心不全における新たな自律神経機能評価方法としての瞳孔対光反応の有用性の検証

• Project/Area Number: 19K19884
• Research Category: Grant-in-Aid for Early-Career Scientists
• Allocation Type: Multi-year Fund
• Review Section: Basic Section 59010:Rehabilitation science-related
• Research Institution: Kitasato University
• Principal Investigator: 野崎 康平 北里大学, 大学病院, 一般職 (30791743)
• Project Period (FY): 2019-04-01 – 2024-03-31
• Project Status: Granted (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2022: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2021: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2019: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 心不全 / 自律神経 / 瞳孔 / 身体機能 / 日常生活活動 / 心臓リハビリテーション / フレイル / 高齢者 / 対光反応

Outline of Research at the Start

心不全の特異的な病態のひとつに自律神経機能異常があり、自律神経機能を臨床で評価することは重要である。しかし、評価に用いられることが多い心拍変動解析は測定と解析が煩雑であり、自律神経機能の評価が蔑ろにされることが多い。そこで、本研究は、容易に測定が可能な瞳孔対光反応で得られる指標が、臨床における新たな自律神経機能の評価方法として応用が可能か否かを明らかにすることを目的として計画した。本研究では、心拍変動解析との整合性や、自律神経機能と関係することが明らかとなっている各指標との関連に加え、縦断的な変化を検証する予定である。

Outline of Annual Research Achievements

本研究は、瞳孔の対光反応が、心不全患者における自律神経活動の評価方法として日常臨床に応用可能か否かを明らかにすることを目的として開始した。一昨年度、COVID-19の流行に伴い感染予防の観点から、瞳孔機能の測定は中断した。本年度は、所属機関から許可を得られ次第測定を再開する予定としていたが、度重なる流行の繰り返しによって診療制限が断続的に続けられており、本年度においても瞳孔機能の測定は中断したままとなっている。そのため、本年度に予定していたほかの自律神経機能指標と瞳孔機能との関連の解析は完結していない。そこで、関連する領域の研究を並行して進めることとした。その結果、入院から外来にかけて心臓リハビリテーションを完遂した心不全患者において、手段的日常生活活動（Instrumental activities of daily living: IADL）の実施頻度が多いと全死亡や全死亡と心不全による再入院で定義される複合イベントが少なくなることを明らかにし、スペイン・バルセロナで開催されたEuropean Society of Cardiology Congress 2022においてその成果を発表した。また論文として執筆し、8月にJournal of cardiovascular development and disease (Impact factor: 4.415)に掲載された。また、急性心不全で入院した患者における入院後早期の歩行速度とアウトカムとの関連を明らかにし、2023年5月に開催予定の欧州心不全学会においてその成果を発表予定であるとともに、現在論文として投稿中である。
今後、研究実施期間を延長してさらなる研究結果を発表していく予定である。

Current Status of Research Progress

2: Research has progressed on the whole more than it was originally planned.

Reason

瞳孔の対光反応測定を行うためには専用の機器（ゴーグル）を眼周囲にあてなければならず、SARS_CoV_2が流行している現状では、感染拡大防止の観点から、測定を中止せざるを得なくっており、データ蓄積は停滞しているが、当初の目標症例数は達成できている。また、関連分野での研究結果を順次発表できており、研究成果を上げることができている。

Strategy for Future Research Activity

症例数は目標に到達したため、瞳孔の対光反応と運動耐容能や他の自律神経活動指標との関連、瞳孔対光反応と身体活動量の関連などについて、前向きが困難なため、暫定的に後ろ向きにデータ収集および解析を行い、その結果を発信していく予定である。
また、関連領域の研究結果も報告していく予定である。

