Development of therapeutic approach to diabetes-related vascular dysfunction targeting DNA sensors

• Project/Area Number: 19K08584
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: Osaka City University (2021); The University of Tokushima (2019-2020)
• Principal Investigator: FUKUDA Daiju 大阪市立大学, 大学院医学研究科, 教授 (40637568)
• Co-Investigator(Kenkyū-buntansha): 佐田 政隆 徳島大学, 大学院医歯薬学研究部(医学域), 教授 (80345214)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2019: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 血管内皮機能障害 / 炎症 / 核酸受容体 / 自然免疫 / 糖尿病 / 血管内皮機能 / STING / 慢性炎症 / 動脈硬化

Outline of Research at the Start

糖尿病による血管病の予防が糖尿病患者の予後の改善に重要である。さまざまな血糖降下薬が存在するが、糖尿病性血管合併症の予防効果は不十分である。血管障害の初期段階である血管内皮機能障害は糖尿病性血管障害の原因として注目されているが、その機序や治療方法の開発はなされていない。本研究では、高血糖で障害を受けた細胞から遊離する核酸断片とその受容体である核酸受容体を介した慢性炎症の役割に注目し、新しい糖尿病性血管内皮機能障害の予防・治療方法の開発を目指す。

Outline of Final Research Achievements

Diabetes mellitus accelerates endothelial dysfunction; however, the underlying mechanism is not fully understood. Induction of diabetes to wild-type mice by streptozotocin injection promoted DNA damage and increased STING expression in the aorta. Induction of diabetes to wild-type mice impaired endothelium-dependent vascular relaxation, while genetic deletion of STING in diabetic wild-type mice attenuated endothelial dysfunction compared with diabetic wild-type. A direct STING agonist, cGAMP, or mitochondrial DNA treatment increased inflammatory molecule expression and decreased eNOS phosphorylation in human umbilical vein endothelial cells. Furthermore, administration of C-176 to diabetic wild-type mice ameliorated endothelial dysfunction. STING activation caused by diabetic change accelerates sterile inflammation in endothelial cells and impairs endothelial function. STING signaling may be a potential therapeutic target for diabetes-induced endothelial dysfunction.

Academic Significance and Societal Importance of the Research Achievements

糖尿病の最大の合併症である血管病の予防は、糖尿病患者の予後改善のために不可欠である。血管内皮機能障害は血管合併症の初期段階であり、可逆的であるために治療標的と考えられているが、現在の血糖降下を主体とする糖尿病治療では、血管内皮機能障害の予防や治療効果は不十分である。よって、糖尿病による血管病の発症予防は、依然として重大なアンメットニーズであり、糖尿病性血管障害の予防・治療には異なるアプローチが必要であると考えられる。本研究は、血管の炎症と機能障害に対する治療標的としての核酸受容体STINGの可能性を示唆しており、糖尿病性血管機能障害の新規治療方針の開発につながることが期待される。

Research Products

• [Journal Article] Activated Factor X Signaling Pathway via Protease-Activated Receptor 2 Is a Novel Therapeutic Target for Preventing Atrial Fibrillation (2021)
  • Author(s): Matsuura Tomomi、Soeki Takeshi、Fukuda Daiju、Uematsu Etsuko、Tobiume Takeshi、Hara Tomoya、Kusunose Kenya、Ise Takayuki、Yamaguchi Koji、Yagi Shusuke、Yamada Hirotsugu、Wakatsuki Tetsuzo、Sata Masataka
  • Journal Title: Circulation Journal Volume: 85 Issue: 8 Pages: 1383-1391
  • DOI: 10.1253/circj.CJ-20-1006
  • NAID: 130008066728
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2021-07-21
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of S1P Receptor 2 Attenuates Endothelial Dysfunction and Inhibits Atherogenesis in Apolipoprotein E-Deficient Mice (2021)
  • Author(s): Ganbaatar Byambasuren、Fukuda Daiju、Shinohara Masakazu、Yagi Shusuke、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Hirata Ken-ichi、Sata Masataka
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 28 Issue: 6 Pages: 630-642
  • DOI: 10.5551/jat.54916
  • NAID: 130008046582
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2021-06-01
  • Peer Reviewed / Open Access
• [Journal Article] Cardiac reserve by 6-minute walk stress echocardiography in systemic sclerosis (2021)
  • Author(s): Arase Miharu、Kusunose Kenya、Morita Sae、Yamaguchi Natsumi、Hirata Yukina、Nishio Susumu、Okushi Yuichiro、Ise Takayuki、Tobiume Takeshi、Yamaguchi Koji、Fukuda Daiju、Yagi Shusuke、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka
  • Journal Title: Open Heart Volume: 8 Issue: 1 Pages: e001559-e001559
  • DOI: 10.1136/openhrt-2020-001559
  • NAID: 120007174426
  • Peer Reviewed / Open Access
• [Journal Article] Frontiers of inflammatory disease research: inflammation in cardiovascular?cerebral diseases (2021)
  • Author(s): Fukuda Daiju、Sata Masataka
  • Journal Title: Inflammation and Regeneration Volume: 41 Issue: 1 Pages: 10-10
  • DOI: 10.1186/s41232-021-00160-z
  • NAID: 120007164931
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Utility of Overlap Time for Incomplete Relaxation to Predict Cardiac Events in Heart Failure (2021)
  • Author(s): Kusunose Kenya、Arase Miharu、Zheng Robert、Hirata Yukina、Nishio Susumu、Ise Takayuki、Yamaguchi Koji、Fukuda Daiju、Yagi Shusuke、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka
  • Journal Title: Journal of Cardiac Failure Volume: 27 Issue: 11 Pages: 1222-1230
  • DOI: 10.1016/j.cardfail.2021.05.018
  • Peer Reviewed
• [Journal Article] Association between Vitamin D and Heart Failure Mortality in 10,974 Hospitalized Individuals (2021)
  • Author(s): Kusunose Kenya、Okushi Yuichiro、Okayama Yoshihiro、Zheng Robert、Abe Miho、Nakai Michikazu、Sumita Yoko、Ise Takayuki、Tobiume Takeshi、Yamaguchi Koji、Yagi Shusuke、Fukuda Daiju、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka
  • Journal Title: Nutrients Volume: 13 Issue: 2 Pages: 335-335
  • DOI: 10.3390/nu13020335
  • NAID: 120007174427
  • Peer Reviewed / Open Access
• [Journal Article] Use of Echocardiography and Heart Failure In-Hospital Mortality from Registry Data in Japan (2021)
  • Author(s): Kusunose Kenya、Okushi Yuichiro、Okayama Yoshihiro、Zheng Robert、Nakai Michikazu、Sumita Yoko、Ise Takayuki、Yamaguchi Koji、Yagi Shusuke、Fukuda Daiju、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka
