The roles of basolateral amygdala in regulation of optimism and pessimism
| Project/Area Number |
19K21807
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| Research Category |
Grant-in-Aid for Challenging Research (Exploratory)
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| Allocation Type | Multi-year Fund |
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| Review Section |
Medium-sized Section 10:Psychology and related fields
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| Research Institution | University of Tsukuba |
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Principal Investigator |
ZHANG Qi 筑波大学, 人間系, 助教 (20525604)
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| Project Period (FY) |
2019-06-28 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2020: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2019: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
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| Keywords | optimism and pessimism / basolateral amygadla / neural circuit / fiber photometry / calcium imaging / optogenetics / basolateral amygdala / cognitive bias, / optimism, / pessimism, / basolateral amygdala, / stereotype, / neural circuit, / retrograde tracing / optimism / pessimism / amygdala / circuit / cognitive bias |
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| Outline of Research at the Start |
Pessimistic individuals have great risks to catch many diseases. Current project will use cutting-edge technology to elucidate the neural mechanisms underlying optimism and pessimism, and in turn to provide a new approach for health improvement, prevention and therapeutic intervention of diseases.
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| Outline of Final Research Achievements |
Human beings show different personality stereotype in their ways of thinking: either more optimistic or more pessimistic. Although fMRI studies in humans implicate that prefrontal cortex and amygdala are involved, the neural circuit mechanisms underlying optimism and pessimism are poorly understood and can only be fully examined in animal models. To date no study has been really done to investigate the cellular and neural circuit mechanisms underlying optimism and pessimism. Current project used advanced behavioral analysis, calcium imaging and optogenetics technology to identify the critical neural populations in basolateral amygdala responsible for optimism and pessimism. This project will provide a new approach for health improvement, and prevention and therapeutic invention of many diseases. It will also deepen our understandings on the neural mechanisms mediating personality stereotypes, which is becoming a hot topic in neuroscience.
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| Academic Significance and Societal Importance of the Research Achievements |
Successful living requires a fine balance between optimistic and pessimistic thinking. Understanding of the neural circuit mechanisms underlying optimism and pessimism will provide a new approach for health improvement, and prevention and therapeutic invention of many diseases.
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Report
(3 results)
Research Products
(15 results)
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[Journal Article] Limb-clasping, cognitive deficit and increased vulnerability to kainic acid - induced seizures in neuronal GPI anchor deficiency mouse models.2021
Author(s)
Kandasamy L, Tsukamoto M, Banov V, Tsetsegee S, Nagasawa Y, Kato M, Matsumoto N, Takeda J, Itohara S, Ogawa S, Young L, Zhang Q
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Journal Title
Human Molecular Genetics
Volume: 30(9)
Issue: 9
Pages: 758-770
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] The important roles of PIGA gene in brain development and epileptic encephalopathy revealed by tissue-specific knockout2020
Author(s)
Kandasamy LC, Kato M, Matsumoto N, Takeda J, Itohara S, Ogawa S, Young LJ, Zhang Q .
Organizer
The 43rd Annual Meeting of Japan Neuroscience Society, Kobe, Japan, July2020
Related Report
Int'l Joint Research
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