Research Products

• [Journal Article] Prognostic value of liver damage assessed through direct bilirubin levels and skeletal muscle weakness in patients with heart failure (2023)
  • Author(s): Noda Takumi、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Maekawa Emi、Terada Tasuku、Reed Jennifer L.、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Heart & Lung Volume: 60 Pages: 87-94
  • DOI: 10.1016/j.hrtlng.2023.03.001
  • Peer Reviewed / Open Access
• [Journal Article] SARC-F predicts poor motor function, quality of life, and prognosis in older patients with cardiovascular disease and cognitive impairment (2023)
  • Author(s): Noda Takumi、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Ueno Kensuke、Maekawa Emi、Terada Tasuku、Reed Jennifer L.、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Experimental Gerontology Volume: 171 Pages: 112021-112021
  • DOI: 10.1016/j.exger.2022.112021
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic impact of the coexistence of hepato-renal dysfunction and frailty in patients with heart failure (2023)
  • Author(s): Noda Takumi、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Maekawa Emi、Terada Tasuku、Reed Jennifer L.、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Journal of Cardiology Volume: 81 Issue: 2 Pages: 215-221
  • DOI: 10.1016/j.jjcc.2022.08.015
  • Peer Reviewed
• [Journal Article] Sex Differences in Frequency of Instrumental Activities of Daily Living after Cardiac Rehabilitation and Its Impact on Outcomes in Patients with Heart Failure (2022)
  • Author(s): Nozaki Kohei、Hamazaki Nobuaki、Kamiya Kentaro、Kariya Hidenori、Uchida Shota、Noda Takumi、Ueno Kensuke、Maekawa Emi、Matsunaga Atsuhiko、Yamaoka-Tojo Minako、Ako Junya
  • Journal Title: Journal of Cardiovascular Development and Disease Volume: 9 Issue: 9 Pages: 289-289
  • DOI: 10.3390/jcdd9090289
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Utility of the Fatigue, Resistance, Ambulation, Illness, and Loss of weight Scale in Older Patients with Cardiovascular Disease (2022)
  • Author(s): Yamato Yohei、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Noda Takumi、Maekawa Emi、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Journal of the American Medical Directors Association Volume: 23 Issue: 12 Pages: 1971-1976.e2
  • DOI: 10.1016/j.jamda.2022.08.006
  • Peer Reviewed
• [Journal Article] Usefulness of measuring maximal gait speed in conjunction with usual gait speed for risk stratification in patients with cardiovascular disease (2022)
  • Author(s): Ueno Kensuke、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Noda Takumi、Maekawa Emi、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Experimental Gerontology Volume: 164 Pages: 111810-111810
  • DOI: 10.1016/j.exger.2022.111810
  • Peer Reviewed / Open Access
• [Journal Article] Optimal cutoff values for physical function tests in elderly patients with heart failure (2022)
  • Author(s): Aida Keita、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Nakamura Takeshi、Yamashita Masashi、Uchida Shota、Maekawa Emi、Reed Jennifer L.、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 6920-6920
  • DOI: 10.1038/s41598-022-10622-0
  • Peer Reviewed / Open Access
• [Journal Article] Correlation between respiratory muscle weakness and frailty status as risk markers for poor outcomes in patients with cardiovascular disease (2022)