  • Journal Title: Journal of Cardiovascular Development and Disease Volume: 8 Issue: 10 Pages: 124-124
  • DOI: 10.3390/jcdd8100124
  • Peer Reviewed / Open Access
• [Journal Article] Predictive value of left atrial function for latent paroxysmal atrial fibrillation as the cause of embolic stroke of undetermined source (2021)
  • Author(s): Kusunose Kenya、Takahashi Hironori、Nishio Susumu、Hirata Yukina、Zheng Robert、Ise Takayuki、Yamaguchi Koji、Yagi Shusuke、Fukuda Daiju、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Shimada Kenji、Kanematsu Yasuhisa、Takagi Yasushi、Sata Masataka
  • Journal Title: Journal of Cardiology Volume: 78 Issue: 5 Pages: 355-361
  • DOI: 10.1016/j.jjcc.2021.05.005
  • Peer Reviewed
• [Journal Article] Comparison of Direct Oral Anticoagulants for Acute Hospital Mortality in Venous Thromboembolism (2021)
  • Author(s): Okushi Yuichiro、Kusunose Kenya、Nakai Michikazu、Sumita Yoko、Ise Takayuki、Yamaguchi Koji、Yagi Shusuke、Fukuda Daiju、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka
  • Journal Title: American Journal of Cardiovascular Drugs Volume: in press Issue: 4 Pages: 407-416
  • DOI: 10.1007/s40256-021-00514-5
  • Peer Reviewed
• [Journal Article] Acute Hospital Mortality of Venous Thromboembolism in Patients With Cancer From Registry Data (2021)
  • Author(s): Okushi Yuichiro、Kusunose Kenya、Okayama Yoshihiro、Zheng Robert、Nakai Michikazu、Sumita Yoko、Ise Takayuki、Tobiume Takeshi、Yamaguchi Koji、Yagi Shusuke、Fukuda Daiju、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka
  • Journal Title: Journal of the American Heart Association Volume: 10 Issue: 11 Pages: 10-10
  • DOI: 10.1161/jaha.120.019373
  • Peer Reviewed / Open Access
• [Journal Article] STING, a cytosolic DNA sensor, plays a critical role in atherogenesis: a link between innate immunity and chronic inflammation caused by lifestyle-related diseases (2021)
  • Author(s): Pham Phuong Tran、Fukuda Daiju、Nishimoto Sachiko、Kim-Kaneyama Joo-Ri、Lei Xiao-Feng、Takahashi Yutaka、Sato Tomohito、Tanaka Kimie、Sata Masataka et al.
  • Journal Title: European Heart Journal Volume: 42 Issue: 42 Pages: 4336-4348
  • DOI: 10.1093/eurheartj/ehab249
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Roles of Epicardial Adipose Tissue in the Pathogenesis of Coronary Atherosclerosis ― An Update on Recent Findings ― (2020)
  • Author(s): Tanaka Kimie、Fukuda Daiju、Sata Masataka
  • Journal Title: Circulation Journal Volume: 85 Issue: 1 Pages: 2-8
  • DOI: 10.1253/circj.CJ-20-0935
  • NAID: 130007961193
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2020-12-25
  • Peer Reviewed / Open Access
• [Journal Article] Biodegradable Extremely-Small-Diameter Vascular Graft Made of Silk Fibroin can be Implanted in Mice (2020)
  • Author(s): Tanaka, K.; Fukuda, D.; Higashikuni, Y.; Hirata, Y.; Komuro, I.; Saotome, T.; Yamashita, Y.; Asakura, T.; Sata, M.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 27 Issue: 12 Pages: 1299-1309
  • DOI: 10.5551/jat.52720
  • NAID: 130007948583
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2020-12-01
  • Peer Reviewed / Open Access
• [Journal Article] Canagliflozin Prevents Diabetes-Induced Vascular Dysfunction in ApoE-Deficient Mice (2020)
  • Author(s): Rahadian Arief、Fukuda Daiju、Salim Hotimah Masdan、Yagi Shusuke、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Sata Masataka
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 27 Issue: 11 Pages: 1141-1151
  • DOI: 10.5551/jat.52100
  • NAID: 130007933946
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2020-11-01
  • Peer Reviewed / Open Access
• [Journal Article] Association between Sarcopenia/Lower Muscle Mass and Short-Term Regression of Deep Vein Thrombosis Using Direct Oral Anticoagulants (2020)
  • Author(s): Torii Yuta、Kusunose Kenya、Zheng Robert、Yamada Hirotsugu、Amano Rie、Matsumoto Rikizo、Hirata Yukina、Nishio Susumu、Yamada Nao、Ise Takayuki、Yamaguchi Koji、Tobiume Takeshi、Fukuda Daiju、Yagi Shusuke、Soeki Takeshi、Wakatsuki Tetsuzo、Okayama Yoshihiro、Sata Masataka
  • Journal Title: International Heart Journal Volume: 61 Issue: 4 Pages: 787-794
  • DOI: 10.1536/ihj.20-032
  • NAID: 130007882193
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2020-07-30
  • Peer Reviewed / Open Access
• [Journal Article] Atherosclerotic Coronary Plaque Is Associated With Adventitial Vasa Vasorum and Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadavers (2020)
  • Author(s): Ito Hiroyuki、Wakatsuki Tetsuzo、Yamaguchi Koji、Fukuda Daiju、Kawabata Yutaka、Matsuura Tomomi、Kusunose Kenya、Ise Takayuki、Tobiume Takeshi、Yagi Shusuke、Yamada Hirotsugu、Soeki Takeshi、Tsuruo Yoshihiro、Sata Masataka
  • Journal Title: Circulation Journal Volume: 84 Issue: 5 Pages: 769-775
  • DOI: 10.1253/circj.CJ-19-0914
  • NAID: 130007835094
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2020-04-24
  • Peer Reviewed / Open Access
• [Journal Article] Association of Local Epicardial Adipose Tissue Depots and Left Ventricular Diastolic Performance in Patients With Preserved Left Ventricular Ejection Fraction (2020)
  • Author(s): Maimaituxun Gulinu、Yamada Hirotsugu、Fukuda Daiju、Yagi Shusuke、Kusunose Kenya、Hirata Yukina、Nishio Susumu、Soeki Takeshi、Masuzaki Hiroaki、Sata Masataka、Shimabukuro Michio
  • Journal Title: Circulation Journal Volume: 84 Issue: 2 Pages: 203-216
  • DOI: 10.1253/circj.CJ-19-0793
  • NAID: 130007789877
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2020-01-24
  • Peer Reviewed / Open Access
• [Journal Article] A Deep Learning Approach for Assessment of Regional Wall Motion?Abnormality From Echocardiographic Images (2020)
