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Central regulatory mechanisms of Drosophila nociception mediated by an evolutionarily conserved neuropeptide

Research Project

Project/Area Number 19K06935
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 46030:Function of nervous system-related
Research InstitutionNational Center for Geriatrics and Gerontology (2020-2022)
University of Tsukuba (2019)

Principal Investigator

Honjo Ken  国立研究開発法人国立長寿医療研究センター, 研究所 認知症先進医療開発センター, 研究員 (50731866)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2019: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords痛覚 / 下行性抑制 / 侵害受容 / コレシストキニン / 神経ぺプチド / ショウジョウバエ / 疼痛 / CCK / DSK / 下行性制御
Outline of Research at the Start

我々の痛みのメカニズムは未だによくわかっていない。多様なモデル動物の利点を生かした研究は、視覚や嗅覚など他の感覚の研究同様、痛みのメカニズム解明を進める上でも重要と考えられる。しかし、哺乳類以外の動物にヒトの痛み制御と共通のメカニズムが見られるかは未知である。私はこれまでの研究で、中枢性制御機構と呼ばれるヒトの痛み制御で中心的な役割を果たすメカニズムが、ショウジョウバエに存在する可能性を見出してきた。そこで本研究では、ショウジョウバエの優れた実験手法を駆使し、ショウジョウバエの中枢神経系における中枢性の侵害受容制御機構の存在検証を進めていく。

Outline of Final Research Achievements

Using vrious model organisms should be beneficial to elucidate the complex control mechanisms of human pain. However, it has been largely unclear whether and to what extent the pain signaling control mechanisms found in the central nervous system of humans and mammals are conserved in non-mammalian animals. Using powerful neurogenetic experimental tools in the fruit flies (Drosophila melanogaster), this study has successfully identified the presence of descending nociceptive control mechanisms in the Drosophila brain, which play an important role in pain control of mammals including humans.

Academic Significance and Societal Importance of the Research Achievements

本研究はヒトや哺乳類で疼痛制御に重要な役割を果たす下行性侵害受容抑制のメカニズムを、史上初めて哺乳類以外の動物に発見したものである。昆虫であるショウジョウバエと哺乳類との間で下行性侵害受容抑制のメカニズムが分子レベルで保存されているという本研究で明らかとなった事実は、脳の下行性侵害受容抑制機能が脊椎動物と無脊椎動物の共通祖先で生じたという新しい仮説を提唱するものである。また本研究の成果は、ショウジョウバエなどの無脊椎動物が痛覚の中枢性制御の研究においてもモデルとして利用できる可能性を支持するものである。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • 2019 Research-status Report
  • Research Products

    (9 results)

All 2023 2022 2021 2020 2019

All Journal Article (2 results) (of which Peer Reviewed: 1 results,  Open Access: 2 results) Presentation (7 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results)

  • [Journal Article] A descending inhibitory mechanism of nociception mediated by an evolutionarily conserved neuropeptide system in Drosophila2023

    • Author(s)
      Oikawa Izumi、Kondo Shu、Hashimoto Kao、Yoshida Akiho、Hamajima Megumi、Tanimoto Hiromu、Furukubo-Tokunaga Katsuo、Honjo Ken
    • Journal Title

      eLife

      Volume: -

    • DOI

      10.7554/elife.85760

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A descending inhibitory mechanism of nociception mediated by an evolutionarily conserved neuropeptide system in Drosophila2022

    • Author(s)
      Izumi Oikawa, Shu Kondo, Kao Hashimoto, Akiho Kashiwabara, Hiromu Tanimoto, Katsuo Furukubo-Tokunaga, Ken Honjo
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2022.03.08.483420

    • Related Report
      2021 Research-status Report
    • Open Access
  • [Presentation] Descending inhibitory mechanism of nociception mediated by an evolutionarily conserved neuropeptide system in Drosophila2022

    • Author(s)
      Honjo, K., Oikawa, I., Kondo, S., Kashiwabara, A., Tanimoto, H., Furukubo-Tokunaga, K.
    • Organizer
      第45回日本基礎老化学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Descending inhibition of nociception mediated by an evolutionally conserved neuropeptide system in Drosophila2021

    • Author(s)
      Oikawa, I., Kondo, S., Hashimoto, K., Kashiwabara, A., Tanimoto, H., Furukubo-Tokunaga, K. and Honjo, K.
    • Organizer
      JDRC14
    • Related Report
      2021 Research-status Report
  • [Presentation] A neuropeptide-mediated descending inhibitory pathway in Drosophila nociception2020

    • Author(s)
      Oikawa, I., Kondo, S., Hashimoto, K., Kashiwabara, A., Tanimoto, H., Furukubo-Tokunaga, K. and Honjo, K.
    • Organizer
      第43回日本分子生物学会年会・ワークショップ「広がる感覚器の世界・感覚器の多様性を生み出す分子基盤とヒト健康維持への応用」
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] A neuropeptide-mediated descending inhibitory pathway in Drosophila nociception2020

    • Author(s)
      Oikawa, I., Kondo, S., Hashimoto, K., Kashiwabara, A., Tanimoto, H., Furukubo-Tokunaga, K. and Honjo, K
    • Organizer
      第43回神経科学会大会・シンポジウム「五感の情報処理 ~感覚情報処理機構の統一的理解に向けて~」
    • Related Report
      2020 Research-status Report
  • [Presentation] A neuropeptide-mediated descending inhibitory pathway in Drosophila nociception.2020

    • Author(s)
      Oikawa, I., Kondo, S., Kashiwabara, A., Hashimoto, K., Tanimoto, H., Furukubo-Tokunaga, K. and Honjo, K.
    • Organizer
      International Workshop on Frontiers in Defensive Survival Circuit Research
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research
  • [Presentation] An evolutionarily conserved neuropeptide pathway that negatively regulates nociception in Drosophila.2019

    • Author(s)
      Oikawa, I., Kondo, S., Kashiwabara, A., Tanimoto, H., Furukubo-Tokunaga, K. and Honjo, K.
    • Organizer
      Neuro2019(第42回日本神経科学大会・第62回日本神経化学会大会 合同大会)
    • Related Report
      2019 Research-status Report
  • [Presentation] A neuropeptide-mediated descending inhibitory pathway in Drosophila nociception.2019

    • Author(s)
      Oikawa, I., Kondo, S., Kashiwabara, A., Tanimoto, H., Furukubo-Tokunaga, K. and Honjo, K.
    • Organizer
      The 48th Naito Conference
    • Related Report
      2019 Research-status Report
    • Int'l Joint Research

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Published: 2019-04-18   Modified: 2024-01-30  

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