  • Author(s): Hamazaki Nobuaki、Kamiya Kentaro、Nozaki Kohei、Yamashita Masashi、Uchida Shota、Noda Takumi、Maekawa Emi、Meguro Kentaro、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: European Journal of Cardiovascular Nursing Volume: in press Issue: 8 Pages: 782-790
  • DOI: 10.1093/eurjcn/zvac014
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Effects of electrical muscle stimulation on physical function in frail older patients with acute heart failure: a randomized controlled trial (2022)
  • Author(s): Tanaka Shinya、Kamiya Kentaro、Matsue Yuya、Yonezawa Ryusuke、Saito Hiroshi、Hamazaki Nobuaki、Matsuzawa Ryota、Nozaki Kohei、Yamashita Masashi、Wakaume Kazuki、Endo Yoshiko、Maekawa Emi、Yamaoka-Tojo Minako、Shiono Takaaki、Inomata Takayuki、Ako Junya
  • Journal Title: European Journal of Preventive Cardiology Volume: in press Issue: 8 Pages: e286-e288
  • DOI: 10.1093/eurjpc/zwac022
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Impact of Preoperative Muscle Strength on Walking Independence After Total Hip Arthroplasty (2022)
  • Author(s): Nozaki Kohei、Nanri Yuta、Yamamoto Shohei、Hamazaki Nobuaki、Noda Takumi、Yamashita Masashi、Shirota Takehiro、Uchiyama Katsufumi、Fukushima Kensuke、Kamiya Kentaro、Takahira Naonobu、Takaso Masashi
  • Journal Title: Journal of the American Medical Directors Association Volume: 23 Issue: 4 Pages: 695-697
  • DOI: 10.1016/j.jamda.2021.11.006
  • Peer Reviewed
• [Journal Article] Work status before admission relates to prognosis in older patients with heart failure partly through social frailty (2022)
  • Author(s): Yamashita Masashi、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、et al.
  • Journal Title: Journal of Cardiology Volume: 79 Issue: 3 Pages: 439-445
  • DOI: 10.1016/j.jjcc.2021.10.029
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Gait speed and 6-minute walking distance are useful for identifying difficulties in activities of daily living in patients with cardiovascular disease (2022)
  • Author(s): Sato Ayaka、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Maekawa Emi、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Heart & Lung Volume: 51 Pages: 46-51
  • DOI: 10.1016/j.hrtlng.2021.09.002
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Relationship between high‐sensitivity cardiac troponin T, B‐type natriuretic peptide, and physical function in patients with heart failure (2021)
  • Author(s): Ueno Kensuke、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Yanagi Naoya、Maekawa Emi、Yamaoka‐Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: ESC Heart Failure Volume: 8 Issue: 6 Pages: 5092-5101
  • DOI: 10.1002/ehf2.13577
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Assessment of Sarcopenia in the Intensive Care Unit and 1-Year Mortality in Survivors of Critical Illness (2021)
  • Author(s): Yanagi Naoya、Koike Tomotaka、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Matsunaga Atsuhiko、Kuroiwa Masayuki、Arai Masayasu
  • Journal Title: Nutrients Volume: 13 Issue: 8 Pages: 2726-2726
  • DOI: 10.3390/nu13082726
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Usefulness of physical function sub-item of SF-36 survey to predict exercise intolerance in patients with heart failure (2021)