  • Author(s): Kusunose Kenya、Abe Takashi、Haga Akihiro、Fukuda Daiju、Yamada Hirotsugu、Harada Masafumi、Sata Masataka
  • Journal Title: JACC: Cardiovascular Imaging Volume: 13 Issue: 2 Pages: 374-381
  • DOI: 10.1016/j.jcmg.2019.02.024
  • NAID: 120006844043
  • Peer Reviewed / Open Access
• [Journal Article] Deterioration of biventricular strain is an early marker of cardiac involvement in confirmed sarcoidosis (2020)
  • Author(s): Kusunose Kenya、Fujiwara Mika、Yamada Hirotsugu、Nishio Susumu、Saijo Yoshihito、Yamada Nao、Hirata Yukina、Torii Yuta、Ise Takayuki、Yamaguchi Koji、Fukuda Daiju、Yagi Shusuke、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka
  • Journal Title: European Heart Journal - Cardiovascular Imaging Volume: 21 Issue: 7 Pages: 796-804
  • DOI: 10.1093/ehjci/jez235
  • Peer Reviewed
• [Journal Article] Clinically Feasible and Accurate View Classification of Echocardiographic Images Using Deep Learning (2020)
  • Author(s): Kenya Kusunose, Akihiro Haga, Mizuki Inoue, Daiju Fukuda, Hirotsugu Yamada and Masataka Sata
  • Journal Title: Biomolecules Volume: 10 Issue: 5 Pages: 665-665
  • DOI: 10.3390/biom10050665
  • NAID: 120006884826
  • Peer Reviewed / Open Access
• [Journal Article] Deep Learning for Assessment of Left Ventricular Ejection Fraction from Echocardiographic Images (2020)
  • Author(s): Kenya Kusunose, Akihiro Haga, Natsumi Yamaguchi, Takashi Abe, Daiju Fukuda, Hirotsugu Yamada, Masafumi Harada and Masataka Sata
  • Journal Title: Journal of the American Society of Echocardiography Volume: 33 Issue: 5 Pages: 632-635
  • DOI: 10.1016/j.echo.2020.01.009
  • Peer Reviewed / Open Access
• [Journal Article] Association Between Right Ventricular Contractile Function and Cardiac Events in Isolated Postcapillary and Combined Pre- and Postcapillary Pulmonary Hypertension (2020)
  • Author(s): Kusunose Kenya、Yamada Nao、Yamada Hirotsugu、Nishio Susumu、Saijo Yoshihito、Hirata Yukina、Torii Yuta、Ise Takayuki、Yamaguchi Koji、Fukuda Daiju、Yagi Shusuke、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka
  • Journal Title: Journal of Cardiac Failure Volume: 26 Issue: 1 Pages: 43-51
  • DOI: 10.1016/j.cardfail.2019.08.021
  • NAID: 120006880921
  • Peer Reviewed
• [Journal Article] Emerging roles of Toll-like receptor 9 in cardiometabolic disorders (2020)
  • Author(s): Nishimoto Sachiko、Fukuda Daiju、Sata Masataka
  • Journal Title: Inflammation and Regeneration Volume: 40 Issue: 1 Pages: 18-18
  • DOI: 10.1186/s41232-020-00118-7
  • NAID: 120007126563
  • Peer Reviewed / Open Access
• [Journal Article] Thrombin inhibition by dabigatran attenuates endothelial dysfunction in diabetic mice (2020)
  • Author(s): Rahadian Arief、Fukuda Daiju、Salim Hotimah Masdan、Yagi Shusuke、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Shimabukuro Michio、Sata Masataka
  • Journal Title: Vascular Pharmacology Volume: 124 Pages: 106632-106632
  • DOI: 10.1016/j.vph.2019.106632
  • NAID: 120007097699
  • Peer Reviewed / Open Access
• [Journal Article] Levels of Adiponectin Expression in Peri-Renal and Subcutaneous Adipose Tissue and Its Determinants in Human Biopsied Samples (2020)
  • Author(s): Maimaituxun Gulinu、Fukuda Daiju、Izaki Hirofumi、Hirata Yoichiro、Kanayama Hiro-omi、Masuzaki Hiroaki、Sata Masataka、Shimabukuro Michio
  • Journal Title: Frontiers in Endocrinology Volume: 10 Pages: 897-897
  • DOI: 10.3389/fendo.2019.00897
  • NAID: 120006953545
  • Peer Reviewed / Open Access
• [Journal Article] Association of Echocardiography Before Major Elective Non-Cardiac Surgery With Improved Postoperative Outcomes ― Possible Implications for Patient Care ― (2019)
  • Author(s): Kusunose Kenya、Torii Yuta、Yamada Hirotsugu、Nishio Susumu、Hirata Yukina、Saijo Yoshihito、Ise Takayuki、Yamaguchi Koji、Fukuda Daiju、Yagi Shusuke、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka
  • Journal Title: Circulation Journal Volume: 83 Issue: 12 Pages: 2512-2519
  • DOI: 10.1253/circj.CJ-19-0663
  • NAID: 130007751193
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-11-25
  • Peer Reviewed
• [Journal Article] Association of Decreased Docosahexaenoic Acid Level After Statin Therapy and Low Eicosapentaenoic Acid Level with In-Stent Restenosis in Patients with Acute Coronary Syndrome (2019)
  • Author(s): Yagi Shusuke、Kondo Daisuke、Yamaguchi Koji、Wakatsuki Tetsuzo、Kawabata Yutaka、Ito Hiroyuki、Saijo Yoshihito、Seno Hiromitsu、Sutou Kumiko、Ueno Rie、Todoroki Takafumi、Kusunose Kenya、Matsuura Tomomi、Tobiume Takeshi、Yamada Hirotsugu、Soeki Takeshi、Shimabukuro Michio、Aihara Ken-ichi、Akaike Masashi、Sata Masataka
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 26 Issue: 3 Pages: 272-281
  • DOI: 10.5551/jat.44735
  • NAID: 130007606848
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2019-03-01
  • Peer Reviewed / Open Access
• [Journal Article] Lambda-like J wave due to acute myocardial infarction of the diagonal branch (2019)
  • Author(s): Yagi Shusuke、Ueno Rie、Sutou Kumiko、Wakatsuki Tetsuzo、Yamaguchi Koji、Saijo Yoshihito、Hara Tomoya、Ise Takayuki、Kusunose Kenya、Bando Mika、Matsuura Tomomi、Tobiume Takeshi、Yamada Hirotsugu、Fukuda Daiju、Soeki Takeshi、Akaike Masashi、Sata Masataka
  • Journal Title: The Journal of Medical Investigation Volume: 66 Issue: 1.2 Pages: 185-187
  • DOI: 10.2152/jmi.66.185
  • NAID: 130007638805
  • ISSN: 1343-1420, 1349-6867
  • Year and Date: 2019-02-15
  • Peer Reviewed
• [Journal Article] Toll‐Like Receptor 9 Plays a Pivotal Role in Angiotensin II Induced Atherosclerosis (2019)
  • Author(s): Fukuda Daiju、Nishimoto Sachiko、Aini Kunduziayi、Tanaka Atsushi、Nishiguchi Tsuyoshi et al.
