback Conference, Symposium 1-3, Poster #86
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Limited Metacognitive Awareness to the Accuracy of Face-Based Trait Inference2019

    • Author(s)
      Suzuki A, Ueno M, Ishikawa K, Kobayashi A, Okubo M, Nakai T
    • Organizer
      60th Annual Meeting of Psychonomic Society #4073
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Overview of functional neuroimaging and the principles of fMRI (educationnal course)2019

    • Author(s)
      Nakai T
    • Organizer
      BrainConnects 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Functional Changes of Aging Brain and Brain Reserve (symposium)2019

    • Author(s)
      Nakai T
    • Organizer
      BrainConnects 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] The Activation in the DLPFC as the Marker of Cognitive Reserve for Attentional Processing During Task Switching in Older Adults2019

    • Author(s)
      Yoshida A, Isoda H, Nakai T
    • Organizer
      BrainConnects 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Age-related differences in emotion and social cognition2019

    • Author(s)
      Suzuki, A
    • Organizer
      BrainConnects 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Multi-ROI 3D-CNNs: a Generalized Discriminator of Motor Imagery from a Functional Brain Image2019

    • Author(s)
      Nakano T, Kato S, Bagarinao E, Yoshida A, Ueno M, Nakai T
    • Organizer
      The 24th Annual Meeting of Organization for Human Brain Mapping # M436
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Incremental SVM training improves real-time neurofeedback brain state classification2019

    • Author(s)
      Bagarinao E, Yoshida A, Terabe K, Kato S, Nakai T
    • Organizer
      The 24th Annual Meeting of Organization for Human Brain Mapping # Th605
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Aging patterns of Japanese auditory semantic processing: an fMRI study2019

    • Author(s)
      Liu H, Miyakoshi M, Nakai T, Chen SHA
    • Organizer
      Eleventh Annual Meeting of the Society for the Neurobiology of Language
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 顔で人柄がわかると信じる人の顔特性推論は実際に正確か2019

    • Author(s)
      鈴木敦命, 江見美果, 石川健太, 小林晃洋, 大久保街亜, 中井敏晴
    • Organizer
      日本心理学会第83回大会
    • Related Report
      2019 Annual Research Report
  • [Book] MRI安全性の考え方 第3版 第一章 MRIの安全性 総論 pp.16-262021

    • Author(s)
      中井敏晴
    • Total Pages
      327
    • Publisher
      学研メディカル秀潤社
    • ISBN
      9784780904178
    • Related Report
      2021 Annual Research Report
  • [Funded Workshop] BrainConnects 2021 - Advanced Neurotechnology and Personalized Modeling for Brain Diseases2021

    • Related Report
      2021 Annual Research Report
  • [Funded Workshop] BrainConnects 2019 (Manila)2019

    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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