  • Author(s): Ueno Kensuke、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Uchida Shota、Kawabata Masashi、Maekawa Emi、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: European Journal of Cardiovascular Nursing Volume: 21 Issue: 2 Pages: 174-177
  • DOI: 10.1093/eurjcn/zvab052
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Clinical usefulness of oxygen uptake during usual gait in patients with cardiovascular disease (2021)
  • Author(s): Hamazaki Nobuaki、Kamiya Kentaro、Nozaki Kohei、Yanagi Naoya、Ichikawa Takafumi、Matsuzawa Ryota、Nakamura Takeshi、Yamashita Masashi、Uchida Shota、Saito Teppei、Maekawa Emi、Meguro Kentaro、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: International Journal of Cardiology Volume: 335 Pages: 118-122
  • DOI: 10.1016/j.ijcard.2021.04.049
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Low skeletal muscle density combined with muscle dysfunction predicts adverse events after adult cardiovascular surgery (2021)
  • Author(s): Yamashita M, Kamiya K, Matsunaga A, Kitamura T, Hamazaki N, Nozaki K, Ichikawa T, Maekawa E, Meguro K, Yamaoka-Tojo M, Ako J, Miyaji K.
  • Journal Title: Nutr Metab Cardiovasc Dis Volume: － Issue: 6 Pages: 1782-1790
  • DOI: 10.1016/j.numecd.2021.02.012
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Associations between kidney function and outcomes of comprehensive cardiac rehabilitation in patients with heart failure (2021)
  • Author(s): Hamazaki Nobuaki、Kamiya Kentaro、Yamamoto Shohei、Nozaki Kohei、Ichikawa Takafumi、Matsuzawa Ryota、Yamashita Masashi、Uchida Shota、Maekawa Emi、Meguro Kentaro、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Clinical Research in Cardiology Volume: 111 Issue: 3 Pages: 253-263
  • DOI: 10.1007/s00392-021-01875-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hemodynamic Changes During Neuromuscular Electrical Stimulation and Mobility Therapy for an Advanced Heart Failure Patient with Impella 5.0 Device (2021)
  • Author(s): Nozaki Kohei、Hamazaki Nobuaki、Ikeda Yuki、Nihei Manami、Kobayashi Shuken、Kamiya Kentaro、Maekawa Emi、Matsunaga Atsuhiko、Yamaoka-Tojo Minako、Ako Junya
  • Journal Title: International Heart Journal Volume: 62 Issue: 3 Pages: 695-699
  • DOI: 10.1536/ihj.20-632
  • NAID: 130008045566
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic utility of dynapenia in patients with cardiovascular disease (2021)
  • Author(s): Uchida Shota、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Nakamura Takeshi、Yamashita Masashi、Maekawa Emi、Reed Jennifer L.、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Clinical Nutrition Volume: 40 Issue: 4 Pages: 2210-2218
  • DOI: 10.1016/j.clnu.2020.09.050
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Validity and Utility of the Questionnaire-based FRAIL Scale in Older Patients with Heart Failure: Findings from the FRAGILE-HF (2021)
  • Author(s): Nozaki K, Kamiya K, Hamazaki N, Saito H, Saito K, Ogasahara Y, Maekawa E, Konishi M, Kitai T, Iwata K, Jujo K, Wada H, Kasai T, Nagamatsu H, Ozawa T, Izawa K, Yamamoto S, Aizawa N, Makino A, Oka K, Momomura SI, Kagiyama N, Matsue Y.
  • Journal Title: J Am Med Dir Assoc Volume: － Issue: 8 Pages: 1621-1626.e2
  • DOI: 10.1016/j.jamda.2021.02.025