  • Journal Title: Journal of the American Heart Association Volume: 8 Issue: 7
  • DOI: 10.1161/jaha.118.010860
  • NAID: 120006602927
  • Peer Reviewed / Open Access
• [Journal Article] Pulmonary Artery Hypertension-Specific Therapy Improves Exercise Tolerance and Outcomes in Exercise-Induced Pulmonary?Hypertension (2019)
  • Author(s): Kusunose Kenya、Yamada Hirotsugu、Nishio Susumu、Hirata Yukina、Saijo Yoshihito、Torii Yuta、Yamada Nao、Ise Takayuki、Yamaguchi Koji、Fukuda Daiju、Yagi Shusuke、Soeki Takeshi、Wakatsuki Tetsuzo、Sata Masataka
  • Journal Title: JACC: Cardiovascular Imaging Volume: 12 Issue: 12 Pages: 2576-2579
  • DOI: 10.1016/j.jcmg.2019.07.002
  • NAID: 120006877712
  • Peer Reviewed
• [Journal Article] Rivaroxaban, a specific FXa inhibitor, improved endothelium-dependent relaxation of aortic segments in diabetic mice (2019)
  • Author(s): Pham Phuong Tran、Fukuda Daiju、Yagi Shusuke、Kusunose Kenya、Yamada Hirotsugu、Soeki Takeshi、Shimabukuro Michio、Sata Masataka
  • Journal Title: Scientific Reports Volume: 9 Issue: 1 Pages: 11206-11206
  • DOI: 10.1038/s41598-019-47474-0
  • NAID: 120006786178
  • Peer Reviewed / Open Access
• [Journal Article] Adult onset of Immunoglobulin A vasculitis – A case report (2019)
  • Author(s): Yagi Shusuke、Endo Itsuro、Murakami Taichi、Hida Tetsuya、Yamamoto Yousuke、Soga Tomohiro、Ise Takayuki、Kusunose Kenya、Yamaguchi Koji、Fukuda Daiju、Yamada Hirotsugu、Soeki Takeshi、Wakatsuki Tetsuzo、Kawahito Shinji、Sata Masataka
  • Journal Title: The Journal of Medical Investigation Volume: 66 Issue: 3.4 Pages: 344-346
  • DOI: 10.2152/jmi.66.344
  • NAID: 130007733026
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed / Open Access
• [Journal Article] Osteolytic primary bone lymphoma in the multiple bones (2019)
  • Author(s): Yagi S, Zheng R, Nishiyama S, Kawabata Y, Ise T, Sugiura K, Yoshinari H, Nishisho T, Bando Y, Kagawa K, Fukuda D, Soga T, Saijo Y, Kusunose K, Yamaguchi K, Yamada H, Soeki T, Wakatsuki T, Kawahito S, Akaike M, Sata M.
  • Journal Title: The Journal of Medical Investigation Volume: 66 Issue: 3.4 Pages: 347-350
  • DOI: 10.2152/jmi.66.347
  • NAID: 130007733002
  • ISSN: 1343-1420, 1349-6867
  • Peer Reviewed / Open Access
• [Journal Article] Left atrial functional response after a marathon in healthy amateur volunteers (2018)
  • Author(s): Hirata Yukina、Kusunose Kenya、Yamada Hirotsugu、Morita Sae、Torii Yuta、Nishio Susumu、Zheng Robert、Saijo Yoshihito、Fukuda Daiju、Yagi Shusuke、Soeki Takeshi、Sata Masataka
  • Journal Title: The International Journal of Cardiovascular Imaging Volume: - Issue: 4 Pages: 633-643
  • DOI: 10.1007/s10554-018-1502-2
  • NAID: 120006844037
  • Peer Reviewed
• [Presentation] 光干渉断層法で観察される冠動脈壁微小管腔構造と局所冠動脈周囲脂肪内炎症および冠動脈プラークの関連 －未固定遺体における検討－. (2021)
  • Author(s): 川端 豊、若槻哲三、山口浩司、福田大受、伊藤浩敬、伊勢孝之、楠瀬賢也、松浦朋美、飛梅 威、八木秀介、山田博胤、添木 武、佐田政隆.
  • Organizer: Beyond Angiography Japan XXV
• [Presentation] DNA Damage Response Associated with Vascular Aging Promotes Sterile Inflammation and Impairs Endothelial Function in Diabetes. (2021)
  • Author(s): Fukuda D, Sata M.
  • Organizer: 第85回日本循環器学会学術集会
• [Presentation] Atherosclerotic Coronary Plaque Is Associated With Adventitial Vasa Vasorum and Local Inflammation in Adjacent Epicardial Adipose Tissue in Fresh Cadavers. (2021)
  • Author(s): Ito H, Wakatsuki T, Yamaguchi K, Fukuda D, Kawabata Y, Matsuura T, Kusunose K, Ise T, Tobiume T,Yagi S, Yamada H, Soeki T, Tsuruo Y, Sata M.
  • Organizer: 第85回日本循環器学会学術集会
• [Presentation] Stimulator of Interferon Genes Plays a Pivotal Role in Vascular Inflammation and Atherosclerosis in Apolipoprotein E-deficient Mice. (2021)
  • Author(s): Pham PT, Fukuda D, Suto K, Yagi S, Kusunose K, Yamada H, Soeki T, Sata M.
  • Organizer: 第85回日本循環器学会学術集会
• [Presentation] DNA Damage Caused by Diabetes Induced Vascular Dysfunction: The Role of The Stimulator of Interferon Genes. (2021)
  • Author(s): Pham PT, Fukuda D, Suto K, Yagi S, Kusunose K, Yamada H, Soeki T, Sata M.
