Elucidation of clinical practice and pathological conditions of myocardial infarction with non-obstructive coronary arteries (MINOCA)
| Project/Area Number |
19K17531
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| Research Category |
Grant-in-Aid for Early-Career Scientists
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| Allocation Type | Multi-year Fund |
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| Review Section |
Basic Section 53020:Cardiology-related
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| Research Institution | Kumamoto University |
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Principal Investigator |
Ishii Masanobu 熊本大学, 大学院生命科学研究部(医), 助教 (70823293)
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| Project Period (FY) |
2019-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2019: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | MINOCA / 大気汚染曝露 / DPCデータ / 冠微小循環 / オミクス解析 / 臨床疫学 / 循環器疫学 / ビッグデータ / 大気汚染 / 黄砂 / オミックス解析 / 冠微小循環障害 / プロテオミクス解析 |
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| Outline of Research at the Start |
急性心筋梗塞に対する治療法の発展により、その予後は改善傾向であるものの、最近、閉塞血管のない心筋梗塞であるMINOCA（myocardial infarction with non-obstructive coronary arteries）の存在が認識され始めたが、日本においてはまだMINOCAに関する報告がほぼなく、MINOCAの実態は不明である。本研究ではビッグデータを用いて日本におけるMINOCAの診療実態を疫学的に明らかにするとともに、その診断に寄与する血液バイオマーカーの探索を行う。
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| Outline of Final Research Achievements |
In recent years, among acute myocardial infarction, MINOCA (myocardial infarction with non-obstructive coronary arteries), which does not have significant stenosis of 50% or more in the epicardial coronary arteries on angiography, has been paid attention. This study clarified the current status of MINOCA in Japan, in which the clinical characteristics were younger women with more extracardiac comorbidities and fewer coronary risk factors, and the prognosis for MINOCA was not better compared to MI-CAD (coronary artery disease). In addition, short-term exposure to dust and PM2.5 was found to be a risk factor. There are various causes of MINOCA, but coronary spasm is considered to be the most common cause, and I am working to further clarify the pathology.
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| Academic Significance and Societal Importance of the Research Achievements |
MINOCAは比較的新しい概念であり、徐々にその認識が広まっている。本研究によって日本におけるMINOCAの診療実態、臨床的特徴が明らかとなったことから、さらに認知度が高まり、診断精度の向上が期待される。しかし、短期予後は閉塞性冠動脈疾患による心筋梗塞と同等か不良であることから、原因の鑑別診断を行い、病因特異的な治療へとつなげることが重要である。
また環境要因として大気汚染物質の曝露がリスクであることが明らかとなったため、大気汚染曝露を避ける患者への生活指導や大気汚染物質を排出させないような技術革新や規制が必要である。
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Report
(5 results)
Research Products
(16 results)
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[Journal Article] Short-term exposure to desert dust and the risk of acute myocardial infarction in Japan: a time-stratified case-crossover study.2020
Author(s)
Ishii M, Seki T, Kaikita K, Sakamoto K, Nakai M, Sumita Y, Nishimura K, Miyamoto Y, Noguchi T, Yasuda S, Tsutsui H, Komuro I, Saito Y, Ogawa H, Tsujita K, Kawakami K; JROAD Investigators.
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Journal Title
European Journal of Epidemiology
Volume: in press
Issue: 5
Pages: 455-464
DOI
Related Report
Peer Reviewed
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[Presentation] Effects of Asian dust on blood pressure and blood cell counts: a cross-sectional study of health check-up data2019
Author(s)
Ishii M, Seki T, Sakamoto K, Kaikita K, Miyamoto Y, Tsujita K, Masuda I, Kawakami K.
Organizer
ESC congress 2019, 2019.8.31-9.4, Paris, France
Related Report
Int'l Joint Research
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[Presentation] Short-term exposure to asian dust is associated with myocardial infarction with nonobstructive coronary arteries.2019
Author(s)
Ishii M, Seki T, Kaikita K, Sakamoto K, Nakai M, Sumita Y, Nishimura K, Miyamoto Y, Noguchi T, Yasuda S, Saito Y, Tsutsui H, Komuro I, Ogawa H, Tsujita K, Kawakami K.
Organizer
ESC congress 2019, 2019.8.31-9.4, Paris, France
Related Report
Int'l Joint Research
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