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Post-intensive care syndrome as a predictor of mortality in patients with critical illness: A cohort study (2021)
  • Author(s): Yanagi Naoya、Kamiya Kentaro、Hamazaki Nobuaki、Matsuzawa Ryota、Nozaki Kohei、Ichikawa Takafumi、Valley Thomas S.、Nakamura Takeshi、Yamashita Masashi、Maekawa Emi、Koike Tomotaka、Yamaoka-Tojo Minako、Arai Masayasu、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: PLOS ONE Volume: 16 Issue: 3 Pages: 0244564-0244564
  • DOI: 10.1371/journal.pone.0244564
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic value of cardio-hepatic-skeletal muscle syndrome in patients with heart failure (2021)
  • Author(s): Noda Takumi、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Nakamura Takeshi、Yamashita Masashi、Uchida Shota、Maekawa Emi、Reed Jennifer L.、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 3715-3715
  • DOI: 10.1038/s41598-020-80641-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quadriceps Strength and Mortality in Older Patients With Heart Failure (2021)
  • Author(s): Nakamura Takeshi、Kamiya Kentaro、Hamazaki Nobuaki、Matsuzawa Ryota、Nozaki Kohei、Ichikawa Takafumi、Yamashita Masashi、Maekawa Emi、Reed Jennifer L.、Noda Chiharu、Meguro Kentaro、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Canadian Journal of Cardiology Volume: 37 Issue: 3 Pages: 476-483
  • DOI: 10.1016/j.cjca.2020.06.019
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The GLIM criteria for defining malnutrition can predict physical function and prognosis in patients with cardiovascular disease (2021)
  • Author(s): Kootaka Yoshifumi、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Ichikawa Takafumi、Nakamura Takeshi、Yamashita Masashi、Maekawa Emi、Reed Jennifer L.、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: Clinical Nutrition Volume: 40 Issue: 1 Pages: 146-152
  • DOI: 10.1016/j.clnu.2020.04.038
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Usefulness of the Simplified Frailty Scale in Predicting Risk of Readmission or Mortality in Elderly Patients Hospitalized with Cardiovascular Disease (2020)
  • Author(s): Aida Keita、Kamiya Kentaro、Hamazaki Nobuaki、Matsuzawa Ryota、Nozaki Kohei、Ichikawa Takafumi、Nakamura Takeshi、Yamashita Masashi、Maekawa Emi、Yamaoka-Tojo Minako、Matsunaga Atsuhiko、Ako Junya
  • Journal Title: International Heart Journal Volume: 61 Issue: 3 Pages: 571-578
  • DOI: 10.1536/ihj.19-557
  • NAID: 130007849596
  • ISSN: 1349-2365, 1349-3299
  • Year and Date: 2020-05-30
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic value of pupil area for all‐cause mortality in patients with heart failure (2020)
  • Author(s): Nozaki Kohei、Hamazaki Nobuaki、Yamamoto Shohei、Kamiya Kentaro、Tanaka Shinya、Ichikawa Takafumi、Nakamura Takeshi、Yamashita Masashi、Maekawa Emi、Matsunaga Atsuhiko、Yamaoka‐Tojo Minako、Ako Junya
  • Journal Title: ESC Heart Failure Volume: 7 Issue: 5 Pages: 3067-3074
  • DOI: 10.1002/ehf2.12933
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Changes in Respiratory Muscle Strength Following Cardiac Rehabilitation for Prognosis in Patients with Heart Failure. (2020)
  • Author(s): Nobuaki Hamazaki,Kentaro Kamiya,Shohei Yamamoto,Kohei Nozaki,Takafumi Ichikawa,Ryota Matsuzawa,Shinya Tanaka,Takeshi Nakamura,Masashi Yamashita,Emi Maekawa,Kentaro Meguro,Chiharu Noda,Minako Yamaoka-Tojo,Atsuhiko Matsunaga,Junya Ako