  • Organizer: 第85回日本循環器学会学術集会
• [Presentation] Macrophage-specific DNase II Deletion Promotes Pro-inflammatory Activation of Macrophages and Atherogenesis. (2021)
  • Author(s): Suto K, Fukuda D, Sata M.
  • Organizer: 第85回日本循環器学会学術集会
• [Presentation] Deep Learning for Detection of Elevated Pulmonary Artery Wedge Pressure Using Standard Chest X-Ray. (2021)
  • Author(s): 平田 有紀奈、楠瀬 賢也、辻 拓将、藤森 康平、山口 夏美、森田 沙瑛、西尾 進、大櫛 祐一郎、瀬野 弘光、高橋 智紀、伊勢 孝之、飛梅 威、山口 浩司、福田 大受、八木 秀介、山田 博胤、添木 武、若槻 哲三、古徳 純一、佐田 政隆.
  • Organizer: 第85回日本循環器学会学術集会
• [Presentation] ディープラーニングによる胸部X-pを用いた肺動脈圧上昇の検出. (2021)
  • Author(s): 平田 有紀奈、楠瀬 賢也、辻 拓将、藤森 康平、山口 夏美、森田 沙瑛、西尾 進、大櫛 祐一郎、瀬野 弘光、高橋 智紀、伊勢 孝之、飛梅 威、山口 浩司、福田 大受、八木 秀介、山田 博胤、添木 武、若槻 哲三、古徳 純一、佐田 政隆.
  • Organizer: 第85回日本循環器学会学術集会
• [Presentation] Relationship between Coronary Intraplaque Microluminal Structure and Epicardial Adipose Tissue and Plaque Formation -A Fresh Cadaveric Study-. (2021)
  • Author(s): 川端 豊、若槻 哲三、山口 浩司、福田 大受、松浦 朋美、伊勢 孝之、楠瀬 賢也、飛梅 威、八木 秀介、山田 博胤、添木 武、佐田 政隆.
  • Organizer: 第85回日本循環器学会学術集会
• [Presentation] Effects of Vitamin D Supplementation on Heart Failure Mortality from Japanese Registry of All Cardiac and Vascular Datasets. (2021)
  • Author(s): 阿部 美保、楠瀬 賢也、大櫛 祐一郎、Robert Zheng、伊勢 孝之、飛梅 威、山口 浩司、八木 秀介、福田 大受、山田 博胤、添木 武、佐田 政隆.
  • Organizer: 第85回日本循環器学会学術集会
• [Presentation] ループ利尿薬使用下における心保護薬併用療法の有用性. (2021)
  • Author(s): 大櫛 祐一郎、楠瀬 賢也、伊勢 孝之、山口 浩司、八木 秀介、福田 大受、山田 博胤、添木 武、若槻 哲三、佐田 政隆.
  • Organizer: 第116回第118回日本循環器学会中国・四国合同地方会
• [Presentation] マクロファージのDNA分解機構が動脈硬化に与える影響. (2021)
  • Author(s): 數籐 久美子、福田 大受、佐田 政隆.
  • Organizer: 第116回第118回日本循環器学会中国・四国合同地方会
• [Presentation] Esaxerenone attenuates vascular dysfunction and atherosclerosis in apolipoprotein E-deficient mice. (2021)
  • Author(s): Ungantsetseg M、Fukuda D、Sata M.
  • Organizer: 第11回日本脳血管・認知症学会総会 VAS-COG
• [Presentation] 動脈硬化性疾患の高リスク患者において大動脈弁の石灰化と血清リポ蛋白との関連. (2021)
  • Author(s): Munkhtsetseg T、八木 秀介、伊勢 孝之、モンフジャルガル ウーガンツェツェグ、バブー オイウンビレグ、門田 宗之、川端 豊、楠瀬 賢也、山口 浩司、福田 大受、山田 博胤、添木 武、若槻 哲三、佐田 政隆.
  • Organizer: 第11回日本脳血管・認知症学会総会 VAS-COG
• [Presentation] Metabolic effects of a selective mineralocorticoid receptor blocker, esaxerenone,in obese mice. (2021)
  • Author(s): Oyunbileg Bavuu、Fukuda D、Sata M.
  • Organizer: 第11回日本脳血管・認知症学会総会 VAS-COG
• [Presentation] カテーテル大動脈弁置換術（TAVI）によって激変した大動脈弁狭窄症治療. (2021)
  • Author(s): 166.伊勢 孝之、門田 宗之、川端 豊、楠瀬 賢也、山口 浩司、八木 秀介、福田 大受、山田 博胤、添木 武、若槻 哲三、佐村 高明、藤本 鋭貴、秦 広樹、佐田 政隆.
  • Organizer: 第263回徳島医学会学術集会
• [Presentation] Metabolic effects of a selective mineralocorticoid receptor blocker, esaxerenone, in obese mine. (2021)
  • Author(s): Oyunbileg B, Fukuda D, Sata M.
  • Organizer: 第263回徳島医学会学術集会
• [Presentation] A selectiv mineralocorticoid receptor blocker, esaxerenone, attenuates vascular dystunction and atherosclerosis in apoliporotein E-deficient mice. (2021)
  • Author(s): Uugantsetseg M, Fukuda D, Sata M.
  • Organizer: 第263回徳島医学会学術集会
• [Presentation] 動脈硬化性疾患の高リスク患者において大動脈弁の石灰化と血清リポ蛋白との関連. (2021)
  • Author(s): Tserensonom M、八木 秀介、伊勢 孝之、門田 宗之、川端 豊、西條 良仁、松浦 朋美、楠瀬 賢也、山口 浩司、福田 大受、山田 博胤、添木 武、若槻 哲三、佐田 政隆.
  • Organizer: 第263回徳島医学会学術集会
• [Presentation] ポスターセッション 左冠動脈主幹部の急性冠症候群の２症例. (2021)
  • Author(s): 手束 一貴、高橋 智紀、西條 良仁、川端 豊、門田 宗之、松浦 朋美、伊勢 孝之、山口 浩司、八木 秀介、福田 大受、山田 博胤、添木 武、若槻 哲三、佐村 高明、藤本 鋭貴、秦 広樹、佐田 政隆.
  • Organizer: 第263回徳島医学会学術集会
• [Presentation] Withコロナに対した心臓カテーテルオンライン臨床実習システムの構築. (2021)
  • Author(s): 伊勢 孝之、川端 豊、高橋 智紀、山口 浩司、福田 大受、若槻 哲三、佐田 政隆.
