Effects of moderate exercise training and in combination with GLP-1 agonist activation on coronary micro-vascular dysfunction in an accelerated atherosclerotic mouse model

• Project/Area Number: 19K17621
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: スクマラン ビジャヤクマー 国立研究開発法人国立循環器病研究センター, 研究所, 特任研究員 (80762244)
• Project Period (FY): 2019-04-01 – 2021-03-31
• Project Status: Granted (Fiscal Year 2019)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2020: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2019: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: Atherosclerosis / Liraglutide / Exercise

Outline of Research at the Start

We expect to demonstrate whether moderate exercise training in combination with GLP-1 agonist treatment improves coronary function in part through amelioration of endothelial dysfunction and improved blood flow distribution in the accelerated atherosclerosis mouse model. In parallel molecular studies we expect to show whether exercise training or in combination with GLP-1 agonist treatment improves the hyperglycemic and hyperlipidemic profile in mice with atherosclerosis.