  • Journal Title: Journal of clinical medicine Volume: 9 Issue: 4 Pages: 952-964
  • DOI: 10.3390/jcm9040952
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Short-Term Change in Gait Speed and Clinical Outcomes in Older Patients With Acute Heart Failure (2019)
  • Author(s): Shinya Tanaka,Kentaro Kamiya,Nobuaki Hamazaki,Ryota Matsuzawa,Kohei Nozaki,Takeshi Nakamura,Masashi Yamashita,Emi Maekawa,Chiharu Noda,Minako Yamaoka-Tojo,Atsuhiko Matsunaga,Takashi Masuda,Junya Ako
  • Journal Title: Circulation Journal Volume: 83 Issue: 9 Pages: 1860-1867
  • DOI: 10.1253/circj.CJ-19-0136
  • NAID: 130007695043
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2019-08-23
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Rising time from bed in acute phase after hospitalization predicts frailty at hospital discharge in patients with acute heart failure. (2019)
  • Author(s): Kohei Nozaki,Nobuaki Hamazaki,Kentaro Kamiya,Takafumi Ichikawa,Takeshi Nakamura,Masashi Yamashita,Emi Maekawa,Atsuhiko Matsunaga,Minako Yamaoka-Tojo,Junya Ako
  • Journal Title: Journal of cardiology Volume: 75 Issue: 6 Pages: 587-593
  • DOI: 10.1016/j.jjcc.2019.12.007
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Papillary light reflex as a new prognostic marker in patients with heart failure. (2019)
  • Author(s): Nozaki K, Kamiya K, Matsue Y, Hamazaki N, Matsuzawa R, Tanaka S, Maekawa E, Kishi T, Matsunaga A, Masuda T, Izumi T, Ako J
  • Journal Title: J Cardiac Fail Volume: 25(3) Issue: 3 Pages: 156-163
  • DOI: 10.1016/j.cardfail.2018.09.009
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic value of instrumental activity of daily living in initial heart failure hospitalization patients aged 65ツ?years or older. (2019)
  • Author(s): Masashi Yamashita,Kentaro Kamiya,Nobuaki Hamazaki,Ryota Matsuzawa,Kohei Nozaki,Takafumi Ichikawa,Takeshi Nakamura,Emi Maekawa,Minako Yamaoka-Tojo,Atsuhiko Matsunaga,Junya Ako
  • Journal Title: Heart and vessels Volume: 35 Issue: 3 Pages: 273-278
  • DOI: 10.1007/s00380-019-01490-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Impact of Gait Speed on the Obesity Paradox in Older Patients With Cardiovascular Disease. (2019)
  • Author(s): Takeshi Nakamura,Kentaro Kamiya,Atsuhiko Matsunaga,Nobuaki Hamazaki,Ryota Matsuzawa,Kohei Nozaki,Masashi Yamashita,Emi Maekawa,Chiharu Noda,Minako Yamaoka-Tojo,Junya Ako
  • Journal Title: The American journal of medicine Volume: 132 Issue: 12 Pages: 1458-1465
  • DOI: 10.1016/j.amjmed.2019.06.047
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic value of sarcopenic obesity estimated by computed tomography in patients with cardiovascular disease and undergoing surgery (2019)
  • Author(s): Yamashita Masashi、Kamiya Kentaro、Matsunaga Atsuhiko、Kitamura Tadashi、Hamazaki Nobuaki、Matsuzawa Ryota、Nozaki Kohei、Tanaka Shinya、Nakamura Takeshi、Maekawa Emi、Masuda Takashi、Ako Junya、Miyaji Kagami
  • Journal Title: Journal of Cardiology Volume: 未決定 Issue: 3 Pages: 273-278
  • DOI: 10.1016/j.jjcc.2019.02.010
  • Peer Reviewed
• [Journal Article] Office-Based Physical Assessment in Patients Aged 75 Years and Older with Cardiovascular Disease (2019)
  • Author(s): Matsuzawa Ryota、Kamiya Kentaro、Hamazaki Nobuaki、Nozaki Kohei、Tanaka Shinya、Maekawa Emi、Matsunaga Atsuhiko、Masuda Takashi、Ako Junya