  • Organizer: 第27回日本心血管インターベンション治療学会(CVIT)中国四国地方会
• [Presentation] 回旋枝入口部線維製性プラークに対してOASを用いstentess PCIを施行で来た１例. (2021)
  • Author(s): 川端 豊、若槻 哲三、山口 浩司、高橋 智紀、伊勢 孝之、福田 大受、佐田 政隆.
  • Organizer: 第27回日本心血管インターベンション治療学会(CVIT)中国四国地方会
• [Presentation] アクセス困難症例に対し、右鎖骨下動脈アプローチでTAVI施行した１例. (2021)
  • Author(s): 伊勢 孝之、川端 豊、高橋 智紀、山口 浩司、福田 大受、若槻 哲三、佐村 高明、藤本 鋭貴、秦 広樹、佐田 政隆.
  • Organizer: 第27回日本心血管インターベンション治療学会(CVIT)中国四国地方会
• [Presentation] TAVI術中に上行大動脈解離を合併し、PCIと自己拡張型TAVI弁留置によってbailoutできた症例. (2021)
  • Author(s): 伊勢 孝之、川端 豊、高橋 智紀、山口 浩司、福田 大受、若槻 哲三、佐村 高明、藤本 鋭貴、秦 広樹、佐田 政隆.
  • Organizer: 第27回日本心血管インターベンション治療学会(CVIT)中国四国地方会
• [Presentation] 心臓周囲脂肪と血管内皮機能. (2021)
  • Author(s): 福田 大受.
  • Organizer: 第69回日本心臓病学会学術集会
  • Invited
• [Presentation] 冠動脈塞栓症を発症した2症例の臨床的検討. (2021)
  • Author(s): 川端 豊、若槻 哲三、山口 浩司、門田 宗之、伊勢 孝之、楠瀬 賢也、松浦 朋美、八木 秀介、 福田 大受、山田 博胤、添木 武、佐田 政隆.
  • Organizer: 第69回日本心臓病学会学術集会
• [Presentation] Stimulator of interferon genesは血管の炎症と動脈硬化を促進する. (2021)
  • Author(s): 福田 大受、Phuong Tran Pham、佐田 政隆.
  • Organizer: 第53回日本動脈硬化学会学術集会
• [Presentation] 心エコー検査によるがん治療関連心筋障害サーベイランスの有効性. (2021)
  • Author(s): 大櫛 祐一郎、楠瀬 賢也、西條 良仁、山口 浩司、八木 秀介、福田 大受、山田 博胤、添木 武、若槻 哲三、佐田 政隆.
  • Organizer: 第119回日本循環器学会四国地方会
• [Presentation] マクロファージ特異的DNaseII欠損が動脈硬化に与える影響. (2021)
  • Author(s): 數藤久美子、福田 大受、伊勢 孝之、楠瀬 賢也、山口 浩司、八木 秀介、山田 博胤、添木 武、若槻 哲三、佐田 政隆.
  • Organizer: 第119回日本循環器学会四国地方会
• [Presentation] 左冠動脈主幹部の急性冠症候群の2例. (2021)
  • Author(s): 手束 一貴、高橋 智紀、西條 良仁、川端 豊、門田 宗之、松浦 朋美、伊勢 孝之、楠瀬 賢也、山口 浩司、八木 秀介、福田 大受、山田 博胤、添木 武、若槻 哲三、佐村 高明、松本 和久、髙橋 智子、秦 広樹、佐田 政隆.
  • Organizer: 第119回日本循環器学会四国地方会
• [Presentation] Macrophage-specific Dnase II Deficiency Stimulates Atherosclerosis In Apolipoprotein E-deficient Mice. (2021)
  • Author(s): Suto K, Fukuda D, Sata M.
  • Organizer: The 19th International Symposium on Atherosclerosis（ISA2021）
  • Int'l Joint Research
• [Presentation] Differences of Cancer Types in Hospital Mortality in Patients With Venous Thromboembolism. (2020)
  • Author(s): Okushi Y, Kusunose K, Ise T, Tobiume T, Yamaguchi K, Yagi S, Fukuda D, Yamada H, Soeki T, Wakatsuki T, Sata M.
  • Organizer: AHA 2020, Dallas, USA
  • Int'l Joint Research
• [Presentation] linical Utility of Noninvasive Assessment of Flow-pressure Relationship in Scleroderma. (2020)
  • Author(s): Arase M, Kusunose K, Morita S, Yamaguchi N, Hirata Y, Nishio S, Ise T, Yamaguchi K, Fukuda D, Yagi S, Yamada H, Soeki T, Wakatsuki T, Sata M.
  • Organizer: AHA 2020, Dallas, USA
  • Int'l Joint Research
• [Presentation] Genetic Deletion of Stimulator of Interferon Genes Attenuates Atherogenesis in Apolipoprotein E-deficient Mice. (2020)
  • Author(s): Phuong Tran Pham, Fukuda D, Sata M.
  • Organizer: AHA 2020, Dallas, USA
  • Int'l Joint Research
• [Presentation] 血管の老化と核酸受容体 (2020)
  • Author(s): 福田 大受
  • Organizer: 第52回日本動脈硬化学会総会学術集会
  • Invited
• [Presentation] Stimulator of Interferon Genes Plays A Crucial Role in Atherogenesis via Macrophages Activation in Apolipoprotein E-Deficient Mice. (2020)
  • Author(s): Pham Tran Phuong 、Daiju Fukuda、 Masataka Sata.
  • Organizer: 第84回日本循環器学会学術集会
• [Presentation] Pemafibrate, a Novel Selective Peroxisome Proliferator-activated Receptor-α Modulator, Attenuates Vascular Inflammation and Endothelial Dysfunction in Diabetic Mice. (2020)
  • Author(s): Kumiko Suto 、Daiju Fukuda、Shusuke Yag、Kenya Kusunose、Hirotsugu Yamad、Takeshi Soeki、Masataka Sata.
  • Organizer: 第84回日本循環器学会学術集会
• [Presentation] S1P2 Receptor Antagonist Attenuates Endothelial Dysfunction and Prevents Atherogenesis in Apolipoprotein-E-deficient Mice. (2020)
  • Author(s): Byambasuren Ganbaatar、Daiju Fukuda、Shusuke Yagi、Kenya Kusunose、Hirotsugu Yamada、Takeshi Soeki、Masataka Sata.
  • Organizer: 第84回日本循環器学会学術集会
• [Presentation] Impact of Epicardial Adipose Tissue on Global Longitudinal Strain in Patients with Normal Left Ventricular Ejection Fraction. (2020)
  • Author(s): Maimaituxun Gulinu、Kenya Kusunose、Daiju Fukuda、Shusuke Yagi、Yukina Hirata、Hirotsugu Yamad、Takeshi Soeki、Masataka Sata、Michio Shimabukuro.
  • Organizer: 第84回日本循環器学会学術集会
• [Presentation] 動脈硬化合併心房細動患者の治療を考える (2020)
  • Author(s): 福田大受
  • Organizer: 第117回日本循環器学会 中国地方会
  • Invited
• [Presentation] 血管の炎症機序としての血液凝固因子の役割と治療標的としての可能性 (2020)
  • Author(s): 福田大受、佐田政隆
  • Organizer: 第62回日本平滑筋学会総会
  • Invited
• [Presentation] Peri-renal fat volume is negatively associated with the adiponectin expression in human. (2019)
  • Author(s): Maimaituxun G, Fukuda D, Yagi S, Hirata Y, Iwase T, Takao S, Matsuura T, Ise T, Kusunose K, Tobiume T, Yamaguchi K, Yamada H, Soeki T, Wakatsuki T, Harada M, Sata M, Shimabukuro M.
  • Organizer: 第4回日本血管不全学会学術集会・総会
• [Presentation] Kidney fat and its impact on coronary artery. (2019)
  • Author(s): Maimaituxun G, Fukuda D, Yagi S, Hirata Y, Iwase T, Takao S, Matsuura T, Ise T, Kusunose K, Tobiume T, Yamaguchi K, Yamada H, Soeki T, Wakatsuki T, Harada M, Sata M, Shimabukuro M.
  • Organizer: 第4回日本血管不全学会学術集会
• [Presentation] Impact of epicardial adipose tissue thickness on left ventricular diastolic dysfunction in human. (2019)
  • Author(s): Maimaituxun G, Kusunose K, Yamada H, Fukuda D, Yagi S, Hirata Y, Iwase T, Soeki T, Sata M, Shimabukuro M.
  • Organizer: 第92回日本内分泌学会学術総会
• [Presentation] Type 2 diabetes but not apicardial adipose tissue thickness is a predictor for coronary artery diseases in women. (2019)
  • Author(s): Maimaituxun G, Fukuda D, Yagi S, Iwase T, Kusunose K, Yamada H, Soeki T, Wakatsuki T, Sata M, Shimabukuro M.
  • Organizer: 第62回日本糖尿病学会年次学術集会
• [Presentation] 経食道心エコーガイド下の経皮的腫瘍生検により早期に診断し得た心臓原発血管肉腫の一例 (2019)
  • Author(s): 中村昌史、川端豊、伊勢孝之、藤本裕太、原田貴文、松本和久、西條良仁、上野理絵、山田なお、伊藤浩敬、轟貴史、楠瀬賢也、飛梅威、山口浩司、福田大受、八木秀介、山田博胤、添木武、若槻哲三、佐田政隆
  • Organizer: 第114回日本循環器学会中国・四国合同地方会
• [Presentation] 先天性二尖弁に対するTAVIの2例 (2019)
  • Author(s): 志村拓哉、伊勢孝之、川端豊、藤本裕太、松本和久、上野理絵、山田なお、伊藤浩敬、松浦朋美、楠瀬賢也、飛梅威、山口浩司、八木秀介、福田大受、山田博胤、添木武、若槻哲三、黒部裕嗣、藤本鋭貴、北川哲也、佐田政隆
  • Organizer: 第114回日本循環器学会中国・四国合同地方会
• [Presentation] 拡張期僧帽弁逆流の治療適応判断に心房心室同時ペーシングが有効であった1例 (2019)
  • Author(s): 谷彰浩、楠瀬賢也、松本和久、松浦朋美、伊勢孝之、飛梅威、山口浩司、八木秀介、福田大受、山田博胤、添木武、若槻哲三、赤池雅史、佐田政隆
  • Organizer: 第114回日本循環器学会中国・四国合同地方会
• [Presentation] 抗凝固薬の新しい可能性、会長企画セッションー心血管薬物治療の新たな可能性ー (2019)
  • Author(s): 添木武，福田大受，松浦朋美，植松悦子，佐田政隆
  • Organizer: 第4回J-ISCP（国際心血管薬物療法学会日本部会）年次学術集会
• [Presentation] A link of adiponectin expression to kidney adipose tissue volume in human. (2019)
  • Author(s): Maimaituxun G，Fukuda D, Izaki H, Hirata Y, Masuzaki H, Kanayama H, Sata M, Shimabukuro M
  • Organizer: 第4回J-ISCP（国際心血管薬物療法学会日本部会）年次学術集会
• [Presentation] Gender specific impact of epicardial adipose tissue thickness on coronary artery disease. (2019)
  • Author(s): Maimaituxun G，Fukuda D, Yagi S, Hirata Y, Iwase S, Matsuura T, Ise T, Kusunose K, Yamaguchi H, Yamada H, Soeki T、Wakatsuki T, Sata M，Shimabukuro M
  • Organizer: 第19回日本抗加齢医学会総会
• [Presentation] 血管の炎症と動脈硬化における核酸断片受容体の役割 (2019)
  • Author(s): 福田大受
  • Organizer: 第51回日本動脈硬化学会総会・学術総会
• [Presentation] 血管の炎症と動脈硬化発症における核酸受容体の役割 (2019)
  • Author(s): 福田大受、佐田政隆
  • Organizer: 第40回日本炎症・再生医学会
• [Presentation] 房室ブロックの予防に順行性速伝導路と順行性遅伝導路のマッピングが有用であった順行性速伝導路の下方偏位を伴う遅速型房室結節リエントリー性頻拍の１例 (2019)
  • Author(s): 井口裕貴、飛梅威、松本和久、坂東左知子、松浦朋美、添木武、志村拓哉、髙橋智子、谷彰浩、藤本裕太、大櫛祐一郎、數藤久美子、髙橋智紀、上野理絵、門田宗之、川端豊、坂東美佳、山田なお、伊藤浩敬、伊勢孝之、楠瀬賢也、山口浩司、八木秀介、福田大受、山田博胤、若槻哲三、佐田政隆
  • Organizer: 第259回徳島医学会学術集会
• [Presentation] 房室ブロックの進行に伴い明らかになり、恒久的ペースメーカー植込み術後のファーフィールドR波センシングへの関与が疑われた束枝心室間副伝導路の１例 (2019)
  • Author(s): 木田貴弘、飛梅威、松本和久、坂東左知子、松浦朋美、添木武、志村拓哉、髙橋智子、谷彰浩、藤本裕太、大櫛祐一郎、數藤久美子、髙橋智紀、上野理絵、門田宗之、川端豊、坂東美佳、山田なお、伊藤浩敬、伊勢孝之、楠瀬賢也、山口浩司、八木秀介、福田大受、山田博胤、若槻哲三、佐田政隆
  • Organizer: 第259回徳島医学会学術集会
• [Presentation] 深層学習を用いた左室駆出率の推定：心エコー図法による検討 (2019)
  • Author(s): 山口夏美、楠瀬賢也、芳賀昭弘、森田沙瑛、平田有紀奈、鳥居裕太、西尾進、山田なお、阿部美保、福田大受、山田博胤、佐田政隆
  • Organizer: 第67回日本心臓病学会学術集会
• [Presentation] Vildagliptin,a DPP-4 Inhibitor,prevents endothelial dysfunction in nondiabetic apolipoprotein E-deficient mice. (2019)
  • Author(s): Kunduziayi Aini，福田大受，八木秀介，楠瀬賢也，山田博胤，添木武，佐田政隆：Vildagliptin,a DPP-4 Inhibitor,prevents endothelial dysfunction in nondiabetic apolipoprotein E-deficient mice.