  • Journal Title: Gerontology Volume: 65 Issue: 2 Pages: 128-135
  • DOI: 10.1159/000493527
  • Peer Reviewed / Open Access
• [Journal Article] Preoperative skeletal muscle density is associated with postoperative mortality in patients with cardiovascular disease (2019)
  • Author(s): Yamashita Masashi、Kamiya Kentaro、Matsunaga Atsuhiko、Kitamura Tadashi、Hamazaki Nobuaki、Matsuzawa Ryota、Nozaki Kohei、Ichikawa Takafumi、Nakamura Takeshi、Yamamoto Shohei、Kariya Hidenori、Maekawa Emi、Meguro Kentaro、Ogura Misao、Yamaoka-Tojo Minako、Ako Junya、Miyaji Kagami
  • Journal Title: Interactive CardioVascular and Thoracic Surgery Volume: 30 Issue: 4 Pages: 515-522
  • DOI: 10.1093/icvts/ivz307
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Presentation] Sex differences in frequency of instrumental activities of daily living after cardiac rehabilitation and its impact on long-term mortality in patients with heart failure (2022)
  • Author(s): Kohei Nozaki, Nobuaki Hamazaki, Kentaro Kamiya, Shota Uchida, Takumi Noda, Emi Maekawa, Atsuhiko Matsunaga, Minako Yamaoka-Tojo, Junya Ako
  • Organizer: ESC Congress 2022
  • Int'l Joint Research
• [Presentation] 急性心不全患者に対する早期リハビリテーションの有用性 (2022)
  • Author(s): 野﨑康平
  • Organizer: 第7回日本心臓リハビリテーション学会関東甲信越支部地方会学術集会
  • Invited
• [Presentation] 循環器理学療法プログラムの最適解を探る～筋消耗・サルコペニアの治療戦略～ 筋力 (2022)
  • Author(s): 野﨑康平
  • Organizer: 第6回日本循環器理学療法学会学術集会
  • Invited
• [Presentation] 心不全患者における外来心臓リハビリテーション終了時のIADLと予後との関係 (2022)
  • Author(s): 野崎康平、神谷健太郎、濱嵜伸明、小林主献、苅谷英紀、前川恵美、東條美奈子、松永篤彦、阿古潤哉
  • Organizer: 第28回日本心臓リハビリテーション学会学術集会
• [Presentation] がんリハの特徴と心リハとの連携 (2022)
  • Author(s): 野﨑康平
  • Organizer: 第28回日本心臓リハビリテーション学会学術集会
  • Invited
• [Presentation] 高齢心不全患者における外来心臓リハビリテーション終了時の手段的日常生活活動実施頻度と予後との関係 (2022)
  • Author(s): 野崎康平、濱嵜伸明、神谷健太郎、苅谷英紀、内田翔太、野田匠、上野兼輔、前川恵美、東條美奈子、松永篤彦、阿古潤哉
  • Organizer: 第26回日本心不全学会学術集会
• [Presentation] Validity and utility of the questionnaire-based FRAIL scale in elderly patients with heart failure: Findings from the FRAGILE-HF (2021)
  • Author(s): Kohei Nozaki
  • Organizer: ESC congress 2021
  • Int'l Joint Research
• [Presentation] IMPELLA 5.0挿入患者に対するリハビリテーションと筋力・活動度の改善―症例報告― (2021)
  • Author(s): 野崎康平
  • Organizer: 第27回日本心臓リハビリテーション学会学術集会
• [Presentation] 高齢心不全の健康寿命と循環器理学療法の最新トピックス (2021)
  • Author(s): 野崎康平
  • Organizer: 第1回循環器理学療法トピックス・症例検討サテライトカンファレンス
  • Invited
• [Presentation] U-40 特別企画1 Pros-Cons 高齢心不全に立ち向かう 有酸素運動の有用性 (2020)
  • Author(s): 野崎康平
  • Organizer: 第25回日本心臓リハビリテーション学会
  • Invited
• [Presentation] 瞳孔面積は心不全患者の予後を予測する新たな指標である (2019)
  • Author(s): 野崎康平、神谷健太郎、中村岳史、山下真司、前川恵美、松永篤彦、東條美奈子、阿古潤哉
  • Organizer: 日本心不全学会学術集会
• [Presentation] 野崎康平、神谷健太郎、濱崎伸明、中村岳史、前川恵美 (2019)
  • Author(s): ステージ Cの運動療法の実際
  • Organizer: 第23回日本心不全学会学術集会
  • Invited
• [Presentation] Pupillary area predicts all-cause mortality in patients with cardiovascular disease (2019)
  • Author(s): Kohei Nozaki, Kentaro Kamiya, Nobuaki Hamazaki, Ryota Matsuzawa, Takafumi Ichikawa, Takeshi Nakamura, Masashi Yamashita, Emi Maekawa, Atsuhiko Matsunaga, Minako Yamaoka-Tojo, Junya Ako
  • Organizer: European Society of Cardiology Congress 2019
  • Int'l Joint Research
• [Presentation] 高齢心不全患者における初回離床時の起き上がり時間は退院時のフレイルを予測する (2019)
  • Author(s): 野崎康平、神谷健太郎、濱嵜伸明、松沢良太、市川貴文、中村岳史、山下真司、前川恵美、松永篤彦、増田卓、阿古潤哉
  • Organizer: 第25回日本心臓リハビリテーション学会学術集会