  • Organizer: 日本性機能学会第30回学術集会
• [Presentation] SGLT2 inhibitor Canagliflozin Ameliorate Endothelial Dysfunction and Atherosclerosis in Diabetic ApoE-/- Mice. (2019)
  • Author(s): Rahadian Arief，福田大授，Salim Hotima，八木秀介，楠瀬賢也，山田博胤，添木武，佐田政隆
  • Organizer: 日本性機能学会第30回学術集会
• [Presentation] Rivaroxaban a direct inhibitor of FXa ttenuated diabetes-induced endothelial dysfunction in wild-type mice. (2019)
  • Author(s): Pham Tran Phuong，福田大受，八木秀介，楠瀬賢也，山田博胤，添木武，島袋充生，佐田政隆
  • Organizer: 日本性機能学会第30回学術集会
• [Presentation] S1P2 antagonist attenuates endothelial dysfunction and inhibits atherogenesis in apolipoprotein-E-deficient Mice. (2019)
  • Author(s): Byambasuren Ganbaatar，福田大受，八木秀介，添木武，佐田政隆
  • Organizer: 日本性機能学会第30回学術集会
• [Presentation] 血管の炎症と動脈硬化における核酸受容体の役割 (2019)
  • Author(s): 福田大受、佐田政隆
  • Organizer: 脳心血管抗加齢研究会2019 （第16回学術大会）
• [Presentation] Vildagliptin reduces inducitiligy of arterial fibrillation in hypertensive rats complicated with diabetes mellitus. (2019)
  • Author(s): Soeki T, Matsumoto K, Fukuda D, Uematsu E, Matsuura T, Tobiume T, Kusunose K, Ise T, Yamaguchi K, Yamada H, Wakatsuki T, Sata M
  • Organizer: ESC Congress 2019, Paris, France.
  • Int'l Joint Research
• [Presentation] Empagliflozin, a SGLT2 inhibitor, attenuates endothelial dysfuntion and atherogenesis by inhibiting inflammatory responses in the vasculature and adipose tissue in diabetic apolipoprotein E-deficient mice. (2019)
  • Author(s): Ganbaatar B, Fukuda D, Yagi S, Kusunose K, Yamada H, Soeki T, Sata M
  • Organizer: ESC Congress 2019, Paris, France.
  • Int'l Joint Research
• [Presentation] Glycemic control with canagliflozin, a SGLT-2 inhibitor, attenuates atherosclerosis and endothelial dysfunction in diabetic apolipoprotein e-deficient mice. (2019)
  • Author(s): Rahadian A, Fukuda D, Salim H, Yagi S, Kusunose K, Yamada H, Soeki T, Sata M
  • Organizer: ESC Congress 2019, Paris, France.
  • Int'l Joint Research
• [Presentation] Adipose tissue surrounding the kidney and its impact on coronary artery disease. (2019)
  • Author(s): Maimaituxun G, Fukuda D, Yagi S, Takao S, Yamada H, Soeki T, Wakatsuki T, Harada M, Sata M, Shimabukuro M
  • Organizer: ESC Congress 2019, Paris, France.
  • Int'l Joint Research
• [Presentation] Impact of epicardial adipose tissue on global longitudinal strain: a study in patients with normal left ventricular ejection fraction. (2019)
  • Author(s): Maimaituxun G, Kusunose K, Fukuda D, Yagi S, Torii Y, Hirata Y, Nishio S, Yamada N, Yamada H, Soeki T, Wakatsuki T, Sata M, Shimabukuro M
  • Organizer: ESC Congress 2019, Paris, France.
  • Int'l Joint Research
• [Presentation] Vildagliptin, a DPP-4 inhibitor, attenuates endothelial dysfunction and atherogenesis independent of its glucose lowering effect in apolipoprotein e-deficient mice. (2019)
  • Author(s): Kunduziayi A, Fukuda D, Yagi S, Kusunose K, Yamada H, Soeki T, Sata M
  • Organizer: AHA2019, Philadelphia, USA.
  • Int'l Joint Research
• [Presentation] Assessment of left ventricular ejection fraction from echocardiographic images using deep learning algorithm. (2019)
  • Author(s): Kusunose K, Haga A, Abe T, Fukuda D, Yamada H, Sata M
  • Organizer: AHA2019, Philadelphia, USA.
  • Int'l Joint Research
• [Presentation] Pemafibrate, a novel selective peroxisome proliferator-activated receptor-a modulator, ameliorated diabetes-induced endothelial dysfunction. (2019)
  • Author(s): Suto K, Fukuda D, Ganbaatar B, Yagi S, Kusunose K, Yamada H, Soeki T, Sata M
  • Organizer: AHA2019, Philadelphia, USA.
  • Int'l Joint Research
• [Presentation] S1p2 Receptor Antagonist Attenuates Endothelial Dysfunction And Inhibits Atherogenesis In Apolipoprotein-e-deficient Mice. (2019)
  • Author(s): Ganbaatar B, Fukuda D, Yagi S, Kusunose K, Yamada H, Soeki T, Sata M
  • Organizer: AHA2019, Philadelphia, USA.
  • Int'l Joint Research
• [Presentation] The relationship among local epicardial adipose tissue, coronary intraplaque microluminal structure, and coronary plaque formation -a fresh cadaveric study. (2019)
  • Author(s): Kawabata Y, Kusunose K, Yagi S, Yamada H, Fukuda D, Soeki T, Sata M
  • Organizer: AHA2019, Philadelphia, USA.
  • Int'l Joint Research